MIXL1

Summary

MIXL1 (Mix paired-like homeobox, HGNC:13363) is a protein-coding gene on chromosome 1q42.12, encoding Homeobox protein MIXL1 (Q9H2W2). Transcription factor that play a central role in proper axial mesendoderm morphogenesis and endoderm formation.

Enables RNA polymerase II-specific DNA-binding transcription factor binding activity and sequence-specific double-stranded DNA binding activity. Predicted to be involved in several processes, including endodermal cell differentiation; negative regulation of hematopoietic progenitor cell differentiation; and positive regulation of mesoderm development. Predicted to act upstream of or within cell migration involved in gastrulation and hemopoiesis. Located in nucleoplasm.

Source: NCBI Gene 83881 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 39 total
• MANE Select transcript: NM_031944

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:13363
Approved symbol	MIXL1
Name	Mix paired-like homeobox
Location	1q42.12
Locus type	gene with protein product
Status	Approved
Aliases	MILD1, MIXL
Ensembl gene	ENSG00000185155
Ensembl biotype	protein_coding
OMIM	609852
Entrez	83881

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 2 protein_coding, 1 protein_coding_CDS_not_defined

ENST00000366810, ENST00000542034, ENST00000557734

RefSeq mRNA: 2 — MANE Select: NM_031944 NM_001282402, NM_031944

CCDS: CCDS1552, CCDS60432

Canonical transcript exons

ENST00000366810 — 2 exons

Exon	Start	End
ENSE00002485896	226225507	226227060
ENSE00003902013	226223664	226224074

Expression profiles

Bgee: expression breadth broad, 100 present calls, max score 88.12.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 1.7337 / max 189.8406, expressed in 156 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
8864	1.4639	94
8863	0.0982	46
8865	0.0873	46
8866	0.0843	37

Top tissues by expression

217 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
oocyte	CL:0000023	88.12	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	80.91	gold quality
secondary oocyte	CL:0000655	80.74	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	78.84	silver quality
bone marrow cell	CL:0002092	76.44	gold quality
lymph node	UBERON:0000029	67.51	gold quality
gingival epithelium	UBERON:0001949	67.46	gold quality
gingiva	UBERON:0001828	64.02	gold quality
vermiform appendix	UBERON:0001154	62.27	gold quality
parotid gland	UBERON:0001831	61.29	gold quality
caecum	UBERON:0001153	60.01	gold quality
epithelium of nasopharynx	UBERON:0001951	59.88	gold quality
tonsil	UBERON:0002372	59.09	gold quality
esophagus squamous epithelium	UBERON:0006920	58.75	gold quality
biceps brachii	UBERON:0001507	58.42	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	57.88	gold quality
colonic epithelium	UBERON:0000397	57.87	silver quality
upper leg skin	UBERON:0004262	57.80	silver quality
amniotic fluid	UBERON:0000173	57.63	gold quality
pigmented layer of retina	UBERON:0001782	57.53	gold quality
oral cavity	UBERON:0000167	57.26	gold quality
cerebellar cortex	UBERON:0002129	57.00	gold quality
duodenum	UBERON:0002114	56.97	gold quality
nasal cavity epithelium	UBERON:0005384	56.80	gold quality
cerebellum	UBERON:0002037	56.75	gold quality
cerebellar hemisphere	UBERON:0002245	56.69	gold quality
Brodmann (1909) area 23	UBERON:0013554	56.25	gold quality
mucosa of transverse colon	UBERON:0004991	56.07	gold quality
rectum	UBERON:0001052	55.93	gold quality
superficial temporal artery	UBERON:0001614	55.89	gold quality

Single-cell (SCXA)

Detected in 9 experiment(s), a significant marker in 6.

Experiment	Marker?	Max mean expression
E-MTAB-5061	yes	1819.12
E-GEOD-109979	yes	1035.13
E-MTAB-7052	yes	152.98
E-CURD-6	yes	39.16
E-MTAB-9067	yes	9.08
E-ANND-3	yes	5.86
E-CURD-97	no	95.71
E-MTAB-7303	no	28.50
E-MTAB-7249	no	18.51

Regulation

Is transcription factor: yes

Downstream targets (CollecTRI)

7 targets.

