MOB1B

Summary

MOB1B (MOB kinase activator 1B, HGNC:29801) is a protein-coding gene on chromosome 4q13.3, encoding MOB kinase activator 1B (Q7L9L4). Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis.

The protein encoded by this gene is similar to the yeast Mob1 protein. Yeast Mob1 binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. Three transcript variants encoding different isoforms have been found for this gene.

Source: NCBI Gene 92597 — RefSeq curated summary.

At a glance

• GWAS associations: 7
• Clinical variants (ClinVar): 35 total
• Druggable target: yes
• MANE Select transcript: NM_173468

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:29801
Approved symbol	MOB1B
Name	MOB kinase activator 1B
Location	4q13.3
Locus type	gene with protein product
Status	Approved
Aliases	MOB4A
Ensembl gene	ENSG00000173542
Ensembl biotype	protein_coding
OMIM	609282
Entrez	92597

Gene structure

Transcript identifiers

Ensembl transcripts: 5 — 3 protein_coding, 1 retained_intron, 1 protein_coding_CDS_not_defined

ENST00000309395, ENST00000396051, ENST00000502869, ENST00000509041, ENST00000511449

RefSeq mRNA: 3 — MANE Select: NM_173468 NM_001244766, NM_001244767, NM_173468

CCDS: CCDS34002, CCDS58903

Canonical transcript exons

ENST00000309395 — 6 exons

Exon	Start	End
ENSE00001322325	70981980	70988168
ENSE00002075662	70902369	70902550
ENSE00002445573	70975153	70975286
ENSE00002453445	70979128	70979291
ENSE00003493456	70969931	70970024
ENSE00003669977	70958874	70959040

Expression profiles

Bgee: expression breadth ubiquitous, 253 present calls, max score 98.63.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 32.3050 / max 816.1955, expressed in 1815 samples.

FANTOM5 promoters (8 alternative TSS)

Promoter ID	TPM avg	Samples expressed
48010	23.9357	1809
48011	5.3076	1566
48014	1.0439	635
48009	0.7745	436
48013	0.6129	330
48015	0.3124	128
48012	0.2414	84
48016	0.0767	18

Top tissues by expression

258 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
renal medulla	UBERON:0000362	98.63	gold quality
thymus	UBERON:0002370	98.57	gold quality
superior surface of tongue	UBERON:0007371	97.07	gold quality
saphenous vein	UBERON:0007318	96.89	gold quality
upper arm skin	UBERON:0004263	96.70	gold quality
kidney epithelium	UBERON:0004819	96.68	gold quality
trabecular bone tissue	UBERON:0002483	96.56	gold quality
tongue	UBERON:0001723	95.65	gold quality
medulla oblongata	UBERON:0001896	95.41	gold quality
trigeminal ganglion	UBERON:0001675	95.17	gold quality
superior vestibular nucleus	UBERON:0007227	94.70	gold quality
body of tongue	UBERON:0011876	94.52	gold quality
pericardium	UBERON:0002407	94.17	gold quality
oviduct epithelium	UBERON:0004804	93.82	gold quality
pharyngeal mucosa	UBERON:0000355	93.31	gold quality
visceral pleura	UBERON:0002401	92.89	gold quality
synovial joint	UBERON:0002217	92.66	gold quality
islet of Langerhans	UBERON:0000006	92.56	gold quality
dorsal root ganglion	UBERON:0000044	92.45	gold quality
tendon of biceps brachii	UBERON:0008188	92.39	gold quality
germinal epithelium of ovary	UBERON:0001304	92.04	gold quality
subthalamic nucleus	UBERON:0001906	91.89	gold quality
vena cava	UBERON:0004087	91.59	gold quality
bone marrow	UBERON:0002371	91.51	gold quality
tibia	UBERON:0000979	91.45	gold quality
palpebral conjunctiva	UBERON:0001812	91.14	gold quality
urethra	UBERON:0000057	91.12	gold quality
ventral tegmental area	UBERON:0002691	91.03	gold quality
parietal pleura	UBERON:0002400	90.88	gold quality
layer of synovial tissue	UBERON:0007616	90.81	gold quality

Single-cell (SCXA)

Detected in 5 experiment(s), a significant marker in 4.

