MORC4

Summary

MORC4 (MORC family CW-type zinc finger 4, HGNC:23485) is a protein-coding gene on chromosome Xq22.3, encoding MORC family CW-type zinc finger protein 4 (Q8TE76). Histone methylation reader which binds to non-methylated (H3K4me0), monomethylated (H3K4me1), dimethylated (H3K4me2) and trimethylated (H3K4me3) ‘Lys-4’ on histone H3.

In human, the four current members of the microrchidia (morc) gene family share an N-terminal ATPase-like ATP-binding region and a CW four-cysteine zinc-finger motif. The protein encoded by this gene also has a nuclear matrix binding domain and a two-stranded coiled-coil motif near its C-terminus. This gene is widely expressed at low levels in normal tissues and has elevated expression in placenta and testis. Alternative splicing results in multiple transcript variants encoding distinct proteins.

Source: NCBI Gene 79710 — RefSeq curated summary.

At a glance

• GWAS associations: 11
• Clinical variants (ClinVar): 298 total
• MANE Select transcript: NM_024657

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:23485
Approved symbol	MORC4
Name	MORC family CW-type zinc finger 4
Location	Xq22.3
Locus type	gene with protein product
Status	Approved
Aliases	ZCW4, FLJ11565
Ensembl gene	ENSG00000133131
Ensembl biotype	protein_coding
OMIM	300970
Entrez	79710

Gene structure

Transcript identifiers

Ensembl transcripts: 7 — 6 protein_coding, 1 retained_intron

ENST00000255495, ENST00000355610, ENST00000478924, ENST00000604604, ENST00000904924, ENST00000966192, ENST00000966193

RefSeq mRNA: 2 — MANE Select: NM_024657 NM_001085354, NM_024657

CCDS: CCDS14525, CCDS48146

Canonical transcript exons

ENST00000355610 — 17 exons

Exon	Start	End
ENSE00000907938	106954913	106955088
ENSE00000907939	106942515	106943205
ENSE00000907940	106941938	106942221
ENSE00001039098	106956480	106956534
ENSE00001039099	106958336	106958464
ENSE00001039101	106978080	106978199
ENSE00001039103	106976584	106976684
ENSE00001039105	106962012	106962110
ENSE00001039108	106956936	106957004
ENSE00001039111	106980891	106981019
ENSE00001680547	106985983	106986200
ENSE00001724793	106940738	106941632
ENSE00001778066	106985096	106985243
ENSE00003546510	106999868	107000212
ENSE00003573849	106981345	106981477
ENSE00003575921	106999677	106999749
ENSE00003672007	106993230	106993362

Expression profiles

Bgee: expression breadth ubiquitous, 248 present calls, max score 98.13.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 9.1456 / max 147.6013, expressed in 1541 samples.

FANTOM5 promoters (8 alternative TSS)

Promoter ID	TPM avg	Samples expressed
200053	5.1253	1393
200054	1.9679	1100
200049	0.7827	482
200050	0.5910	364
200051	0.3328	179
200052	0.1840	59
200047	0.0871	28
200048	0.0747	22

Top tissues by expression

277 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
colonic epithelium	UBERON:0000397	98.13	gold quality
placenta	UBERON:0001987	96.78	gold quality
tendon of biceps brachii	UBERON:0008188	94.81	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	93.72	gold quality
right adrenal gland cortex	UBERON:0035827	91.15	gold quality
right adrenal gland	UBERON:0001233	90.75	gold quality
left adrenal gland	UBERON:0001234	90.12	gold quality
adrenal gland	UBERON:0002369	89.77	gold quality
left adrenal gland cortex	UBERON:0035825	89.56	gold quality
adrenal cortex	UBERON:0001235	89.43	gold quality
sural nerve	UBERON:0015488	88.85	gold quality
tendon	UBERON:0000043	88.58	gold quality
synovial joint	UBERON:0002217	86.97	gold quality
calcaneal tendon	UBERON:0003701	86.61	gold quality
mucosa of stomach	UBERON:0001199	85.97	gold quality
body of pancreas	UBERON:0001150	85.67	gold quality
stromal cell of endometrium	CL:0002255	85.37	gold quality
seminal vesicle	UBERON:0000998	85.37	gold quality
skin of hip	UBERON:0001554	85.25	gold quality
cartilage tissue	UBERON:0002418	85.08	gold quality
ovary	UBERON:0000992	84.92	gold quality
ventricular zone	UBERON:0003053	84.85	gold quality
adrenal tissue	UBERON:0018303	84.55	gold quality
corpus epididymis	UBERON:0004359	84.50	gold quality
parietal pleura	UBERON:0002400	84.36	gold quality
skin of abdomen	UBERON:0001416	84.35	gold quality
left ovary	UBERON:0002119	84.02	gold quality
pancreas	UBERON:0001264	83.73	gold quality
vagina	UBERON:0000996	83.63	gold quality
skin of leg	UBERON:0001511	83.55	gold quality

