MORN1

Summary

MORN1 (MORN repeat containing 1, HGNC:25852) is a protein-coding gene on chromosome 1p36.32, encoding MORN repeat-containing protein 1 (Q5T089).

At a glance

• GWAS associations: 7
• Clinical variants (ClinVar): 122 total
• MANE Select transcript: NM_024848

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:25852
Approved symbol	MORN1
Name	MORN repeat containing 1
Location	1p36.32
Locus type	gene with protein product
Status	Approved
Aliases	FLJ13941
Ensembl gene	ENSG00000116151
Ensembl biotype	protein_coding
Entrez	79906

Gene structure

Transcript identifiers

Ensembl transcripts: 19 — 12 protein_coding, 4 retained_intron, 2 protein_coding_CDS_not_defined, 1 nonsense_mediated_decay

ENST00000378525, ENST00000378529, ENST00000378531, ENST00000419785, ENST00000449373, ENST00000469374, ENST00000475812, ENST00000494279, ENST00000606372, ENST00000607031, ENST00000607342, ENST00000874224, ENST00000874225, ENST00000874226, ENST00000874227, ENST00000874228, ENST00000963688, ENST00000963689, ENST00000963690

RefSeq mRNA: 2 — MANE Select: NM_024848 NM_001301060, NM_024848

CCDS: CCDS40, CCDS72688

Canonical transcript exons

ENST00000378531 — 14 exons

Exon	Start	End
ENSE00001660875	2321253	2321579
ENSE00001696171	2324097	2324143
ENSE00001708274	2336717	2336850
ENSE00001775365	2336469	2336548
ENSE00001784328	2358592	2358715
ENSE00001801066	2357432	2357598
ENSE00003474519	2374461	2374557
ENSE00003499657	2385807	2385897
ENSE00003510320	2388239	2388337
ENSE00003537185	2384978	2385065
ENSE00003642799	2372481	2372591
ENSE00003675973	2387419	2387529
ENSE00003699163	2389925	2389996
ENSE00003845182	2391458	2391554

Expression profiles

Bgee: expression breadth ubiquitous, 173 present calls, max score 96.31.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 10.7538 / max 244.2561, expressed in 1744 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
9895	9.4586	1737
9896	0.6373	349
9893	0.3563	41
9897	0.2518	117
9894	0.0497	27

Top tissues by expression

283 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right uterine tube	UBERON:0001302	96.31	gold quality
type B pancreatic cell	CL:0000169	92.75	gold quality
olfactory bulb	UBERON:0002264	92.58	gold quality
right hemisphere of cerebellum	UBERON:0014890	92.18	gold quality
cerebellar hemisphere	UBERON:0002245	91.97	gold quality
cerebellar cortex	UBERON:0002129	91.89	gold quality
cerebellum	UBERON:0002037	90.70	gold quality
triceps brachii	UBERON:0001509	89.30	gold quality
vena cava	UBERON:0004087	89.02	gold quality
tendon of biceps brachii	UBERON:0008188	88.11	silver quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	86.42	gold quality
gluteal muscle	UBERON:0002000	86.38	gold quality
nasal cavity epithelium	UBERON:0005384	86.08	gold quality
male germ cell	CL:0000015	85.37	gold quality
buccal mucosa cell	CL:0002336	85.30	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	85.20	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	85.18	gold quality
sperm	CL:0000019	84.53	gold quality
sural nerve	UBERON:0015488	84.52	gold quality
left lobe of thyroid gland	UBERON:0001120	84.12	gold quality
right lobe of thyroid gland	UBERON:0001119	84.10	gold quality
thyroid gland	UBERON:0002046	83.75	gold quality
lateral nuclear group of thalamus	UBERON:0002736	83.57	gold quality
vastus lateralis	UBERON:0001379	83.55	gold quality
left testis	UBERON:0004533	83.43	gold quality
right testis	UBERON:0004534	83.29	gold quality
tongue squamous epithelium	UBERON:0006919	83.29	gold quality
inferior olivary complex	UBERON:0002127	82.78	gold quality
body of tongue	UBERON:0011876	82.73	gold quality
nasal cavity mucosa	UBERON:0001826	82.67	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	7.04

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

3 targeting MORN1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4508	90.37	59.62	240
HSA-MIR-6889-5P	90.26	64.13	291
HSA-MIR-6777-5P	88.76	62.64	222

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
mus_musculus	Morn1	ENSMUSG00000029049
rattus_norvegicus	Morn1	ENSRNOG00000014642
drosophila_melanogaster	CG14490	FBGN0034281

Paralogs (7): MORN3 (ENSG00000139714), SETD7 (ENSG00000145391), RSPH10B (ENSG00000155026), RSPH1 (ENSG00000160188), RSPH10B2 (ENSG00000169402), ALS2CL (ENSG00000178038), MORN2 (ENSG00000188010)

