MOB1A

Summary

MOB1A (MOB kinase activator 1A, HGNC:16015) is a protein-coding gene on chromosome 2p13.1, encoding MOB kinase activator 1A (Q9H8S9). Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis.

The protein encoded by this gene is a component of the Hippo signaling pathway, which controls organ size and tumor growth by enhancing apoptosis. Loss of the encoded protein results in cell proliferation and cancer formation. The encoded protein is also involved in the control of microtubule stability during cytokinesis. Several transcript variants encoding different isoforms have been found for this gene.

Source: NCBI Gene 55233 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 21 total
• MANE Select transcript: NM_018221

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:16015
Approved symbol	MOB1A
Name	MOB kinase activator 1A
Location	2p13.1
Locus type	gene with protein product
Status	Approved
Aliases	FLJ10788, MOB1, FLJ11595, Mob4B, Mats1
Ensembl gene	ENSG00000114978
Ensembl biotype	protein_coding
OMIM	609281
Entrez	55233

Gene structure

Transcript identifiers

Ensembl transcripts: 12 — 7 protein_coding, 4 protein_coding_CDS_not_defined, 1 retained_intron

ENST00000396049, ENST00000463975, ENST00000488006, ENST00000494600, ENST00000495286, ENST00000497054, ENST00000882070, ENST00000882071, ENST00000882072, ENST00000925501, ENST00000925502, ENST00000925503

RefSeq mRNA: 4 — MANE Select: NM_018221 NM_001317110, NM_001317111, NM_001317112, NM_018221

CCDS: CCDS46340

Canonical transcript exons

ENST00000396049 — 6 exons

Exon	Start	End
ENSE00001813102	74152528	74156645
ENSE00002465743	74159091	74159254
ENSE00003480355	74167014	74167107
ENSE00003530028	74178661	74178879
ENSE00003574525	74165218	74165351
ENSE00003617334	74172586	74172752

Expression profiles

Bgee: expression breadth ubiquitous, 295 present calls, max score 98.40.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 93.5224 / max 835.0217, expressed in 1827 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
29166	93.5224	1827

Top tissues by expression

295 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
monocyte	CL:0000576	98.40	gold quality
mononuclear cell	CL:0000842	98.40	gold quality
leukocyte	CL:0000738	98.29	gold quality
epithelium of nasopharynx	UBERON:0001951	97.77	gold quality
superficial temporal artery	UBERON:0001614	97.72	gold quality
secondary oocyte	CL:0000655	97.54	gold quality
bone marrow cell	CL:0002092	97.31	gold quality
oocyte	CL:0000023	97.30	gold quality
lymph node	UBERON:0000029	97.11	gold quality
caecum	UBERON:0001153	97.07	gold quality
vermiform appendix	UBERON:0001154	97.07	gold quality
hair follicle	UBERON:0002073	96.86	gold quality
bone marrow	UBERON:0002371	96.82	gold quality
esophagus squamous epithelium	UBERON:0006920	96.67	gold quality
palpebral conjunctiva	UBERON:0001812	96.49	gold quality
adrenal tissue	UBERON:0018303	96.41	gold quality
penis	UBERON:0000989	96.22	gold quality
endometrium	UBERON:0001295	96.13	gold quality
synovial joint	UBERON:0002217	96.13	gold quality
epithelium of esophagus	UBERON:0001976	96.03	gold quality
tonsil	UBERON:0002372	96.02	gold quality
colonic epithelium	UBERON:0000397	96.00	gold quality
tongue squamous epithelium	UBERON:0006919	95.98	gold quality
gingiva	UBERON:0001828	95.96	gold quality
gingival epithelium	UBERON:0001949	95.92	gold quality
blood	UBERON:0000178	95.90	gold quality
endometrium epithelium	UBERON:0004811	95.74	gold quality
upper arm skin	UBERON:0004263	95.65	gold quality
lower lobe of lung	UBERON:0008949	95.63	gold quality
germinal epithelium of ovary	UBERON:0001304	95.60	gold quality

Single-cell (SCXA)

Detected in 4 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-CURD-97	no	1290.02
E-CURD-88	no	3.80
E-MTAB-5061	no	3.69
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

