MKNK1-AS1

Summary

MKNK1-AS1 (MKNK1 antisense RNA 1, HGNC:44129) is a long non-coding RNA gene on chromosome 1p33.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:44129
Approved symbol	MKNK1-AS1
Name	MKNK1 antisense RNA 1
Location	1p33
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000269956
Ensembl biotype	lncRNA
Entrez	100507423
RNAcentral	URS00004D32AE — lncRNA, 2445 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 3 — 3 lncRNA

ENST00000602433, ENST00000657773, ENST00000835360

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000602433 — 8 exons

Exon	Start	End
ENSE00003252286	46538696	46538794
ENSE00003261565	46568206	46568297
ENSE00003270503	46558225	46558342
ENSE00003317890	46568482	46570255
ENSE00003348331	46540930	46541009
ENSE00003352396	46563512	46563576
ENSE00003385458	46559670	46559811
ENSE00003403601	46543694	46543768

Expression profiles

Bgee: expression breadth ubiquitous, 152 present calls, max score 84.41.

Top tissues by expression

239 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	84.41	gold quality
sperm	CL:0000019	72.18	gold quality
body of pancreas	UBERON:0001150	68.94	gold quality
right uterine tube	UBERON:0001302	66.84	gold quality
blood	UBERON:0000178	63.01	gold quality
bone marrow cell	CL:0002092	62.86	silver quality
oviduct epithelium	UBERON:0004804	62.79	silver quality
pancreas	UBERON:0001264	62.59	gold quality
colonic epithelium	UBERON:0000397	62.52	silver quality
monocyte	CL:0000576	59.89	gold quality
leukocyte	CL:0000738	59.58	gold quality
cortical plate	UBERON:0005343	58.92	gold quality
hindlimb stylopod muscle	UBERON:0004252	58.56	gold quality
descending thoracic aorta	UBERON:0002345	58.54	gold quality
ganglionic eminence	UBERON:0004023	57.90	silver quality
stromal cell of endometrium	CL:0002255	57.58	gold quality
left testis	UBERON:0004533	57.17	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	57.00	gold quality
granulocyte	CL:0000094	56.80	gold quality
testis	UBERON:0000473	55.87	gold quality
spleen	UBERON:0002106	55.31	gold quality
right testis	UBERON:0004534	55.16	gold quality
prefrontal cortex	UBERON:0000451	54.83	gold quality
fallopian tube	UBERON:0003889	54.62	gold quality
muscle of leg	UBERON:0001383	54.61	gold quality
left adrenal gland	UBERON:0001234	54.53	gold quality
left adrenal gland cortex	UBERON:0035825	54.53	gold quality
nucleus accumbens	UBERON:0001882	54.51	gold quality
thoracic aorta	UBERON:0001515	54.37	gold quality
ascending aorta	UBERON:0001496	54.22	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	1.27

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.