MNT

Summary

MNT (MAX network transcriptional repressor, HGNC:7188) is a protein-coding gene on chromosome 17p13.3, encoding Max-binding protein MNT (Q99583). Binds DNA as a heterodimer with MAX and represses transcription.

The Myc/Max/Mad network comprises a group of transcription factors that co-interact to regulate gene-specific transcriptional activation or repression. This gene encodes a protein member of the Myc/Max/Mad network. This protein has a basic-Helix-Loop-Helix-zipper domain (bHLHzip) with which it binds the canonical DNA sequence CANNTG, known as the E box, following heterodimerization with Max proteins. This protein is likely a transcriptional repressor and an antagonist of Myc-dependent transcriptional activation and cell growth. This protein represses transcription by binding to DNA binding proteins at its N-terminal Sin3-interaction domain.

Source: NCBI Gene 4335 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 91 total
• Transcription factor: yes — 11 downstream targets (CollecTRI)
• MANE Select transcript: NM_020310

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:7188
Approved symbol	MNT
Name	MAX network transcriptional repressor
Location	17p13.3
Locus type	gene with protein product
Status	Approved
Aliases	ROX, MXD6, MAD6, bHLHd3, lncRNA-HAL
Ensembl gene	ENSG00000070444
Ensembl biotype	protein_coding
OMIM	603039
Entrez	4335

Gene structure

Transcript identifiers

Ensembl transcripts: 10 — 5 protein_coding_CDS_not_defined, 3 protein_coding, 2 retained_intron

ENST00000174618, ENST00000571232, ENST00000571836, ENST00000572892, ENST00000573384, ENST00000574559, ENST00000575374, ENST00000575394, ENST00000575402, ENST00000860066

RefSeq mRNA: 1 — MANE Select: NM_020310 NM_020310

CCDS: CCDS11018

Canonical transcript exons

ENST00000174618 — 6 exons

Exon	Start	End
ENSE00000947170	2394875	2395454
ENSE00000947171	2394305	2394346
ENSE00000947172	2394043	2394154
ENSE00001279419	2384073	2387649
ENSE00001490476	2400640	2401060
ENSE00003597659	2387857	2388049

Expression profiles

Bgee: expression breadth ubiquitous, 288 present calls, max score 98.39.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 18.4432 / max 217.0966, expressed in 1803 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
163825	12.5656	1783
163826	3.9441	1633
163824	1.1854	737
163822	0.4332	122
163823	0.3149	131

Top tissues by expression

292 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
cervix squamous epithelium	UBERON:0006922	98.39	gold quality
Brodmann (1909) area 23	UBERON:0013554	96.21	gold quality
middle temporal gyrus	UBERON:0002771	95.90	gold quality
CA1 field of hippocampus	UBERON:0003881	95.74	gold quality
endothelial cell	CL:0000115	95.68	gold quality
dorsal motor nucleus of vagus nerve	UBERON:0002870	94.73	gold quality
Brodmann (1909) area 10	UBERON:0013541	93.61	gold quality
sural nerve	UBERON:0015488	93.54	gold quality
gingival epithelium	UBERON:0001949	93.46	silver quality
orbitofrontal cortex	UBERON:0004167	93.12	gold quality
tongue squamous epithelium	UBERON:0006919	93.06	gold quality
tendon of biceps brachii	UBERON:0008188	92.52	gold quality
cervix epithelium	UBERON:0004801	92.28	gold quality
pancreatic ductal cell	CL:0002079	91.90	silver quality
epithelium of mammary gland	UBERON:0003244	91.70	gold quality
mammary duct	UBERON:0001765	91.58	gold quality
seminal vesicle	UBERON:0000998	91.11	gold quality
oviduct epithelium	UBERON:0004804	91.10	gold quality
inferior olivary complex	UBERON:0002127	90.87	gold quality
entorhinal cortex	UBERON:0002728	90.65	gold quality
primary visual cortex	UBERON:0002436	90.61	gold quality
gingiva	UBERON:0001828	90.56	gold quality
occipital lobe	UBERON:0002021	90.15	gold quality
blood	UBERON:0000178	90.10	gold quality
hair follicle	UBERON:0002073	89.91	silver quality
Brodmann (1909) area 46	UBERON:0006483	89.91	gold quality
lateral nuclear group of thalamus	UBERON:0002736	89.28	gold quality
olfactory bulb	UBERON:0002264	89.16	silver quality
germinal epithelium of ovary	UBERON:0001304	89.10	gold quality
parietal pleura	UBERON:0002400	89.07	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	7.28