Single-cell (SCXA)

Detected in 13 experiment(s), a significant marker in 8.

Experiment	Marker?	Max mean expression
E-GEOD-89232	yes	8819.65
E-MTAB-8205	yes	583.67
E-MTAB-5061	yes	435.25
E-MTAB-6701	yes	117.61
E-CURD-122	yes	19.62
E-MTAB-9388	yes	10.90
E-GEOD-137537	yes	6.34
E-ANND-3	yes	5.64
E-HCAD-56	no	882.86
E-ENAD-27	no	465.71
E-GEOD-81608	no	428.43
E-ENAD-20	no	398.84
E-GEOD-70580	no	238.29

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

61 targeting MORC4, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4510	100.00	66.60	2050
HSA-MIR-6127	100.00	66.76	2188
HSA-MIR-6129	100.00	66.46	2080
HSA-MIR-6130	100.00	66.69	2012
HSA-MIR-6133	100.00	66.48	2064
HSA-MIR-568	99.98	69.86	2084
HSA-MIR-9-3P	99.96	70.88	2068
HSA-MIR-493-5P	99.96	72.47	2382
HSA-MIR-4666A-3P	99.96	71.71	3434
HSA-MIR-3910	99.95	71.13	2227
HSA-MIR-515-5P	99.92	69.82	2343
HSA-MIR-519E-5P	99.92	69.62	2358
HSA-MIR-124-3P	99.89	73.74	3043
HSA-MIR-506-3P	99.89	73.55	3057
HSA-MIR-4728-5P	99.85	69.39	4718
HSA-MIR-548AR-3P	99.85	71.26	3889
HSA-MIR-1321	99.84	65.30	1811
HSA-MIR-4739	99.84	65.25	1832
HSA-MIR-4756-5P	99.84	64.98	1809
HSA-MIR-5010-3P	99.83	70.60	2357
HSA-MIR-6785-5P	99.82	68.68	4428
HSA-MIR-548AZ-3P	99.82	70.56	3549
HSA-MIR-548BC	99.82	70.61	3524
HSA-MIR-548E-3P	99.82	70.59	3514
HSA-MIR-548F-3P	99.82	70.59	3540
HSA-MIR-149-3P	99.72	68.22	3963
HSA-MIR-4306	99.72	70.50	3630
HSA-MIR-3714	99.71	70.74	2671
HSA-MIR-6883-5P	99.69	68.05	3785
HSA-MIR-4499	99.62	67.29	1470

Literature-anchored findings (GeneRIF, showing 7)