Target	Regulation
CXCR4	Activation
GSC	Activation
HBA1	Activation
KDR	Activation
MIXL1
PDGFRA	Activation
TBXT	Activation

JASPAR motifs

Motif	Name	Family
MA0662.1	MIXL1	Paired-related HD factors
MA0662.2	MIXL1	Paired-related HD factors

JASPAR matrix evidence (PMIDs): PMID:19711456

Upstream regulators (CollecTRI, top): FOXH1, GLI3, GSC, KDM6B, MIXL1

miRNA regulators (miRDB)

61 targeting MIXL1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-150-5P	99.99	66.69	1976
HSA-MIR-12136	99.98	72.81	5713
HSA-MIR-302E	99.96	70.74	2669
HSA-MIR-1468-3P	99.96	72.74	3797
HSA-MIR-10527-5P	99.91	72.28	3754
HSA-MIR-302A-3P	99.89	71.23	1777
HSA-MIR-302B-3P	99.89	71.23	1777
HSA-MIR-302C-3P	99.89	71.20	1778
HSA-MIR-302D-3P	99.89	71.25	1777
HSA-MIR-659-3P	99.85	70.69	1620
HSA-MIR-4728-5P	99.85	69.39	4718
HSA-MIR-373-3P	99.84	70.68	1668
HSA-MIR-520E-3P	99.84	70.55	1698
HSA-MIR-372-3P	99.83	70.58	1691
HSA-MIR-520A-3P	99.83	70.59	1687
HSA-MIR-520B-3P	99.83	70.56	1699
HSA-MIR-520C-3P	99.83	70.56	1699
HSA-MIR-520D-3P	99.83	70.78	1676
HSA-MIR-1323	99.83	69.89	2471
HSA-MIR-6785-5P	99.82	68.68	4428
HSA-MIR-4639-5P	99.81	67.37	1028
HSA-MIR-2052	99.79	69.37	2031
HSA-MIR-548AJ-5P	99.78	71.12	3085
HSA-MIR-548F-5P	99.78	71.02	3093
HSA-MIR-548G-5P	99.78	71.12	3085
HSA-MIR-548X-5P	99.78	71.12	3085
HSA-MIR-6764-5P	99.75	67.89	2304
HSA-MIR-548O-3P	99.74	69.30	2228
HSA-MIR-4306	99.72	70.50	3630
HSA-MIR-149-3P	99.72	68.22	3963

Literature-anchored findings (GeneRIF, showing 7)

• shows functional similarity to Xenopus Mix.1 (PMID:12070013)
• These results demonstrate for a functional role for TGF-beta ligands in regulation of mammalian Mixl1, identify FoxH1 as an essential co-activator, and implicate Nodal as the embryonic regulator of Mixl1 in mesendoderm morphogenesis. (PMID:15982639)
• MIXL1 protein is differentially expressed in non-Hodgkin lymphoma and Hodgkin lymphoma; findings suggest that MIXL1 overexpression may play a role in driving proliferatin or blocking differentiation in lymphoma oncogenesis (PMID:17303500)
• Targeted insertion in human embryonic stem cells of sequences encoding green fluorescent protein (GFP) into the locus of MIXL1, a gene transiently expressed in the primitive streak during embryogenesis. (PMID:18032708)
• Brachyury and related Tbx proteins interact with the Mixl1 homeodomain protein and negatively regulate Mixl1 transcriptional activity (PMID:22164283)
• results demonstrate that Mixl1 and Flk1 play roles…during dimethyl sulfoxide-induced mesodermal specification in P19 cells. (PMID:25521758)
• Findings support the existence of a novel MIXL1-c REL mediated survival axis in AML that can be targeted by BMPR1 inhibitors. (MIXL1- human gene, Mixl1- mouse ortholog, MIXL1- protein). (PMID:25544748)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	mixl1	ENSDARG00000069252
mus_musculus	Mixl1	ENSMUSG00000026497
rattus_norvegicus	Mixl1	ENSRNOG00000003176

Paralogs (50): ARX (ENSG00000004848), PAX6 (ENSG00000007372), PAX7 (ENSG00000009709), ALX4 (ENSG00000052850), GSC2 (ENSG00000063515), PITX1 (ENSG00000069011), PAX2 (ENSG00000075891), RHOXF1 (ENSG00000101883), CRX (ENSG00000105392), EVX1 (ENSG00000106038), PAX4 (ENSG00000106331), NOBOX (ENSG00000106410), PITX3 (ENSG00000107859), PHOX2B (ENSG00000109132), OTX1 (ENSG00000115507), PRRX1 (ENSG00000116132), VSX2 (ENSG00000119614), ESX1 (ENSG00000123576), PAX8 (ENSG00000125618), PAX1 (ENSG00000125813), RHOXF2 (ENSG00000131721), GSC (ENSG00000133937), RAX (ENSG00000134438), PAX3 (ENSG00000135903), ALX3 (ENSG00000156150), HESX1 (ENSG00000163666), PITX2 (ENSG00000164093), UNCX (ENSG00000164853), PHOX2A (ENSG00000165462), OTX2 (ENSG00000165588), DRGX (ENSG00000165606), PRRX2 (ENSG00000167157), SHOX2 (ENSG00000168779), OTP (ENSG00000171540), RAX2 (ENSG00000173976), EVX2 (ENSG00000174279), PROP1 (ENSG00000175325), ISX (ENSG00000175329), ALX1 (ENSG00000180318), SHOX (ENSG00000185960)

