MOB4

Summary

MOB4 (MOB family member 4, phocein, HGNC:17261) is a protein-coding gene on chromosome 2q33.1, encoding MOB-like protein phocein (Q9Y3A3). Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. It is a selective cancer dependency (DepMap: 57.1% of cell lines).

This gene was identified based on its similarity with the mouse counterpart. Studies of the mouse counterpart suggest that the expression of this gene may be regulated during oocyte maturation and preimplantation following zygotic gene activation. Alternatively spliced transcript variants encoding distinct isoforms have been observed. Naturally occurring read-through transcription occurs between this locus and the neighboring locus HSPE1.

Source: NCBI Gene 25843 — RefSeq curated summary.

At a glance

• GWAS associations: 12
• Clinical variants (ClinVar): 1 total — 1 pathogenic
• Cancer dependency (DepMap): dependent in 57.1% of screened cell lines
• MANE Select transcript: NM_015387

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:17261
Approved symbol	MOB4
Name	MOB family member 4, phocein
Location	2q33.1
Locus type	gene with protein product
Status	Approved
Aliases	MOB3, DKFZP564M112, CGI-95, 2C4D, PHOCN
Ensembl gene	ENSG00000115540
Ensembl biotype	protein_coding
OMIM	609361
Entrez	25843

Gene structure

Transcript identifiers

Ensembl transcripts: 11 — 8 protein_coding, 2 nonsense_mediated_decay, 1 protein_coding_CDS_not_defined

ENST00000233892, ENST00000323303, ENST00000409355, ENST00000409360, ENST00000409916, ENST00000417097, ENST00000448447, ENST00000497443, ENST00000853551, ENST00000924868, ENST00000924869

RefSeq mRNA: 4 — MANE Select: NM_015387 NM_001100819, NM_001204094, NM_015387, NM_199482

CCDS: CCDS2321, CCDS2322, CCDS46480

Canonical transcript exons

ENST00000323303 — 8 exons

Exon	Start	End
ENSE00000803180	197550515	197553699
ENSE00001813004	197516066	197516146
ENSE00003460959	197535530	197535630
ENSE00003480693	197548336	197548415
ENSE00003511242	197540351	197540437
ENSE00003557830	197523624	197523686
ENSE00003616498	197550275	197550386
ENSE00003636966	197540111	197540153

Expression profiles

Bgee: expression breadth ubiquitous, 292 present calls, max score 99.60.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 47.3418 / max 504.2526, expressed in 1813 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
24486	47.1348	1813
24484	0.1126	41
24485	0.0944	32

Top tissues by expression

298 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	99.60	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	96.15	gold quality
heart right ventricle	UBERON:0002080	96.13	gold quality
biceps brachii	UBERON:0001507	96.09	gold quality
diaphragm	UBERON:0001103	96.05	silver quality
deltoid	UBERON:0001476	95.80	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	95.46	gold quality
vastus lateralis	UBERON:0001379	95.43	gold quality
myocardium	UBERON:0002349	95.42	gold quality
quadriceps femoris	UBERON:0001377	95.38	gold quality
triceps brachii	UBERON:0001509	95.28	gold quality
cortical plate	UBERON:0005343	95.26	gold quality
tibialis anterior	UBERON:0001385	95.25	gold quality
left ventricle myocardium	UBERON:0006566	95.23	gold quality
tongue squamous epithelium	UBERON:0006919	95.22	silver quality
Brodmann (1909) area 46	UBERON:0006483	95.06	gold quality
gluteal muscle	UBERON:0002000	94.91	gold quality
skeletal muscle tissue	UBERON:0001134	94.34	gold quality
muscle tissue	UBERON:0002385	94.13	gold quality
cardiac muscle of right atrium	UBERON:0003379	93.79	gold quality
ganglionic eminence	UBERON:0004023	93.48	gold quality
right adrenal gland cortex	UBERON:0035827	93.45	gold quality
islet of Langerhans	UBERON:0000006	93.17	gold quality
oral cavity	UBERON:0000167	92.99	gold quality
adrenal gland	UBERON:0002369	92.91	gold quality
ventricular zone	UBERON:0003053	92.87	gold quality
endothelial cell	CL:0000115	92.85	gold quality
cauda epididymis	UBERON:0004360	92.82	gold quality
orbitofrontal cortex	UBERON:0004167	92.79	gold quality
mammalian vulva	UBERON:0000997	92.70	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

