MMGT1

Summary

MMGT1 (membrane magnesium transporter 1, HGNC:28100) is a protein-coding gene on chromosome Xq26.3, encoding ER membrane protein complex subunit 5 (Q8N4V1). Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. It is a selective cancer dependency (DepMap: 37.2% of cell lines).

Contributes to membrane insertase activity. Involved in protein insertion into ER membrane by stop-transfer membrane-anchor sequence and tail-anchored membrane protein insertion into ER membrane. Located in endoplasmic reticulum membrane. Part of EMC complex.

Source: NCBI Gene 93380 — RefSeq curated summary.

At a glance

• Gene–disease (curated): neurodevelopmental disorder (Moderate, GenCC)
• Clinical variants (ClinVar): 66 total
• Druggable target: yes
• Cancer dependency (DepMap): dependent in 37.2% of screened cell lines
• MANE Select transcript: NM_173470

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:28100
Approved symbol	MMGT1
Name	membrane magnesium transporter 1
Location	Xq26.3
Locus type	gene with protein product
Status	Approved
Aliases	EMC5
Ensembl gene	ENSG00000169446
Ensembl biotype	protein_coding
OMIM	301098
Entrez	93380

Gene structure

Transcript identifiers

Ensembl transcripts: 6 — 6 protein_coding

ENST00000305963, ENST00000679621, ENST00000680510, ENST00000681201, ENST00000871526, ENST00000922959

RefSeq mRNA: 2 — MANE Select: NM_173470 NM_001330000, NM_173470

CCDS: CCDS14653

Canonical transcript exons

ENST00000305963 — 4 exons

Exon	Start	End
ENSE00001174129	135967390	135967493
ENSE00001174137	135971058	135971110
ENSE00001931815	135960588	135965183
ENSE00003914796	135973597	135973988

Expression profiles

Bgee: expression breadth ubiquitous, 257 present calls, max score 97.80.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 37.2560 / max 610.8207, expressed in 1823 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
200628	18.9312	1809
200625	14.2351	1773
200624	2.6726	1312
200627	0.7775	457
200629	0.6395	394

Top tissues by expression

258 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
secondary oocyte	CL:0000655	97.80	gold quality
cardiac muscle of right atrium	UBERON:0003379	97.45	gold quality
ileal mucosa	UBERON:0000331	97.25	gold quality
left ventricle myocardium	UBERON:0006566	97.21	gold quality
oocyte	CL:0000023	97.02	gold quality
upper arm skin	UBERON:0004263	96.83	gold quality
cartilage tissue	UBERON:0002418	95.97	gold quality
tibialis anterior	UBERON:0001385	95.79	gold quality
corpus epididymis	UBERON:0004359	95.79	gold quality
myocardium	UBERON:0002349	95.69	gold quality
oviduct epithelium	UBERON:0004804	95.64	gold quality
parotid gland	UBERON:0001831	95.60	gold quality
kidney epithelium	UBERON:0004819	95.57	gold quality
cauda epididymis	UBERON:0004360	95.51	gold quality
deltoid	UBERON:0001476	95.40	gold quality
parietal pleura	UBERON:0002400	94.62	gold quality
lower lobe of lung	UBERON:0008949	94.40	gold quality
layer of synovial tissue	UBERON:0007616	94.36	gold quality
caput epididymis	UBERON:0004358	94.18	gold quality
decidua	UBERON:0002450	94.03	gold quality
visceral pleura	UBERON:0002401	93.94	gold quality
superficial temporal artery	UBERON:0001614	93.88	gold quality
epithelial cell of pancreas	CL:0000083	93.86	gold quality
mammary duct	UBERON:0001765	93.69	gold quality
epithelium of mammary gland	UBERON:0003244	93.69	gold quality
mucosa of sigmoid colon	UBERON:0004993	93.61	gold quality
heart right ventricle	UBERON:0002080	93.60	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	93.59	gold quality
trabecular bone tissue	UBERON:0002483	93.46	gold quality
colonic mucosa	UBERON:0000317	93.20	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-MTAB-6075	no	531.76
E-ANND-3	no	4.40