152 targeting MOB1A, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-450A-1-3P	100.00	69.33	1837
HSA-MIR-6798-5P	100.00	65.77	699
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-29A-3P	100.00	73.11	1835
HSA-MIR-29B-3P	100.00	73.18	1833
HSA-MIR-29C-3P	100.00	73.15	1833
HSA-MIR-9-5P	100.00	72.28	2361
HSA-MIR-7110-3P	100.00	73.18	2486
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-371B-5P	99.99	75.34	4759
HSA-MIR-186-5P	99.99	70.83	3707
HSA-MIR-196A-1-3P	99.99	72.15	2772
HSA-MIR-548AW	99.99	72.57	3559
HSA-MIR-4531	99.99	69.70	3181
HSA-MIR-373-5P	99.98	75.36	4753
HSA-MIR-616-5P	99.98	75.58	4775
HSA-MIR-548P	99.98	72.25	3784
HSA-MIR-4775	99.98	75.00	6394
HSA-MIR-1250-3P	99.96	70.04	4038
HSA-MIR-570-3P	99.96	72.41	4910
HSA-MIR-590-3P	99.96	74.34	6478
HSA-MIR-548AJ-3P	99.96	73.38	5345
HSA-MIR-548X-3P	99.96	73.38	5345
HSA-MIR-548AA	99.96	70.64	3753
HSA-MIR-548AP-3P	99.96	70.64	3753
HSA-MIR-548T-3P	99.96	70.64	3753
HSA-MIR-548J-3P	99.94	72.61	4881
HSA-MIR-651-3P	99.94	73.48	5177
HSA-MIR-548AE-3P	99.93	72.66	4867

Literature-anchored findings (GeneRIF, showing 16)

• Mats1 can rescue the lethality associated with loss of Mats function in Drosophila; As Mats1 is mutated in human tumors, Mats-mediated growth inhibition and tumor suppression is likely conserved in humans (PMID:15766530)
• MATS1 mRNA expression is suppressed in tumor tissue and its low expression is associated with tumor growth, invasion and metastasis of colorectal cancer (PMID:17611689)
• hMOB1A and hMOB1B are 2 LATS-binding proteins that may function as tumor suppressors in human cancer cells. (PMID:19739119)
• Results suggest that Mob1 and the other mammalian orthologues of the mitotic exit network regulate mitotic progression by facilitating the timely mobilization of the chromosomal passenger complex to the spindle midzone. (PMID:19955215)
• Mob1A and Mob1B are needed for cell abscission and centriole re-joining after telophase and cytokinesis. (PMID:22454515)
• The RING ligase praja2 ubiquitylates and degrades Mob, a core component of NDR/LATS kinase and a positive regulator of the tumour-suppressor Hippo cascade. (PMID:23652010)
• No relationship has been found between the MOBKL1B-NS5A interaction and hepatitis C virus replication. (PMID:25031347)
• Through a comprehensive set of biochemical, biophysical, mutational and structural studies, we quantitatively assess how phosphorylation of MOB1A regulates its interaction with both MST kinases and LATS/NDR family kinases in vitro. (PMID:28373297)
• In this study, we investigated the mechanisms behind the recruitment of MST1 and MST2 kinases to MOB1, which facilitate signal transmission in the Hippo pathway by bringing the MST1 and MST2 kinases in close vicinity to their substrates, the LATS family kinases. (PMID:28373298)
• validated the functional importance of an identified interaction network by characterizing a distinct novel interaction between PTPN5 and Mob1a. (PMID:28675297)
• MOB1 binds differently to the NDR2 and LATS1 kinases.MOB1 interaction with Hippo and MST protein is not essential for development and tissue growth control. (PMID:28947795)
• The Legionella kinase LegK7 exploits the Hippo pathway scaffold protein MOB1A for allostery and substrate phosphorylation. (PMID:32513747)
• RNA-binding protein Musashi2 regulates Hippo signaling via SAV1 and MOB1 in pancreatic cancer. (PMID:32780197)
• Circular RNA circCCDC85A inhibits breast cancer progression via acting as a miR-550a-5p sponge to enhance MOB1A expression. (PMID:34983617)
• Oxidative stress-CBP axis modulates MOB1 acetylation and activates the Hippo signaling pathway. (PMID:35349706)
• CAF-derived exosomal WEE2-AS1 facilitates colorectal cancer progression via promoting degradation of MOB1A to inhibit the Hippo pathway. (PMID:36123327)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	mob1a	ENSDARG00000102320
mus_musculus	Mob1a	ENSMUSG00000043131
rattus_norvegicus	Mob1a	ENSRNOG00000059474
rattus_norvegicus	Mob1a-ps1	ENSRNOG00000065539
drosophila_melanogaster	mats	FBGN0038965