144 targeting MOB4, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-8485	100.00	77.57	4731
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-3924	100.00	72.09	2394
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-3064-3P	100.00	70.09	1254
HSA-MIR-4262	100.00	73.26	3931
HSA-MIR-5692B	100.00	71.32	2622
HSA-MIR-5692C	100.00	71.32	2622
HSA-MIR-4789-3P	99.99	70.75	2484
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-513B-5P	99.99	69.96	2150
HSA-MIR-4500	99.99	72.72	2367
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-548AW	99.99	72.57	3559
HSA-LET-7F-2-3P	99.98	70.98	2588
HSA-MIR-1185-1-3P	99.98	71.04	2593
HSA-MIR-1185-2-3P	99.98	71.04	2593
HSA-MIR-12136	99.98	72.81	5713
HSA-MIR-4803	99.98	71.99	3117
HSA-MIR-4775	99.98	75.00	6394
HSA-MIR-4789-5P	99.98	70.76	2721
HSA-MIR-548AN	99.97	70.91	2817
HSA-MIR-548AA	99.96	70.64	3753
HSA-MIR-548AP-3P	99.96	70.64	3753
HSA-MIR-548T-3P	99.96	70.64	3753
HSA-MIR-2110	99.96	66.68	1930
HSA-MIR-4666A-3P	99.96	71.71	3434
HSA-MIR-570-3P	99.96	72.41	4910

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 57.1% of screened cell lines.

Literature-anchored findings (GeneRIF, showing 4)

• phosphorylation of MOB1 at Thr74 by MST2 is essential to make a complex of MOB1, MST2 and NDR1, and to fully activate NDR1 (PMID:18362890)
• hMOB3 modulates MST1 apoptotic signaling and supports tumor growth in glioblastoma multiforme. (PMID:24872389)
• Because of divergent evolution of key interface residues, MST4 and MOB4 could disrupt assembly of the MST1-MOB1 complex through alternative pairing and thereby increased YAP activity. Collectively, these findings identify the MST4-MOB4 complex as a noncanonical regulator of the Hippo-YAP pathway with an oncogenic role in PC (PMID:30072378)
• Mob4 is essential for spermatogenesis in Drosophila melanogaster. (PMID:37259670)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	mob4	ENSDARG00000056085
mus_musculus	Mob4	ENSMUSG00000025979
rattus_norvegicus	Mob4	ENSRNOG00000014980
drosophila_melanogaster	Mob4	FBGN0259483
caenorhabditis_elegans		WBGENE00016238

Paralogs (6): MOB1A (ENSG00000114978), MOB3B (ENSG00000120162), MOB3C (ENSG00000142961), MOB3A (ENSG00000172081), MOB1B (ENSG00000173542), MOB2 (ENSG00000182208)

Protein

Protein identifiers

MOB-like protein phocein — Q9Y3A3 (reviewed: Q9Y3A3)

Alternative names: 2C4D, Class II mMOB1, Mob1 homolog 3, Mps one binder kinase activator-like 3, Preimplantation protein 3

All UniProt accessions (4): B4DM50, Q9Y3A3, F8W8B0, F8WAQ8

UniProt curated annotations — full annotation on UniProt →

Function. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation.

Subunit / interactions. Binds STRN4. Interacts with DNM1 and EPS15. Interacts with nucleoside diphosphate kinase. Interacts with CTTNBP2. Interacts with CTTNBP2NL. Part of the core of STRIPAK complexes composed of PP2A catalytic and scaffolding subunits, the striatins (PP2A regulatory subunits), the striatin-associated proteins MOB4, STRIP1 and STRIP2, PDCD10 and members of the STE20 kinases, such as STK24 and STK26.

Subcellular location. Cytoplasm. Perinuclear region. Membrane. Golgi apparatus. Golgi stack membrane.

Post-translational modifications. Phosphorylated on serine residues.

Similarity. Belongs to the MOB1/phocein family.

Isoforms (3)

UniProt ID	Names	Canonical?
Q9Y3A3-1	1	yes
Q9Y3A3-2	2
Q9Y3A3-3	3

RefSeq proteins (4): NP_001094289, NP_001191023, NP_056202, NP_955776 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR005301	MOB_kinase_act_fam	Family
IPR036703	MOB_kinase_act_sf	Homologous_superfamily

Pfam: PF03637

UniProt features (31 total): helix 9, binding site 8, turn 4, sequence conflict 3, splice variant 2, strand 2, chain 1, region of interest 1, mutagenesis site 1

Structure

Experimental structures (PDB)

2 structures.