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

193 targeting MMGT1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-200B-3P	100.00	73.31	2693
HSA-MIR-200C-3P	100.00	73.35	2685
HSA-MIR-429	100.00	73.44	2698
HSA-MIR-126-5P	100.00	72.71	3180
HSA-MIR-4283	100.00	66.42	2097
HSA-MIR-1277-5P	100.00	73.95	5056
HSA-MIR-4795-3P	100.00	74.62	4024
HSA-MIR-196A-1-3P	99.99	72.15	2772
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-548AW	99.99	72.57	3559
HSA-MIR-5696	99.98	72.36	4487
HSA-MIR-520D-5P	99.98	73.34	4883
HSA-MIR-524-5P	99.98	73.43	4882
HSA-MIR-19A-3P	99.98	75.33	2762
HSA-MIR-19B-3P	99.98	75.44	2754
HSA-MIR-27A-3P	99.98	72.13	2955
HSA-MIR-27B-3P	99.98	72.13	2955
HSA-MIR-9985	99.98	72.11	2939
HSA-MIR-548N	99.98	71.94	4170
HSA-MIR-3065-5P	99.97	71.56	3281
HSA-MIR-8075	99.97	67.20	962
HSA-MIR-548AJ-3P	99.96	73.38	5345
HSA-MIR-548X-3P	99.96	73.38	5345
HSA-MIR-570-3P	99.96	72.41	4910
HSA-MIR-548AA	99.96	70.64	3753
HSA-MIR-548AP-3P	99.96	70.64	3753
HSA-MIR-548T-3P	99.96	70.64	3753
HSA-MIR-3658	99.96	73.87	4379

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 37.2% of screened cell lines.

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	mmgt1	ENSDARG00000010553
mus_musculus	Mmgt1	ENSMUSG00000061273
rattus_norvegicus	Mmgt1	ENSRNOG00000065883

Paralogs (1): NDUFAF6 (ENSG00000156170)

Protein

Protein identifiers

ER membrane protein complex subunit 5 — Q8N4V1 (reviewed: Q8N4V1)

Alternative names: Membrane magnesium transporter 1, Transmembrane protein 32

All UniProt accessions (3): A0A7P0T9E6, A0A7P0TBL5, Q8N4V1

UniProt curated annotations — full annotation on UniProt →

Function. Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues. Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices. It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes. By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors. By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes. May be involved in Mg(2+) transport.

Subunit / interactions. Component of the ER membrane protein complex (EMC).

Subcellular location. Endoplasmic reticulum membrane. Golgi apparatus membrane. Early endosome membrane.

Similarity. Belongs to the membrane magnesium transporter (TC 1.A.67) family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q8N4V1-1	1	yes
Q8N4V1-2	2

RefSeq proteins (2): NP_001316929, NP_775741* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR018937	MMgT	Family

Pfam: PF10270

UniProt features (16 total): helix 6, topological domain 3, strand 2, transmembrane region 2, chain 1, modified residue 1, splice variant 1

Structure

Experimental structures (PDB)

10 structures.

PDB	Method	Resolution (Å)
8J0O	ELECTRON MICROSCOPY	3.32
7ADO	ELECTRON MICROSCOPY	3.39
6WW7	ELECTRON MICROSCOPY	3.4
8EOI	ELECTRON MICROSCOPY	3.4
8J0N	ELECTRON MICROSCOPY	3.47
7ADP	ELECTRON MICROSCOPY	3.6
8S9S	ELECTRON MICROSCOPY	3.6
9ZZ6	ELECTRON MICROSCOPY	4.16
6Z3W	ELECTRON MICROSCOPY	6.4
9C7V	ELECTRON MICROSCOPY	6.6

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8N4V1-F1	78.88	0.34

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 120

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-5223345	Miscellaneous transport and binding events