Paralogs (6): MOB4 (ENSG00000115540), MOB3B (ENSG00000120162), MOB3C (ENSG00000142961), MOB3A (ENSG00000172081), MOB1B (ENSG00000173542), MOB2 (ENSG00000182208)

Protein

Protein identifiers

MOB kinase activator 1A — Q9H8S9 (reviewed: Q9H8S9)

Alternative names: Mob1 alpha, Mob1 homolog 1B, Mps one binder kinase activator-like 1B

All UniProt accessions (1): Q9H8S9

UniProt curated annotations — full annotation on UniProt →

Function. Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38 and STK38L. Acts cooperatively with STK3/MST2 to activate STK38.

Subunit / interactions. Binds STK38 and STK38L. Interacts with LATS1 and LATS2. Forms a tripartite complex with STK38 and STK3/MST2.

Tissue specificity. Adrenal gland, bone marrow, brain, placenta, prostate, salivary gland, skeletal muscle, testis, thymus, thyroid gland, heart, spinal cord, fetal brain and fetal liver.

Post-translational modifications. Phosphorylated by STK3/MST2 and STK4/MST1 and this phosphorylation enhances its binding to LATS1.

Miscellaneous. May be due to an intron retention.

Similarity. Belongs to the MOB1/phocein family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q9H8S9-1	1	yes
Q9H8S9-2	2

RefSeq proteins (4): NP_001304039, NP_001304040, NP_001304041, NP_060691* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR005301	MOB_kinase_act_fam	Family
IPR036703	MOB_kinase_act_sf	Homologous_superfamily

Pfam: PF03637

UniProt features (35 total): helix 11, modified residue 5, strand 5, turn 4, binding site 4, splice variant 2, sequence conflict 2, initiator methionine 1, chain 1

Structure

Experimental structures (PDB)

11 structures.

PDB	Method	Resolution (Å)
4J1V	X-RAY DIFFRACTION	1.95
1PI1	X-RAY DIFFRACTION	2
4JIZ	X-RAY DIFFRACTION	2.1
5XQZ	X-RAY DIFFRACTION	2.1
5BRK	X-RAY DIFFRACTION	2.3
5TWG	X-RAY DIFFRACTION	2.3
5TWH	X-RAY DIFFRACTION	2.5
6MCP	X-RAY DIFFRACTION	2.5
6MCQ	X-RAY DIFFRACTION	2.57
5BRM	X-RAY DIFFRACTION	2.65
5TWF	X-RAY DIFFRACTION	3.14

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9H8S9-F1	88.59	0.75

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (4): 79; 84; 161; 166

Post-translational modifications (5): 181, 2, 12, 35, 74

Function

Pathways and Gene Ontology

Reactome pathways

2 pathways

ID	Pathway
R-HSA-2028269	Signaling by Hippo
R-HSA-162582	Signal Transduction

MSigDB gene sets: 181 (showing top): GSE45365_NK_CELL_VS_CD8_TCELL_DN, BORCZUK_MALIGNANT_MESOTHELIOMA_UP, RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_UP, RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_UP, GOBP_HIPPO_SIGNALING, PUJANA_CHEK2_PCC_NETWORK, GOMF_KINASE_ACTIVATOR_ACTIVITY, MARTINEZ_RB1_TARGETS_UP, RUTELLA_RESPONSE_TO_CSF2RB_AND_IL4_UP, BLALOCK_ALZHEIMERS_DISEASE_UP, RUTELLA_RESPONSE_TO_HGF_VS_CSF2RB_AND_IL4_DN, SENESE_HDAC1_TARGETS_UP, MULLIGHAN_NPM1_SIGNATURE_3_DN, MARTINEZ_RB1_AND_TP53_TARGETS_UP, MARSON_BOUND_BY_FOXP3_UNSTIMULATED

