MNDA

Summary

MNDA (myeloid cell nuclear differentiation antigen, HGNC:7183) is a protein-coding gene on chromosome 1q23.1, encoding Myeloid cell nuclear differentiation antigen (P41218). May act as a transcriptional activator/repressor in the myeloid lineage.

The myeloid cell nuclear differentiation antigen (MNDA) is detected only in nuclei of cells of the granulocyte-monocyte lineage. A 200-amino acid region of human MNDA is strikingly similar to a region in the proteins encoded by a family of interferon-inducible mouse genes, designated Ifi-201, Ifi-202, and Ifi-203, that are not regulated in a cell- or tissue-specific fashion. The 1.8-kb MNDA mRNA, which contains an interferon-stimulated response element in the 5-prime untranslated region, was significantly upregulated in human monocytes exposed to interferon alpha. MNDA is located within 2,200 kb of FCER1A, APCS, CRP, and SPTA1. In its pattern of expression and/or regulation, MNDA resembles IFI16, suggesting that these genes participate in blood cell-specific responses to interferons.

Source: NCBI Gene 4332 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• Clinical variants (ClinVar): 640 total — 1 pathogenic
• MANE Select transcript: NM_002432

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:7183
Approved symbol	MNDA
Name	myeloid cell nuclear differentiation antigen
Location	1q23.1
Locus type	gene with protein product
Status	Approved
Aliases	PYHIN3
Ensembl gene	ENSG00000163563
Ensembl biotype	protein_coding
OMIM	159553
Entrez	4332

Gene structure

Transcript identifiers

Ensembl transcripts: 7 — 6 protein_coding, 1 protein_coding_CDS_not_defined

ENST00000368141, ENST00000438394, ENST00000491210, ENST00000867925, ENST00000867926, ENST00000963510, ENST00000963511

RefSeq mRNA: 1 — MANE Select: NM_002432 NM_002432

CCDS: CCDS1177

Canonical transcript exons

ENST00000368141 — 7 exons

Exon	Start	End
ENSE00001075996	158843955	158844122
ENSE00001075997	158845587	158846003
ENSE00001075998	158843279	158843415
ENSE00001075999	158847728	158847916
ENSE00001446406	158849190	158849502
ENSE00001446407	158842134	158842418
ENSE00001446408	158831351	158831557

Expression profiles

Bgee: expression breadth ubiquitous, 268 present calls, max score 99.69.

FANTOM5 (CAGE): breadth broad, TPM avg 47.6526 / max 10342.7847, expressed in 454 samples.

FANTOM5 promoters (10 alternative TSS)

Promoter ID	TPM avg	Samples expressed
5895	45.6028	452
5896	0.3743	92
5898	0.3668	117
5900	0.3208	103
5910	0.2489	68
5897	0.2010	81
5909	0.1939	58
5908	0.1482	55
5899	0.1058	47
5907	0.0900	33

Top tissues by expression

289 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
monocyte	CL:0000576	99.69	gold quality
mononuclear cell	CL:0000842	99.66	gold quality
leukocyte	CL:0000738	99.64	gold quality
trabecular bone tissue	UBERON:0002483	99.59	gold quality
blood	UBERON:0000178	99.45	gold quality
granulocyte	CL:0000094	99.29	gold quality
bone marrow	UBERON:0002371	98.77	gold quality
periodontal ligament	UBERON:0008266	98.62	gold quality
germinal epithelium of ovary	UBERON:0001304	98.29	gold quality
bone marrow cell	CL:0002092	98.21	gold quality
spleen	UBERON:0002106	96.12	gold quality
palpebral conjunctiva	UBERON:0001812	94.07	gold quality
right lung	UBERON:0002167	92.67	gold quality
vermiform appendix	UBERON:0001154	92.43	gold quality
lower lobe of lung	UBERON:0008949	90.91	gold quality
upper lobe of left lung	UBERON:0008952	89.16	gold quality
upper lobe of lung	UBERON:0008948	88.99	gold quality
gall bladder	UBERON:0002110	88.81	gold quality
lung	UBERON:0002048	88.57	gold quality
decidua	UBERON:0002450	87.54	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	87.12	silver quality
caecum	UBERON:0001153	86.13	gold quality
visceral pleura	UBERON:0002401	85.47	gold quality
calcaneal tendon	UBERON:0003701	85.15	gold quality
pleura	UBERON:0000977	85.04	gold quality
parietal pleura	UBERON:0002400	84.13	gold quality
amniotic fluid	UBERON:0000173	82.84	gold quality
right adrenal gland cortex	UBERON:0035827	82.68	gold quality
lymph node	UBERON:0000029	82.52	gold quality
layer of synovial tissue	UBERON:0007616	81.39	gold quality