Protein

Protein identifiers

Homeobox protein MIXL1 — Q9H2W2 (reviewed: Q9H2W2)

Alternative names: Homeodomain protein MIX, MIX1 homeobox-like protein 1, Mix.1 homeobox-like protein

All UniProt accessions (1): Q9H2W2

UniProt curated annotations — full annotation on UniProt →

Function. Transcription factor that play a central role in proper axial mesendoderm morphogenesis and endoderm formation. Required for efficient differentiation of cells from the primitive streak stage to blood, by acting early in the recruitment and/or expansion of mesodermal progenitors to the hemangioblastic and hematopoietic lineages. Also involved in the morphogenesis of the heart and the gut during embryogenesis. Acts as a negative regulator of brachyury expression.

Subcellular location. Nucleus.

Tissue specificity. Restricted to progenitors and secondary lymph tissues. In normal hematopoiesis, it is restricted to immature B- and T-lymphoid cells. Present in differentiating embryonic stem cells (at protein level).

Post-translational modifications. Phosphorylated at multiple sites.

Similarity. Belongs to the paired homeobox family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q9H2W2-1	1	yes
Q9H2W2-2	2

RefSeq proteins (2): NP_001269331, NP_114150* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001356	HD	Domain
IPR009057	Homeodomain-like_sf	Homologous_superfamily
IPR017970	Homeobox_CS	Conserved_site
IPR042917	MIXL1	Family

Pfam: PF00046

UniProt features (8 total): compositionally biased region 3, chain 1, DNA-binding region 1, region of interest 1, modified residue 1, splice variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9H2W2-F1	67.02	0.25

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 20

Function

Pathways and Gene Ontology

Reactome pathways

4 pathways

ID	Pathway
R-HSA-9754189	Germ layer formation at gastrulation
R-HSA-9823730	Formation of definitive endoderm
R-HSA-1266738	Developmental Biology
R-HSA-9758941	Gastrulation

MSigDB gene sets: 97 (showing top): GOBP_HEMATOPOIETIC_PROGENITOR_CELL_DIFFERENTIATION, GOBP_FORMATION_OF_PRIMARY_GERM_LAYER, GOBP_AMEBOIDAL_TYPE_CELL_MIGRATION, GOBP_DIGESTIVE_SYSTEM_DEVELOPMENT, GOBP_NEGATIVE_REGULATION_OF_HEMATOPOIETIC_PROGENITOR_CELL_DIFFERENTIATION, GOBP_REGULATION_OF_MESODERM_DEVELOPMENT, GOBP_CELL_MIGRATION_INVOLVED_IN_GASTRULATION, GOBP_GASTRULATION, GOBP_ENDODERM_DEVELOPMENT, GOBP_REGULATION_OF_HEMATOPOIETIC_PROGENITOR_CELL_DIFFERENTIATION, GOBP_NEGATIVE_REGULATION_OF_DEVELOPMENTAL_PROCESS, GOBP_ENDODERM_FORMATION, GOBP_EMBRYO_DEVELOPMENT, GOBP_POSITIVE_REGULATION_OF_DEVELOPMENTAL_PROCESS, GOBP_MESODERM_DEVELOPMENT

GO Biological Process (15): endoderm formation (GO:0001706), hematopoietic progenitor cell differentiation (GO:0002244), regulation of transcription by RNA polymerase II (GO:0006357), gastrulation (GO:0007369), endoderm development (GO:0007492), heart development (GO:0007507), endodermal cell differentiation (GO:0035987), cell migration involved in gastrulation (GO:0042074), positive regulation of transcription by RNA polymerase II (GO:0045944), digestive tract development (GO:0048565), negative regulation of hematopoietic progenitor cell differentiation (GO:1901533), positive regulation of mesoderm development (GO:2000382), regulation of DNA-templated transcription (GO:0006355), hemopoiesis (GO:0030097), cell differentiation (GO:0030154)