• Findings suggest that a variant of the CLDN2-MORC4 region predisposes to Crohn’s disease in a Swedish population. (PMID:23946598)
• Single nucleotide polymorphism is a risk factor developing chronic alcoholic pancreatitis. (PMID:25253127)
• Genetic variants in CLDN2 and MORC4 genes were associated with chronic pancreatitis in Indian patients. (PMID:26820620)
• Genetic variation in MORC4, CD14, and TLR4 may affect the outcome of allogeneic stem cell transplantation. (PMID:26827181)
• SNP in the MORC4-rs 12837024 is associated with Chronic pancreatitis. (PMID:28913878)
• These results identified MORC4 as differentially expressed in breast cancer cells and tissues and its downregulation by miR-193b-3p, as well as its roles in regulating the growth of breast cancer cells via regulation of apoptosis. (PMID:30320920)
• MORC4 plays a tumor-promoting role in colorectal cancer via regulating PCGF1/CDKN1A axis in vitro and in vivo. (PMID:36932196)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	morc3b	ENSDARG00000043271
danio_rerio	morc3a	ENSDARG00000056679
danio_rerio	zgc:152774	ENSDARG00000104408
mus_musculus	Morc4	ENSMUSG00000031434
rattus_norvegicus	Morc4	ENSRNOG00000060846

Paralogs (1): MORC3 (ENSG00000159256)

Protein

Protein identifiers

MORC family CW-type zinc finger protein 4 — Q8TE76 (reviewed: Q8TE76)

Alternative names: Zinc finger CW-type coiled-coil domain protein 2, Zinc finger CW-type domain protein 4

All UniProt accessions (2): Q8TE76, S4R3U3

UniProt curated annotations — full annotation on UniProt →

Function. Histone methylation reader which binds to non-methylated (H3K4me0), monomethylated (H3K4me1), dimethylated (H3K4me2) and trimethylated (H3K4me3) ‘Lys-4’ on histone H3. The order of binding preference is H3K4me3 > H3K4me2 > H3K4me1 > H3K4me0.

Subcellular location. Nucleus.

Tissue specificity. Expressed at low levels in normal tissues, with highest expression levels in placenta and testis. Expression is significantly increased in subset of diffuse large B-cell lymphomas.

Domain organisation. The CW-TYPE zinc finger mediates its binding to trimethylated histone H3K4me3.

Isoforms (3)

UniProt ID	Names	Canonical?
Q8TE76-1	1	yes
Q8TE76-2	2
Q8TE76-3	3

RefSeq proteins (2): NP_001078823, NP_078933* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR011124	Znf_CW	Domain
IPR036890	HATPase_C_sf	Homologous_superfamily
IPR041006	Morc_S5	Domain
IPR045261	MORC_ATPase	Family

Pfam: PF07496, PF13589, PF17942

UniProt features (48 total): strand 18, helix 12, binding site 4, sequence conflict 3, turn 3, sequence variant 2, splice variant 2, chain 1, zinc finger region 1, region of interest 1, coiled-coil region 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
7K7T	X-RAY DIFFRACTION	2.94

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8TE76-F1	68.48	0.35

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (4): 429; 432; 453; 464

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 123 (showing top): AAGCAAT_MIR137, GCANCTGNY_MYOD_Q6, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_UP, GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_UP, BRUECKNER_TARGETS_OF_MIRLET7A3_DN, DAVICIONI_RHABDOMYOSARCOMA_PAX_FOXO1_FUSION_UP, MOLENAAR_TARGETS_OF_CCND1_AND_CDK4_DN, SHETH_LIVER_CANCER_VS_TXNIP_LOSS_PAM2, DODD_NASOPHARYNGEAL_CARCINOMA_UP, TGGNNNNNNKCCAR_UNKNOWN, TIEN_INTESTINE_PROBIOTICS_24HR_UP, GATA1_02, SOX5_01, MEF2_Q6_01, TGCCTTA_MIR124A

GO Biological Process (1): chromatin organization (GO:0006325)

GO Molecular Function (5): zinc ion binding (GO:0008270), ATP hydrolysis activity (GO:0016887), histone H3K4me3 reader activity (GO:0140002), protein binding (GO:0005515), metal ion binding (GO:0046872)

GO Cellular Component (2): nucleus (GO:0005634), nucleoplasm (GO:0005654)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular component organization	1
transition metal ion binding	1
ribonucleoside triphosphate phosphatase activity	1
ATP-dependent activity	1
histone H3 reader activity	1
binding	1
cation binding	1
intracellular membrane-bounded organelle	1
nuclear lumen	1
cellular anatomical structure	1

