MLIP-IT1

Summary

MLIP-IT1 (MLIP intronic transcript 1, HGNC:41461) is a long non-coding RNA gene on chromosome 6p12.1.

At a glance

• Clinical variants (ClinVar): 1 total

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:41461
Approved symbol	MLIP-IT1
Name	MLIP intronic transcript 1
Location	6p12.1
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000236996
Entrez	100874282
RNAcentral	URS00003D1289 — lncRNA, 643 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 0

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

None — 0 exons

Expression profiles

Bgee: expression breadth broad, 94 present calls, max score 72.34.

Top tissues by expression

94 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
skin of abdomen	UBERON:0001416	72.34	gold quality
zone of skin	UBERON:0000014	71.98	gold quality
skin of leg	UBERON:0001511	71.63	gold quality
sural nerve	UBERON:0015488	70.50	gold quality
esophagus mucosa	UBERON:0002469	63.10	gold quality
lower esophagus mucosa	UBERON:0035834	59.52	gold quality
vagina	UBERON:0000996	59.43	gold quality
left ovary	UBERON:0002119	58.18	gold quality
right lobe of thyroid gland	UBERON:0001119	57.90	gold quality
endometrium	UBERON:0001295	57.78	gold quality
ectocervix	UBERON:0012249	57.37	gold quality
tonsil	UBERON:0002372	57.13	gold quality
left lobe of thyroid gland	UBERON:0001120	57.09	gold quality
saliva-secreting gland	UBERON:0001044	56.91	gold quality
esophagus	UBERON:0001043	56.84	gold quality
thyroid gland	UBERON:0002046	56.64	gold quality
minor salivary gland	UBERON:0001830	56.59	gold quality
duodenum	UBERON:0002114	55.57	gold quality
multicellular organism	UBERON:0000468	55.01	gold quality
subcutaneous adipose tissue	UBERON:0002190	54.85	gold quality
lymph node	UBERON:0000029	54.67	gold quality
uterine cervix	UBERON:0000002	54.60	gold quality
gall bladder	UBERON:0002110	54.27	gold quality
prefrontal cortex	UBERON:0000451	53.94	gold quality
liver	UBERON:0002107	52.54	gold quality
adipose tissue	UBERON:0001013	52.47	gold quality
islet of Langerhans	UBERON:0000006	51.98	gold quality
calcaneal tendon	UBERON:0003701	51.73	gold quality
ovary	UBERON:0000992	51.61	gold quality
right lobe of liver	UBERON:0001114	51.47	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.43

Regulation

Is transcription factor: no

Cross-species orthologs

0 orthologs

Protein

Protein identifiers

Canonical reviewed UniProt: None (reviewed: )

All UniProt accessions (0):

RefSeq proteins (0): (*=MANE)

Domains & families (InterPro)

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 0 (showing top):

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (0):

Protein interactions and networks

STRING

0 interactions, top by confidence (×1000):

IntAct

0 interactions, top by confidence:

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

1 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

0 scored. Top likely-pathogenic:

dbSNP variants (sampled 300 via entrez): RS1000091692 (6:54001289 T>C), RS1000401003 (6:54002067 G>A,T), RS1000577823 (6:54007277 A>G), RS1000989619 (6:54006619 T>C), RS1001625970 (6:54001694 C>T), RS1001711192 (6:54002472 T>C), RS1001921895 (6:53997910 G>A), RS1001950682 (6:54001446 T>A), RS1002048338 (6:54003636 G>A), RS1002102194 (6:54003804 G>T), RS1002392233 (6:53998210 T>A), RS1003362727 (6:54005749 C>T), RS1003661855 (6:53999546 T>G), RS1003693889 (6:54000376 C>CCTGT), RS1004014530 (6:53999334 A>G)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 0 entries

CTD chemical–gene interactions

1 total (human), top 1 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Propofol	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.