MOB3C

Summary

MOB3C (MOB kinase activator 3C, HGNC:29800) is a protein-coding gene on chromosome 1p33, encoding MOB kinase activator 3C (Q70IA8). May regulate the activity of kinases.

The protein encoded by this gene is similar to the yeast Mob1 protein. Yeast Mob1 binds Mps1p, a protein kinase essential for spindle pole body duplication and mitotic checkpoint regulation. Alternatively spliced transcript variants encoding distinct isoforms have been observed.

Source: NCBI Gene 148932 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• Clinical variants (ClinVar): 57 total
• MANE Select transcript: NM_201403

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:29800
Approved symbol	MOB3C
Name	MOB kinase activator 3C
Location	1p33
Locus type	gene with protein product
Status	Approved
Aliases	MOB1E
Ensembl gene	ENSG00000142961
Ensembl biotype	protein_coding
OMIM	620804
Entrez	148932

Gene structure

Transcript identifiers

Ensembl transcripts: 8 — 8 protein_coding

ENST00000271139, ENST00000319928, ENST00000371940, ENST00000871612, ENST00000871613, ENST00000871614, ENST00000936346, ENST00000961858

RefSeq mRNA: 2 — MANE Select: NM_201403 NM_145279, NM_201403

CCDS: CCDS540

Canonical transcript exons

ENST00000319928 — 4 exons

Exon	Start	End
ENSE00001843838	46607719	46609684
ENSE00001905126	46616711	46616811
ENSE00003561115	46612904	46613371
ENSE00003675714	46610002	46610204

Expression profiles

Bgee: expression breadth ubiquitous, 242 present calls, max score 90.24.

Top tissues by expression

254 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
body of pancreas	UBERON:0001150	90.24	gold quality
granulocyte	CL:0000094	88.69	gold quality
apex of heart	UBERON:0002098	87.85	gold quality
tibialis anterior	UBERON:0001385	87.37	silver quality
gastrocnemius	UBERON:0001388	87.17	gold quality
muscle of leg	UBERON:0001383	86.91	gold quality
right coronary artery	UBERON:0001625	86.81	gold quality
descending thoracic aorta	UBERON:0002345	86.57	gold quality
omental fat pad	UBERON:0010414	86.37	gold quality
peritoneum	UBERON:0002358	86.34	gold quality
pancreas	UBERON:0001264	85.96	gold quality
adipose tissue of abdominal region	UBERON:0007808	85.80	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	85.69	gold quality
hindlimb stylopod muscle	UBERON:0004252	85.65	gold quality
pancreatic ductal cell	CL:0002079	85.56	silver quality
leukocyte	CL:0000738	85.43	gold quality
thoracic aorta	UBERON:0001515	85.41	gold quality
monocyte	CL:0000576	85.34	gold quality
ascending aorta	UBERON:0001496	85.26	gold quality
lower esophagus	UBERON:0013473	84.99	gold quality
lower esophagus muscularis layer	UBERON:0035833	84.99	gold quality
blood	UBERON:0000178	84.79	gold quality
coronary artery	UBERON:0001621	84.77	gold quality
left coronary artery	UBERON:0001626	84.76	gold quality
right atrium auricular region	UBERON:0006631	84.72	gold quality
vena cava	UBERON:0004087	84.63	gold quality
lower esophagus mucosa	UBERON:0035834	84.57	gold quality
cardiac atrium	UBERON:0002081	84.21	gold quality
esophagus	UBERON:0001043	83.97	gold quality
ileal mucosa	UBERON:0000331	83.89	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	4.13

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

89 targeting MOB3C, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-8485	100.00	77.57	4731
HSA-MIR-4533	100.00	69.48	2758
HSA-MIR-4481	100.00	66.42	1669
HSA-MIR-4455	100.00	65.48	1587
HSA-MIR-196A-1-3P	99.99	72.15	2772
HSA-MIR-4745-5P	99.98	65.95	1028
HSA-MIR-8075	99.97	67.20	962
HSA-MIR-4267	99.96	66.53	2368
HSA-MIR-7107-3P	99.93	66.73	627
HSA-MIR-6753-3P	99.93	66.57	637
HSA-MIR-515-5P	99.92	69.82	2343
HSA-MIR-519E-5P	99.92	69.62	2358
HSA-MIR-329-3P	99.91	66.56	1234
HSA-MIR-362-3P	99.91	66.38	1267
HSA-MIR-137-3P	99.87	74.74	2401
HSA-MIR-3941	99.86	70.54	2735
HSA-MIR-3934-3P	99.76	65.51	1351
HSA-MIR-2681-5P	99.75	67.64	1655
HSA-MIR-4524A-3P	99.72	66.85	2406
HSA-MIR-10393-3P	99.72	66.56	961
HSA-MIR-6801-5P	99.72	66.50	981
HSA-MIR-3202	99.66	67.70	2737
HSA-MIR-4527	99.66	67.43	714
HSA-MIR-3679-3P	99.64	69.88	1599
HSA-MIR-1827	99.63	68.57	3265
HSA-MIR-24-3P	99.59	69.97	1934
HSA-MIR-2113	99.58	71.22	1521
HSA-MIR-3942-3P	99.57	69.03	2854
HSA-MIR-642A-5P	99.51	65.10	1152
HSA-MIR-3128	99.50	67.85	1258