Experiment	Marker?	Max mean expression
E-CURD-119	yes	40.25
E-MTAB-5061	yes	28.34
E-GEOD-83139	yes	8.56
E-ANND-3	yes	6.52
E-ENAD-27	no	7.60

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

289 targeting MOB1B, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-1277-5P	100.00	73.95	5056
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-656-3P	100.00	72.15	2788
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-6873-3P	100.00	71.42	2626
HSA-MIR-6833-3P	100.00	70.63	3197
HSA-MIR-6867-5P	100.00	82.21	3464
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-4795-3P	100.00	74.62	4024
HSA-MIR-518D-5P	100.00	67.51	979
HSA-MIR-518E-5P	100.00	67.66	954
HSA-MIR-518F-5P	100.00	67.51	979
HSA-MIR-519A-5P	100.00	67.66	954
HSA-MIR-519B-5P	100.00	67.66	954
HSA-MIR-519C-5P	100.00	67.66	954
HSA-MIR-520C-5P	100.00	67.51	979
HSA-MIR-522-5P	100.00	67.66	954
HSA-MIR-523-5P	100.00	67.66	954
HSA-MIR-526A-5P	100.00	67.51	979
HSA-MIR-4768-5P	100.00	69.49	2861
HSA-MIR-126-5P	100.00	72.71	3180
HSA-MIR-340-5P	100.00	72.50	4437
HSA-LET-7A-3P	100.00	74.03	3932
HSA-LET-7B-3P	100.00	74.08	3913
HSA-LET-7F-1-3P	100.00	74.02	3928
HSA-MIR-98-3P	100.00	74.08	3907
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-4282	99.99	75.36	6408

Literature-anchored findings (GeneRIF, showing 3)

• Mob1A and Mob1B are needed for cell abscission and centriole re-joining after telophase and cytokinesis. (PMID:22454515)
• MOB1A/B has an essential function for intestinal epithelial homeostasis. (PMID:30349003)
• miR-548ag functions as an oncogene by suppressing MOB1B in the development of obesity-related endometrial cancer. (PMID:36445107)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	mob1ba	ENSDARG00000009169
danio_rerio	mob1bb	ENSDARG00000012953
mus_musculus	Mob1b	ENSMUSG00000006262
rattus_norvegicus	Mob1b	ENSRNOG00000010996
drosophila_melanogaster	mats	FBGN0038965

Paralogs (6): MOB1A (ENSG00000114978), MOB4 (ENSG00000115540), MOB3B (ENSG00000120162), MOB3C (ENSG00000142961), MOB3A (ENSG00000172081), MOB2 (ENSG00000182208)

Protein

Protein identifiers

MOB kinase activator 1B — Q7L9L4 (reviewed: Q7L9L4)

Alternative names: Mob1 homolog 1A, Mob1B, Mps one binder kinase activator-like 1A

All UniProt accessions (2): Q7L9L4, D6RCK3

UniProt curated annotations — full annotation on UniProt →

Function. Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L.

Subunit / interactions. Binds STK38L. Interacts with LATS1 and LATS2.

Subcellular location. Cytoplasm. Nucleus.

Tissue specificity. Adrenal gland, bone marrow, brain, lung, placenta, prostate, salivary gland, skeletal muscle, testis, thymus, thyroid gland, uterus, colon with mucosa, fetal brain and fetal liver.

Post-translational modifications. Phosphorylated by STK3/MST2 and STK4/MST1 and this phosphorylation enhances its binding to LATS1.

Similarity. Belongs to the MOB1/phocein family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q7L9L4-1	1	yes
Q7L9L4-2	2

RefSeq proteins (3): NP_001231695, NP_001231696, NP_775739* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR005301	MOB_kinase_act_fam	Family
IPR036703	MOB_kinase_act_sf	Homologous_superfamily

Pfam: PF03637

UniProt features (10 total): binding site 4, modified residue 3, initiator methionine 1, chain 1, splice variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q7L9L4-F1	88.91	0.74

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (4): 79; 84; 161; 166

Post-translational modifications (3): 2, 12, 35

Function

Pathways and Gene Ontology

Reactome pathways

2 pathways

ID	Pathway
R-HSA-2028269	Signaling by Hippo
R-HSA-162582	Signal Transduction

MSigDB gene sets: 226 (showing top): GOBP_REGULATION_OF_PHOSPHORYLATION, AAGCCAT_MIR135A_MIR135B, GOBP_HIPPO_SIGNALING, AATGGAG_MIR136, chr4q13, GOMF_KINASE_ACTIVATOR_ACTIVITY, GTGCCTT_MIR506, GOBP_REGULATION_OF_PROTEIN_AUTOPHOSPHORYLATION, GOBP_PROTEIN_AUTOPHOSPHORYLATION, GOBP_REGULATION_OF_PHOSPHORUS_METABOLIC_PROCESS, GOCC_NUCLEOLUS, GOBP_REGULATION_OF_PROTEIN_MODIFICATION_PROCESS, GOMF_PROTEIN_SERINE_THREONINE_KINASE_ACTIVATOR_ACTIVITY, GOMF_ENZYME_ACTIVATOR_ACTIVITY, GOMF_ENZYME_REGULATOR_ACTIVITY