Protein

Protein identifiers

MORN repeat-containing protein 1 — Q5T089 (reviewed: Q5T089)

All UniProt accessions (4): B4DRE3, Q5T089, Q5T088, U3KQS9

Isoforms (2)

UniProt ID	Names	Canonical?
Q5T089-1	1	yes
Q5T089-2	2

RefSeq proteins (2): NP_001287989, NP_079124* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR003409	MORN	Repeat

Pfam: PF02493

UniProt features (15 total): repeat 7, region of interest 3, splice variant 2, sequence variant 2, chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q5T089-F1	75.53	0.55

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 57 (showing top): CATRRAGC_UNKNOWN, chr1p36, MARTENS_TRETINOIN_RESPONSE_DN, BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_D, CTIP_DN.V1_DN, ARNT2_TARGET_GENES, HDAC4_TARGET_GENES, RBM34_TARGET_GENES, SKIL_TARGET_GENES, ZBTB12_TARGET_GENES, GSE13484_UNSTIM_VS_12H_YF17D_VACCINE_STIM_PBMC_UP, GSE14350_IL2RB_KO_VS_WT_TEFF_UP, HU_FETAL_RETINA_RPE, DESCARTES_MAIN_FETAL_CILIATED_EPITHELIAL_CELLS, ZBED4_TARGET_GENES

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (0):

Protein interactions and networks

STRING

594 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
MORN1	CETN2	P41208	688
MORN1	CETN1	Q12798	677
MORN1	TBCCD1	Q9NVR7	580
MORN1	MORN5	Q5VZ52	514
MORN1	ZNF251	Q9BRH9	475
MORN1	WAC	Q9BTA9	463
MORN1	DHFR	P00374	456
MORN1	SHLD1	Q8IYI0	450
MORN1	NUF2	Q9BZD4	431
MORN1	MEGF6	O75095	426
MORN1	ZNF705A	Q6ZN79	422
MORN1	JPH4	Q96JJ6	395
MORN1	CACNA1S	Q13698	372
MORN1	BCCIP	Q9P287	357
MORN1	RPS27	P42677	355

IntAct

3 interactions, top by confidence:

A	B	Type	Score
MORN1	H2BC12L	psi-mi:“MI:0915”(physical association)	0.400
TFAP2A	MORN1	psi-mi:“MI:0915”(physical association)	0.370

BioGRID (7): MORN1 (Affinity Capture-RNA), MORN1 (Proximity Label-MS), MORN1 (Affinity Capture-MS), MORN1 (Affinity Capture-RNA), MORN1 (Affinity Capture-MS), MORN1 (Proximity Label-MS), MORN1 (Proximity Label-MS)

ESM2 similar proteins: A0JNJ4, A2APT9, A2VDT4, A4IHR5, A7UKY7, D3YYM0, E1BDF2, F6WEQ6, G5E869, O00110, O00221, O14753, O88282, O94989, O95785, P52746, Q15654, Q32KV8, Q3SX26, Q3U381, Q3UV31, Q4VA45, Q52KG4, Q5PPH4, Q5R866, Q5T089, Q5VTJ3, Q8BI73, Q8CDC7, Q8CE64, Q8CIV7, Q8N143, Q8N554, Q96BV0, Q96C00, Q96JB3, Q96K62, Q96T92, Q9BRP0, Q9BU19

Diamond homologs: Q5T089, Q641X6

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

122 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	95
Likely benign	10
Benign	2

Top pathogenic / likely-pathogenic (0)

SpliceAI

4076 predictions. Top by Δscore:

Variant	Effect	Δscore
1:2372479:A:AC	donor_gain	1.0000
1:2372480:C:CC	donor_gain	1.0000
1:2372480:CT:C	donor_gain	1.0000
1:2372592:C:CC	acceptor_gain	1.0000
1:2384975:TACC:T	donor_loss	1.0000
1:2384976:AC:A	donor_loss	1.0000
1:2384977:C:CG	donor_loss	1.0000
1:2385805:A:AC	donor_gain	1.0000
1:2385806:C:CC	donor_gain	1.0000
1:2387421:T:TA	donor_gain	1.0000
1:2387422:C:A	donor_gain	1.0000
1:2387442:T:TA	donor_gain	1.0000
1:2387444:C:A	donor_gain	1.0000
1:2387453:A:C	donor_gain	1.0000
1:2322431:C:A	donor_gain	0.9900
1:2358586:A:AC	donor_gain	0.9900
1:2358587:C:CC	donor_gain	0.9900
1:2358590:A:AC	donor_gain	0.9900
1:2358591:C:CC	donor_gain	0.9900
1:2358720:C:CT	acceptor_gain	0.9900
1:2358720:C:T	acceptor_gain	0.9900
1:2358721:A:T	acceptor_gain	0.9900
1:2372479:ACT:A	donor_gain	0.9900
1:2372480:CTC:C	donor_gain	0.9900
1:2372590:TT:T	acceptor_gain	0.9900
1:2372592:C:G	acceptor_loss	0.9900
1:2372593:T:A	acceptor_loss	0.9900
1:2374456:CCTA:C	donor_loss	0.9900
1:2374457:CTA:C	donor_loss	0.9900
1:2374458:TA:T	donor_loss	0.9900