Protein interactions and networks

STRING

386 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
MORC4	PRSS2	P07478	577
MORC4	CLDN2	P57739	545
MORC4	PRSS1	P07477	542
MORC4	PRSS58	Q8IYP2	511
MORC4	TYW2	Q53H54	451
MORC4	H3-3A	P06351	429
MORC4	H3C14	Q71DI3	429
MORC4	H3-5	Q6NXT2	429
MORC4	H3C1	P02295	429
MORC4	H3-4	Q16695	429
MORC4	H3-7	Q5TEC6	429
MORC4	MLPH	Q9BV36	421
MORC4	SPINK1	P00995	419
MORC4	PHLDB2	Q86SQ0	395
MORC4	RIPPLY1	Q0D2K3	391

IntAct

61 interactions, top by confidence:

A	B	Type	Score
RYBP	BMI1	psi-mi:“MI:0914”(association)	0.850
NFIC	NFIB	psi-mi:“MI:2364”(proximity)	0.690
YAF2	E2F6	psi-mi:“MI:0914”(association)	0.640
SKP1	MYCBP2	psi-mi:“MI:0914”(association)	0.640
PCGF1	CBX4	psi-mi:“MI:0914”(association)	0.530
FHL2	CNOT1	psi-mi:“MI:0914”(association)	0.530
STAT3	MORC4	psi-mi:“MI:0915”(physical association)	0.510
MORC4	STAT3	psi-mi:“MI:0915”(physical association)	0.510
ETV7	NFIB	psi-mi:“MI:2364”(proximity)	0.470
EN1	NFIB	psi-mi:“MI:2364”(proximity)	0.470
MORC4		psi-mi:“MI:0407”(direct interaction)	0.440
MORC4	AHNAK	psi-mi:“MI:0915”(physical association)	0.400
MORC4	PRKAA1	psi-mi:“MI:0915”(physical association)	0.370
MORC4	GEMIN4	psi-mi:“MI:0915”(physical association)	0.370
MORC4	SKIL	psi-mi:“MI:0915”(physical association)	0.370
MORC4		psi-mi:“MI:0915”(physical association)	0.370
HIF1AN	CNOT1	psi-mi:“MI:0914”(association)	0.350
FAM167A	SHTN1	psi-mi:“MI:0914”(association)	0.350
SMYD2	HSPA4L	psi-mi:“MI:0914”(association)	0.350
ATG16L1	ESYT2	psi-mi:“MI:0914”(association)	0.350
S100B	PLEKHG3	psi-mi:“MI:0914”(association)	0.350
PNMA2	TARS3	psi-mi:“MI:0914”(association)	0.350
WHAMMP3	EXOC5	psi-mi:“MI:0914”(association)	0.350
SKP1	BHLHE40	psi-mi:“MI:0914”(association)	0.350
PCGF1	ZNF609	psi-mi:“MI:0914”(association)	0.350

BioGRID (93): MORC4 (Affinity Capture-RNA), MORC4 (Affinity Capture-RNA), MORC4 (Affinity Capture-RNA), MORC4 (Affinity Capture-RNA), MORC4 (Affinity Capture-MS), MORC4 (Affinity Capture-MS), MORC4 (Affinity Capture-MS), MORC4 (Affinity Capture-MS), MORC4 (Affinity Capture-MS), MORC4 (Affinity Capture-MS), MORC4 (Affinity Capture-MS), MORC4 (Affinity Capture-MS), MORC4 (Proximity Label-MS), MORC4 (Affinity Capture-MS), MORC4 (Proximity Label-MS)

ESM2 similar proteins: A0A1B0GUJ8, A1A5R7, A2CJ06, A7E3N2, B1H224, B8QB46, D3Z8Y2, D3ZSP7, O55036, P0CG32, P54274, P70371, Q14BQ3, Q29RJ0, Q2HJ46, Q2T9U5, Q3TTP0, Q4R8X0, Q4R9F7, Q4VA55, Q5DTT8, Q5RBH9, Q5TKR9, Q5U310, Q5ZIX8, Q6DJS0, Q6ZQF7, Q71M44, Q7Z2W4, Q7Z7J5, Q80VH0, Q80VM8, Q8BMD7, Q8BZ21, Q8CCG4, Q8CDN1, Q8JZW8, Q8ND61, Q8TE76, Q8VD24