MSigDB gene sets: 190 (showing top): BERTUCCI_MEDULLARY_VS_DUCTAL_BREAST_CANCER_DN, GOBP_TRANSITION_METAL_ION_TRANSPORT, ATACCTC_MIR202, CHIANG_LIVER_CANCER_SUBCLASS_UNANNOTATED_DN, GOBP_MAGNESIUM_ION_TRANSPORT, GOBP_IRON_ION_TRANSPORT, GOBP_COPPER_ION_TRANSPORT, GOBP_MONOATOMIC_CATION_TRANSPORT, CREB_Q4, GOBP_ESTABLISHMENT_OF_PROTEIN_LOCALIZATION_TO_MEMBRANE, AAAGGGA_MIR204_MIR211, GOBP_ENDOMEMBRANE_SYSTEM_ORGANIZATION, CREB_Q2_01, GOBP_PROTEIN_LOCALIZATION_TO_ORGANELLE, GOBP_MEMBRANE_ORGANIZATION

GO Biological Process (9): copper ion transport (GO:0006825), magnesium ion transport (GO:0015693), protein insertion into ER membrane by stop-transfer membrane-anchor sequence (GO:0045050), tail-anchored membrane protein insertion into ER membrane (GO:0071816), monoatomic cation transport (GO:0006812), cobalt ion transport (GO:0006824), iron ion transport (GO:0006826), iron ion transmembrane transport (GO:0034755), magnesium ion transmembrane transport (GO:1903830)

GO Molecular Function (6): cobalt ion transmembrane transporter activity (GO:0015087), ferrous iron transmembrane transporter activity (GO:0015093), magnesium ion transmembrane transporter activity (GO:0015095), obsolete inorganic cation transmembrane transporter activity (GO:0022890), protein binding (GO:0005515), membrane insertase activity (GO:0032977)

GO Cellular Component (11): Golgi membrane (GO:0000139), early endosome (GO:0005769), endoplasmic reticulum membrane (GO:0005789), Golgi apparatus (GO:0005794), plasma membrane (GO:0005886), membrane (GO:0016020), early endosome membrane (GO:0031901), EMC complex (GO:0072546), cytoplasm (GO:0005737), endosome (GO:0005768), endoplasmic reticulum (GO:0005783)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Transport of small molecules	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
transition metal ion transport	3
monoatomic cation transmembrane transport	3
endomembrane system	3
protein insertion into ER membrane	2
cytoplasm	2
intracellular membrane-bounded organelle	2
cellular anatomical structure	2
metal ion transport	1
monoatomic ion transport	1
iron ion transport	1
magnesium ion transport	1
cobalt ion transport	1
transition metal ion transmembrane transporter activity	1
iron ion transmembrane transporter activity	1
metal ion transmembrane transporter activity	1
magnesium ion transmembrane transport	1
binding	1
establishment of protein localization to membrane	1
protein carrier activity	1
Golgi apparatus	1
bounding membrane of organelle	1
endosome	1
organelle membrane	1
nuclear outer membrane-endoplasmic reticulum membrane network	1
endoplasmic reticulum subcompartment	1
membrane	1
cell periphery	1
early endosome	1
endosome membrane	1
endoplasmic reticulum membrane	1
membrane protein complex	1
endoplasmic reticulum protein-containing complex	1
intracellular anatomical structure	1
cytoplasmic vesicle	1

Protein interactions and networks

STRING

1136 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
MMGT1	EMC1	Q8N766	914
MMGT1	EMC4	Q5J8M3	907
MMGT1	EMC6	Q9BV81	898
MMGT1	EMC3	Q9P0I2	885
MMGT1	EMC2	Q15006	873
MMGT1	EMC7	Q9NPA0	852
MMGT1	EMC8	O43402	823
MMGT1	EMC10	Q5UCC4	800
MMGT1	EMC9	Q9Y3B6	736
MMGT1	NIPAL1	Q6NVV3	643
MMGT1	NIPAL3	Q6P499	575
MMGT1	SLC41A1	Q8IVJ1	572
MMGT1	MAGT1	Q9H0U3	567
MMGT1	MRS2	Q9HD23	560
MMGT1	DDOST	P39656	542

IntAct

261 interactions, top by confidence:

A	B	Type	Score
EMC2	EMC8	psi-mi:“MI:0914”(association)	0.940
EMC8	EMC2	psi-mi:“MI:0914”(association)	0.940
MMGT1	EMC6	psi-mi:“MI:0915”(physical association)	0.810
EMC6	MMGT1	psi-mi:“MI:0915”(physical association)	0.810
EMC7	EMC8	psi-mi:“MI:0914”(association)	0.790
MMGT1	EMC8	psi-mi:“MI:0914”(association)	0.730
NDUFA3	MMGT1	psi-mi:“MI:0915”(physical association)	0.670
MFSD5	MMGT1	psi-mi:“MI:0915”(physical association)	0.670
EMC1	EMC8	psi-mi:“MI:0914”(association)	0.640
EMC10	EMC8	psi-mi:“MI:0915”(physical association)	0.620
PEX16	MMGT1	psi-mi:“MI:0915”(physical association)	0.560
MMGT1	TMEM229B	psi-mi:“MI:0915”(physical association)	0.560
SLC35E4	MMGT1	psi-mi:“MI:0915”(physical association)	0.560
STX3	MMGT1	psi-mi:“MI:0915”(physical association)	0.560
MMGT1	TMEM14C	psi-mi:“MI:0915”(physical association)	0.560
ORMDL2	MMGT1	psi-mi:“MI:0915”(physical association)	0.560
SEC22B	MMGT1	psi-mi:“MI:0915”(physical association)	0.560
TMED8	MMGT1	psi-mi:“MI:0915”(physical association)	0.560
MMGT1	TMEM60	psi-mi:“MI:0915”(physical association)	0.560
STX12	MMGT1	psi-mi:“MI:0915”(physical association)	0.560
MMGT1	LNPEP	psi-mi:“MI:0915”(physical association)	0.560
TMBIM6	MMGT1	psi-mi:“MI:0915”(physical association)	0.560
MMGT1	ADGRE2	psi-mi:“MI:0915”(physical association)	0.560
MMGT1	ARLN	psi-mi:“MI:0915”(physical association)	0.560
MMGT1	FXYD6	psi-mi:“MI:0915”(physical association)	0.560

BioGRID (528): MMGT1 (Affinity Capture-MS), MMGT1 (Affinity Capture-MS), MMGT1 (Affinity Capture-MS), EMC9 (Affinity Capture-MS), UBQLN2 (Affinity Capture-MS), EMC8 (Affinity Capture-MS), EMC2 (Affinity Capture-MS), EMC3 (Affinity Capture-MS), EMC10 (Affinity Capture-MS), EMC6 (Affinity Capture-MS), EMC1 (Affinity Capture-MS), EMC7 (Affinity Capture-MS), MMGT1 (Affinity Capture-MS), MMGT1 (Affinity Capture-MS), EMC4 (Affinity Capture-MS)

ESM2 similar proteins: A0A0N7L4N2, A5WV69, B9G4M9, C5DQ18, D0NMF4, E2AX35, F4JP36, O13980, O43085, O60291, O96838, P0CO33, P0CV11, P34335, P34535, P34553, P39718, P53117, P53224, P53938, P58239, P60571, P62512, P85831, P87139, Q09446, Q10109, Q19192, Q20687, Q4WIN1, Q5B8K7, Q5R9E4, Q624D2, Q6C3U1, Q6CAP3, Q6TLE4, Q700C2, Q74ZY6, Q756T2, Q75C24

Diamond homologs: B5DF51, Q05AU4, Q28HV5, Q2HIM5, Q32LC4, Q5RA70, Q6GQ49, Q6P719, Q6TLE4, Q86J02, Q8K273, Q8N4V1, Q8R3L0

SIGNOR signaling

2 interactions.