GO Biological Process (2): regulation of protein autophosphorylation (GO:0031952), hippo signaling (GO:0035329)

GO Molecular Function (6): kinase activator activity (GO:0019209), kinase binding (GO:0019900), protein kinase activator activity (GO:0030295), protein serine/threonine kinase activator activity (GO:0043539), metal ion binding (GO:0046872), protein binding (GO:0005515)

GO Cellular Component (4): nucleus (GO:0005634), cytoplasm (GO:0005737), cytosol (GO:0005829), extracellular exosome (GO:0070062)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Signal Transduction	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	2
regulation of protein phosphorylation	1
regulation of protein kinase activity	1
protein autophosphorylation	1
intracellular signal transduction	1
enzyme activator activity	1
kinase activity	1
kinase regulator activity	1
enzyme binding	1
protein kinase activity	1
kinase activator activity	1
protein kinase regulator activity	1
protein serine/threonine kinase activity	1
protein kinase activator activity	1
cation binding	1
binding	1
intracellular membrane-bounded organelle	1
intracellular anatomical structure	1
cytoplasm	1
extracellular vesicle	1

Protein interactions and networks

STRING

1152 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
MOB1B	LATS1	O95835	993
MOB1B	LATS2	Q9NRM7	918
MOB1B	SAV1	Q9H4B6	860
MOB1B	GFER	P55789	726
MOB1B	STK4	Q13043	707
MOB1B	STK24	Q9Y6E0	677
MOB1B	STK38L	Q9Y2H1	613
MOB1B	STK38	Q15208	608
MOB1B	WWTR1	Q9GZV5	585
MOB1B	YAP1	P46937	576
MOB1B	TEAD1	P28347	554
MOB1B	RASSF1	Q9NS23	523
MOB1B	DOCK6	Q96HP0	515
MOB1B	PPP6C	O00743	500
MOB1B	A0A0B4J2F2	A0A0B4J2F2	497

IntAct

58 interactions, top by confidence:

A	B	Type	Score
STK38L	MOB2	psi-mi:“MI:0914”(association)	0.910
MOB1B	LATS1	psi-mi:“MI:0914”(association)	0.840
MOB1B	LATS1	psi-mi:“MI:0915”(physical association)	0.840
LATS1	MOB1B	psi-mi:“MI:0915”(physical association)	0.840
LATS2	MOB1B	psi-mi:“MI:0915”(physical association)	0.830
STK3	MOB1B	psi-mi:“MI:0915”(physical association)	0.690
MOB1B	STK4	psi-mi:“MI:0217”(phosphorylation reaction)	0.630
MOB1B	STK4	psi-mi:“MI:0914”(association)	0.630
MOB1B	NT5C2	psi-mi:“MI:0915”(physical association)	0.560
MOB1B	TNIP1	psi-mi:“MI:0915”(physical association)	0.560
WASHC3	MOB1B	psi-mi:“MI:0915”(physical association)	0.560
TNIP1	MOB1B	psi-mi:“MI:0915”(physical association)	0.560
MOB1B	PPP6C	psi-mi:“MI:0914”(association)	0.480
MOB1B	PPP6C	psi-mi:“MI:2364”(proximity)	0.480
MOB1B	PPP6C	psi-mi:“MI:0403”(colocalization)	0.480
MOB1B	PPP6R1	psi-mi:“MI:0403”(colocalization)	0.480
MOB1B	ANKRD28	psi-mi:“MI:0914”(association)	0.420
Stk38	STK38	psi-mi:“MI:0915”(physical association)	0.400
MST1	MOB1B	psi-mi:“MI:0915”(physical association)	0.400
		psi-mi:“MI:0914”(association)	0.350

BioGRID (144): MOB1B (Two-hybrid), MOB1B (Two-hybrid), MOB1B (Two-hybrid), LATS1 (Affinity Capture-MS), MOB1A (Affinity Capture-MS), STK38L (Affinity Capture-MS), MOB1B (Affinity Capture-MS), MOB1B (Affinity Capture-Western), STK38L (Affinity Capture-MS), MOB1A (Affinity Capture-MS), LATS1 (Affinity Capture-MS), LATS2 (Affinity Capture-MS), STK38 (Affinity Capture-MS), LRCH2 (Affinity Capture-MS), DOCK7 (Affinity Capture-MS)

