MMP28

Summary

MMP28 (matrix metallopeptidase 28, HGNC:14366) is a protein-coding gene on chromosome 17q12, encoding Matrix metalloproteinase-28 (Q9H239). Can degrade casein.

Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix for both normal physiological processes, such as embryonic development, reproduction and tissue remodeling, and disease processes, such as asthma and metastasis. This gene encodes a secreted enzyme that degrades casein. Its expression pattern suggests that it plays a role in tissue homeostasis and in wound repair. Alternative splicing of this gene results in multiple transcript variants.

Source: NCBI Gene 79148 — RefSeq curated summary.

At a glance

• GWAS associations: 4
• Clinical variants (ClinVar): 29 total
• MANE Select transcript: NM_024302

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:14366
Approved symbol	MMP28
Name	matrix metallopeptidase 28
Location	17q12
Locus type	gene with protein product
Status	Approved
Aliases	MMP-25, MM28, EPILYSIN, MMP-28
Ensembl gene	ENSG00000271447
Ensembl biotype	protein_coding
OMIM	608417
Entrez	79148

Gene structure

Transcript identifiers

Ensembl transcripts: 19 — 17 protein_coding, 1 retained_intron, 1 nonsense_mediated_decay

ENST00000605424, ENST00000612292, ENST00000612672, ENST00000615136, ENST00000615317, ENST00000616383, ENST00000619655, ENST00000863250, ENST00000863251, ENST00000863252, ENST00000863253, ENST00000863254, ENST00000863255, ENST00000863256, ENST00000959303, ENST00000959304, ENST00000959305, ENST00000959306, ENST00000959307

RefSeq mRNA: 3 — MANE Select: NM_024302 NM_001032278, NM_024302, NM_032950

CCDS: CCDS45651, CCDS74036, CCDS76996

Canonical transcript exons

ENST00000605424 — 8 exons

Exon	Start	End
ENSE00003498482	35778888	35779075
ENSE00003556183	35770067	35770312
ENSE00003602726	35767752	35767919
ENSE00003644063	35773180	35773404
ENSE00003657110	35768230	35768379
ENSE00003674701	35779244	35779323
ENSE00003726135	35795267	35795641
ENSE00003746791	35765865	35766894

Expression profiles

Bgee: expression breadth ubiquitous, 133 present calls, max score 95.80.

FANTOM5 (CAGE): breadth broad, TPM avg 2.1501 / max 86.6053, expressed in 439 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
165388	2.1501	439

Top tissues by expression

134 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
tibial nerve	UBERON:0001323	95.80	gold quality
right testis	UBERON:0004534	93.47	gold quality
left testis	UBERON:0004533	92.82	gold quality
testis	UBERON:0000473	92.47	gold quality
skin of abdomen	UBERON:0001416	92.05	gold quality
zone of skin	UBERON:0000014	91.02	gold quality
transverse colon	UBERON:0001157	90.92	gold quality
right lung	UBERON:0002167	90.82	gold quality
upper lobe of left lung	UBERON:0008952	90.72	gold quality
rectum	UBERON:0001052	90.69	gold quality
mucosa of transverse colon	UBERON:0004991	90.55	gold quality
lower esophagus	UBERON:0013473	90.52	gold quality
lower esophagus muscularis layer	UBERON:0035833	90.51	gold quality
skin of leg	UBERON:0001511	90.18	gold quality
nucleus accumbens	UBERON:0001882	90.07	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	89.57	gold quality
lower esophagus mucosa	UBERON:0035834	89.16	gold quality
amygdala	UBERON:0001876	89.11	gold quality
temporal lobe	UBERON:0001871	89.04	gold quality
colon	UBERON:0001155	88.99	gold quality
esophagus	UBERON:0001043	88.87	gold quality
putamen	UBERON:0001874	88.73	gold quality
muscle layer of sigmoid colon	UBERON:0035805	88.58	gold quality
subcutaneous adipose tissue	UBERON:0002190	88.21	gold quality
adipose tissue	UBERON:0001013	88.14	gold quality
omental fat pad	UBERON:0010414	88.11	gold quality
caudate nucleus	UBERON:0001873	87.74	gold quality
esophagus mucosa	UBERON:0002469	87.59	gold quality
lung	UBERON:0002048	87.54	gold quality
intestine	UBERON:0000160	87.51	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-MTAB-9388	yes	11.41
E-ANND-3	yes	11.26