A	Effect	B	Mechanism
MMGT1	“form complex”	“Endoplasmic reticulum membrane complex- EMC9 variant”	binding
MMGT1	“form complex”	“Endoplasmic reticulum membrane complex, EMC8 variant”	binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 93 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

GO biological processes:

GO term	Partners	Fold	FDR
tail-anchored membrane protein insertion into ER membrane	8	102.6×	6e-13
obsolete vesicle docking	6	63.0×	5e-08
vesicle fusion	6	49.5×	2e-07

Disease & clinical

Clinical variants and AI predictions

ClinVar

66 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	13
Likely benign	1
Benign	3

Top pathogenic / likely-pathogenic (0)

SpliceAI

548 predictions. Top by Δscore:

Variant	Effect	Δscore
X:135965183:CCT:C	acceptor_gain	1.0000
X:135965185:T:C	acceptor_gain	1.0000
X:135965185:T:TC	acceptor_gain	1.0000
X:135967388:A:AC	donor_gain	1.0000
X:135967389:C:CT	donor_gain	1.0000
X:135967389:CTTA:C	donor_gain	1.0000
X:135967392:A:AC	donor_gain	1.0000
X:135967490:CTAT:C	acceptor_gain	1.0000
X:135971056:A:AC	donor_gain	1.0000
X:135971057:C:CC	donor_gain	1.0000
X:135971057:CA:C	donor_gain	1.0000
X:135971057:CAT:C	donor_gain	1.0000
X:135971107:CGAT:C	acceptor_gain	1.0000
X:135971111:C:CC	acceptor_gain	1.0000
X:135973595:A:AC	donor_gain	1.0000
X:135973596:C:CC	donor_gain	1.0000
X:135973596:CG:C	donor_gain	1.0000
X:135973596:CGCTG:C	donor_gain	1.0000
X:135965184:C:CC	acceptor_gain	0.9900
X:135967382:AGACT:A	donor_loss	0.9900
X:135967383:GACT:G	donor_loss	0.9900
X:135967384:ACTTA:A	donor_loss	0.9900
X:135967385:C:CG	donor_loss	0.9900
X:135967386:T:TC	donor_loss	0.9900
X:135967387:TAC:T	donor_loss	0.9900
X:135967388:ACT:A	donor_loss	0.9900
X:135967389:CTT:C	donor_gain	0.9900
X:135967389:CTTAT:C	donor_gain	0.9900
X:135967393:T:C	donor_gain	0.9900
X:135967493:TC:T	acceptor_loss	0.9900

AlphaMissense

832 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
X:135967450:C:T	G59D	1.000
X:135967451:C:G	G59R	1.000
X:135973638:C:T	G13D	1.000
X:135973639:C:G	G13R	1.000
X:135965134:G:T	R96S	0.999
X:135965150:A:C	F90L	0.999
X:135965150:A:T	F90L	0.999
X:135965152:A:G	F90L	0.999
X:135965162:A:C	N86K	0.999
X:135965162:A:T	N86K	0.999
X:135967399:A:G	L76P	0.999
X:135967426:A:G	F67S	0.999
X:135967457:A:G	C57R	0.999
X:135967492:A:T	I45K	0.999
X:135971107:C:G	R28P	0.999
X:135973605:G:T	A24D	0.999
X:135973614:G:T	A21D	0.999
X:135965130:C:T	G97D	0.998
X:135965131:C:G	G97R	0.998
X:135965141:A:C	F93L	0.998
X:135965141:A:T	F93L	0.998
X:135965142:A:G	F93S	0.998
X:135965143:A:G	F93L	0.998
X:135965151:A:G	F90S	0.998
X:135967444:A:T	V61D	0.998
X:135967447:A:T	I60K	0.998
X:135967492:A:C	I45R	0.998
X:135971065:G:T	P42Q	0.998
X:135971095:C:G	R32P	0.998
X:135973603:C:G	A25P	0.998

dbSNP variants (sampled 300 via entrez): RS1000118806 (X:135970638 G>A,T), RS1000519796 (X:135970385 C>T), RS1000935744 (X:135963283 A>C), RS1000981854 (X:135963634 G>A), RS1001114875 (X:135972869 C>T), RS1001301501 (X:135970321 C>A,T), RS1001687263 (X:135969974 G>A), RS1002063114 (X:135962599 G>A), RS1002708008 (X:135972566 A>C,G), RS1002956244 (X:135968167 T>G), RS1003376804 (X:135968544 T>C), RS1004069630 (X:135967748 T>A), RS1005648025 (X:135964436 C>T), RS1005741404 (X:135965258 C>T), RS1006375541 (X:135974827 G>A,T)

Disease associations

OMIM: gene MIM:301098 | disease phenotypes:

GenCC curated gene-disease

Disease	Classification	Inheritance
neurodevelopmental disorder	Moderate	Autosomal dominant

Mondo (1): neurodevelopmental disorder (MONDO:0700092)

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

MeSH disease descriptors (1)

Descriptor	Name	Tree numbers
D065886	Neurodevelopmental Disorders	F03.625

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL6067286 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

ChEMBL bioactivities

2 potent at pChembl≥5 of 2 total, top 2 by pChembl (potency: 10 = 0.1 nM, 6 = 1 µM).

pChembl	Type	Value	Unit	Molecule
5.59	Kd	2597	nM	CHEMBL5653589
5.59	ED50	2597	nM	CHEMBL5653589

PubChem BioAssay actives

1 with measured affinity, of 2 total; 1 most potent distinct compounds. Largely complementary to BindingDB; screening values are coarse (µM, 4 dp), so sub-nM hits tie at the floor.

Compound	Assay	Type	Value	Unit
4-methyl-3-[(2-methyl-6-pyridin-3-ylpyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-[3-(trifluoromethyl)phenyl]benzamide	2148758: Binding affinity to human MMGT1 incubated for 45 mins by Kinobead based pull down assay	kd	2.5967	uM

CTD chemical–gene interactions

21 total (human), top 21 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
FR900359	decreases phosphorylation	1
bisphenol F	affects cotreatment, increases expression	1
sodium arsenite	increases expression	1
K 7174	increases expression	1
abrine	decreases expression	1
(4-amino-1,4-dihydro-3-(2-pyridyl)-5-thioxo-1,2,4-triazole)copper(II)	decreases expression	1
jinfukang	decreases expression	1
Air Pollutants	decreases expression, increases abundance	1
Arbutin	increases expression	1
Benzo(a)pyrene	affects methylation, decreases methylation	1
Caffeine	decreases phosphorylation	1
Coal	decreases expression, increases abundance	1
Dexamethasone	affects cotreatment, increases expression	1
Doxorubicin	decreases expression	1
Gold	decreases expression	1
Indomethacin	affects cotreatment, increases expression	1
Ivermectin	decreases expression	1
Smoke	decreases expression, increases abundance	1
Tretinoin	decreases expression	1
1-Methyl-3-isobutylxanthine	affects cotreatment, increases expression	1
Cyclosporine	increases expression	1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL5651800	Binding	Binding affinity to human MMGT1 incubated for 45 mins by Kinobead based pull down assay	NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family. — ChemMedChem

Clinical trials (associated diseases)

202 trials via MONDO — disease-level, not drug-specific.

