MORN2

Summary

MORN2 (MORN repeat containing 2, HGNC:30166) is a protein-coding gene on chromosome 2p22.1, encoding MORN repeat-containing protein 2 (Q502X0). Might have a role in spermatogenesis.

Predicted to be involved in cell differentiation and spermatogenesis. Predicted to be located in acrosomal vesicle and nucleus.

Source: NCBI Gene 729967 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 16 total
• MANE Select transcript: NM_001145450

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:30166
Approved symbol	MORN2
Name	MORN repeat containing 2
Location	2p22.1
Locus type	gene with protein product
Status	Approved
Aliases	MOPT
Ensembl gene	ENSG00000188010
Ensembl biotype	protein_coding
Entrez	729967

Gene structure

Transcript identifiers

Ensembl transcripts: 5 — 5 protein_coding

ENST00000409077, ENST00000409131, ENST00000409665, ENST00000410014, ENST00000644631

RefSeq mRNA: 1 — MANE Select: NM_001145450 NM_001145450

CCDS: CCDS46262

Canonical transcript exons

ENST00000644631 — 5 exons

Exon	Start	End
ENSE00001376023	38882413	38882709
ENSE00001384448	38881442	38881578
ENSE00001708801	38875976	38876110
ENSE00003816619	38880179	38880229
ENSE00003819045	38880600	38880706

Expression profiles

Bgee: expression breadth ubiquitous, 240 present calls, max score 98.85.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 26.6228 / max 531.8351, expressed in 1793 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
19841	26.6228	1793

Top tissues by expression

252 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
left testis	UBERON:0004533	98.85	gold quality
right testis	UBERON:0004534	98.71	gold quality
right uterine tube	UBERON:0001302	98.66	gold quality
bronchial epithelial cell	CL:0002328	98.44	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	98.36	gold quality
bronchus	UBERON:0002185	98.00	gold quality
testis	UBERON:0000473	97.27	gold quality
adenohypophysis	UBERON:0002196	95.62	gold quality
pituitary gland	UBERON:0000007	95.21	gold quality
caudate nucleus	UBERON:0001873	94.73	gold quality
nucleus accumbens	UBERON:0001882	94.57	gold quality
putamen	UBERON:0001874	94.07	gold quality
hypothalamus	UBERON:0001898	94.03	gold quality
mucosa of paranasal sinus	UBERON:0005030	94.00	gold quality
anterior cingulate cortex	UBERON:0009835	93.54	gold quality
adult mammalian kidney	UBERON:0000082	93.49	gold quality
adult organism	UBERON:0007023	93.39	gold quality
amygdala	UBERON:0001876	93.23	gold quality
sperm	CL:0000019	92.92	gold quality
islet of Langerhans	UBERON:0000006	92.79	gold quality
left lobe of thyroid gland	UBERON:0001120	92.44	gold quality
right adrenal gland cortex	UBERON:0035827	92.40	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	92.21	gold quality
right adrenal gland	UBERON:0001233	92.08	gold quality
prefrontal cortex	UBERON:0000451	92.02	gold quality
right frontal lobe	UBERON:0002810	92.02	gold quality
thyroid gland	UBERON:0002046	91.83	gold quality
left adrenal gland	UBERON:0001234	91.79	gold quality
left adrenal gland cortex	UBERON:0035825	91.75	gold quality
Brodmann (1909) area 9	UBERON:0013540	91.59	gold quality

Single-cell (SCXA)

Detected in 10 experiment(s), a significant marker in 8.

Experiment	Marker?	Max mean expression
E-CURD-114	yes	1581.91
E-MTAB-6701	yes	626.15
E-HCAD-1	yes	32.86
E-GEOD-134144	yes	30.79
E-MTAB-10287	yes	27.94
E-GEOD-130148	yes	13.51
E-MTAB-9388	yes	7.46
E-CURD-10	no	173.78
E-GEOD-99795	no	89.20
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• MOPT is associated with dynamic regulation of acrosome biogenesis during late spermiogenesis. (PMID:19913896)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	morn2	ENSDARG00000071360
mus_musculus	Morn2	ENSMUSG00000045257
rattus_norvegicus		ENSRNOG00000082556

Paralogs (7): MORN1 (ENSG00000116151), MORN3 (ENSG00000139714), SETD7 (ENSG00000145391), RSPH10B (ENSG00000155026), RSPH1 (ENSG00000160188), RSPH10B2 (ENSG00000169402), ALS2CL (ENSG00000178038)

Protein

Protein identifiers

MORN repeat-containing protein 2 — Q502X0 (reviewed: Q502X0)

Alternative names: MORN motif protein in testis

All UniProt accessions (4): Q502X0, A0A2R8YE86, B8ZZ40, B8ZZN7

UniProt curated annotations — full annotation on UniProt →

Function. Might have a role in spermatogenesis.

Subcellular location. Cytoplasmic vesicle. Secretory vesicle. Acrosome. Nucleus.