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): CREB1, HDAC1, SP1, SP3

miRNA regulators (miRDB)

26 targeting MMP28, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-6825-5P	99.96	69.81	3431
HSA-MIR-9983-3P	99.94	71.48	3631
HSA-MIR-7162-3P	99.89	68.16	1682
HSA-MIR-129-5P	99.88	70.26	3273
HSA-MIR-12119	99.87	68.35	1653
HSA-MIR-92A-2-5P	99.75	67.01	2164
HSA-MIR-6512-3P	99.65	66.07	1468
HSA-MIR-6720-5P	99.65	66.22	1459
HSA-MIR-488-3P	99.61	68.79	1731
HSA-MIR-516A-3P	99.46	67.96	1378
HSA-MIR-516B-3P	99.46	67.96	1378
HSA-MIR-7162-5P	99.46	68.08	1368
HSA-MIR-544B	99.18	67.41	1632
HSA-MIR-6852-5P	99.17	66.69	2073
HSA-MIR-6815-3P	99.13	68.98	1530
HSA-MIR-491-5P	99.13	65.98	1468
HSA-MIR-7854-3P	99.08	66.26	1117
HSA-MIR-6830-5P	99.01	68.73	1884
HSA-MIR-6728-3P	98.63	67.63	1534
HSA-MIR-3188	98.58	65.60	878
HSA-MIR-561-5P	98.25	68.13	1365
HSA-MIR-4303	98.01	68.13	2304
HSA-MIR-1913	97.07	66.20	1417
HSA-MIR-6729-3P	96.91	66.79	703
HSA-MIR-617	96.79	65.96	738
HSA-MIR-431-5P	96.16	66.50	652

Literature-anchored findings (GeneRIF, showing 22)

• Epilysin (MMP-28) expression is associated with cell proliferation during epithelial repair. (PMID:12164918)
• Results suggest inhibition of MMP-28 may be beneficial under conditions of dysmyelination. (PMID:18778487)
• Data demonstrate that expression of MMP28 alters keratinocyte phenotype towards a more adhesive, less migratory behaviour. (PMID:19375502)
• Epilysin (MMP-28) is deposited to the basolateral extracellular matrix of epithelial cells. (PMID:19379669)
• Expression of MMP-21 and MMP-28 seems to associate with the Merkel cell carcinoma of lesser malignant potential. (PMID:19921252)
• Findings presented here show the first documentation of intervertebral disc expression and production of MMP28 (PMID:20003223)
• MMP28 gene expression is regulated by Sp1 transcription factor acetylation. (PMID:20144149)
• MMP28 is frequently overexpressed during progression of gastric carcinoma, and contributes to tumor cell invasion and metastasis. (PMID:21615884)
• basal expression of MMP-2, MMP-9, MMP-28, and Filaggrin was evaluated in oral keratinocytes to collect information about ability of cigarette smoke to modify basal expression pattern of these key enzymes in the absence of clinical signs in oral epithelium (PMID:21723775)
• Gene expression of MMP28 in the intervertebral disk is not regulated by inflammatory mechanisms, is donor-dependent and cannot be positively or negatively linked to the grade of degeneration and only weakly to the occurrence of trauma. (PMID:21801383)
• Over-expression of MMP28 provides protection against apoptosis induced by either serum-deprivation or treatment with a protein kinase inhibitor. (PMID:22040290)
• Data established a seven-gene (AR, ESR2, GATA3, GBX2, KRT16, MMP28 and WNT11) prognostic signature to define a subset of triple-negative breast cancer (TNBC). (PMID:23549873)
• Inhibition of BCMO1 expression is associated with increased invasiveness of colon cancer cells and increased expression of MMP7 and MMP28. beta-Carotene can upregulate BCMO1 and reverse these effects. (PMID:23803888)
• MMP28 mRNA expression is highest in healthy tissues when compared to diseased periodontal tissues. (PMID:24167355)
• A decreased level of IL-33 and an elevated concentration of MMP-28 were found in coronary heart disease patients and correlated with disease severity. (PMID:24710352)
• These results proved for the first time that epilysin expression was significantly elevated in glioblastoma (PMID:25429835)
• Results suggest a crucial role of MMP9 at the early stage of carcinogenesis in the large intestine. The increase in MMP9 and TIMP1 mRNA concentration and the decrease in MMP28 in the large intestinal tissue may be a confirmation of cancer. (PMID:28293015)
• MMP28 is upregulated in epithelial cells from Idiopathic pulmonary fibrosis lungs. (PMID:29373068)
• Circulating MMP-28 was elevated in atrial fibrillation (PMID:29729262)
• Real-time PCR and dual-luciferase assay indicated that KLF9 directly inhibited MMP28 transcription. Decreased invasion and metastasis capability of GC cells caused by ectopic KLF9 expression could be rescued via reinforcing MMP28 expression in vivo. Collectively, our study indicates that KLF9 significantly suppresses GC cell invasion and metastasis through inhibiting MMP28 transcription. (PMID:30913394)
• Increased bronchoalveolar lavage fluid MMP28 concentrations were associated with increased % percentage alveolar neutrophils and total protein concentrations (PMID:32268921)
• Expression and Clinical Significance of MMP-28 in Bladder Cancer. (PMID:33191847)