Diamond homologs: A0A0P0X9Z7, Q0DIQ5, Q0DRX6, Q8BMD7, Q8TE76, F4JPP0, F4JRS4, F4K2G3, F4KAF2, F7BJB9, Q14149, Q56Y74, Q5FV35, Q84WV6, Q86VD1, Q9WVL5, Q8C5W4, Q5CCK4, Q69ZX6, Q6IR42, Q9M1I1, Q9Y6X9, Q08EN7, Q504Y3, Q6Z3U3, Q23243, Q2LAE1, Q9H0M4, E1BYJ2, O96028, P52701, P54276, Q8BVE8, B5BT18, F4J9M5, O43065, P79051, Q06554, Q9UTL9

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 74 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

GO biological processes:

GO term	Partners	Fold	FDR
positive regulation of miRNA transcription	5	20.8×	3e-04
anatomical structure morphogenesis	8	15.9×	5e-06
transcription by RNA polymerase II	12	12.1×	5e-08
chromatin remodeling	9	9.4×	5e-05
central nervous system development	5	8.2×	6e-03
negative regulation of apoptotic process	10	5.0×	1e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

298 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	85
Likely benign	4
Benign	2

Top pathogenic / likely-pathogenic (0)

SpliceAI

7660 predictions. Top by Δscore:

Variant	Effect	Δscore
X:106818653:A:AG	acceptor_gain	1.0000
X:106818658:A:AG	acceptor_gain	1.0000
X:106818658:AACAG:A	acceptor_gain	1.0000
X:106818659:A:G	acceptor_gain	1.0000
X:106818660:CAGG:C	acceptor_loss	1.0000
X:106818661:A:AG	acceptor_gain	1.0000
X:106818661:AG:A	acceptor_gain	1.0000
X:106818661:AGG:A	acceptor_gain	1.0000
X:106818662:G:GT	acceptor_gain	1.0000
X:106818662:GG:G	acceptor_gain	1.0000
X:106818662:GGG:G	acceptor_gain	1.0000
X:106818771:GTG:G	donor_gain	1.0000
X:106818771:GTGGT:G	donor_loss	1.0000
X:106818772:TG:T	donor_gain	1.0000
X:106818772:TGG:T	donor_loss	1.0000
X:106818773:GG:G	donor_gain	1.0000
X:106818774:G:GG	donor_gain	1.0000
X:106818775:T:G	donor_loss	1.0000
X:106820994:GA:G	donor_gain	1.0000
X:106820996:G:GG	donor_gain	1.0000
X:106822087:GAA:G	donor_gain	1.0000
X:106822090:G:GG	donor_gain	1.0000
X:106840037:T:TA	acceptor_gain	1.0000
X:106840041:A:AG	acceptor_gain	1.0000
X:106840044:A:AG	acceptor_gain	1.0000
X:106840045:C:G	acceptor_gain	1.0000
X:106840046:A:AG	acceptor_gain	1.0000
X:106840046:A:AT	acceptor_loss	1.0000
X:106840046:AGTT:A	acceptor_gain	1.0000
X:106840047:G:GA	acceptor_gain	1.0000