Single-cell (SCXA)

Detected in 29 experiment(s), a significant marker in 29.

Experiment	Marker?	Max mean expression
E-CURD-112	yes	4826.20
E-GEOD-149689	yes	3848.26
E-MTAB-9801	yes	3584.86
E-GEOD-150728	yes	3127.81
E-MTAB-10042	yes	2795.47
E-HCAD-32	yes	2019.12
E-HCAD-10	yes	1428.75
E-CURD-55	yes	1351.29
E-MTAB-9067	yes	914.22
E-MTAB-6678	yes	840.45
E-GEOD-130473	yes	819.99
E-MTAB-9906	yes	797.01
E-CURD-79	yes	704.63
E-ANND-5	yes	675.08
E-HCAD-4	yes	216.76

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): SP1, SPI1

miRNA regulators (miRDB)

20 targeting MNDA, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-6077	99.99	68.04	2299
HSA-MIR-5696	99.98	72.36	4487
HSA-MIR-548P	99.98	72.25	3784
HSA-MIR-8068	99.98	73.85	2376
HSA-MIR-27A-3P	99.98	72.13	2955
HSA-MIR-27B-3P	99.98	72.13	2955
HSA-MIR-9985	99.98	72.11	2939
HSA-MIR-10527-5P	99.91	72.28	3754
HSA-MIR-8063	99.91	69.76	3146
HSA-MIR-548E-5P	99.89	72.73	4486
HSA-MIR-380-3P	99.89	70.18	1978
HSA-MIR-4698	99.84	71.41	4303
HSA-MIR-3180-5P	99.82	69.12	2422
HSA-MIR-494-3P	99.70	71.45	2795
HSA-MIR-12132	99.47	68.90	1341
HSA-MIR-889-3P	99.40	69.76	2103
HSA-MIR-3146	98.85	66.77	601
HSA-MIR-6796-3P	98.68	65.49	689
HSA-MIR-3152-5P	96.98	66.88	819

Literature-anchored findings (GeneRIF, showing 13)

• Retroviral mediated expression of the human myeloid nuclear antigen in a null cell line upregulates Dlk1 expression (PMID:12112016)
• variation in MNDA expression appeared to change with phenotypic specialization of monocytes in atherosclerosis consistent with its association with inflammation and suspected roles in regulating gene expression or in mediating cell death (PMID:15778972)
• MNDA has a role regulating programmed cell death in myeloid progenitor cells, and that its down-regulation in myelodysplastic syndromes is related to granulocyte-macrophage progenitor cell sensitivity to TRAIL-induced programmed cell death. (PMID:16651415)
• MNDA expression is a useful tool for the recognition of nodal marginal zone lymphoma (PMID:19474799)
• Myeloid antigen expression is a predictor of a poor response to chemotherapy, and an adverse prognostic factor in adult T-lymphoblastic lymphoma, but not in children with T-LBL. (PMID:20193116)
• Studied the HIN domain of recombinant myeloid nuclear differentiation antigen (MNDA). (PMID:24557068)
• these data support the inclusion of MNDA in the diagnostic evaluation of extramedullary B-cell lymphomas, particularly those in which the differential diagnosis is between low-grade follicular lymphoma and marginal zone lymphoma. (PMID:24925224)
• MFC adds significant information on dyspoiesis in the diagnostic work up for MDS and provides prognostic information. MNDA expression can be assessed by MFC and may facilitate evaluation of dyspoiesis when added to MDS MFC panels. (PMID:26184452)
• MNDA expression is an independent marker for the evaluation of dyspoiesis and may be added to the standard panel for quantitative assessment by FCM. (PMID:26822549)
• IRTA1 and MNDA are useful markers in the differential diagnosis of marginal zone lymphomas (MZLs). (PMID:30346478)
• MNDA controls the expression of MCL-1 and BCL-2 in chronic lymphocytic leukemia cells. (PMID:32682001)
• MNDA, a PYHIN factor involved in transcriptional regulation and apoptosis control in leukocytes. (PMID:38680493)
• Myeloid cell-expressed MNDA enhances M2 polarization to facilitate the metastasis of hepatocellular carcinoma. (PMID:38904028)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
mus_musculus	Ifi202b	ENSMUSG00000026535
mus_musculus	Ifi211	ENSMUSG00000026536
mus_musculus	Ifi205	ENSMUSG00000054203
mus_musculus	Mndal	ENSMUSG00000090272
rattus_norvegicus	Mnda	ENSRNOG00000003486