AlphaMissense

3207 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:2387507:A:C	F90L	0.989
1:2387507:A:T	F90L	0.989
1:2387509:A:G	F90L	0.989
1:2336786:G:C	F367L	0.985
1:2336786:G:T	F367L	0.985
1:2336788:A:G	F367L	0.985
1:2374551:A:G	W182R	0.985
1:2374551:A:T	W182R	0.985
1:2385848:G:C	F136L	0.985
1:2385848:G:T	F136L	0.985
1:2385850:A:G	F136L	0.985
1:2388288:A:C	F66L	0.985
1:2388288:A:T	F66L	0.985
1:2388290:A:G	F66L	0.985
1:2374482:A:G	W205R	0.982
1:2374482:A:T	W205R	0.982
1:2388325:A:G	L54S	0.982
1:2321574:A:G	Y435H	0.980
1:2336787:A:G	F367S	0.978
1:2389962:A:C	F37L	0.973
1:2389962:A:T	F37L	0.973
1:2389964:A:G	F37L	0.973
1:2385040:A:G	W159R	0.972
1:2385040:A:T	W159R	0.972
1:2388296:C:A	G64W	0.972
1:2385862:A:C	Y132D	0.971
1:2388274:A:G	I71T	0.971
1:2388306:A:C	S60R	0.971
1:2388306:A:T	S60R	0.971
1:2388308:T:G	S60R	0.971

dbSNP variants (sampled 300 via entrez): RS1000012807 (1:2337840 G>A,T), RS1000026745 (1:2369276 C>G,T), RS1000089100 (1:2361020 T>C), RS1000164671 (1:2323255 G>A,T), RS1000245935 (1:2368555 C>A,T), RS1000347829 (1:2344878 G>C), RS1000438809 (1:2392973 C>A,T), RS1000445673 (1:2340887 C>A), RS1000453424 (1:2347828 T>C), RS1000473346 (1:2378552 T>C), RS1000517095 (1:2381444 C>T), RS1000557843 (1:2322689 G>A), RS1000576523 (1:2325525 T>A,G), RS1000588541 (1:2382273 A>G), RS1000609641 (1:2348023 C>T)

Disease associations

OMIM: gene `` | disease phenotypes: MIM:615373

GenCC curated gene-disease

Mondo (1): left ventricular noncompaction 8 (MONDO:0014152)

Orphanet (2): Familial isolated dilated cardiomyopathy (Orphanet:154), Left ventricular noncompaction (Orphanet:54260)

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

7 associations (top):

Study	Trait	p-value
GCST005194_229	Coronary artery disease	1.000000e-08
GCST005195_101	Coronary artery disease	1.000000e-08
GCST005196_176	Coronary artery disease	3.000000e-08
GCST005951_34	Body mass index	3.000000e-08
GCST005951_35	Body mass index	4.000000e-08
GCST006137_2	Serum folate levels	7.000000e-06
GCST011365_81	Myocardial infarction	4.000000e-07

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0004340	body mass index

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

24 total (human), top 24 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol F	affects cotreatment, increases expression	1
propionaldehyde	decreases expression	1
bisphenol A	decreases methylation	1
sodium arsenite	affects cotreatment, decreases expression, increases abundance	1
manganese chloride	affects cotreatment, decreases expression, increases abundance	1
benzo(e)pyrene	increases methylation	1
di-n-butylphosphoric acid	affects expression	1
Grape Seed Proanthocyanidins	affects cotreatment, increases expression	1
jinfukang	increases expression	1
Sunitinib	increases expression	1
Arsenic	affects cotreatment, decreases expression, increases abundance	1
Benzo(a)pyrene	affects methylation	1
Catechin	affects cotreatment, increases expression	1
Cisplatin	decreases expression	1
Dexamethasone	increases expression, affects cotreatment	1
Indomethacin	affects cotreatment, increases expression	1
Manganese	affects cotreatment, decreases expression, increases abundance	1
Methapyrilene	increases methylation	1
Smoke	decreases expression	1
Tobacco Smoke Pollution	decreases expression	1
Urethane	decreases expression	1
1-Methyl-3-isobutylxanthine	affects cotreatment, increases expression	1
Aflatoxin B1	decreases methylation	1
Particulate Matter	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.