Cross-species orthologs

8 orthologs

Organism	Symbol	Gene ID
danio_rerio	mmp28	ENSDARG00000059029
mus_musculus	Mmp28	ENSMUSG00000020682
rattus_norvegicus	Mmp28	ENSRNOG00000047940
caenorhabditis_elegans		WBGENE00010524
caenorhabditis_elegans		WBGENE00012185
caenorhabditis_elegans		WBGENE00012364
caenorhabditis_elegans		WBGENE00016283
caenorhabditis_elegans		WBGENE00194737

Paralogs (23): MMP25 (ENSG00000008516), MMP2 (ENSG00000087245), MMP11 (ENSG00000099953), MMP9 (ENSG00000100985), MMP15 (ENSG00000102996), HPX (ENSG00000110169), MMP8 (ENSG00000118113), MMP19 (ENSG00000123342), MMP24 (ENSG00000125966), MMP7 (ENSG00000137673), MMP20 (ENSG00000137674), MMP27 (ENSG00000137675), MMP13 (ENSG00000137745), MMP3 (ENSG00000149968), MMP21 (ENSG00000154485), MMP16 (ENSG00000156103), MMP14 (ENSG00000157227), MMP10 (ENSG00000166670), MMP26 (ENSG00000167346), MMP23B (ENSG00000189409), MMP1 (ENSG00000196611), MMP17 (ENSG00000198598), MMP12 (ENSG00000262406)

Protein

Protein identifiers

Matrix metalloproteinase-28 — Q9H239 (reviewed: Q9H239)

Alternative names: Epilysin

All UniProt accessions (5): A0A087WZ56, A0A087X1Y9, B3KV06, C0H5X0, Q9H239

UniProt curated annotations — full annotation on UniProt →

Function. Can degrade casein. Could play a role in tissues homeostasis and repair.

Subcellular location. Secreted. Extracellular space. Extracellular matrix.

Tissue specificity. Expressed at high levels in testes and lung. Low levels are detected in kidney, pancreas and skin. Also expressed in fetal lung, brain, skeletal muscle and kidney. Expressed selectively in keratinocytes. Widely expressed in several carcinomas as well. Is up-regulated in response to injury in the skin.

Post-translational modifications. The precursor is cleaved by a furin endopeptidase.

Cofactor. Binds 1 zinc ion per subunit.

Domain organisation. The conserved cysteine present in the cysteine-switch motif binds the catalytic zinc ion, thus inhibiting the enzyme. The dissociation of the cysteine from the zinc ion upon the activation-peptide release activates the enzyme.

