MOB3A

Summary

MOB3A (MOB kinase activator 3A, HGNC:29802) is a protein-coding gene on chromosome 19p13.3, encoding MOB kinase activator 3A (Q96BX8). May regulate the activity of kinases.

Predicted to enable protein kinase activator activity. Predicted to be involved in signal transduction. Predicted to be active in cytoplasm and nucleus.

Source: NCBI Gene 126308 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 61 total
• MANE Select transcript: NM_130807

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:29802
Approved symbol	MOB3A
Name	MOB kinase activator 3A
Location	19p13.3
Locus type	gene with protein product
Status	Approved
Aliases	MOB1C, MOB-LAK, moblak
Ensembl gene	ENSG00000172081
Ensembl biotype	protein_coding
OMIM	620929
Entrez	126308

Gene structure

Transcript identifiers

Ensembl transcripts: 19 — 18 protein_coding, 1 protein_coding_CDS_not_defined

ENST00000357066, ENST00000586676, ENST00000588048, ENST00000589902, ENST00000591236, ENST00000591326, ENST00000591638, ENST00000592143, ENST00000592280, ENST00000876943, ENST00000876944, ENST00000876945, ENST00000876946, ENST00000876947, ENST00000876948, ENST00000919060, ENST00000962430, ENST00000962431, ENST00000962432

RefSeq mRNA: 1 — MANE Select: NM_130807 NM_130807

CCDS: CCDS12081

Canonical transcript exons

ENST00000357066 — 5 exons

Exon	Start	End
ENSE00001150999	2076811	2077013
ENSE00001224443	2071036	2073424
ENSE00001345510	2085175	2085328
ENSE00001372571	2078140	2078679
ENSE00002919587	2096226	2096326

Expression profiles

Bgee: expression breadth ubiquitous, 233 present calls, max score 97.55.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 27.8018 / max 874.6394, expressed in 1807 samples.

FANTOM5 promoters (8 alternative TSS)

Promoter ID	TPM avg	Samples expressed
178130	15.5167	1796
178125	9.6139	358
178124	1.5100	229
178131	0.6226	298
178129	0.2065	78
178123	0.1979	77
178122	0.0892	28
178126	0.0449	17

Top tissues by expression

243 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
blood	UBERON:0000178	97.55	gold quality
leukocyte	CL:0000738	97.27	gold quality
monocyte	CL:0000576	97.22	gold quality
granulocyte	CL:0000094	97.20	gold quality
bone marrow cell	CL:0002092	95.41	gold quality
lymph node	UBERON:0000029	95.29	gold quality
vermiform appendix	UBERON:0001154	94.62	gold quality
spleen	UBERON:0002106	93.68	gold quality
ileal mucosa	UBERON:0000331	93.49	gold quality
caecum	UBERON:0001153	93.33	gold quality
thymus	UBERON:0002370	92.50	gold quality
stromal cell of endometrium	CL:0002255	92.35	gold quality
superficial temporal artery	UBERON:0001614	91.85	gold quality
left uterine tube	UBERON:0001303	91.19	gold quality
bone marrow	UBERON:0002371	91.18	gold quality
muscle layer of sigmoid colon	UBERON:0035805	90.89	gold quality
lower esophagus muscularis layer	UBERON:0035833	90.57	gold quality
lower esophagus	UBERON:0013473	90.56	gold quality
tonsil	UBERON:0002372	90.30	gold quality
smooth muscle tissue	UBERON:0001135	89.85	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	89.53	gold quality
lower esophagus mucosa	UBERON:0035834	89.42	gold quality
mucosa of stomach	UBERON:0001199	89.36	gold quality
sural nerve	UBERON:0015488	89.21	gold quality
body of uterus	UBERON:0009853	88.88	gold quality
small intestine Peyer’s patch	UBERON:0003454	88.84	gold quality
endocervix	UBERON:0000458	88.47	gold quality
lower lobe of lung	UBERON:0008949	88.45	gold quality
nipple	UBERON:0002030	88.32	gold quality
myometrium	UBERON:0001296	88.19	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	11.25
E-CURD-112	no	2.83