PDB	Method	Resolution (Å)
5YF4	X-RAY DIFFRACTION	1.9
7K36	ELECTRON MICROSCOPY	3.3

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9Y3A3-F1	91.29	0.83

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (8): 92; 97; 110; 113; 119; 127; 169; 174

Mutagenesis-validated functional residues (1):

Position	Phenotype
161–165	decreased formation of stripak core complex.

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 201 (showing top): RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_UP, MODULE_255, TGCTGCT_MIR15A_MIR16_MIR15B_MIR195_MIR424_MIR497, ATACCTC_MIR202, MODULE_317, TATTATA_MIR374, GOBP_HIPPO_SIGNALING, BONCI_TARGETS_OF_MIR15A_AND_MIR16_1, GOBP_NEGATIVE_REGULATION_OF_INTRACELLULAR_SIGNAL_TRANSDUCTION, WEI_MYCN_TARGETS_WITH_E_BOX, MILI_PSEUDOPODIA_HAPTOTAXIS_UP, GCM_NUMA1, TGACATY_UNKNOWN, DEBIASI_APOPTOSIS_BY_REOVIRUS_INFECTION_UP, GCM_NF2

GO Biological Process (1): negative regulation of hippo signaling (GO:0035331)

GO Molecular Function (3): protein-macromolecule adaptor activity (GO:0030674), metal ion binding (GO:0046872), protein binding (GO:0005515)

GO Cellular Component (8): cytoplasm (GO:0005737), Golgi apparatus (GO:0005794), Golgi cisterna membrane (GO:0032580), perinuclear region of cytoplasm (GO:0048471), FAR/SIN/STRIPAK complex (GO:0090443), postsynapse (GO:0098794), glutamatergic synapse (GO:0098978), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	4
cytoplasm	2
synapse	2
hippo signaling	1
regulation of hippo signaling	1
negative regulation of intracellular signal transduction	1
protein binding	1
molecular adaptor activity	1
cation binding	1
binding	1
intracellular anatomical structure	1
endomembrane system	1
intracellular membrane-bounded organelle	1
organelle membrane	1
Golgi cisterna	1
protein-containing complex	1

Protein interactions and networks

STRING

978 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
MOB4	STRN	O43815	999
MOB4	STK26	Q9P289	991
MOB4	STRIP1	Q5VSL9	990
MOB4	PDCD10	Q9BUL8	982
MOB4	STRIP2	Q9ULQ0	981
MOB4	STK25	O00506	952
MOB4	PPP2R1A	P30153	949
MOB4	PPP2CA	P05323	923
MOB4	SLMAP	Q14BN4	915
MOB4	STK24	Q9Y6E0	876
MOB4	STRN4	Q9NRL3	842
MOB4	CTTNBP2NL	Q9P2B4	807
MOB4	SIKE1	Q9BRV8	794
MOB4	STRN3	Q13033	790
MOB4	MOB2	Q70IA6	781

IntAct

175 interactions, top by confidence:

A	B	Type	Score
PPP2R1A	PPP2CA	psi-mi:“MI:0914”(association)	0.990
PDCD10	STK25	psi-mi:“MI:0914”(association)	0.980
NPHP1	NPHP4	psi-mi:“MI:2364”(proximity)	0.930
STRN3	PPP2R1A	psi-mi:“MI:0914”(association)	0.920
STK25	STRN	psi-mi:“MI:0914”(association)	0.900
STK24	STK25	psi-mi:“MI:0914”(association)	0.890
PPP2R1A	STRN	psi-mi:“MI:0914”(association)	0.880
PPP2R1A	STRN	psi-mi:“MI:2364”(proximity)	0.880
STRN3	STK25	psi-mi:“MI:0914”(association)	0.880
CTTNBP2NL	STK25	psi-mi:“MI:0914”(association)	0.880
STRN3	STRN	psi-mi:“MI:0914”(association)	0.880
STRN3	STRN	psi-mi:“MI:2364”(proximity)	0.880
STK24	STRN	psi-mi:“MI:0914”(association)	0.870
STRIP1	PPP2CB	psi-mi:“MI:0914”(association)	0.870
STK26	STRN	psi-mi:“MI:0914”(association)	0.860
PRDM14	CBFA2T2	psi-mi:“MI:0914”(association)	0.860
PPP2CA	STRN	psi-mi:“MI:0914”(association)	0.840
STRIP1	STK25	psi-mi:“MI:0914”(association)	0.840
STRN3	PPP2R1A	psi-mi:“MI:0914”(association)	0.830
CTTNBP2NL	STRN	psi-mi:“MI:2364”(proximity)	0.820
STRN	MOB4	psi-mi:“MI:0915”(physical association)	0.790