Regulation

Is transcription factor: yes

Downstream targets (CollecTRI)

11 targets.

Target	Regulation
CCND2
ERG	Unknown
GLMN
HAP1
IL1B
KRAS
MAX
MNT
RSPH1	Unknown
TERT
TP53

JASPAR motifs

Motif	Name	Family
MA0825.1	MNT	bHLH-ZIP
MA0825.2	MNT	bHLH-ZIP

JASPAR matrix evidence (PMIDs): PMID:12695332

Upstream regulators (CollecTRI, top): APEX1, MNT, MYC

miRNA regulators (miRDB)

172 targeting MNT, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-6867-5P	100.00	82.21	3464
HSA-MIR-4673	100.00	66.64	1490
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-4789-3P	99.99	70.75	2484
HSA-MIR-6870-5P	99.99	68.55	2115
HSA-MIR-4645-5P	99.98	65.81	1284
HSA-MIR-4723-5P	99.97	68.70	2034
HSA-MIR-5698	99.97	68.49	2029
HSA-MIR-7111-5P	99.97	68.48	2062
HSA-MIR-302E	99.96	70.74	2669
HSA-LET-7C-3P	99.95	73.42	2862
HSA-MIR-128-3P	99.95	71.17	2484
HSA-MIR-216A-3P	99.95	71.19	2505
HSA-MIR-185-3P	99.95	67.01	1743
HSA-MIR-144-3P	99.94	73.98	2698
HSA-MIR-1-3P	99.93	72.35	1914
HSA-MIR-206	99.93	72.50	1893
HSA-MIR-6721-5P	99.93	68.92	2981
HSA-MIR-205-3P	99.92	69.92	3165
HSA-MIR-497-5P	99.92	71.83	2674
HSA-MIR-613	99.91	71.50	1710
HSA-MIR-15A-5P	99.90	72.80	2787
HSA-MIR-15B-5P	99.90	72.78	2798
HSA-MIR-16-5P	99.90	72.80	2780
HSA-MIR-195-5P	99.90	72.81	2805
HSA-MIR-424-5P	99.89	71.90	2641
HSA-MIR-6838-5P	99.89	71.94	2690
HSA-MIR-302A-3P	99.89	71.23	1777
HSA-MIR-302B-3P	99.89	71.23	1777
HSA-MIR-302C-3P	99.89	71.20	1778

Literature-anchored findings (GeneRIF, showing 13)