Similarity. Belongs to the peptidase M10A family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q9H239-1	1	yes
Q9H239-2	2

RefSeq proteins (3): NP_001027449, NP_077278, NP_116568 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000585	Hemopexin-like_dom	Domain
IPR001818	Pept_M10_metallopeptidase	Domain
IPR002477	Peptidoglycan-bd-like	Domain
IPR006026	Peptidase_Metallo	Domain
IPR018487	Hemopexin-like_repeat	Repeat
IPR021190	Pept_M10A	Family
IPR024079	MetalloPept_cat_dom_sf	Homologous_superfamily
IPR033739	M10A_MMP	Domain
IPR036365	PGBD-like_sf	Homologous_superfamily
IPR036375	Hemopexin-like_dom_sf	Homologous_superfamily

Pfam: PF00045, PF00413, PF01471

UniProt features (19 total): binding site 4, repeat 4, glycosylation site 2, splice variant 2, signal peptide 1, propeptide 1, disulfide bond 1, sequence conflict 1, chain 1, short sequence motif 1, active site 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9H239-F1	81.35	0.53

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Catalytic / active sites (1): 241

Ligand- & substrate-binding residues (4): 240; 244; 250; 91 (in inhibited form)

Disulfide bonds (1): 324–510

Glycosylation sites (2): 164, 355

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 106 (showing top): GOBP_MYELOID_LEUKOCYTE_MIGRATION, GOBP_CELL_CHEMOTAXIS, GOMF_METALLOPEPTIDASE_ACTIVITY, JAEGER_METASTASIS_DN, SABATES_COLORECTAL_ADENOMA_SIZE_DN, GGGTGGRR_PAX4_03, GOBP_REGULATION_OF_LEUKOCYTE_MIGRATION, GOBP_LEUKOCYTE_CHEMOTAXIS, GOBP_REGULATION_OF_MONONUCLEAR_CELL_MIGRATION, GOBP_TAXIS, GOBP_LEUKOCYTE_MIGRATION, RICKMAN_METASTASIS_DN, GOBP_REGULATION_OF_MACROPHAGE_CHEMOTAXIS, GOBP_NEGATIVE_REGULATION_OF_LEUKOCYTE_MIGRATION, GOBP_NEGATIVE_REGULATION_OF_CHEMOTAXIS

GO Biological Process (4): proteolysis (GO:0006508), negative regulation of macrophage chemotaxis (GO:0010760), extracellular matrix organization (GO:0030198), collagen catabolic process (GO:0030574)

GO Molecular Function (7): metalloendopeptidase activity (GO:0004222), zinc ion binding (GO:0008270), protein binding (GO:0005515), peptidase activity (GO:0008233), metallopeptidase activity (GO:0008237), hydrolase activity (GO:0016787), metal ion binding (GO:0046872)

GO Cellular Component (4): obsolete extracellular space (GO:0005615), cytoplasm (GO:0005737), extracellular matrix (GO:0031012), extracellular region (GO:0005576)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	2
protein metabolic process	1
negative regulation of leukocyte chemotaxis	1
regulation of macrophage chemotaxis	1
macrophage chemotaxis	1
negative regulation of macrophage migration	1
extracellular structure organization	1
external encapsulating structure organization	1
catabolic process	1
collagen metabolic process	1
endopeptidase activity	1
metallopeptidase activity	1
transition metal ion binding	1
binding	1
hydrolase activity	1
catalytic activity, acting on a protein	1
peptidase activity	1
catalytic activity	1
cation binding	1
intracellular anatomical structure	1
external encapsulating structure	1

Protein interactions and networks

STRING

716 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
MMP28	HPX	P02790	855
MMP28	FURIN	P09958	745
MMP28	TIMP1	P01033	532
MMP28	MMP8	P22894	525
MMP28	TIMP4	Q99727	511
MMP28	TIMP2	P16035	506
MMP28	TIMP3	P35625	497
MMP28	ANKRD22	Q5VYY1	422
MMP28	PGK1	P00558	411
MMP28	ADAM8	P78325	410
MMP28	ADAM19	Q9H013	403
MMP28	HEATR9	A2RTY3	395
MMP28	H2AX	P16104	376
MMP28	HIPK2	Q9H2X6	375
MMP28	PTBP1	P26599	374

IntAct

8 interactions, top by confidence:

A	B	Type	Score
MMP28	FURIN	psi-mi:“MI:0915”(physical association)	0.560
MMP28	FURIN	psi-mi:“MI:0403”(colocalization)	0.560
MMP28	TRIM68	psi-mi:“MI:0915”(physical association)	0.560
MMP28	TRIM68	psi-mi:“MI:0914”(association)	0.560
MMP28	H2BC9	psi-mi:“MI:0915”(physical association)	0.400
MMP28	HSPA5	psi-mi:“MI:0914”(association)	0.350

BioGRID (12): SND1 (Affinity Capture-MS), TRIM68 (Affinity Capture-MS), TRIM68 (Affinity Capture-MS), MMP28 (Two-hybrid), MMP28 (Proximity Label-MS), SND1 (Affinity Capture-MS), TRIM68 (Affinity Capture-MS), NDUFAF1 (Affinity Capture-MS), ITPA (Affinity Capture-MS), HSPA5 (Affinity Capture-MS), TANGO6 (Affinity Capture-MS), MMP28 (Affinity Capture-MS)

ESM2 similar proteins: A2RUV9, A5A6K7, O54732, O54858, P04836, P09958, P14616, P14617, P15087, P15169, P16870, P23188, P23377, P29122, P42787, P50281, P51511, P52176, P53690, P58215, Q00493, Q28193, Q2KJ83, Q3U435, Q499S5, Q4R4M3, Q5RES1, Q63415, Q64716, Q66K79, Q8BGQ4, Q8MJ24, Q8N436, Q8QGP3, Q8R4V4, Q924C6, Q95220, Q96JB6, Q96SM3, Q99PW6

Diamond homologs: A4KX75, D0EM77, G5EBU3, O04529, O18733, O18767, O18927, O23507, O55123, O55761, O60882, O62806, O77656, P03956, P03957, P07152, P08253, P08254, P09237, P09238, P13943, P14780, P21692, P22757, P23097, P28862, P28863, P29136, P33434, P33435, P33436, P34960, P39900, P41245, P41246, P45452, P50280, P50281, P50282, P50757

SIGNOR signaling

2 interactions.

A	Effect	B	Mechanism
MMP28	up-regulates	ECM_disassembly
MMP28	down-regulates	ECM

Disease & clinical

Clinical variants and AI predictions

ClinVar

29 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	20
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1927 predictions. Top by Δscore:

Variant	Effect	Δscore
17:35766782:C:CT	acceptor_gain	1.0000
17:35766783:A:T	acceptor_gain	1.0000
17:35770061:CCTCA:C	donor_loss	1.0000
17:35770062:CTCA:C	donor_loss	1.0000
17:35770063:TCACC:T	donor_loss	1.0000
17:35770065:ACC:A	donor_loss	1.0000
17:35770071:CAGG:C	donor_gain	1.0000
17:35773145:T:TA	donor_gain	1.0000
17:35778885:CA:C	donor_loss	1.0000
17:35778887:C:CG	donor_loss	1.0000
17:35778887:CCTTG:C	donor_gain	1.0000
17:35778910:ACG:A	donor_gain	1.0000
17:35778911:CGC:C	donor_gain	1.0000
17:35779072:CGCT:C	acceptor_gain	1.0000
17:35779073:GCTC:G	acceptor_loss	1.0000
17:35779074:CT:C	acceptor_gain	1.0000
17:35779076:C:CC	acceptor_gain	1.0000
17:35779077:T:A	acceptor_loss	1.0000
17:35779239:CCTA:C	donor_loss	1.0000
17:35779240:CTA:C	donor_loss	1.0000
17:35779243:CCTGA:C	donor_loss	1.0000
17:35779321:TGC:T	acceptor_gain	1.0000
17:35779321:TGCC:T	acceptor_loss	1.0000
17:35779324:C:CC	acceptor_gain	1.0000
17:35779325:T:G	acceptor_loss	1.0000
17:35764004:CA:C	acceptor_loss	0.9900
17:35764005:A:AG	acceptor_gain	0.9900
17:35764006:G:GG	acceptor_gain	0.9900
17:35764006:GGT:G	acceptor_gain	0.9900
17:35764006:GGTGT:G	acceptor_gain	0.9900