BioGRID (270): MOB4 (Affinity Capture-MS), MOB4 (Affinity Capture-MS), MOB4 (Two-hybrid), MOB4 (Two-hybrid), MOB4 (Affinity Capture-MS), MOB4 (Affinity Capture-MS), MOB4 (Affinity Capture-MS), MOB4 (Affinity Capture-MS), MOB4 (Co-fractionation), MOB4 (Co-fractionation), SF3B1 (Co-fractionation), STRN (Co-fractionation), STRN3 (Co-fractionation), STRN4 (Co-fractionation), MOB4 (Proximity Label-MS)

ESM2 similar proteins: A0A223HDI2, A2BG43, B0BLT4, B0BNM9, B0YN54, O22797, O64587, O94360, P40124, P68265, P68266, Q01518, Q08163, Q0VCQ0, Q2WBN3, Q3SYV4, Q3T1J9, Q4R4I6, Q54XJ0, Q5F495, Q5HZ92, Q5RAE0, Q5RDB1, Q5TA50, Q5XIS2, Q63ZQ3, Q66JG2, Q6DBQ8, Q6NLQ3, Q6NU44, Q6PEB6, Q6Z6S1, Q70IA6, Q7L9L4, Q8BPB0, Q8BS40, Q8GYX0, Q8VI63, Q921Y0, Q949G5

Diamond homologs: P34349, Q5F495, Q5RDB1, Q6PEB6, Q7K0E3, Q9QYW3, Q9Y3A3

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 143 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Degradation of beta-catenin by the destruction complex	8	15.6×	1e-05
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha	6	13.3×	6e-04
Anchoring of the basal body to the plasma membrane	10	12.7×	3e-06
Defective CFTR causes cystic fibrosis	5	12.3×	3e-03
Orc1 removal from chromatin	5	10.0×	5e-03
Loss of Nlp from mitotic centrosomes	5	8.9×	5e-03
Loss of proteins required for interphase microtubule organization from the centrosome	5	8.9×	5e-03
AURKA Activation by TPX2	5	8.6×	5e-03

GO biological processes:

GO term	Partners	Fold	FDR
negative regulation of hippo signaling	7	39.3×	3e-07
regulation of MAPK cascade	5	18.2×	1e-03
protein autophosphorylation	9	10.5×	9e-05
protein phosphorylation	11	6.0×	7e-04
intracellular signal transduction	14	4.3×	9e-04

Disease & clinical

Clinical variants and AI predictions

ClinVar

1 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	1
Likely pathogenic	0
Uncertain significance	0
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (1)

Variant ID	HGVS	Classification
150620	GRCh38/hg38 2q31.3-36.2(chr2:180513793-224302848)x3	Pathogenic

SpliceAI

1076 predictions. Top by Δscore:

Variant	Effect	Δscore
2:197516145:AGGTA:A	donor_loss	1.0000
2:197516146:GGTAC:G	donor_loss	1.0000
2:197516147:G:GC	donor_loss	1.0000
2:197523618:TTATA:T	acceptor_loss	1.0000
2:197523619:TATA:T	acceptor_loss	1.0000
2:197523621:TA:T	acceptor_loss	1.0000
2:197523622:A:AC	acceptor_loss	1.0000
2:197523622:A:AG	acceptor_gain	1.0000
2:197523623:G:GG	acceptor_gain	1.0000
2:197523623:G:GT	acceptor_loss	1.0000
2:197535528:A:AG	acceptor_gain	1.0000
2:197535529:G:GA	acceptor_gain	1.0000
2:197535529:G:GC	acceptor_gain	1.0000
2:197535529:GT:G	acceptor_gain	1.0000
2:197535529:GTA:G	acceptor_gain	1.0000
2:197535529:GTAT:G	acceptor_gain	1.0000
2:197535529:GTATA:G	acceptor_gain	1.0000
2:197540109:A:AG	acceptor_gain	1.0000
2:197540110:G:GG	acceptor_gain	1.0000
2:197540435:GAG:G	donor_gain	1.0000
2:197548334:A:AG	acceptor_gain	1.0000
2:197548335:G:GA	acceptor_gain	1.0000
2:197548335:G:GG	acceptor_gain	1.0000
2:197548335:GT:G	acceptor_gain	1.0000
2:197550270:TCTA:T	acceptor_loss	1.0000
2:197550272:TA:T	acceptor_loss	1.0000
2:197550273:A:AG	acceptor_gain	1.0000
2:197550273:AG:A	acceptor_gain	1.0000
2:197550274:G:GA	acceptor_loss	1.0000
2:197550274:G:GG	acceptor_gain	1.0000