Paralogs (3): PYHIN1 (ENSG00000163564), IFI16 (ENSG00000163565), AIM2 (ENSG00000163568)

Protein

Protein identifiers

Myeloid cell nuclear differentiation antigen — P41218 (reviewed: P41218)

All UniProt accessions (3): P41218, H0Y6P3, Q5VUU6

UniProt curated annotations — full annotation on UniProt →

Function. May act as a transcriptional activator/repressor in the myeloid lineage. Plays a role in the granulocyte/monocyte cell-specific response to interferon. Stimulates the DNA binding of the transcriptional repressor protein YY1.

Subunit / interactions. Participates in a ternary complex with YY1 and the YY1 target DNA element. Binds nucleolin and nucleophosmin/NPM/B23.

Subcellular location. Nucleus. Cytoplasm.

Tissue specificity. Expressed constitutively in cells of the myeloid lineage. Found in promyelocyte stage cells as well as in all other stage cells including peripheral blood monocytes and granulocytes. Also appears in myeloblast cells in some cases of acute myeloid Leukemia.

Domain organisation. Its N-terminal half (200 amino acids) is sufficient for maximum enhancement of YY1 DNA binding and a portion of this sequence is responsible for binding YY1.

Induction. Strongly induced by alpha interferon which selectively affects expression in late stage cells in the monocytic but not the granulocytic lineage. Induced in vitro by dimethylsulfoxide and 1,25 dihydroxyvitamin D3.

RefSeq proteins (1): NP_002423* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR004020	DAPIN	Domain
IPR004021	HIN200/IF120x	Domain
IPR011029	DEATH-like_dom_sf	Homologous_superfamily
IPR012340	NA-bd_OB-fold	Homologous_superfamily
IPR040205	HIN-200	Family

Pfam: PF02758, PF02760

UniProt features (38 total): strand 14, helix 13, sequence variant 3, domain 2, compositionally biased region 2, chain 1, turn 1, region of interest 1, short sequence motif 1

Structure

Experimental structures (PDB)

4 structures.

PDB	Method	Resolution (Å)
5H7Q	X-RAY DIFFRACTION	1.45
5WPZ	X-RAY DIFFRACTION	2
8I6K	X-RAY DIFFRACTION	2.4
2DBG	SOLUTION NMR

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P41218-F1	78.60	0.62

Function

Pathways and Gene Ontology

Reactome pathways

3 pathways

ID	Pathway
R-HSA-6798695	Neutrophil degranulation
R-HSA-168249	Innate Immune System
R-HSA-168256	Immune System