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

112 targeting MOB3A, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-6748-5P	100.00	65.81	1057
HSA-MIR-4533	100.00	69.48	2758
HSA-MIR-4283	100.00	66.42	2097
HSA-MIR-6077	99.99	68.04	2299
HSA-MIR-6870-5P	99.99	68.55	2115
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-4534	99.99	66.58	1907
HSA-MIR-25-3P	99.98	74.60	1817
HSA-MIR-32-5P	99.98	75.21	1964
HSA-MIR-363-3P	99.98	74.72	1821
HSA-MIR-367-3P	99.98	74.83	1819
HSA-MIR-92A-3P	99.98	75.21	1960
HSA-MIR-92B-3P	99.98	75.25	1955
HSA-MIR-4723-5P	99.97	68.70	2034
HSA-MIR-5698	99.97	68.49	2029
HSA-MIR-7111-5P	99.97	68.48	2062
HSA-MIR-6825-5P	99.96	69.81	3431
HSA-MIR-4731-5P	99.89	67.23	2537
HSA-MIR-6783-3P	99.89	67.92	2059
HSA-MIR-6780A-5P	99.88	66.69	2776
HSA-MIR-4728-5P	99.85	69.39	4718
HSA-MIR-765	99.84	68.24	2442
HSA-MIR-6785-5P	99.82	68.68	4428
HSA-MIR-3180-5P	99.82	69.12	2422
HSA-MIR-4694-3P	99.79	69.53	2640
HSA-MIR-1273H-5P	99.77	66.32	2471
HSA-MIR-1299	99.77	71.24	2389
HSA-MIR-3150A-3P	99.76	64.44	1640
HSA-MIR-6763-5P	99.76	64.68	1767

Literature-anchored findings (GeneRIF, showing 1)

• MOB3A Bypasses BRAF and RAS Oncogene-Induced Senescence by Engaging the Hippo Pathway. (PMID:35046109)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	mob3a	ENSDARG00000019113
mus_musculus	Mob3a	ENSMUSG00000003348
rattus_norvegicus	Mob3a	ENSRNOG00000018971
drosophila_melanogaster	Mob3	FBGN0259482
caenorhabditis_elegans		WBGENE00020447

Paralogs (6): MOB1A (ENSG00000114978), MOB4 (ENSG00000115540), MOB3B (ENSG00000120162), MOB3C (ENSG00000142961), MOB1B (ENSG00000173542), MOB2 (ENSG00000182208)

Protein

Protein identifiers

MOB kinase activator 3A — Q96BX8 (reviewed: Q96BX8)

Alternative names: MOB-LAK, Mob1 homolog 2A, Mps one binder kinase activator-like 2A

All UniProt accessions (7): Q96BX8, K7EKK6, K7ELH3, K7ELS3, K7EPX7, K7ESA9, K7ESI3

UniProt curated annotations — full annotation on UniProt →

Function. May regulate the activity of kinases.

Similarity. Belongs to the MOB1/phocein family.

RefSeq proteins (1): NP_570719* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR005301	MOB_kinase_act_fam	Family
IPR036703	MOB_kinase_act_sf	Homologous_superfamily

Pfam: PF03637

UniProt features (5 total): binding site 4, chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q96BX8-F1	89.66	0.72

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (4): 83; 88; 165; 170

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 139 (showing top): GSE45365_NK_CELL_VS_BCELL_UP, IVANOVA_HEMATOPOIESIS_LATE_PROGENITOR, GOMF_KINASE_ACTIVATOR_ACTIVITY, RICKMAN_METASTASIS_DN, NAKAMURA_TUMOR_ZONE_PERIPHERAL_VS_CENTRAL_DN, MARSON_BOUND_BY_FOXP3_UNSTIMULATED, chr19p13, GOMF_ENZYME_ACTIVATOR_ACTIVITY, ZHAN_MULTIPLE_MYELOMA_MS_DN, GOMF_ENZYME_REGULATOR_ACTIVITY, MOREAUX_MULTIPLE_MYELOMA_BY_TACI_UP, WANG_RESPONSE_TO_GSK3_INHIBITOR_SB216763_DN, TORCHIA_TARGETS_OF_EWSR1_FLI1_FUSION_DN, KRIEG_HYPOXIA_NOT_VIA_KDM3A, LINDGREN_BLADDER_CANCER_HIGH_RECURRENCE

GO Biological Process (1): signal transduction (GO:0007165)

GO Molecular Function (2): protein kinase activator activity (GO:0030295), metal ion binding (GO:0046872)