AlphaMissense

1507 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
2:197516132:G:C	G16R	1.000
2:197516133:G:A	G16D	1.000
2:197523636:T:A	W25R	1.000
2:197523636:T:C	W25R	1.000
2:197535537:A:C	Q44P	1.000
2:197535540:A:C	Q45P	1.000
2:197535611:T:A	W69R	1.000
2:197535611:T:C	W69R	1.000
2:197535612:G:C	W69S	1.000
2:197535613:G:C	W69C	1.000
2:197535613:G:T	W69C	1.000
2:197535617:T:C	Y71H	1.000
2:197535617:T:G	Y71D	1.000
2:197535620:G:A	E72K	1.000
2:197535624:A:C	H73P	1.000
2:197535630:G:C	R75T	1.000
2:197535630:G:T	R75M	1.000
2:197540111:G:C	R75S	1.000
2:197540111:G:T	R75S	1.000
2:197540113:A:C	Q76P	1.000
2:197540118:T:C	C78R	1.000
2:197540120:C:G	C78W	1.000
2:197540128:T:C	L81P	1.000
2:197540132:T:A	N82K	1.000
2:197540132:T:G	N82K	1.000
2:197540140:C:A	A85D	1.000
2:197540149:T:C	L88P	1.000
2:197540357:T:A	C92S	1.000
2:197540357:T:C	C92R	1.000
2:197540358:G:A	C92Y	1.000

dbSNP variants (sampled 300 via entrez): RS1000030238 (2:197521807 T>A), RS1000084624 (2:197532820 C>T), RS1000153737 (2:197536496 G>T), RS1000250120 (2:197516361 C>A), RS1000308524 (2:197542764 A>G), RS1000309502 (2:197545039 A>G,T), RS1000373025 (2:197536799 T>C), RS1000408628 (2:197519442 G>A,C), RS1000409964 (2:197530725 C>T), RS1000552461 (2:197514284 C>T), RS1000606152 (2:197532667 C>T), RS1000749848 (2:197552033 G>T), RS1000793167 (2:197538778 A>G), RS1000820314 (2:197548584 C>G), RS1000861957 (2:197514775 G>A,C)

Disease associations

OMIM: gene MIM:609361 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

12 associations (top):

Study	Trait	p-value
GCST004132_35	Crohn’s disease	7.000000e-08
GCST004521_180	Autism spectrum disorder or schizophrenia	3.000000e-11
GCST004521_275	Autism spectrum disorder or schizophrenia	7.000000e-09
GCST006803_21	Schizophrenia	4.000000e-13
GCST009600_91	Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy)	1.000000e-08
GCST009719_15	Allergic rhinitis	2.000000e-10
GCST010698_25	Subcortical volume (min-P)	2.000000e-08
GCST010699_24	Brain morphology (min-P)	1.000000e-09
GCST010700_25	Cortical thickness (MOSTest)	2.000000e-10
GCST010701_25	Cortical surface area (MOSTest)	2.000000e-37
GCST010702_65	Subcortical volume (MOSTest)	1.000000e-11
GCST010703_197	Brain morphology (MOSTest)	1.000000e-11

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0004346	neuroimaging measurement
EFO:0004840	cortical thickness

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

28 total (human), top 28 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	decreases expression, increases expression	2
Tobacco Smoke Pollution	increases expression	2
aristolochic acid I	decreases expression	1
FR900359	decreases phosphorylation	1
triphenyl phosphate	affects expression	1
2-methyl-4-isothiazolin-3-one	increases expression	1
1-nitropyrene	increases expression	1
CGP 52608	affects binding, increases reaction	1
jinfukang	decreases expression	1
PCI 5002	affects cotreatment, increases expression	1
Acetaminophen	increases expression	1
Air Pollutants	affects expression, increases abundance	1
Cannabidiol	increases expression	1
Dichlorodiphenyl Dichloroethylene	increases expression	1
Doxorubicin	decreases expression	1
Gold	decreases expression	1
Lead	affects splicing	1
Methyl Methanesulfonate	increases expression	1
Ozone	affects expression, increases abundance	1
Thiram	decreases expression	1
Valproic Acid	decreases methylation	1
Zinc	affects cotreatment, increases expression	1
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	decreases expression	1
8-Bromo Cyclic Adenosine Monophosphate	increases expression	1
Aflatoxin B1	increases methylation	1
Aflatoxin M1	decreases expression	1
Cadmium Chloride	decreases expression	1
Copper Sulfate	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.