ESM2 similar proteins: A0A223HDI2, A2BG43, B0BLT4, B0BNM9, B0YN54, O22797, O64587, O94360, P40124, P68265, P68266, Q01518, Q08163, Q0VCQ0, Q2WBN3, Q3SYV4, Q3T1J9, Q4R4I6, Q54XJ0, Q5F495, Q5HZ92, Q5RAE0, Q5RDB1, Q5TA50, Q5XIS2, Q63ZQ3, Q66JG2, Q6DBQ8, Q6NLQ3, Q6NU44, Q6PEB6, Q6Z6S1, Q70IA6, Q7L9L4, Q8BPB0, Q8BS40, Q8GYX0, Q8VI63, Q921Y0, Q949G5

Diamond homologs: F4K494, F4K495, O74558, O94360, P40484, P43563, Q29RK9, Q2LZ59, Q2WBN3, Q3T1J9, Q54BM4, Q54CR8, Q54QV0, Q54XJ0, Q58D63, Q5ABC6, Q5EAA4, Q5R5Z0, Q5RAE0, Q70IA6, Q70IA8, Q7L9L4, Q86TA1, Q8BJG4, Q8BPB0, Q8BSU7, Q8GYX0, Q8IQG1, Q8VE04, Q8VI63, Q921Y0, Q949G5, Q95RA8, Q96BX8, Q9FHI1, Q9H8S9, Q9P601, Q9VL13

SIGNOR signaling

13 interactions.

A	Effect	B	Mechanism
MOB1B	up-regulates	LATS1	binding
MOB1B	up-regulates	LATS2	binding
STK3	up-regulates	MOB1B	phosphorylation
STK4	up-regulates	MOB1B	phosphorylation
MOB1B	up-regulates	LATS1/2	binding
STK3/4	up-regulates	MOB1B	phosphorylation
PTPN5	“up-regulates activity”	MOB1B	dephosphorylation

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 36 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Signaling by Hippo	5	100.7×	1e-07

GO biological processes:

GO term	Partners	Fold	FDR
hippo signaling	5	118.2×	2e-07
canonical Wnt signaling pathway	5	24.7×	5e-05
negative regulation of canonical Wnt signaling pathway	5	19.0×	1e-04
protein phosphorylation	8	17.5×	2e-06
positive regulation of apoptotic process	7	12.8×	4e-05
intracellular signal transduction	7	8.6×	2e-04

Disease & clinical

Clinical variants and AI predictions

ClinVar

35 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	23
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

2487 predictions. Top by Δscore:

Variant	Effect	Δscore
4:70902548:GTT:G	donor_gain	1.0000
4:70902551:G:GG	donor_gain	1.0000
4:70942883:G:GG	donor_gain	1.0000
4:70958866:A:AG	acceptor_gain	1.0000
4:70958867:T:G	acceptor_gain	1.0000
4:70958870:A:AG	acceptor_gain	1.0000
4:70958870:ATAGT:A	acceptor_gain	1.0000
4:70958871:T:G	acceptor_gain	1.0000
4:70958872:A:AG	acceptor_gain	1.0000
4:70958872:AGT:A	acceptor_gain	1.0000
4:70958872:AGTG:A	acceptor_gain	1.0000
4:70958873:G:GA	acceptor_gain	1.0000
4:70958873:GT:G	acceptor_gain	1.0000
4:70958873:GTG:G	acceptor_gain	1.0000
4:70958873:GTGG:G	acceptor_gain	1.0000
4:70958873:GTGGT:G	acceptor_gain	1.0000
4:70959036:TAACA:T	donor_gain	1.0000
4:70959037:AACA:A	donor_gain	1.0000
4:70959038:ACA:A	donor_gain	1.0000
4:70959039:CA:C	donor_gain	1.0000
4:70959040:AG:A	donor_loss	1.0000
4:70959041:G:GG	donor_gain	1.0000
4:70970025:G:GG	donor_gain	1.0000
4:70975146:A:AG	acceptor_gain	1.0000
4:70975152:GATAT:G	acceptor_gain	1.0000
4:70975283:A:AG	donor_gain	1.0000
4:70982061:G:GT	donor_gain	1.0000
4:70982101:TG:T	donor_gain	1.0000
4:70982102:GG:G	donor_gain	1.0000
4:70998061:C:G	acceptor_gain	1.0000