GO Cellular Component (2): nucleus (GO:0005634), cytoplasm (GO:0005737)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
protein kinase activity	1
kinase activator activity	1
protein kinase regulator activity	1
cation binding	1
intracellular membrane-bounded organelle	1
intracellular anatomical structure	1
cellular anatomical structure	1

Protein interactions and networks

STRING

500 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
MOB3A	MOB4	Q9Y3A3	684
MOB3A	STK38	Q15208	632
MOB3A	STK4	Q13043	583
MOB3A	ZNF888	P0CJ79	507
MOB3A	STK38L	Q9Y2H1	505
MOB3A	LATS2	Q9NRM7	410
MOB3A	TXNDC15	Q96J42	400
MOB3A	LATS1	O95835	398
MOB3A	CCNI2	Q6ZMN8	383
MOB3A	SSNA1	O43805	368
MOB3A	SPATA25	Q9BR10	350
MOB3A	PPP1R2C	O14990	348
MOB3A	SPANXN1	Q5VSR9	348
MOB3A	PRMT2IP	Q6ZRI6	348
MOB3A	IZUMO4	Q1ZYL8	339

IntAct

0 interactions, top by confidence:

BioGRID (29): MOB3A (Synthetic Lethality), TGIF1 (Two-hybrid), MOB3A (Biochemical Activity), MOB3A (Proximity Label-MS), HDHD3 (Co-fractionation), TRIOBP (Co-fractionation), MOB3A (Affinity Capture-MS), POLH (Proximity Label-MS), MAP4K4 (Proximity Label-MS), CENPC (Proximity Label-MS), GLTSCR2 (Proximity Label-MS), COIL (Proximity Label-MS), PPP6R1 (Proximity Label-MS), SHMT2 (Proximity Label-MS), IMMT (Proximity Label-MS)

ESM2 similar proteins: A0A223HDI2, A2BG43, B0BLT4, B0BNM9, B0YN54, O22797, O64587, O94360, P40124, P68265, P68266, Q01518, Q08163, Q0VCQ0, Q2WBN3, Q3SYV4, Q3T1J9, Q4R4I6, Q54XJ0, Q5F495, Q5HZ92, Q5RAE0, Q5RDB1, Q5TA50, Q5XIS2, Q63ZQ3, Q66JG2, Q6DBQ8, Q6NLQ3, Q6NU44, Q6PEB6, Q6Z6S1, Q70IA6, Q7L9L4, Q8BPB0, Q8BS40, Q8GYX0, Q8VI63, Q921Y0, Q949G5

Diamond homologs: F4K494, F4K495, O74558, O94360, P40484, P43563, Q29RK9, Q2LZ59, Q2WBN3, Q3T1J9, Q54BM4, Q54CR8, Q54QV0, Q54XJ0, Q58D63, Q5ABC6, Q5EAA4, Q5R5Z0, Q5RAE0, Q70IA6, Q70IA8, Q7L9L4, Q86TA1, Q8BJG4, Q8BPB0, Q8BSU7, Q8GYX0, Q8IQG1, Q8VE04, Q8VI63, Q921Y0, Q949G5, Q95RA8, Q96BX8, Q9FHI1, Q9H8S9, Q9P601, Q9VL13

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

61 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	51
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

739 predictions. Top by Δscore:

Variant	Effect	Δscore
19:2073421:CTTT:C	acceptor_gain	1.0000
19:2073425:C:CC	acceptor_gain	1.0000
19:2076806:CGCA:C	donor_loss	1.0000
19:2076807:GCACC:G	donor_loss	1.0000
19:2076808:CACCA:C	donor_loss	1.0000
19:2076809:A:AC	donor_gain	1.0000
19:2076809:A:C	donor_loss	1.0000
19:2076810:C:CC	donor_gain	1.0000
19:2076824:T:TA	donor_gain	1.0000
19:2076825:C:CA	donor_gain	1.0000
19:2077014:C:CC	acceptor_gain	1.0000
19:2078136:TCAC:T	donor_loss	1.0000
19:2078137:CACC:C	donor_loss	1.0000
19:2078138:A:AC	donor_gain	1.0000
19:2078139:C:CC	donor_gain	1.0000
19:2078139:CCAA:C	donor_gain	1.0000
19:2073422:TTT:T	acceptor_gain	0.9900
19:2073423:TT:T	acceptor_gain	0.9900
19:2073425:C:CA	acceptor_loss	0.9900
19:2073426:T:G	acceptor_loss	0.9900
19:2076788:C:CA	donor_gain	0.9900
19:2076805:GCGCA:G	donor_loss	0.9900
19:2077010:GTGC:G	acceptor_gain	0.9900
19:2077011:TGC:T	acceptor_gain	0.9900
19:2077012:GCC:G	acceptor_loss	0.9900
19:2078134:ACTC:A	donor_loss	0.9900
19:2078137:CACCA:C	donor_gain	0.9900
19:2078138:ACCAA:A	donor_gain	0.9900
19:2078139:CCA:C	donor_gain	0.9900
19:2078139:CCAAC:C	donor_gain	0.9900