MSigDB gene sets: 268 (showing top): WAMUNYOKOLI_OVARIAN_CANCER_LMP_DN, GOBP_REGULATION_OF_CELL_ACTIVATION, GOBP_REGULATION_OF_LEUKOCYTE_PROLIFERATION, REACTOME_INNATE_IMMUNE_SYSTEM, MCLACHLAN_DENTAL_CARIES_UP, GOBP_RESPONSE_TO_PEPTIDE, GOBP_B_CELL_ACTIVATION, GOCC_SECRETORY_GRANULE, GOBP_NEGATIVE_REGULATION_OF_LEUKOCYTE_PROLIFERATION, MODULE_151, CHUNG_BLISTER_CYTOTOXICITY_DN, MODULE_45, GRAESSMANN_APOPTOSIS_BY_SERUM_DEPRIVATION_UP, GRAESSMANN_RESPONSE_TO_MC_AND_SERUM_DEPRIVATION_UP, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP

GO Biological Process (7): activation of innate immune response (GO:0002218), cellular defense response (GO:0006968), DNA damage response (GO:0006974), negative regulation of B cell proliferation (GO:0030889), cellular response to interferon-beta (GO:0035458), positive regulation of apoptotic process (GO:0043065), B cell receptor signaling pathway (GO:0050853)

GO Molecular Function (3): double-stranded DNA binding (GO:0003690), DNA binding (GO:0003677), protein binding (GO:0005515)

GO Cellular Component (9): extracellular region (GO:0005576), nucleoplasm (GO:0005654), nucleolus (GO:0005730), cytosol (GO:0005829), azurophil granule lumen (GO:0035578), extracellular exosome (GO:0070062), ficolin-1-rich granule lumen (GO:1904813), nucleus (GO:0005634), cytoplasm (GO:0005737)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
Innate Immune System	1
Immune System	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	4
nuclear lumen	2
activation of immune response	1
positive regulation of innate immune response	1
defense response	1
cellular response to stress	1
regulation of B cell proliferation	1
B cell proliferation	1
negative regulation of lymphocyte proliferation	1
negative regulation of B cell activation	1
response to interferon-beta	1
cellular response to cytokine stimulus	1
apoptotic process	1
regulation of apoptotic process	1
positive regulation of programmed cell death	1
antigen receptor-mediated signaling pathway	1
DNA binding	1
nucleic acid binding	1
binding	1
intracellular membraneless organelle	1
cytoplasm	1
vacuolar lumen	1
secretory granule lumen	1
azurophil granule	1
extracellular vesicle	1
intracellular organelle lumen	1
ficolin-1-rich granule	1
intracellular membrane-bounded organelle	1
intracellular anatomical structure	1

Protein interactions and networks

STRING

1552 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
MNDA	MEFV	O15553	727
MNDA	SPTA1	P02549	542
MNDA	FCER1A	P12319	528
MNDA	PYCARD	Q9ULZ3	518
MNDA	CD53	P19397	517
MNDA	IFNA16	P05015	514
MNDA	IFNA8	P01565	511
MNDA	IFNA7	P01567	507
MNDA	IFNA21	P01568	507
MNDA	FPR1	P21462	507
MNDA	IFNA5	P01569	506
MNDA	IFNA14	P01570	505
MNDA	TLR8	Q9NR97	504
MNDA	LYZ	P00695	494
MNDA	IFNA6	P05013	492

IntAct

96 interactions, top by confidence:

A	B	Type	Score
HEMGN	NPM1	psi-mi:“MI:0914”(association)	0.600
MNDA	A2M	psi-mi:“MI:0915”(physical association)	0.560
MNDA	DNM2	psi-mi:“MI:0915”(physical association)	0.560
TOR1A	MNDA	psi-mi:“MI:0915”(physical association)	0.560
MNDA		psi-mi:“MI:0915”(physical association)	0.560
GRN	MNDA	psi-mi:“MI:0915”(physical association)	0.560
MNDA	MET	psi-mi:“MI:0915”(physical association)	0.560
MNDA	NDUFV1	psi-mi:“MI:0915”(physical association)	0.560
MNDA	PEX1	psi-mi:“MI:0915”(physical association)	0.560
PSEN2	MNDA	psi-mi:“MI:0915”(physical association)	0.560
MNDA	TTR	psi-mi:“MI:0915”(physical association)	0.560
YWHAG	MNDA	psi-mi:“MI:0915”(physical association)	0.560
SETDB1	MNDA	psi-mi:“MI:0915”(physical association)	0.560
KAT5	MNDA	psi-mi:“MI:0915”(physical association)	0.560
LMO3	MNDA	psi-mi:“MI:0915”(physical association)	0.560
MNDA	HTT	psi-mi:“MI:0915”(physical association)	0.560