Trial	Phase	Status	Title
NCT04586348	PHASE4	UNKNOWN	Prenatal Iodine Supplementation and Early Childhood Neurodevelopment
NCT04873115	PHASE4	UNKNOWN	Double-blind, Placebo-controlled, Randomized Clinical Trial Comparing the Efficacy and Safety of Sialanar Plus orAl rehabiLitation Against Placebo Plus Oral Rehabilitation for chIldren and Adolescents With seVere Sialorrhoea and Neurodisabilties,
NCT02559102	PHASE3	COMPLETED	Dexmedetomidine Sedation Versus General Anaesthesia for Inguinal Hernia Surgery in Infants
NCT02757079	PHASE3	COMPLETED	Study of the Efficacy and Safety of NPC-15 for Sleep Disorders of Children With Neurodevelopmental Disorders
NCT06915480	PHASE3	RECRUITING	Reducing Missed Appointments
NCT07377032	PHASE3	RECRUITING	TAP-GRIN: Interventional Study on Patients With GRIN-related Neurodevelopmental Disorders
NCT02909959	PHASE2	COMPLETED	Sulforaphane for the Treatment of Young Men With Autism Spectrum Disorder
NCT06081348	PHASE2	RECRUITING	Sertraline vs. Placebo in the Treatment of Anxiety in Children and AdoLescents With NeurodevelopMental Disorders
NCT06352372	PHASE2	COMPLETED	Safety and Efficacy of tPBM for Epileptiform Activity in Autism
NCT00503191	PHASE1	COMPLETED	NeuroModulation Technique Treatment of Autism
NCT04475848	PHASE1	COMPLETED	A Study to Investigate the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Food Effect of RO6953958 in Healthy Participants
NCT06300398	PHASE1	COMPLETED	IAMA-6 Oral Dose Study in Healthy Adults
NCT01783041	PHASE2/PHASE3	COMPLETED	Effect of Early L-Carnitine Supplementation on Neurodevelopmental Outcomes in Very Preterm Infants
NCT05767385	PHASE2/PHASE3	RECRUITING	Fetal Cerebrovascular Autoregulation in Congenital Heart Disease and Association With Neonatal Neurobehavior
NCT05675098	EARLY_PHASE1	NOT_YET_RECRUITING	Central Nervous System Stimulants and Physical Function in Children With Cerebral Palsy
NCT00783783	Not specified	COMPLETED	CYP2D6 Pharmacogenetics in Risperidone-Treated Children
NCT01778504	Not specified	RECRUITING	Studying Childhood-onset Behavioral, Psychiatric, and Developmental Disorders
NCT01850784	Not specified	UNKNOWN	High Energy Formula Feeding in Infants With Congenital Heart Disease
NCT01922791	Not specified	COMPLETED	Nutrition and Pregnancy Intervention Study
NCT01942525	Not specified	UNKNOWN	Influence of Intrauterine Growth Restriction on Amplitude-integrated EEG in Preterm Infants
NCT02003170	Not specified	COMPLETED	Etiology and Early Diagnosis of Neurodevelopmental Disorders
NCT02118649	Not specified	ACTIVE_NOT_RECRUITING	Enhancing Behavior and Brain Response to Visual Targets Using a Computer Game
NCT02557191	Not specified	TERMINATED	Biomarkers, Neurodevelopment and Preterm Infants
NCT02690675	Not specified	COMPLETED	Iron Supplement Effect on Child Development
NCT02694003	Not specified	COMPLETED	Better Nights, Better Days for Children With Neurodevelopment Disorders
NCT02792894	Not specified	COMPLETED	Family Networks (FaNs) for Children With Developmental Disorders and Delays
NCT02871674	Not specified	UNKNOWN	Good Night Project: Behavioural Sleep Interventions for Children With ADHD: A Randomised Controlled Trial
NCT02887157	Not specified	COMPLETED	Analyzing Retinal Microanatomy in ROP
NCT02898298	Not specified	COMPLETED	Positive Emotion Regulation Training in Children, Adolescents and Young Adults With and Without Developmental Disorder
NCT02912780	Not specified	UNKNOWN	Introduction of Microsystems in a Level 3 Neonatal Intensive Care Unit
NCT03023293	Not specified	COMPLETED	n-3 PUFAs, Irisin and Maternal Glucose Metabolism From Pregnancy to Postpartum
NCT03023644	Not specified	COMPLETED	Improving Neurodevelopmental Outcomes in Children With Congenital Heart Disease: An Intervention Study
NCT03032991	Not specified	UNKNOWN	Early Biomarkers of Neurodevelopment in Offspring of Diabetic Mothers
NCT03088189	Not specified	TERMINATED	Effect of Parental Peri-conceptional Vitamin B12 Supplementation on Infant Neurocognitive Development in Offspring
NCT03096028	Not specified	COMPLETED	Developmental Origins of Mental Health Disorders
NCT03148782	Not specified	COMPLETED	Brain Plasticity Underlying Acquisition of New Organizational Skills in Children-R61 Phase
NCT03172104	Not specified	COMPLETED	Neurobehavioural Development of Infants Born <30 Weeks Gestational Age Between Birth and Five Years of Age
NCT03222375	Not specified	RECRUITING	SQUED™ Series 28.1 Home-use and Treatment of Autowave Reverberator of Autism
NCT03229928	Not specified	COMPLETED	Clinical Testing of a Real-Time Behavior Measurement Tool: Measuring Outcomes for CHAnge
NCT03232489	Not specified	UNKNOWN	Study for the Evaluation of the Feasibility of Applying Advanced MRI Scanning in Pediatric Clinical Practice