• downregulation MYCN was reflected in a decreased MYCN/Max DNA-binding activity while the Mnt/Max binding did not change during differentiation (PMID:15258910)
• Serum stimulation of quiescent cells results in phosphorylation of Mnt and disruption of the critical Mnt-mSin3-HDAC1 interaction. This in turn leads to increased expression of the Myc/Mnt target gene cyclin D2. Review. (PMID:17419941)
• Mad1, Mxi1 and Rox genes were expressed and displayed mutations in haematological malignancies. (PMID:17577784)
• Mxd1 D112a and Max N78a and H81d, which are located in the leucine zippers of the proteins, can dictate the specificity of heterodimerization and whether or not the Mxd1/Max/DNA complex forms. (PMID:18155722)
• Missense mutations in Mad1, Mxi1 and Rox were found in acute leukemia patients. (PMID:18457265)
• The switch from Mnt-Max to Myc-Max during bile duct ligation (cholestasis) and in hepatocytes treated with lithocholic acid is responsible for the induction in p53 and cyclin D1 expression and contributes to apoptosis. (PMID:19086036)
• The results suggest that MNT, via interaction with Nck1, inhibits hepatoma cell migration. (PMID:22964333)
• The data demonstrate that the balance between c-Myc and Mnt activity determines the transcriptional outcome of the hTERT promoter by modulation of the chromatin architecture. (PMID:23860446)
• Here we review the activities of MYC, MNT and other MAX interacting proteins in the setting of T and B cell activation and oncogenesis (PMID:24731854)
• In vitro, uremia induced dysregulation of DNA methylation in differentiating monocytes, which affected several transcription regulators important for monocyte differentiation (e.g., FLT3, HDAC1, MNT) and led to enhanced generation of intermediate monocytes. (PMID:27018948)
• The MNT transcription factor autoregulates its expression and supports proliferation in MYC-associated factor X (MAX)-deficient cells. (PMID:31919096)
• Mnt Represses Epithelial Identity To Promote Epithelial-to-Mesenchymal Transition. (PMID:34460331)
• MNT inhibits lung adenocarcinoma ferroptosis and chemosensitivity by suppressing SAT1. (PMID:38831092)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	mnta	ENSDARG00000101859
mus_musculus	Mnt	ENSMUSG00000000282
rattus_norvegicus	Mnt	ENSRNOG00000002894
caenorhabditis_elegans		WBGENE00003163

Paralogs (4): MXD1 (ENSG00000059728), MXI1 (ENSG00000119950), MXD4 (ENSG00000123933), MXD3 (ENSG00000213347)

Protein

Protein identifiers

Max-binding protein MNT — Q99583 (reviewed: Q99583)

Alternative names: Class D basic helix-loop-helix protein 3, Myc antagonist MNT, Protein ROX

All UniProt accessions (2): Q99583, V9GY02

UniProt curated annotations — full annotation on UniProt →

Function. Binds DNA as a heterodimer with MAX and represses transcription. Binds to the canonical E box sequence 5’-CACGTG-3’ and, with higher affinity, to 5’-CACGCG-3'.

Subunit / interactions. Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a homodimer or a heterodimer with MAX.

Subcellular location. Nucleus.

RefSeq proteins (1): NP_064706* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR011598	bHLH_dom	Domain
IPR036638	HLH_DNA-bd_sf	Homologous_superfamily

Pfam: PF00010

UniProt features (19 total): compositionally biased region 11, region of interest 3, initiator methionine 1, chain 1, modified residue 1, sequence variant 1, domain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q99583-F1	60.87	0.24

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 2

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 377 (showing top): RNGTGGGC_UNKNOWN, BROWNE_HCMV_INFECTION_6HR_DN, PAX4_01, FISCHER_G1_S_CELL_CYCLE, LFA1_Q6, ATACCTC_MIR202, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN, TGACCTY_ERR1_Q2, AP2_Q3, CACCAGC_MIR138, GOBP_CELLULAR_SENESCENCE, GGGTGGRR_PAX4_03, USF_C, YY1_Q6, AACWWCAANK_UNKNOWN

GO Biological Process (7): negative regulation of transcription by RNA polymerase II (GO:0000122), regulation of transcription by RNA polymerase II (GO:0006357), transcription by RNA polymerase II (GO:0006366), regulation of cell cycle (GO:0051726), cellular senescence (GO:0090398), negative regulation of apoptotic signaling pathway (GO:2001234), regulation of DNA-templated transcription (GO:0006355)

GO Molecular Function (10): RNA polymerase II transcription regulatory region sequence-specific DNA binding (GO:0000977), RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978), DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981), DNA-binding transcription repressor activity, RNA polymerase II-specific (GO:0001227), chromatin binding (GO:0003682), DNA-binding transcription factor activity (GO:0003700), identical protein binding (GO:0042802), protein dimerization activity (GO:0046983), DNA binding (GO:0003677), protein binding (GO:0005515)