GO Biological Process (1): hippo signaling (GO:0035329)

GO Molecular Function (4): protein kinase activator activity (GO:0030295), protein serine/threonine kinase activator activity (GO:0043539), metal ion binding (GO:0046872), protein binding (GO:0005515)

GO Cellular Component (4): nucleus (GO:0005634), cytoplasm (GO:0005737), cytosol (GO:0005829), extracellular exosome (GO:0070062)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Signal Transduction	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	2
intracellular signal transduction	1
protein kinase activity	1
kinase activator activity	1
protein kinase regulator activity	1
protein serine/threonine kinase activity	1
protein kinase activator activity	1
cation binding	1
binding	1
intracellular membrane-bounded organelle	1
intracellular anatomical structure	1
cytoplasm	1
extracellular vesicle	1

Protein interactions and networks

STRING

1436 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
MOB1A	LATS1	O95835	994
MOB1A	SAV1	Q9H4B6	918
MOB1A	LATS2	Q9NRM7	914
MOB1A	STK4	Q13043	904
MOB1A	STK38L	Q9Y2H1	849
MOB1A	STK24	Q9Y6E0	803
MOB1A	GFER	P55789	765
MOB1A	STK38	Q15208	729
MOB1A	WWTR1	Q9GZV5	662
MOB1A	TEAD1	P28347	654
MOB1A	YAP1	P46937	641
MOB1A	NF2	P35240	592
MOB1A	AMOT	Q4VCS5	546
MOB1A	WWC1	Q8IX03	545
MOB1A	VGLL4	Q14135	534

IntAct

122 interactions, top by confidence:

A	B	Type	Score
STK38L	MOB2	psi-mi:“MI:0914”(association)	0.910
MOB1A	STK38L	psi-mi:“MI:0915”(physical association)	0.900
MOB1B	LATS1	psi-mi:“MI:0914”(association)	0.840
MOB1A	STK4	psi-mi:“MI:0915”(physical association)	0.750
LATS2	MOB1A	psi-mi:“MI:0915”(physical association)	0.740
MOB1A	LATS2	psi-mi:“MI:0915”(physical association)	0.740
LATS2	MOB1A	psi-mi:“MI:0914”(association)	0.740
MOB1A	TDO2	psi-mi:“MI:0915”(physical association)	0.720
KANK2	MOB1A	psi-mi:“MI:0915”(physical association)	0.720
SEPTIN3	MOB1A	psi-mi:“MI:0915”(physical association)	0.720
MOB1A	KANK2	psi-mi:“MI:0915”(physical association)	0.720
MOB1A	SEPTIN3	psi-mi:“MI:0915”(physical association)	0.720
TDO2	MOB1A	psi-mi:“MI:0915”(physical association)	0.720
STK38	MOB2	psi-mi:“MI:0914”(association)	0.710
CFTR	ESYT2	psi-mi:“MI:2364”(proximity)	0.710
KXD1	MOB1A	psi-mi:“MI:0915”(physical association)	0.670
LATS1	MOB1A	psi-mi:“MI:0915”(physical association)	0.670
MOB1A	LATS1	psi-mi:“MI:0914”(association)	0.670

BioGRID (193): MOB1A (Two-hybrid), MOB1A (Two-hybrid), MOB1A (Two-hybrid), SEPT3 (Two-hybrid), CMTM3 (Two-hybrid), FAM9B (Two-hybrid), LATS2 (Affinity Capture-Western), MOB1A (Affinity Capture-MS), MOB1A (Affinity Capture-MS), KXD1 (Two-hybrid), MOB1A (Two-hybrid), MOB1A (Affinity Capture-MS), MOB1A (Affinity Capture-MS), MOB1A (Affinity Capture-Western), MOB1A (Affinity Capture-Western)

