MKX-AS1

Summary

MKX-AS1 (MKX antisense RNA 1, HGNC:50686) is a long non-coding RNA gene on chromosome 10p12.1.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50686
Approved symbol	MKX-AS1
Name	MKX antisense RNA 1
Location	10p12.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000230500
Ensembl biotype	lncRNA
Entrez	101929202
RNAcentral	URS000075DE1B — lncRNA, 788 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 2 — 2 lncRNA

ENST00000412244, ENST00000419777

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000412244 — 3 exons

Exon	Start	End
ENSE00001636303	27767358	27767793
ENSE00001687111	27761589	27761774
ENSE00001780680	27764651	27764773

Expression profiles

Bgee: expression breadth ubiquitous, 103 present calls, max score 91.02.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.1550 / max 48.0263, expressed in 49 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
104463	0.0604	27
104465	0.0313	9
104461	0.0286	8
104462	0.0214	8
104464	0.0133	4

Top tissues by expression

103 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	91.02	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	79.06	gold quality
calcaneal tendon	UBERON:0003701	68.68	gold quality
lower esophagus	UBERON:0013473	68.42	gold quality
lower esophagus muscularis layer	UBERON:0035833	68.35	gold quality
right coronary artery	UBERON:0001625	68.01	gold quality
prostate gland	UBERON:0002367	67.99	gold quality
skeletal muscle tissue	UBERON:0001134	66.64	gold quality
urinary bladder	UBERON:0001255	66.64	gold quality
tibial artery	UBERON:0007610	64.80	gold quality
popliteal artery	UBERON:0002250	64.72	gold quality
left coronary artery	UBERON:0001626	63.50	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	63.25	gold quality
muscle layer of sigmoid colon	UBERON:0035805	63.20	gold quality
ganglionic eminence	UBERON:0004023	62.57	gold quality
stromal cell of endometrium	CL:0002255	62.23	gold quality
esophagus	UBERON:0001043	60.62	gold quality
descending thoracic aorta	UBERON:0002345	58.42	gold quality
ascending aorta	UBERON:0001496	57.85	gold quality
thoracic aorta	UBERON:0001515	57.83	gold quality
placenta	UBERON:0001987	57.48	gold quality
mucosa of stomach	UBERON:0001199	57.45	gold quality
body of stomach	UBERON:0001161	57.41	gold quality
colon	UBERON:0001155	57.22	gold quality
adenohypophysis	UBERON:0002196	56.90	gold quality
kidney	UBERON:0002113	56.84	gold quality
stomach	UBERON:0000945	56.83	gold quality
fundus of stomach	UBERON:0001160	56.77	gold quality
heart	UBERON:0000948	56.61	gold quality
prefrontal cortex	UBERON:0000451	56.59	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.29

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.