AlphaMissense

3351 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
17:35770245:C:A	W224C	0.998
17:35770245:C:G	W224C	0.998
17:35770290:G:C	F209L	0.998
17:35770290:G:T	F209L	0.998
17:35770292:A:G	F209L	0.998
17:35773190:A:C	F198L	0.998
17:35773190:A:T	F198L	0.998
17:35773192:A:G	F198L	0.998
17:35770264:A:G	F218S	0.997
17:35770247:A:G	W224R	0.996
17:35770247:A:T	W224R	0.996
17:35773191:A:C	F198C	0.996
17:35773229:G:C	F185L	0.996
17:35773229:G:T	F185L	0.996
17:35773231:A:G	F185L	0.996
17:35773300:A:G	W162R	0.996
17:35773300:A:T	W162R	0.996
17:35770199:G:C	H240D	0.995
17:35773298:C:A	W162C	0.995
17:35773298:C:G	W162C	0.995
17:35770185:G:C	H244Q	0.994
17:35770185:G:T	H244Q	0.994
17:35770194:C:A	E241D	0.994
17:35770194:C:G	E241D	0.994
17:35770195:T:A	E241V	0.994
17:35770266:G:C	H217Q	0.994
17:35770266:G:T	H217Q	0.994
17:35770296:G:C	H207Q	0.994
17:35770296:G:T	H207Q	0.994
17:35770298:G:C	H207D	0.994

dbSNP variants (sampled 300 via entrez): RS1000026322 (17:35770282 C>A,G,T), RS1000041298 (17:35785733 C>T), RS1000231544 (17:35768768 C>A), RS1000355399 (17:35782263 G>C), RS1000431161 (17:35782655 A>T), RS1000582005 (17:35768497 G>A), RS1000693606 (17:35780637 C>T), RS1000835952 (17:35755938 A>G), RS1000971030 (17:35766999 A>T), RS1001016079 (17:35773175 A>T), RS1001349388 (17:35771601 A>G), RS1001371601 (17:35779616 G>A), RS1001401751 (17:35772159 A>G), RS1001456651 (17:35794281 T>C,G), RS1001559717 (17:35794714 C>A)

Disease associations

OMIM: gene MIM:608417 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

4 associations (top):

Study	Trait	p-value
GCST007001_12	Cerebrospinal AB1-42 levels in normal cognition	4.000000e-07
GCST90002385_413	High light scatter reticulocyte count	3.000000e-09
GCST90002386_185	High light scatter reticulocyte percentage of red cells	1.000000e-09
GCST90002406_460	Reticulocyte fraction of red cells	1.000000e-11

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0004670	beta-amyloid 1-42 measurement
EFO:0007986	reticulocyte count

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

GtoPdb / IUPHAR curated pharmacology

(IUPHAR/BPS Guide to Pharmacology — expert-curated)

Target class: enzyme — M10: Matrix metallopeptidase

CTD chemical–gene interactions

28 total (human), top 28 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Arsenic Trioxide	decreases expression	2
Particulate Matter	decreases expression, increases abundance	2
lead acetate	decreases expression	1
sulforaphane	decreases expression	1
sodium arsenite	decreases expression	1
cupric chloride	decreases expression	1
nutlin 3	affects cotreatment, increases expression	1
jinfukang	affects cotreatment, increases expression	1
Air Pollutants	decreases expression, increases abundance	1
Amphotericin B	decreases expression	1
Arsenic	affects methylation	1
Benzo(a)pyrene	increases expression	1
Cisplatin	increases expression, affects cotreatment	1
Dactinomycin	affects cotreatment, increases expression	1
Dichlorodiphenyl Dichloroethylene	decreases expression	1
Diethylhexyl Phthalate	increases expression	1
Drugs, Chinese Herbal	increases expression	1
Estradiol	affects cotreatment, decreases expression	1
Latex	increases expression	1
Naphthoquinones	increases expression	1
Smoke	decreases expression	1
Thiram	decreases expression	1
Tretinoin	increases expression	1
Triclosan	increases expression	1
Valproic Acid	affects expression	1
Antirheumatic Agents	increases expression	1
Okadaic Acid	decreases expression	1
Simvastatin	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.