ESM2 similar proteins: A0A223HDI2, A2BG43, B0BLT4, B0BNM9, B0YN54, O22797, O64587, O94360, P40124, P68265, P68266, Q01518, Q08163, Q0VCQ0, Q2WBN3, Q3SYV4, Q3T1J9, Q4R4I6, Q54XJ0, Q5F495, Q5HZ92, Q5RAE0, Q5RDB1, Q5TA50, Q5XIS2, Q63ZQ3, Q66JG2, Q6DBQ8, Q6NLQ3, Q6NU44, Q6PEB6, Q6Z6S1, Q70IA6, Q7L9L4, Q8BPB0, Q8BS40, Q8GYX0, Q8VI63, Q921Y0, Q949G5

Diamond homologs: F4K494, F4K495, O74558, O94360, P40484, P43563, Q29RK9, Q2LZ59, Q2WBN3, Q3T1J9, Q54BM4, Q54CR8, Q54QV0, Q54XJ0, Q58D63, Q5ABC6, Q5EAA4, Q5R5Z0, Q5RAE0, Q70IA6, Q70IA8, Q7L9L4, Q86TA1, Q8BJG4, Q8BPB0, Q8BSU7, Q8GYX0, Q8IQG1, Q8VE04, Q8VI63, Q921Y0, Q949G5, Q95RA8, Q96BX8, Q9FHI1, Q9H8S9, Q9P601, Q9VL13

SIGNOR signaling

13 interactions.

A	Effect	B	Mechanism
MOB1A	up-regulates	LATS1	binding
MOB1A	up-regulates	LATS2	binding
STK3	up-regulates	MOB1A	phosphorylation
STK4	up-regulates	MOB1A	phosphorylation
MOB1A	up-regulates	LATS1/2	binding
STK3/4	up-regulates	MOB1A	phosphorylation

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 61 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Signaling by Hippo	6	90.6×	9e-09

GO biological processes:

GO term	Partners	Fold	FDR
hippo signaling	6	78.5×	6e-08
keratinocyte differentiation	6	26.6×	3e-05
negative regulation of canonical Wnt signaling pathway	5	10.5×	5e-03
protein phosphorylation	7	8.5×	2e-03
positive regulation of apoptotic process	7	7.1×	3e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

21 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	15
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

989 predictions. Top by Δscore:

Variant	Effect	Δscore
2:74156571:T:C	donor_gain	1.0000
2:74165211:AACT:A	donor_loss	1.0000
2:74165212:ACTC:A	donor_loss	1.0000
2:74165213:C:CG	donor_loss	1.0000
2:74165215:CAC:C	donor_loss	1.0000
2:74165216:ACCAA:A	donor_loss	1.0000
2:74165217:CCAAT:C	donor_gain	1.0000
2:74165347:CATAT:C	acceptor_gain	1.0000
2:74165352:C:CC	acceptor_gain	1.0000
2:74167010:GTA:G	donor_loss	1.0000
2:74167011:TA:T	donor_loss	1.0000
2:74167012:ACC:A	donor_loss	1.0000
2:74167013:CCTCG:C	donor_loss	1.0000
2:74167105:CAG:C	acceptor_gain	1.0000
2:74167108:C:CC	acceptor_gain	1.0000
2:74172579:AACTT:A	donor_loss	1.0000
2:74172580:ACTTA:A	donor_loss	1.0000
2:74172583:TA:T	donor_loss	1.0000
2:74172584:A:AC	donor_gain	1.0000
2:74172585:C:CT	donor_gain	1.0000
2:74172585:CT:C	donor_gain	1.0000
2:74172585:CTG:C	donor_gain	1.0000
2:74172585:CTGTT:C	donor_gain	1.0000
2:74172656:T:TA	donor_gain	1.0000
2:74172748:TGCTG:T	acceptor_gain	1.0000
2:74172750:CTG:C	acceptor_gain	1.0000
2:74172751:TG:T	acceptor_gain	1.0000
2:74172752:GCTG:G	acceptor_loss	1.0000
2:74172753:C:CC	acceptor_gain	1.0000
2:74172754:T:C	acceptor_loss	1.0000