AlphaMissense

1455 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
4:70958942:T:C	L28P	1.000
4:70958966:T:A	L36H	1.000
4:70958990:C:A	A44D	1.000
4:70958993:T:A	V45D	1.000
4:70959025:T:A	W56R	1.000
4:70959025:T:C	W56R	1.000
4:70959026:G:C	W56S	1.000
4:70959027:G:C	W56C	1.000
4:70959027:G:T	W56C	1.000
4:70959031:G:C	A58P	1.000
4:70959032:C:A	A58E	1.000
4:70969942:T:C	F65L	1.000
4:70969944:C:A	F65L	1.000
4:70969944:C:G	F65L	1.000
4:70969949:A:C	Q67P	1.000
4:70969961:T:C	L71P	1.000
4:70969984:T:C	C79R	1.000
4:70969985:G:A	C79Y	1.000
4:70969986:T:G	C79W	1.000
4:70969999:T:C	C84R	1.000
4:70970010:G:A	M87I	1.000
4:70970010:G:C	M87I	1.000
4:70970010:G:T	M87I	1.000
4:70970015:C:A	A89D	1.000
4:70970017:G:C	G90R	1.000
4:70975160:T:C	Y95H	1.000
4:70975160:T:G	Y95D	1.000
4:70975166:T:A	W97R	1.000
4:70975166:T:C	W97R	1.000
4:70975167:G:C	W97S	1.000

dbSNP variants (sampled 300 via entrez): RS1000074886 (4:70935347 C>T), RS1000087094 (4:70956083 G>A), RS1000096731 (4:70930869 G>A), RS1000125119 (4:70962757 G>A,T), RS1000151489 (4:70971334 G>A), RS10002884 (4:70914858 T>C), RS10003046 (4:70940632 G>A,T), RS1000317148 (4:70936631 G>C), RS1000337249 (4:70944116 C>T), RS1000354185 (4:70987126 G>A), RS1000366753 (4:70908197 T>G), RS1000408196 (4:70948284 A>G), RS1000418954 (4:70908819 A>T), RS1000514613 (4:70953002 G>A), RS1000580326 (4:70915110 C>T)

Disease associations

OMIM: gene MIM:609282 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

7 associations (top):

Study	Trait	p-value
GCST007847_102	Type 2 diabetes	3.000000e-09
GCST009856_16	Leukocyte telomere length	2.000000e-08
GCST010118_37	Type 2 diabetes	5.000000e-16
GCST012490_521	Femur bone mineral density x serum urate levels interaction	8.000000e-09
GCST90002392_659	Mean corpuscular volume	6.000000e-10
GCST90002396_226	Mean reticulocyte volume	8.000000e-11
GCST90002397_10	Mean spheric corpuscular volume	5.000000e-11

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0004531	urate measurement
EFO:0010701	mean reticulocyte volume

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL4295878 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

25 total (human), top 25 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol S	decreases methylation, increases expression	2
aristolochic acid I	decreases expression	1
FR900359	increases phosphorylation	1
triphenyl phosphate	affects expression	1
bisphenol A	increases expression	1
2-butenal	decreases expression	1
sodium arsenite	increases expression	1
perfluorooctane sulfonic acid	decreases expression	1
jinfukang	decreases expression	1
Fulvestrant	increases methylation	1
Air Pollutants	decreases expression, increases abundance	1
Clorgyline	increases expression	1
Dinitrochlorobenzene	affects binding	1
Doxorubicin	decreases expression	1
Ethyl Methanesulfonate	increases expression	1
Gold	decreases expression	1
Methyl Methanesulfonate	increases expression	1
Quercetin	decreases expression	1
Tobacco Smoke Pollution	affects expression	1
Toluene	increases expression	1
Urethane	increases expression	1
Valproic Acid	decreases expression	1
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	decreases expression	1
Copper Sulfate	increases expression	1
Particulate Matter	decreases expression, increases abundance	1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL4118617	Binding	Binding affinity to MOB1B in human NCI-H23 cells at 1 uM by mass spectrometry based pull down assay	Studies of TAK1-centered polypharmacology with novel covalent TAK1 inhibitors. — Bioorg Med Chem

Cellosaurus cell lines

4 cell lines: 3 cancer cell line, 1 transformed cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_D7V9	Ubigene A-549 MOB1B KO	Cancer cell line	Male
CVCL_D8QS	Ubigene HCT 116 MOB1B KO	Cancer cell line	Male
CVCL_D9KL	Ubigene HEK293 MOB1B KO	Transformed cell line	Female
CVCL_E0IA	Ubigene HeLa MOB1B KO	Cancer cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.