AlphaMissense

1446 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
19:2078260:A:G	W101R	1.000
19:2078260:A:T	W101R	1.000
19:2078340:A:G	L74P	1.000
19:2076876:A:C	Y187D	0.999
19:2076954:G:T	R161S	0.999
19:2078154:A:G	F136S	0.999
19:2078196:A:G	L122P	0.999
19:2078258:C:A	W101C	0.999
19:2078258:C:G	W101C	0.999
19:2078259:C:G	W101S	0.999
19:2078266:A:G	Y99H	0.999
19:2078283:C:T	G93E	0.999
19:2078299:A:G	C88R	0.999
19:2078349:C:G	R71P	0.999
19:2078376:G:T	A62D	0.999
19:2078381:C:A	W60C	0.999
19:2078381:C:G	W60C	0.999
19:2078383:A:G	W60R	0.999
19:2078383:A:T	W60R	0.999
19:2078469:A:G	L31P	0.999
19:2076812:A:G	L208P	0.998
19:2076871:C:A	K188N	0.998
19:2076871:C:G	K188N	0.998
19:2076940:G:C	H165Q	0.998
19:2076940:G:T	H165Q	0.998
19:2076942:G:C	H165D	0.998
19:2076953:C:G	R161P	0.998
19:2076954:G:C	R161G	0.998
19:2076959:A:G	L159P	0.998
19:2077003:A:C	F144L	0.998

dbSNP variants (sampled 300 via entrez): RS1000054568 (19:2079369 G>T), RS1000231388 (19:2089112 G>A), RS1000393 (19:2075667 A>T), RS1000570680 (19:2074910 G>T), RS1000700208 (19:2092249 C>T), RS1000762431 (19:2086692 G>T), RS1000854334 (19:2086938 C>T), RS1000954445 (19:2087743 C>A), RS1000975361 (19:2097184 A>C), RS1001023040 (19:2078304 T>G), RS1001049712 (19:2091690 A>G), RS1001239130 (19:2087925 G>T), RS1001239262 (19:2082777 A>G), RS1001305158 (19:2079853 A>G), RS1001497127 (19:2071034 T>C)

Disease associations

OMIM: gene MIM:620929 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

27 total (human), top 27 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	increases expression, increases methylation	2
sodium arsenite	decreases expression, increases abundance, increases expression	2
Benzo(a)pyrene	affects methylation, increases expression	2
Valproic Acid	decreases expression, increases expression, increases methylation	2
aristolochic acid I	decreases expression	1
GSK-J4	decreases expression	1
bisphenol F	increases expression, affects cotreatment	1
dicrotophos	increases expression	1
triphenyl phosphate	affects expression	1
ferrous chloride	decreases expression	1
abrine	decreases expression	1
Bortezomib	decreases expression	1
Temozolomide	decreases expression	1
Acetaminophen	increases expression	1
Air Pollutants	increases expression, increases abundance	1
Arsenic	increases abundance, increases expression	1
Dexamethasone	affects cotreatment, increases expression	1
Doxorubicin	decreases expression	1
Indomethacin	increases expression, affects cotreatment	1
Smoke	increases expression	1
Thiram	decreases expression	1
Tobacco Smoke Pollution	decreases methylation	1
Tretinoin	increases expression	1
1-Methyl-3-isobutylxanthine	affects cotreatment, increases expression	1
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	decreases expression	1
Cadmium Chloride	decreases expression	1
Particulate Matter	increases abundance, increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.