AlphaMissense

6182 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
X:106958413:T:A	R436S	1.000
X:106958413:T:G	R436S	1.000
X:106986131:C:A	K126N	1.000
X:106986131:C:G	K126N	1.000
X:106958364:A:G	C453R	0.999
X:106958370:A:G	W451R	0.999
X:106958370:A:T	W451R	0.999
X:106958414:C:G	R436T	0.999
X:106958418:A:G	W435R	0.999
X:106958418:A:T	W435R	0.999
X:106958427:A:G	C432R	0.999
X:106958436:A:G	C429R	0.999
X:106976613:T:A	K376N	0.999
X:106976613:T:G	K376N	0.999
X:106976614:T:A	K376I	0.999
X:106978120:C:G	R339P	0.999
X:106978174:C:T	G321E	0.999
X:106985120:C:G	R217P	0.999
X:106986003:A:T	V169D	0.999
X:106986009:G:T	P167Q	0.999
X:106986060:A:G	L150P	0.999
X:106986063:C:T	G149E	0.999
X:106986064:C:G	G149R	0.999
X:106986064:C:T	G149R	0.999
X:106986066:A:T	V148D	0.999
X:106986096:A:T	V138D	0.999
X:106986099:A:G	L137P	0.999
X:106986133:T:C	K126E	0.999
X:106986135:A:G	F125S	0.999
X:106993245:A:G	L98P	0.999

dbSNP variants (sampled 300 via entrez): RS1000094563 (X:106973851 C>A), RS1000162019 (X:106957525 CCTTT>C), RS1000293038 (X:106984754 C>A,G), RS1000388438 (X:106984229 T>C), RS1000388588 (X:106967785 C>A,G), RS1000445758 (X:106995112 T>C), RS1000535626 (X:106979802 C>G), RS1000637697 (X:106974463 C>G), RS1000685306 (X:106945611 T>C), RS1000721756 (X:106949683 T>C), RS1000783359 (X:106992649 G>T), RS1000800086 (X:106949220 T>A,C,G), RS1000937123 (X:106958686 A>G), RS1000959357 (X:106968186 T>C), RS1000990241 (X:106967617 C>T)

Disease associations

OMIM: gene MIM:300970 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

11 associations (top):

Study	Trait	p-value
GCST001741_2	Pancreatitis	2.000000e-22
GCST004860_112	Alcoholic chronic pancreatitis	1.000000e-06
GCST004860_126	Alcoholic chronic pancreatitis	1.000000e-06
GCST004860_24	Alcoholic chronic pancreatitis	4.000000e-13
GCST004860_54	Alcoholic chronic pancreatitis	2.000000e-07
GCST004860_60	Alcoholic chronic pancreatitis	1.000000e-12
GCST004860_64	Alcoholic chronic pancreatitis	8.000000e-16
GCST004860_73	Alcoholic chronic pancreatitis	2.000000e-29
GCST004860_77	Alcoholic chronic pancreatitis	6.000000e-15
GCST004860_78	Alcoholic chronic pancreatitis	2.000000e-19
GCST004860_91	Alcoholic chronic pancreatitis	2.000000e-12

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

35 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects cotreatment, increases expression, affects expression, increases methylation	8
sodium arsenite	increases abundance, increases expression, affects cotreatment	2
Acetaminophen	increases expression	2
Air Pollutants	decreases expression, increases abundance, increases expression	2
Arsenic	affects methylation, affects cotreatment, increases abundance, increases expression	2
Benzo(a)pyrene	affects methylation, increases expression, increases methylation	2
Phenylmercuric Acetate	affects cotreatment, increases expression	2
Aflatoxin B1	affects expression, increases expression	2
Particulate Matter	decreases expression, increases abundance, increases expression	2
aristolochic acid I	decreases expression	1
dicrotophos	decreases expression	1
triphenyl phosphate	affects expression	1
pirinixic acid	affects binding, decreases expression, increases activity	1
beta-lapachone	increases expression	1
manganese chloride	affects cotreatment, increases abundance, increases expression	1
2,3,5-(triglutathion-S-yl)hydroquinone	increases ADP-ribosylation	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, increases expression	1
abrine	decreases expression	1
dorsomorphin	affects cotreatment, increases expression	1
jinfukang	affects cotreatment, increases expression	1
Sunitinib	increases expression	1
Cisplatin	affects cotreatment, increases expression	1
Dimethyl Sulfoxide	increases expression	1
Hydrogen Peroxide	affects expression	1
Manganese	increases expression, affects cotreatment, increases abundance	1
Phthalic Acids	decreases methylation	1
Quercetin	increases expression	1
Silver	increases expression	1
Testosterone	decreases expression	1
Tretinoin	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.