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	mob3c	ENSDARG00000043705
mus_musculus	Mob3c	ENSMUSG00000028709
rattus_norvegicus	Mob3c	ENSRNOG00000037620
drosophila_melanogaster	Mob3	FBGN0259482
caenorhabditis_elegans		WBGENE00020447

Paralogs (6): MOB1A (ENSG00000114978), MOB4 (ENSG00000115540), MOB3B (ENSG00000120162), MOB3A (ENSG00000172081), MOB1B (ENSG00000173542), MOB2 (ENSG00000182208)

Protein

Protein identifiers

MOB kinase activator 3C — Q70IA8 (reviewed: Q70IA8)

Alternative names: Mob1 homolog 2C, Mps one binder kinase activator-like 2C

All UniProt accessions (2): Q70IA8, X6R3L3

UniProt curated annotations — full annotation on UniProt →

Function. May regulate the activity of kinases.

Similarity. Belongs to the MOB1/phocein family.

RefSeq proteins (2): NP_660322, NP_958805* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR005301	MOB_kinase_act_fam	Family
IPR036703	MOB_kinase_act_sf	Homologous_superfamily

Pfam: PF03637

UniProt features (5 total): binding site 4, chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q70IA8-F1	89.18	0.72

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (4): 82; 87; 164; 169

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 103 (showing top): GSE45365_CD8A_DC_VS_CD11B_DC_IFNAR_KO_MCMV_INFECTION_UP, CREL_01, ZHAN_MULTIPLE_MYELOMA_PR_DN, LINDGREN_BLADDER_CANCER_CLUSTER_3_DN, CAGCTG_AP4_Q5, NFKB_Q6, GOMF_KINASE_ACTIVATOR_ACTIVITY, NFKB_C, TGCTGAY_UNKNOWN, PU1_Q6, LASTOWSKA_NEUROBLASTOMA_COPY_NUMBER_DN, RGAGGAARY_PU1_Q6, ACEVEDO_METHYLATED_IN_LIVER_CANCER_DN, KRIGE_RESPONSE_TO_TOSEDOSTAT_24HR_UP, GOMF_ENZYME_ACTIVATOR_ACTIVITY

GO Biological Process (1): signal transduction (GO:0007165)

GO Molecular Function (3): protein kinase activator activity (GO:0030295), metal ion binding (GO:0046872), protein binding (GO:0005515)

GO Cellular Component (2): nucleus (GO:0005634), cytoplasm (GO:0005737)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
protein kinase activity	1
kinase activator activity	1
protein kinase regulator activity	1
cation binding	1
binding	1
intracellular membrane-bounded organelle	1
intracellular anatomical structure	1
cellular anatomical structure	1

Protein interactions and networks

STRING

424 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
MOB3C	MOB4	Q9Y3A3	663
MOB3C	ANKDD1B	A6NHY2	535
MOB3C	STK38	Q15208	505
MOB3C	MYADML2	A6NDP7	505
MOB3C	DPH5	Q9H2P9	493
MOB3C	NAA20	P61599	492
MOB3C	OR2T12	Q8NG77	474
MOB3C	TMEM218	A2RU14	466
MOB3C	OR4F6	Q8NGB9	449
MOB3C	RNGTT	O60942	448
MOB3C	ZNF117	Q03924	447
MOB3C	CCDC144NL	Q6NUI1	445
MOB3C	OR51Q1	Q8NH59	438
MOB3C	MARVELD1	Q9BSK0	423
MOB3C	ABHD14B	Q96IU4	421

IntAct

51 interactions, top by confidence:

A	B	Type	Score
ZBTB10	MOB3C	psi-mi:“MI:0915”(physical association)	0.670
MOB3C	FAM118A	psi-mi:“MI:0915”(physical association)	0.670
MOB3C	ZBTB10	psi-mi:“MI:0915”(physical association)	0.670
FAM118A	MOB3C	psi-mi:“MI:0915”(physical association)	0.670
MOB3C	TDO2	psi-mi:“MI:0915”(physical association)	0.560
NT5C2	MOB3C	psi-mi:“MI:0915”(physical association)	0.560
TFCP2	MOB3C	psi-mi:“MI:0915”(physical association)	0.560
TNIP1	MOB3C	psi-mi:“MI:0915”(physical association)	0.560
MOB3C	KRT40	psi-mi:“MI:0915”(physical association)	0.560
SIAH1	MOB3C	psi-mi:“MI:0915”(physical association)	0.560
CMTM3	MOB3C	psi-mi:“MI:0915”(physical association)	0.560
TDO2	MOB3C	psi-mi:“MI:0915”(physical association)	0.560
MOB3C	SIAH1	psi-mi:“MI:0915”(physical association)	0.560
MOB3C	TFCP2	psi-mi:“MI:0915”(physical association)	0.560
MOB3C	TNIP1	psi-mi:“MI:0915”(physical association)	0.560
MOB3C	CMTM3	psi-mi:“MI:0915”(physical association)	0.560
MAU2	MOB3C	psi-mi:“MI:0915”(physical association)	0.560

BioGRID (383): MOB3C (Two-hybrid), MOB3C (Two-hybrid), MOB3C (Two-hybrid), MOB3C (Two-hybrid), MOB3C (Two-hybrid), MOB3C (Two-hybrid), MOB3C (Two-hybrid), MOB3C (Two-hybrid), MOB3C (Two-hybrid), MOB3C (Affinity Capture-MS), MOB3C (Affinity Capture-MS), MOB3C (Affinity Capture-RNA), MOB3C (Biochemical Activity), MOB3C (Synthetic Lethality), MOB3C (Two-hybrid)

ESM2 similar proteins: A2BG43, A8XG63, B0BNM9, B0YN54, F4K494, F4K495, O01763, O74558, O94360, P34349, P68265, P68266, Q29RK9, Q2WBN3, Q3T1J9, Q54BM4, Q54CR8, Q54QV0, Q54XJ0, Q58D63, Q5EAA4, Q5F495, Q5R5Z0, Q5RAE0, Q5RDB1, Q6NU44, Q6PEB6, Q70IA6, Q70IA8, Q7K0E3, Q7L9L4, Q86TA1, Q8BJG4, Q8BPB0, Q8BSU7, Q8GYX0, Q8VE04, Q8VI63, Q921Y0, Q949G5

Diamond homologs: F4K494, F4K495, O74558, O94360, P40484, P43563, Q29RK9, Q2LZ59, Q2WBN3, Q3T1J9, Q54BM4, Q54CR8, Q54QV0, Q54XJ0, Q58D63, Q5ABC6, Q5EAA4, Q5R5Z0, Q5RAE0, Q70IA6, Q70IA8, Q7L9L4, Q86TA1, Q8BJG4, Q8BPB0, Q8BSU7, Q8GYX0, Q8IQG1, Q8VE04, Q8VI63, Q921Y0, Q949G5, Q95RA8, Q96BX8, Q9FHI1, Q9H8S9, Q9P601, Q9VL13

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

57 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	53
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

566 predictions. Top by Δscore:

Variant	Effect	Δscore
1:46609681:CCCT:C	acceptor_gain	1.0000
1:46609682:CCTC:C	acceptor_gain	1.0000
1:46609683:CT:C	acceptor_gain	1.0000
1:46609685:C:CC	acceptor_gain	1.0000
1:46609996:CCTCA:C	donor_loss	1.0000
1:46609997:CTCAC:C	donor_loss	1.0000
1:46609998:TCA:T	donor_loss	1.0000
1:46609999:CA:C	donor_loss	1.0000
1:46610000:A:AC	donor_gain	1.0000
1:46610001:C:CC	donor_gain	1.0000
1:46610001:C:CT	donor_loss	1.0000
1:46610202:CTC:C	acceptor_gain	1.0000
1:46610203:TC:T	acceptor_gain	1.0000
1:46610204:CC:C	acceptor_gain	1.0000
1:46610205:C:CC	acceptor_gain	1.0000
1:46610206:T:G	acceptor_loss	1.0000
1:46610213:C:CT	acceptor_gain	1.0000
1:46610214:A:T	acceptor_gain	1.0000
1:46612897:CACTC:C	donor_loss	1.0000
1:46612898:ACTCA:A	donor_loss	1.0000
1:46612899:CTCAC:C	donor_loss	1.0000
1:46612900:TCA:T	donor_loss	1.0000
1:46612902:A:AC	donor_gain	1.0000
1:46612902:A:C	donor_loss	1.0000
1:46612903:C:CC	donor_gain	1.0000
1:46612903:CCA:C	donor_gain	1.0000
1:46612903:CCAA:C	donor_gain	1.0000
1:46616611:T:A	donor_gain	1.0000
1:46616709:A:AC	donor_gain	1.0000
1:46616710:C:CC	donor_gain	1.0000