BioGRID (189): MNDA (Synthetic Lethality), MNDA (Two-hybrid), MNDA (Two-hybrid), MNDA (Two-hybrid), MNDA (Biochemical Activity), MNDA (Proximity Label-MS), AATF (Affinity Capture-MS), ATXN2 (Affinity Capture-MS), ATXN2L (Affinity Capture-MS), BMS1 (Affinity Capture-MS), BOP1 (Affinity Capture-MS), BRIX1 (Affinity Capture-MS), BYSL (Affinity Capture-MS), KNOP1 (Affinity Capture-MS), C7orf50 (Affinity Capture-MS)

ESM2 similar proteins: A6H5X4, B1AUS7, D0QMC3, O35368, O60224, O60225, P0C6Y7, P0DOV1, P0DOV2, P23497, P41218, Q15361, Q16384, Q16385, Q16666, Q2KIN0, Q3U827, Q3ZCI6, Q4R7Q1, Q504N7, Q5H9L4, Q5I0E2, Q5I0J8, Q5RAK3, Q5RCZ8, Q5RD14, Q5W0A0, Q62187, Q6K0P9, Q71F23, Q7RTT3, Q7RTT4, Q7RTT5, Q7RTT6, Q86T96, Q8BV49, Q8BVM9, Q8C0V1, Q8C6C7, Q8CGE8

Diamond homologs: D0QMC3, O14862, O35368, P0DOV1, P0DOV2, P41218, Q16666, Q3V3Q4, Q504N7, Q5RD14, Q6K0P9, Q8BV49, Q8CGE8, Q8SPH9, Q91VJ1, Q9R002, W6CW81

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

640 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	1
Likely pathogenic	0
Uncertain significance	409
Likely benign	225
Benign	0

Top pathogenic / likely-pathogenic (1)

Variant ID	HGVS	Classification
3247947	NC_000001.10:g.(?158581054)(158819027_?)del	Pathogenic

SpliceAI

924 predictions. Top by Δscore:

Variant	Effect	Δscore
1:158831556:AGGTG:A	donor_loss	1.0000
1:158831558:GTGAG:G	donor_loss	1.0000
1:158843273:T:TA	acceptor_gain	1.0000
1:158843274:GTCA:G	acceptor_loss	1.0000
1:158843275:TCAGT:T	acceptor_loss	1.0000
1:158843277:A:AG	acceptor_gain	1.0000
1:158843277:A:C	acceptor_loss	1.0000
1:158843277:AGTT:A	acceptor_gain	1.0000
1:158843278:G:A	acceptor_loss	1.0000
1:158843278:G:GC	acceptor_gain	1.0000
1:158843278:GT:G	acceptor_gain	1.0000
1:158843278:GTT:G	acceptor_gain	1.0000
1:158843278:GTTG:G	acceptor_gain	1.0000
1:158843278:GTTGC:G	acceptor_gain	1.0000
1:158844524:A:G	donor_gain	1.0000
1:158847727:GA:G	acceptor_gain	1.0000
1:158847727:GAAAA:G	acceptor_gain	1.0000
1:158847934:GAGAA:G	donor_gain	1.0000
1:158832452:ATTTT:A	donor_gain	0.9900
1:158842132:A:AG	acceptor_gain	0.9900
1:158842133:G:GG	acceptor_gain	0.9900
1:158843280:T:A	acceptor_gain	0.9900
1:158843411:CTCAG:C	donor_loss	0.9900
1:158843412:TCAG:T	donor_loss	0.9900
1:158843413:CAGGT:C	donor_loss	0.9900
1:158843416:G:T	donor_loss	0.9900
1:158843417:T:G	donor_loss	0.9900
1:158844514:GACA:G	donor_gain	0.9900
1:158845802:G:GT	donor_gain	0.9900
1:158847724:GCAG:G	acceptor_loss	0.9900