RefSeq proteins (1): NP_001138922* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR003409	MORN	Repeat
IPR052849	MORN_repeat_protein	Family

Pfam: PF02493

UniProt features (4 total): repeat 2, chain 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q502X0-F1	91.47	0.79

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 87 (showing top): CCAWYNNGAAR_UNKNOWN, GOCC_SECRETORY_GRANULE, CHIANG_LIVER_CANCER_SUBCLASS_UNANNOTATED_DN, GOBP_MALE_GAMETE_GENERATION, SENGUPTA_NASOPHARYNGEAL_CARCINOMA_DN, GOBP_DEVELOPMENTAL_PROCESS_INVOLVED_IN_REPRODUCTION, RFX1_02, ACEVEDO_METHYLATED_IN_LIVER_CANCER_DN, CUI_TCF21_TARGETS_2_UP, GOCC_SECRETORY_VESICLE, GOCC_ACROSOMAL_VESICLE, SCGGAAGY_ELK1_02, DODD_NASOPHARYNGEAL_CARCINOMA_DN, KRIGE_RESPONSE_TO_TOSEDOSTAT_6HR_DN, chr2p22

GO Biological Process (2): spermatogenesis (GO:0007283), cell differentiation (GO:0030154)

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (3): acrosomal vesicle (GO:0001669), nucleus (GO:0005634), cytoplasmic vesicle (GO:0031410)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
developmental process involved in reproduction	1
male gamete generation	1
cellular developmental process	1
binding	1
secretory granule	1
intracellular membrane-bounded organelle	1
cytoplasm	1
intracellular vesicle	1

Protein interactions and networks

STRING

228 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
MORN2	C11orf97	A0A1B0GVM6	693
MORN2	TMEM239	Q8WW34	506
MORN2	MORN4	Q8NDC4	435
MORN2	ARHGEF33	A8MVX0	433
MORN2	ANKRD35	Q8N283	404
MORN2	DHX57	Q6P158	392
MORN2	MORN3	Q6PF18	378
MORN2	CNBD2	Q96M20	370
MORN2	THSD1	Q9NS62	350
MORN2	AIRIM	Q9NX04	348
MORN2	IQCF1	Q8N6M8	325
MORN2	PPP1R37	O75864	323
MORN2	CDKL4	Q5MAI5	296
MORN2	ZNF358	Q9NW07	288
MORN2	RAPGEF5	Q92565	284

IntAct

11 interactions, top by confidence:

A	B	Type	Score
CCDC120	AIP	psi-mi:“MI:0914”(association)	0.640
GORASP2	MORN2	psi-mi:“MI:0915”(physical association)	0.560
MORN2	GORASP2	psi-mi:“MI:0915”(physical association)	0.560
C8orf74	FGFR2	psi-mi:“MI:0914”(association)	0.530
RSPH1	MORN2	psi-mi:“MI:0915”(physical association)	0.000
MPP3	MORN2	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (8): MORN2 (Two-hybrid), MORN2 (Affinity Capture-MS), MORN2 (Synthetic Growth Defect), MORN2 (Affinity Capture-MS), MORN2 (Affinity Capture-MS), MORN2 (Affinity Capture-MS), MORN2 (Affinity Capture-MS), MORN2 (Two-hybrid)

ESM2 similar proteins: B6CZ17, B6CZ18, O00423, P10830, P53671, Q05BC3, Q08CH7, Q09537, Q15326, Q1XHL7, Q21029, Q28FE4, Q32KM6, Q32KU3, Q32LL6, Q49HM9, Q4R3N2, Q4R842, Q4V8C3, Q4VBJ9, Q502X0, Q569C2, Q5PPV3, Q5TYQ3, Q5VZ52, Q5ZIJ9, Q622Z7, Q63651, Q641X6, Q6GNY1, Q6IND7, Q6PF18, Q6VTH5, Q7DMA9, Q7Z0G7, Q804S5, Q80SY4, Q86YT6, Q8C5T4, Q8K4M9

Diamond homologs: Q32KU3, Q502X0, Q6UL01

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

16 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	7
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

446 predictions. Top by Δscore:

Variant	Effect	Δscore
2:38876106:GCCAA:G	donor_gain	1.0000
2:38876111:G:GG	donor_gain	1.0000
2:38880172:A:AG	acceptor_gain	1.0000
2:38880596:TTAG:T	acceptor_loss	1.0000
2:38880598:A:AG	acceptor_gain	1.0000
2:38880598:AGAT:A	acceptor_gain	1.0000
2:38880599:G:GA	acceptor_gain	1.0000
2:38880599:G:GC	acceptor_loss	1.0000
2:38880599:GA:G	acceptor_gain	1.0000
2:38880599:GAT:G	acceptor_gain	1.0000
2:38880599:GATG:G	acceptor_gain	1.0000
2:38880687:G:GT	donor_gain	1.0000
2:38880695:A:T	donor_gain	1.0000
2:38880702:ACAAG:A	donor_loss	1.0000
2:38880704:AAGG:A	donor_loss	1.0000
2:38880705:AGGTA:A	donor_loss	1.0000
2:38880706:GG:G	donor_loss	1.0000
2:38880707:G:C	donor_loss	1.0000
2:38880708:T:A	donor_loss	1.0000
2:38881436:A:AG	acceptor_gain	1.0000
2:38881437:AACAG:A	acceptor_loss	1.0000
2:38881438:ACAGA:A	acceptor_loss	1.0000
2:38881439:CAGAT:C	acceptor_loss	1.0000
2:38881440:A:AG	acceptor_gain	1.0000
2:38881440:A:C	acceptor_loss	1.0000
2:38881441:G:A	acceptor_loss	1.0000
2:38881441:G:GG	acceptor_gain	1.0000
2:38881441:GAT:G	acceptor_gain	1.0000
2:38881441:GATGA:G	acceptor_gain	1.0000
2:38880173:A:G	acceptor_gain	0.9900

AlphaMissense

1001 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
2:38881523:G:T	G28W	0.989
2:38881529:T:G	Y30D	0.989
2:38881560:G:A	G40E	0.989
2:38882432:T:G	Y53D	0.989
2:38881553:T:G	Y38D	0.988
2:38881565:T:C	F42L	0.986
2:38881567:C:A	F42L	0.986
2:38881567:C:G	F42L	0.986
2:38881497:T:C	F19S	0.984
2:38881560:G:T	G40V	0.984
2:38881484:T:G	Y15D	0.983
2:38881491:G:A	G17E	0.983
2:38881566:T:C	F42S	0.983
2:38881496:T:C	F19L	0.981
2:38881498:T:A	F19L	0.981
2:38881498:T:G	F19L	0.981
2:38881461:T:C	L7P	0.979
2:38881491:G:T	G17V	0.979
2:38881490:G:A	G17R	0.978
2:38881490:G:C	G17R	0.978
2:38881518:G:T	G26V	0.976
2:38881524:G:A	G28E	0.976
2:38882426:G:T	G51W	0.975
2:38882468:T:C	F65L	0.974
2:38882470:T:A	F65L	0.974
2:38882470:T:G	F65L	0.974
2:38881559:G:A	G40R	0.972
2:38881559:G:C	G40R	0.972
2:38881523:G:A	G28R	0.971
2:38881523:G:C	G28R	0.971

dbSNP variants (sampled 300 via entrez): RS1000149694 (2:38880036 G>A,T), RS1000520205 (2:38878372 T>C), RS1000568303 (2:38882240 G>A,T), RS1000987807 (2:38874064 A>T), RS1001005568 (2:38880200 G>A,C), RS1001151622 (2:38878724 C>T), RS1001613764 (2:38874380 T>C), RS1002270976 (2:38878290 C>G), RS1003015825 (2:38882610 A>G), RS1003273766 (2:38882339 T>C), RS1003302099 (2:38877087 C>T), RS1003436143 (2:38878260 C>G), RS1003503492 (2:38882631 A>C), RS1004155648 (2:38875492 C>A), RS1004423752 (2:38874327 G>C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

37 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Air Pollutants	affects cotreatment, increases abundance, increases expression, decreases expression	4
Valproic Acid	affects expression, increases expression	3
bisphenol A	decreases expression, increases expression	2
Smoke	decreases expression, increases abundance, increases expression	2
dicrotophos	decreases expression	1
methylmercuric chloride	decreases expression	1
alpha-pinene	affects cotreatment, increases expression, increases abundance	1
arsenite	affects binding, increases reaction	1
sodium arsenite	increases abundance, increases expression	1
manganese chloride	increases abundance, increases expression	1
methacrylaldehyde	increases abundance, affects cotreatment, increases expression	1
CGP 52608	affects binding, increases reaction	1
deguelin	decreases expression	1
K 7174	decreases expression	1
fenpyroximate	decreases expression	1
4-chloro-N-((4-(1,1-dimethylethyl)phenyl)methyl)-3-ethyl-1-methyl-1H-pyrazole-5-carboxamide	decreases expression	1
pyrimidifen	decreases expression	1
Resveratrol	affects cotreatment, increases expression	1
Acrolein	affects cotreatment, increases expression, increases abundance	1
Antimycin A	decreases expression	1
Arsenic	increases abundance, increases expression	1
Coal	increases abundance, decreases expression	1
Estradiol	decreases expression	1
Ethyl Methanesulfonate	increases expression	1
Formaldehyde	increases expression	1
Manganese	increases abundance, increases expression	1
Methyl Methanesulfonate	increases expression	1
Ozone	affects cotreatment, increases expression, increases abundance	1
Plant Extracts	increases expression, affects cotreatment	1
Quercetin	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.