AlphaMissense

1433 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:46610067:A:C	Y186D	0.999
1:46613022:C:A	W100C	0.999
1:46613022:C:G	W100C	0.999
1:46613024:A:G	W100R	0.999
1:46613024:A:T	W100R	0.999
1:46613030:A:G	Y98H	0.999
1:46613104:A:G	L73P	0.999
1:46613113:C:G	R70P	0.999
1:46613147:A:G	W59R	0.999
1:46613147:A:T	W59R	0.999
1:46610062:C:A	K187N	0.998
1:46610062:C:G	K187N	0.998
1:46610078:A:T	V182D	0.998
1:46610135:A:T	V163D	0.998
1:46610144:C:G	R160P	0.998
1:46610150:A:G	L158P	0.998
1:46610194:G:C	F143L	0.998
1:46610194:G:T	F143L	0.998
1:46610196:A:G	F143L	0.998
1:46612918:A:G	F135S	0.998
1:46612960:A:G	L121P	0.998
1:46613023:C:G	W100S	0.998
1:46613118:G:C	F68L	0.998
1:46613118:G:T	F68L	0.998
1:46613120:A:G	F68L	0.998
1:46613140:G:T	A61D	0.998
1:46613145:C:A	W59C	0.998
1:46613145:C:G	W59C	0.998
1:46610068:G:C	C185W	0.997
1:46610070:A:G	C185R	0.997

dbSNP variants (sampled 300 via entrez): RS1000413335 (1:46618373 C>A,G,T), RS1000721527 (1:46612502 A>G), RS1000951570 (1:46618606 G>A), RS1001470741 (1:46618264 G>A), RS1001920197 (1:46617331 C>T), RS1002724929 (1:46609179 T>C), RS1003733781 (1:46612790 C>G,T), RS1003915758 (1:46609947 C>T), RS1004097081 (1:46617203 C>G,T), RS1004302129 (1:46617358 G>A), RS1004599705 (1:46617905 A>G), RS1004749542 (1:46611713 A>T), RS1005076575 (1:46617576 C>G), RS1005466310 (1:46614776 G>A), RS1005668448 (1:46607577 C>T)

Disease associations

OMIM: gene MIM:620804 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST003050_19	Schizophrenia	2.000000e-06
GCST010477_5	Hypertension	5.000000e-07
GCST010478_4	Chronic kidney disease	5.000000e-08

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

28 total (human), top 28 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Cisplatin	affects expression, affects cotreatment, increases expression	2
aristolochic acid I	increases expression	1
methylmercuric chloride	increases expression	1
alpha-pinene	affects cotreatment, decreases expression, increases oxidation, increases abundance	1
sodium arsenite	increases expression	1
methacrylaldehyde	decreases expression, increases oxidation, increases abundance, affects cotreatment	1
S-(1,2-dichlorovinyl)cysteine	affects response to substance, increases expression, affects cotreatment	1
di-n-butylphosphoric acid	affects expression	1
erucylphospho-N,N,N-trimethylpropylammonium	increases expression	1
jinfukang	affects cotreatment, increases expression	1
Decitabine	affects expression	1
Sunitinib	decreases expression	1
Leflunomide	decreases expression	1
Acrolein	affects cotreatment, decreases expression, increases oxidation, increases abundance	1
Air Pollutants	affects cotreatment, decreases expression, increases abundance, increases oxidation	1
Atrazine	decreases expression	1
Benzo(a)pyrene	decreases methylation	1
Doxorubicin	decreases expression	1
Gallic Acid	increases expression	1
Lipopolysaccharides	increases expression, affects response to substance, affects cotreatment	1
Ozone	increases oxidation, increases abundance, affects cotreatment, decreases expression	1
Silicon Dioxide	increases expression	1
Smoke	decreases expression	1
Testosterone	increases expression	1
Tobacco Smoke Pollution	increases expression	1
Valproic Acid	increases methylation	1
Cadmium Chloride	increases expression	1
Volatile Organic Compounds	increases oxidation, affects cotreatment, decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.