AlphaMissense

2694 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:158845794:T:C	F260L	0.988
1:158845796:T:A	F260L	0.988
1:158845796:T:G	F260L	0.988
1:158845989:T:C	F325L	0.987
1:158845991:T:A	F325L	0.987
1:158845991:T:G	F325L	0.987
1:158845722:T:C	F236L	0.986
1:158845724:T:A	F236L	0.986
1:158845724:T:G	F236L	0.986
1:158845728:G:C	A238P	0.985
1:158847905:A:C	S389R	0.983
1:158847907:C:A	S389R	0.983
1:158847907:C:G	S389R	0.983
1:158845738:C:A	A241D	0.982
1:158845795:T:C	F260S	0.979
1:158845723:T:C	F236S	0.978
1:158845729:C:A	A238D	0.976
1:158845795:T:G	F260C	0.975
1:158845737:G:C	A241P	0.971
1:158847767:G:C	D343H	0.970
1:158842319:T:C	F56L	0.969
1:158842321:C:A	F56L	0.969
1:158842321:C:G	F56L	0.969
1:158845990:T:C	F325S	0.968
1:158847762:T:A	I341K	0.966
1:158845983:G:T	G323W	0.965
1:158845735:T:A	V240E	0.961
1:158845666:T:C	L217P	0.959
1:158847848:T:C	F370L	0.959
1:158847850:C:A	F370L	0.959

dbSNP variants (sampled 300 via entrez): RS1000020171 (1:158831854 G>A), RS1000041657 (1:158845366 T>C), RS1000104626 (1:158847583 T>A), RS1000140086 (1:158838491 T>C), RS1000261373 (1:158838779 A>G), RS1000386485 (1:158844495 C>A,T), RS1000634142 (1:158833985 CT>C), RS1000849837 (1:158839713 A>G,T), RS1000963958 (1:158833622 C>T), RS1001318188 (1:158846433 A>C), RS1001477663 (1:158833312 T>C), RS1001547798 (1:158833585 G>C), RS1001663143 (1:158846796 C>T), RS1001689962 (1:158830327 C>A,T), RS1001963614 (1:158836325 G>T)

Disease associations

OMIM: gene MIM:159553 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST001762_657	Obesity-related traits	1.000000e-06
GCST008765_1	Perceived intensity of aspartame	3.000000e-06
GCST009391_61	Metabolite levels	5.000000e-06

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0003939	energy intake
EFO:0010352	diacylglycerol 34:1 measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

GtoPdb / IUPHAR curated pharmacology

(IUPHAR/BPS Guide to Pharmacology — expert-curated)

Target class: other protein — Absent in melanoma (AIM)-like receptors (ALRs)

CTD chemical–gene interactions

20 total (human), top 20 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Nickel	decreases expression, increases expression	3
Tretinoin	increases expression	2
triphenyl phosphate	affects expression	1
sulforaphane	increases expression	1
tetrathiomolybdate	increases expression	1
4-hydroxy-2-nonenal	decreases expression	1
S-(1,2-dichlorovinyl)cysteine	affects response to substance, increases expression, affects cotreatment, decreases expression	1
di-n-butylphosphoric acid	affects expression	1
Air Pollutants	affects expression, increases abundance	1
Air Pollutants, Occupational	decreases expression	1
Benzo(a)pyrene	decreases expression	1
Cadmium	decreases expression, increases abundance	1
Caffeine	increases phosphorylation	1
Lipopolysaccharides	affects response to substance, increases expression, affects cotreatment, decreases expression	1
Ozone	affects expression, increases abundance	1
Zidovudine	affects cotreatment, increases expression	1
Asbestos, Serpentine	decreases expression	1
Uranium Compounds	increases expression	1
Antirheumatic Agents	decreases expression	1
Cadmium Chloride	decreases expression, increases abundance	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.