GO Cellular Component (3): chromatin (GO:0000785), nucleoplasm (GO:0005654), nucleus (GO:0005634)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
RNA polymerase II transcription regulatory region sequence-specific DNA binding	3
regulation of transcription by RNA polymerase II	2
transcription by RNA polymerase II	2
regulation of DNA-templated transcription	2
DNA-templated transcription	2
transcription cis-regulatory region binding	2
binding	2
protein binding	2
cellular anatomical structure	2
negative regulation of DNA-templated transcription	1
cell cycle	1
regulation of cellular process	1
cellular process	1
cellular response to stress	1
negative regulation of signal transduction	1
negative regulation of apoptotic process	1
apoptotic signaling pathway	1
regulation of apoptotic signaling pathway	1
regulation of gene expression	1
regulation of RNA biosynthetic process	1
cis-regulatory region sequence-specific DNA binding	1
chromatin	1
DNA-binding transcription factor activity	1
negative regulation of transcription by RNA polymerase II	1
DNA-binding transcription factor activity, RNA polymerase II-specific	1
DNA-binding transcription repressor activity	1
transcription regulator activity	1
nucleic acid binding	1
chromosome	1
nuclear lumen	1
intracellular membrane-bounded organelle	1

Protein interactions and networks

STRING

784 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
MNT	MXD4	Q14582	895
MNT	MLX	Q9UH92	872
MNT	MYC	P01106	776
MNT	MLXIPL	Q9NP71	729
MNT	SIN3A	Q96ST3	724
MNT	MYCN	P04198	697
MNT	NIF3L1	Q9GZT8	666
MNT	MXD1	Q05195	623
MNT	CISD1	Q9NZ45	591
MNT	PKLR	P11973	588
MNT	MAX	P25912	570
MNT	MLXIP	Q9HAP2	568
MNT	HIC1	Q14526	555
MNT	MYCL	P12524	549
MNT	WSB1	Q9Y6I7	548

IntAct

33 interactions, top by confidence:

A	B	Type	Score
MNT	MAX	psi-mi:“MI:0915”(physical association)	0.810
MAX	MNT	psi-mi:“MI:0915”(physical association)	0.810
MAX	E2F6	psi-mi:“MI:0914”(association)	0.710
NCK2	MNT	psi-mi:“MI:0915”(physical association)	0.560
MNT	MNT	psi-mi:“MI:0915”(physical association)	0.510
Sin3a	MNT	psi-mi:“MI:0915”(physical association)	0.510
Dlg4	MNT	psi-mi:“MI:0407”(direct interaction)	0.440
MNT	SMS	psi-mi:“MI:0915”(physical association)	0.400
MNT	ITGB1	psi-mi:“MI:0915”(physical association)	0.400
MNT	TPR	psi-mi:“MI:0915”(physical association)	0.400
SIN3	MNT	psi-mi:“MI:0915”(physical association)	0.370
MLX	MNT	psi-mi:“MI:0915”(physical association)	0.370
Max	PABPN1	psi-mi:“MI:0914”(association)	0.350
FOXK2	PHF20L1	psi-mi:“MI:0914”(association)	0.350
MAX	SMARCA5	psi-mi:“MI:0914”(association)	0.350
MXD3	SAP30	psi-mi:“MI:0914”(association)	0.350
MAX	AGRN	psi-mi:“MI:0914”(association)	0.350
MLX	MGA	psi-mi:“MI:0914”(association)	0.350
KLF8	USP27X	psi-mi:“MI:2364”(proximity)	0.270
KLF9	SEC16A	psi-mi:“MI:2364”(proximity)	0.270

