MKLN1-AS
gene geneOn this page
Summary
MKLN1-AS (MKLN1 antisense RNA, HGNC:40374) is a long non-coding RNA gene on chromosome 7q32.3.
At a glance
- Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).
Identifiers
Gene identifiers
| Field | Value |
|---|---|
| HGNC ID | HGNC:40374 |
| Approved symbol | MKLN1-AS |
| Name | MKLN1 antisense RNA |
| Location | 7q32.3 |
| Locus type | RNA, long non-coding |
| Status | Approved |
| Ensembl gene | ENSG00000236753 |
| Ensembl biotype | lncRNA |
| Entrez | 100506881 |
| RNAcentral | URS000075C425 — lncRNA, 2046 nt, 1 organism(s) |
Gene structure
Transcript identifiers
Ensembl transcripts: 17 — 16 lncRNA, 1 retained_intron
ENST00000416220, ENST00000429067, ENST00000444245, ENST00000447514, ENST00000447904, ENST00000454515, ENST00000648242, ENST00000653124, ENST00000653823, ENST00000655177, ENST00000656389, ENST00000656518, ENST00000659539, ENST00000663485, ENST00000669897, ENST00000670684, ENST00000822765
RefSeq mRNA: 0 — MANE Select: None
Canonical transcript exons
ENST00000416220 — 4 exons
| Exon | Start | End |
|---|---|---|
| ENSE00001731348 | 131324303 | 131324425 |
| ENSE00001744285 | 131326806 | 131326895 |
| ENSE00003853764 | 131327615 | 131327763 |
| ENSE00003987482 | 131322405 | 131323868 |
Expression profiles
Bgee: expression breadth ubiquitous, 135 present calls, max score 85.18.
FANTOM5 (CAGE): breadth ubiquitous, TPM avg 2.5473 / max 48.3036, expressed in 1379 samples.
FANTOM5 promoters (1 alternative TSS)
| Promoter ID | TPM avg | Samples expressed |
|---|---|---|
| 86264 | 2.5473 | 1379 |
Top tissues by expression
138 total, by Bgee expression score (0-100, higher = more expressed):
| Tissue | Anatomy ID | Expression score | Quality |
|---|---|---|---|
| primordial germ cell in gonad | CL:0000670 ∩ UBERON:0000991 | 85.18 | gold quality |
| male germ line stem cell (sensu Vertebrata) in testis | CL:0000089 ∩ UBERON:0000473 | 75.81 | gold quality |
| skeletal muscle tissue | UBERON:0001134 | 75.72 | gold quality |
| duodenum | UBERON:0002114 | 75.46 | gold quality |
| calcaneal tendon | UBERON:0003701 | 75.13 | gold quality |
| metanephros cortex | UBERON:0010533 | 75.10 | gold quality |
| gastrocnemius | UBERON:0001388 | 74.35 | gold quality |
| thymus | UBERON:0002370 | 74.33 | silver quality |
| islet of Langerhans | UBERON:0000006 | 74.29 | gold quality |
| muscle of leg | UBERON:0001383 | 74.23 | gold quality |
| adult mammalian kidney | UBERON:0000082 | 74.04 | gold quality |
| muscle tissue | UBERON:0002385 | 74.03 | gold quality |
| hindlimb stylopod muscle | UBERON:0004252 | 73.26 | gold quality |
| tonsil | UBERON:0002372 | 73.19 | gold quality |
| kidney | UBERON:0002113 | 73.07 | gold quality |
| stromal cell of endometrium | CL:0002255 | 72.46 | gold quality |
| colonic epithelium | UBERON:0000397 | 72.37 | gold quality |
| right adrenal gland cortex | UBERON:0035827 | 71.71 | gold quality |
| cortex of kidney | UBERON:0001225 | 71.59 | gold quality |
| apex of heart | UBERON:0002098 | 71.45 | gold quality |
| endometrium | UBERON:0001295 | 71.43 | gold quality |
| bone marrow cell | CL:0002092 | 71.21 | silver quality |
| right adrenal gland | UBERON:0001233 | 70.83 | gold quality |
| heart left ventricle | UBERON:0002084 | 70.68 | gold quality |
| left adrenal gland | UBERON:0001234 | 70.54 | gold quality |
| sural nerve | UBERON:0015488 | 70.51 | gold quality |
| pancreas | UBERON:0001264 | 70.23 | gold quality |
| popliteal artery | UBERON:0002250 | 70.08 | gold quality |
| saliva-secreting gland | UBERON:0001044 | 70.07 | gold quality |
| tibial artery | UBERON:0007610 | 70.05 | gold quality |
Single-cell (SCXA)
Detected in 1 experiment(s), a significant marker in 1.
| Experiment | Marker? | Max mean expression |
|---|---|---|
| E-ANND-3 | yes | 3.43 |
Regulation
Is transcription factor: no
Literature-anchored findings (GeneRIF, showing 6)
- Long noncoding RNA MKLN1AS aggravates hepatocellular carcinoma progression by functioning as a molecular sponge for miR6543p, thereby promoting hepatomaderived growth factor expression. (PMID:33000222)
- Long non-coding RNA muskelin 1 antisense RNA (MKLN1-AS) is a potential diagnostic and prognostic biomarker and therapeutic target for hepatocellular carcinoma. (PMID:33878313)
- ETS Proto-Oncogene 1-activated muskelin 1 antisense RNA drives the malignant progression of hepatocellular carcinoma by targeting miR-22-3p to upregulate ETS Proto-Oncogene 1. (PMID:34983308)
- SOX9/MKLN1-AS Axis Induces Hepatocellular Carcinoma Proliferation and Epithelial-Mesenchymal Transition. (PMID:35138470)
- Long non-coding RNA muskelin 1 antisense RNA as a potential therapeutic target in hepatocellular carcinoma treatment. (PMID:35579449)
- MKLN1-AS promotes pancreatic cancer progression as a crucial downstream mediator of HIF-1alpha through miR-185-5p/TEAD1 pathway. (PMID:38740637)
Cross-species orthologs
0 orthologs
Protein
Non-coding RNA — no protein product; not a drug target.
Function
No curated pathway, Gene-Ontology, or interaction data.
Disease & clinical
No curated disease, variant, or cancer-driver associations.
Drugs & pharmacology
No drug or pharmacology data — not an established drug target.
Related Atlas pages
No linked Atlas pages yet — the cross-entity mesh grows as the corpus expands.