AlphaMissense

1452 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
2:74156608:A:G	L204P	1.000
2:74156635:A:G	L195P	1.000
2:74159120:A:G	S182P	1.000
2:74159128:A:G	L179P	1.000
2:74159185:G:T	A160D	1.000
2:74159191:A:T	V158D	1.000
2:74159193:C:A	R157S	1.000
2:74159193:C:G	R157S	1.000
2:74159194:C:A	R157M	1.000
2:74159194:C:G	R157T	1.000
2:74159200:A:G	L155P	1.000
2:74159204:G:T	R154S	1.000
2:74159244:A:C	F140L	1.000
2:74159244:A:T	F140L	1.000
2:74159246:A:G	F140L	1.000
2:74165229:G:T	P133H	1.000
2:74165232:A:G	F132S	1.000
2:74165250:A:G	L126P	1.000
2:74165259:T:G	Q123P	1.000
2:74165266:A:G	W121R	1.000
2:74165266:A:T	W121R	1.000
2:74165274:A:C	L118W	1.000
2:74165287:A:G	Y114H	1.000
2:74165335:C:G	A98P	1.000
2:74165336:C:A	W97C	1.000
2:74165336:C:G	W97C	1.000
2:74165337:C:G	W97S	1.000
2:74165338:A:G	W97R	1.000
2:74165338:A:T	W97R	1.000
2:74165344:A:C	Y95D	1.000

dbSNP variants (sampled 300 via entrez): RS1000021936 (2:74156328 A>G), RS1000075578 (2:74163212 A>G), RS1000096307 (2:74154839 G>C), RS1000175767 (2:74156985 T>C), RS1000209295 (2:74175437 A>G), RS1000227905 (2:74157414 T>A), RS1000247456 (2:74174047 C>T), RS1000469696 (2:74162858 T>A,C), RS1000552196 (2:74175832 T>C), RS1000612664 (2:74179239 G>T), RS1000622734 (2:74179522 A>G), RS1000871054 (2:74167686 G>A), RS1000893456 (2:74179751 T>TC), RS1000899455 (2:74162633 A>C), RS1000923406 (2:74168003 G>C)

Disease associations

OMIM: gene MIM:609281 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST004899_10	Gestational age at birth (maternal effect)	2.000000e-07

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0005112	gestational age
EFO:0005939	parental genotype effect measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

39 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
trichostatin A	affects cotreatment, decreases expression	3
Air Pollutants	affects cotreatment, increases abundance, increases oxidation, affects expression	2
Ozone	increases oxidation, increases abundance, affects expression, affects cotreatment	2
Valproic Acid	affects expression, increases methylation	2
alpha-pinene	affects cotreatment, increases oxidation, increases abundance	1
beta-lapachone	increases expression	1
arsenite	affects binding, increases reaction	1
11-nor-delta(9)-tetrahydrocannabinol-9-carboxylic acid	affects methylation, increases abundance	1
methacrylaldehyde	affects cotreatment, increases oxidation, increases abundance	1
CD 437	decreases expression	1
motexafin gadolinium	affects reaction, increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
3-(4’-hydroxy-3’-adamantylbiphenyl-4-yl)acrylic acid	decreases expression	1
abrine	decreases expression	1
dorsomorphin	decreases expression, affects cotreatment	1
jinfukang	decreases expression	1
picoxystrobin	increases expression	1
Temozolomide	increases expression	1
Vorinostat	decreases expression	1
Leflunomide	decreases expression	1
Acetaminophen	increases expression	1
Acrolein	affects cotreatment, increases oxidation, increases abundance	1
Cannabinoids	affects methylation, increases abundance	1
Dinitrochlorobenzene	affects binding	1
Ivermectin	decreases expression	1
Mercuric Chloride	decreases expression	1
Methyl Methanesulfonate	decreases expression	1
Nickel	increases expression	1
Piroxicam	decreases expression	1
Rotenone	increases expression	1

Cellosaurus cell lines

4 cell lines: 3 cancer cell line, 1 transformed cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_D7V8	Ubigene A-549 MOB1A KO	Cancer cell line	Male
CVCL_D8QR	Ubigene HCT 116 MOB1A KO	Cancer cell line	Male
CVCL_D9KK	Ubigene HEK293 MOB1A KO	Transformed cell line	Female
CVCL_E0I9	Ubigene HeLa MOB1A KO	Cancer cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.