BioGRID (55): MNT (Two-hybrid), MNT (Affinity Capture-MS), MNT (Affinity Capture-MS), MNT (Affinity Capture-MS), MNT (Reconstituted Complex), MNT (Affinity Capture-Western), UBE3A (Affinity Capture-Western), MNT (Affinity Capture-MS), MNT (Affinity Capture-MS), MNT (Affinity Capture-MS), MNT (Affinity Capture-MS), MNT (Affinity Capture-MS), MNT (Positive Genetic), MNT (Protein-RNA), MNT (Affinity Capture-MS)

ESM2 similar proteins: A4IFD2, A4QNP0, O08789, O89038, O94842, P09086, P15257, P20823, P22361, P42128, P48436, P58462, P61753, P61754, P85037, Q00196, Q01167, Q0P5K4, Q0VH32, Q14814, Q29013, Q2LE08, Q3LHL9, Q3UCQ1, Q498D1, Q4VYS1, Q58NQ4, Q5F3U0, Q5M7C3, Q5R6A9, Q62901, Q63943, Q6DDH6, Q6DJL0, Q6IRR0, Q7ZUV7, Q7ZX03, Q8BIH0, Q8BU11, Q8CHI8

Diamond homologs: O08789, P28574, P50538, P50539, P52162, P52164, P61244, P61245, Q05195, Q07016, Q0VFI9, Q0VH32, Q0VH33, Q0VH34, Q28DB3, Q62912, Q7SX95, Q80US8, Q99583, Q9BW11, G5EG44, O09015, P50540, P50541, Q14582, Q60948, A1YG22, A2T7L5, B8XIA5, G5EEH5, O02818, P01106, P01108, P01109, P01110, P03966, P04198, P06171, P06295, P06646

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
MAX	“up-regulates activity”	MNT	binding

Disease & clinical

Clinical variants and AI predictions

ClinVar

91 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	80
Likely benign	3
Benign	2

Top pathogenic / likely-pathogenic (0)

SpliceAI

1424 predictions. Top by Δscore:

Variant	Effect	Δscore
17:2387646:CCCT:C	acceptor_gain	1.0000
17:2387647:CCTC:C	acceptor_gain	1.0000
17:2387851:GCTCA:G	donor_loss	1.0000
17:2387852:CTCA:C	donor_loss	1.0000
17:2387853:TCAC:T	donor_loss	1.0000
17:2387854:CA:C	donor_loss	1.0000
17:2387855:A:C	donor_loss	1.0000
17:2387856:C:A	donor_loss	1.0000
17:2388047:GGA:G	acceptor_gain	1.0000
17:2388049:AC:A	acceptor_loss	1.0000
17:2388050:C:CC	acceptor_gain	1.0000
17:2388054:C:CT	acceptor_gain	1.0000
17:2388058:CAGAG:C	acceptor_gain	1.0000
17:2388062:G:GC	acceptor_gain	1.0000
17:2394150:CCCTC:C	acceptor_gain	1.0000
17:2394151:CCTCC:C	acceptor_gain	1.0000
17:2394152:CTC:C	acceptor_gain	1.0000
17:2395455:C:CC	acceptor_gain	1.0000
17:2400639:CCA:C	donor_gain	1.0000
17:2387648:CT:C	acceptor_gain	0.9900
17:2387650:C:CC	acceptor_gain	0.9900
17:2387855:A:AC	donor_gain	0.9900
17:2387856:C:CC	donor_gain	0.9900
17:2387886:T:TA	donor_gain	0.9900
17:2388045:AGGGA:A	acceptor_gain	0.9900
17:2388046:GGGA:G	acceptor_gain	0.9900
17:2388048:GA:G	acceptor_gain	0.9900
17:2388056:C:CT	acceptor_gain	0.9900
17:2388059:A:T	acceptor_gain	0.9900
17:2388062:G:C	acceptor_gain	0.9900