GO Molecular Function (9): RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), cis-regulatory region sequence-specific DNA binding (GO:0000987), DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228), protein homodimerization activity (GO:0042803), RNA polymerase II-specific DNA-binding transcription factor binding (GO:0061629), sequence-specific double-stranded DNA binding (GO:1990837), DNA binding (GO:0003677), identical protein binding (GO:0042802)

GO Cellular Component (3): chromatin (GO:0000785), nucleoplasm (GO:0005654), nucleus (GO:0005634)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
Gastrulation	2
Developmental Biology	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
RNA polymerase II transcription regulatory region sequence-specific DNA binding	3
cell differentiation	2
transcription by RNA polymerase II	2
endoderm formation	2
regulation of transcription by RNA polymerase II	2
cellular anatomical structure	2
formation of primary germ layer	1
endoderm development	1
hemopoiesis	1
regulation of DNA-templated transcription	1
ectoderm formation	1
mesoderm formation	1
embryonic morphogenesis	1
tissue development	1
animal organ development	1
circulatory system development	1
ameboidal-type cell migration	1
gastrulation	1
positive regulation of DNA-templated transcription	1
tube development	1
digestive system development	1
hematopoietic progenitor cell differentiation	1
negative regulation of cell differentiation	1
regulation of hematopoietic progenitor cell differentiation	1
mesoderm development	1
positive regulation of developmental process	1
regulation of mesoderm development	1
DNA-templated transcription	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
cell development	1
cellular developmental process	1
cis-regulatory region sequence-specific DNA binding	1
chromatin	1
DNA-binding transcription factor activity	1
transcription cis-regulatory region binding	1
DNA-binding transcription factor activity, RNA polymerase II-specific	1
DNA-binding transcription activator activity	1
positive regulation of transcription by RNA polymerase II	1
identical protein binding	1

Protein interactions and networks

STRING

1042 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
MIXL1	FOXH1	O75593	856
MIXL1	SOX17	Q9H6I2	839
MIXL1	FOXA2	Q9Y261	793
MIXL1	EOMES	O95936	775
MIXL1	NANOG	Q9H9S0	742
MIXL1	FOXA1	P55317	689
MIXL1	POU5F1	P31359	650
MIXL1	GATA4	P43694	645
MIXL1	SOX1	O00570	632
MIXL1	TBX6	O95947	628
MIXL1	GATA6	P78327	618
MIXL1	MESP1	Q9BRJ9	614
MIXL1	NODAL	Q96S42	597
MIXL1	BMP4	P12644	591
MIXL1	GATA1	P15976	591

IntAct

2 interactions, top by confidence:

A	B	Type	Score
MIXL1	TBXT	psi-mi:“MI:0915”(physical association)	0.400

BioGRID (1): MIXL1 (Proximity Label-MS)

ESM2 similar proteins: A1YEV8, A1YF08, A1YG25, A1YG85, A2RU54, A2T711, A2T756, A8MTQ0, O14813, O15522, O35160, O35602, O43763, O70218, P28360, P42580, P43687, P50223, P52945, P52946, P52947, P70118, P70354, P81062, Q06348, Q2VL79, Q2VL84, Q2VL85, Q2VL87, Q2VL88, Q61663, Q62066, Q62782, Q6XYB7, Q7YRX0, Q96IS3, Q99811, Q9DED6, Q9ER42, Q9GK08

Diamond homologs: A0A1W2PPF3, A1YEV8, A1YG25, A1YGA2, A2T711, A2T777, A6NLW8, F1NEA7, L8E946, O35602, O42201, O42250, O42356, O42357, O42358, O42567, O43186, O43812, O54751, O73592, O75360, O97039, O97670, P06601, P09082, P09083, P0CJ85, P0CJ86, P0CJ87, P0CJ88, P0CJ89, P0CJ90, P21711, P22810, P23759, P23760, P24610, P32242, P32243, P47239

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

39 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	38
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

111 predictions. Top by Δscore:

Variant	Effect	Δscore
1:226224071:CCAGG:C	donor_loss	1.0000
1:226224072:CAGGT:C	donor_loss	1.0000
1:226224073:AGGTG:A	donor_loss	1.0000
1:226224074:GGTGA:G	donor_loss	1.0000
1:226224075:GTG:G	donor_loss	1.0000
1:226225502:TCCA:T	acceptor_loss	1.0000
1:226225504:CA:C	acceptor_loss	1.0000
1:226225505:A:T	acceptor_loss	1.0000
1:226225506:GGT:G	acceptor_gain	1.0000
1:226225506:GGTAT:G	acceptor_gain	1.0000
1:226224075:G:GG	donor_gain	0.9900
1:226225506:GGTA:G	acceptor_gain	0.9900
1:226225503:CCAGG:C	acceptor_gain	0.9800
1:226225504:CAGG:C	acceptor_gain	0.9800
1:226225505:A:AG	acceptor_gain	0.9800
1:226225505:AG:A	acceptor_gain	0.9800
1:226225506:G:GA	acceptor_gain	0.9800
1:226225506:GG:G	acceptor_gain	0.9800
1:226225502:TCCAG:T	acceptor_gain	0.9700
1:226225505:AGGTA:A	acceptor_gain	0.9600
1:226225506:G:T	acceptor_gain	0.9400
1:226224176:C:T	donor_gain	0.9200
1:226225501:TTCCA:T	acceptor_gain	0.8900
1:226224068:G:GT	donor_gain	0.8200
1:226224134:C:A	donor_gain	0.8200
1:226224194:GCTC:G	donor_gain	0.8200
1:226225748:A:C	acceptor_gain	0.8200
1:226224224:A:AG	donor_gain	0.8000
1:226224522:C:T	donor_gain	0.7800
1:226224165:G:T	donor_gain	0.7200

AlphaMissense

1474 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:226223994:T:C	F105L	1.000
1:226223996:C:A	F105L	1.000
1:226223996:C:G	F105L	1.000
1:226225513:T:C	F134L	1.000
1:226225515:C:A	F134L	1.000
1:226225515:C:G	F134L	1.000
1:226223958:T:C	F93L	0.999
1:226223960:C:A	F93L	0.999
1:226223960:C:G	F93L	0.999
1:226225510:T:A	W133R	0.999
1:226225510:T:C	W133R	0.999
1:226225512:G:C	W133C	0.999
1:226225512:G:T	W133C	0.999
1:226225513:T:G	F134V	0.999
1:226225514:T:C	F134S	0.999
1:226225514:T:G	F134C	0.999
1:226225519:A:G	N136D	0.999
1:226225520:A:G	N136S	0.999
1:226225521:C:A	N136K	0.999
1:226225521:C:G	N136K	0.999
1:226223959:T:C	F93S	0.998
1:226223959:T:G	F93C	0.998
1:226223994:T:A	F105I	0.998
1:226223994:T:G	F105V	0.998
1:226223995:T:C	F105S	0.998
1:226224010:A:G	Y110C	0.998
1:226224012:C:T	P111S	0.998
1:226224013:C:A	P111H	0.998
1:226224070:T:C	I130T	0.998
1:226225513:T:A	F134I	0.998

dbSNP variants (sampled 300 via entrez): RS1000995714 (1:226221872 T>C), RS1001495271 (1:226221925 T>G), RS1001642615 (1:226222575 T>C), RS1001716258 (1:226222173 G>A), RS1003169200 (1:226223395 G>A), RS1003391854 (1:226223747 C>A,G,T), RS1004083090 (1:226226488 G>A), RS1005484128 (1:226224932 G>A,T), RS1005622947 (1:226223757 G>A,T), RS1006095294 (1:226223043 G>T), RS1006211732 (1:226222218 G>C), RS1006636683 (1:226222633 TAAG>T), RS1006729625 (1:226223377 T>A,C), RS1007603776 (1:226222656 A>G), RS1007802946 (1:226222962 G>A,C)

Disease associations

OMIM: gene MIM:609852 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

28 total (human), top 28 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	increases methylation, affects methylation, decreases expression	3
Cyclosporine	decreases expression	3
Tetrachlorodibenzodioxin	decreases expression	2
Aflatoxin B1	affects expression, decreases expression	2
aristolochic acid I	increases expression	1
dicrotophos	increases expression	1
bisphenol A	affects expression	1
terbufos	increases methylation	1
tris(2-butoxyethyl) phosphate	affects expression	1
Sunitinib	decreases expression	1
Leflunomide	increases expression	1
Dolutegravir	increases expression	1
Azathioprine	decreases expression	1
Cadmium	decreases expression	1
Carbamazepine	affects expression	1
Fonofos	increases methylation	1
Hydrogen Peroxide	affects expression	1
Lead	decreases expression	1
Parathion	increases methylation	1
Quercetin	decreases expression	1
Tretinoin	affects expression	1
Triclosan	decreases expression	1
Valproic Acid	affects expression	1
Oxyquinoline	decreases expression	1
Sodium Selenite	increases expression	1
Cadmium Chloride	decreases expression	1
tert-Butylhydroperoxide	affects expression	1
Vitamin K 3	affects expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.