AlphaMissense

3711 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
17:2387997:C:G	R287P	1.000
17:2388003:A:G	L285P	1.000
17:2388045:A:G	L271P	1.000
17:2394047:A:T	I268N	1.000
17:2394056:A:G	L265P	1.000
17:2394059:G:T	A264E	1.000
17:2394060:C:G	A264P	1.000
17:2394068:A:C	L261R	1.000
17:2394068:A:G	L261P	1.000
17:2394068:A:T	L261Q	1.000
17:2394077:A:G	L258P	1.000
17:2394077:A:T	L258Q	1.000
17:2394079:A:C	N257K	1.000
17:2394079:A:T	N257K	1.000
17:2394081:T:C	N257D	1.000
17:2394083:G:A	S256F	1.000
17:2394083:G:T	S256Y	1.000
17:2394118:C:A	K244N	1.000
17:2394118:C:G	K244N	1.000
17:2394122:A:C	L243R	1.000
17:2394122:A:G	L243P	1.000
17:2394122:A:T	L243Q	1.000
17:2394130:A:C	F240L	1.000
17:2394130:A:T	F240L	1.000
17:2394131:A:C	F240C	1.000
17:2394131:A:G	F240S	1.000
17:2394132:A:C	F240V	1.000
17:2394132:A:G	F240L	1.000
17:2394132:A:T	F240I	1.000
17:2394133:G:C	C239W	1.000

dbSNP variants (sampled 300 via entrez): RS1000120213 (17:2401705 C>G,T), RS1000171535 (17:2390744 T>G), RS1000213502 (17:2393245 G>A,C), RS1000214954 (17:2383834 A>T), RS1000234548 (17:2389023 G>A), RS1000310696 (17:2384178 C>T), RS1000350059 (17:2389205 C>T), RS1000408412 (17:2388948 C>T), RS1000496770 (17:2392784 C>T), RS1000599309 (17:2392920 C>G), RS1000683026 (17:2388237 G>A), RS1000765055 (17:2401608 C>T), RS1000796163 (17:2401441 G>A), RS1000881694 (17:2401712 A>G,T), RS1000954827 (17:2392700 C>A,G,T)

Disease associations

OMIM: gene MIM:603039 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST003130_4	Autism spectrum disorder	9.000000e-06
GCST90000025_117	Appendicular lean mass	2.000000e-11

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0004980	appendicular lean mass

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

46 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	affects expression, increases abundance, increases expression	4
Cisplatin	decreases expression	2
Valproic Acid	affects expression, decreases expression	2
Cyclosporine	increases expression	2
Cadmium Chloride	decreases expression, increases abundance, increases expression	2
GSK-J4	increases expression	1
dicrotophos	increases expression	1
triphenyl phosphate	affects expression	1
bisphenol A	decreases methylation	1
geraniol	increases expression	1
arsenite	decreases methylation	1
mono-(2-ethylhexyl)phthalate	increases expression	1
butyraldehyde	decreases expression	1
manganese chloride	increases abundance, increases expression	1
beta-methylcholine	affects expression	1
celastrol	increases expression	1
di-n-butylphosphoric acid	affects expression	1
gedunin	increases expression	1
PCI 5002	affects cotreatment, increases expression	1
Sunitinib	increases expression	1
Arsenic Trioxide	decreases expression	1
Air Pollutants	affects expression, increases abundance	1
Arsenic	increases abundance, increases expression	1
Atrazine	increases expression	1
Cadmium	decreases expression, increases abundance	1
Doxorubicin	decreases expression	1
Hydrogen Peroxide	affects expression	1
Ivermectin	decreases expression	1
Manganese	increases abundance, increases expression	1
Methotrexate	decreases expression	1

Cellosaurus cell lines

3 cell lines: 3 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_SY71	HAP1 MNT (-) 1	Cancer cell line	Male
CVCL_SY72	HAP1 MNT (-) 2	Cancer cell line	Male
CVCL_SY73	HAP1 MNT (-) 3	Cancer cell line	Male

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.