MORN4

Summary

MORN4 (MORN repeat containing 4, HGNC:24001) is a protein-coding gene on chromosome 10q24.2, encoding MORN repeat-containing protein 4 (Q8NDC4). Plays a role in promoting axonal degeneration following neuronal injury by toxic insult or trauma.

Predicted to be involved in response to axon injury. Located in cytoplasm and filopodium tip.

Source: NCBI Gene 118812 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 21 total
• MANE Select transcript: NM_178832

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:24001
Approved symbol	MORN4
Name	MORN repeat containing 4
Location	10q24.2
Locus type	gene with protein product
Status	Approved
Aliases	bA548K23.4, FLJ25925, rtp
Ensembl gene	ENSG00000171160
Ensembl biotype	protein_coding
OMIM	617736
Entrez	118812

Gene structure

Transcript identifiers

Ensembl transcripts: 8 — 8 protein_coding

ENST00000307450, ENST00000370635, ENST00000478953, ENST00000929312, ENST00000929313, ENST00000929314, ENST00000955198, ENST00000955199

RefSeq mRNA: 2 — MANE Select: NM_178832 NM_001098831, NM_178832

CCDS: CCDS7468

Canonical transcript exons

ENST00000307450 — 5 exons

Exon	Start	End
ENSE00001239953	97616678	97616787
ENSE00001239957	97617208	97617322
ENSE00001855906	97633347	97633500
ENSE00002290846	97619587	97619683
ENSE00003588596	97614555	97616411

Expression profiles

Bgee: expression breadth ubiquitous, 220 present calls, max score 91.47.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 4.7004 / max 78.0778, expressed in 1486 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
110939	3.3097	1346
110938	1.3907	760

Top tissues by expression

250 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
cortical plate	UBERON:0005343	91.47	gold quality
hypothalamus	UBERON:0001898	90.73	gold quality
prefrontal cortex	UBERON:0000451	90.48	gold quality
anterior cingulate cortex	UBERON:0009835	90.39	gold quality
nucleus accumbens	UBERON:0001882	90.31	gold quality
right frontal lobe	UBERON:0002810	90.06	gold quality
left ventricle myocardium	UBERON:0006566	89.71	gold quality
Brodmann (1909) area 9	UBERON:0013540	89.41	gold quality
adenohypophysis	UBERON:0002196	89.22	gold quality
kidney epithelium	UBERON:0004819	88.95	silver quality
dorsolateral prefrontal cortex	UBERON:0009834	88.67	gold quality
ganglionic eminence	UBERON:0004023	88.59	gold quality
embryo	UBERON:0000922	88.58	gold quality
amygdala	UBERON:0001876	88.48	gold quality
pituitary gland	UBERON:0000007	88.47	gold quality
neocortex	UBERON:0001950	88.39	gold quality
frontal cortex	UBERON:0001870	88.25	gold quality
caudate nucleus	UBERON:0001873	87.99	gold quality
putamen	UBERON:0001874	87.86	gold quality
forebrain	UBERON:0001890	87.20	gold quality
ventricular zone	UBERON:0003053	86.89	gold quality
cerebral cortex	UBERON:0000956	86.81	gold quality
myocardium	UBERON:0002349	86.46	silver quality
brain	UBERON:0000955	86.40	gold quality
pancreatic ductal cell	CL:0002079	86.22	silver quality
substantia nigra	UBERON:0002038	86.14	gold quality
midbrain	UBERON:0001891	85.59	gold quality
heart right ventricle	UBERON:0002080	85.52	gold quality
heart left ventricle	UBERON:0002084	85.05	gold quality
cardiac ventricle	UBERON:0002082	85.03	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-GEOD-111727	yes	306.68
E-ANND-3	no	3.14

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

85 targeting MORN4, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-4262	100.00	73.26	3931
HSA-MIR-371B-5P	99.99	75.34	4759
HSA-MIR-373-5P	99.98	75.36	4753
HSA-MIR-616-5P	99.98	75.58	4775
HSA-MIR-101-3P	99.94	75.03	2230
HSA-MIR-144-3P	99.94	73.98	2698
HSA-MIR-381-3P	99.93	71.87	2854
HSA-MIR-300	99.92	71.76	2856
HSA-MIR-374B-5P	99.90	69.98	2734
HSA-MIR-374A-5P	99.90	71.34	2923
HSA-MIR-3919	99.87	69.45	2489
HSA-MIR-579-3P	99.86	71.66	3628
HSA-MIR-383-3P	99.85	65.84	1359
HSA-MIR-664B-3P	99.84	71.65	3590
HSA-MIR-1321	99.84	65.30	1811
HSA-MIR-4739	99.84	65.25	1832
HSA-MIR-4756-5P	99.84	64.98	1809
HSA-MIR-3121-3P	99.82	71.96	3630
HSA-MIR-139-5P	99.80	69.50	1399
HSA-MIR-34B-5P	99.78	67.56	1175
HSA-MIR-449C-5P	99.78	67.63	1168
HSA-MIR-4719	99.73	72.10	3329
HSA-MIR-2682-5P	99.73	67.38	1055
HSA-MIR-4446-5P	99.72	69.19	2544
HSA-MIR-548AU-3P	99.70	68.22	1373
HSA-MIR-452-5P	99.65	69.63	1762
HSA-MIR-4676-3P	99.65	69.31	1733
HSA-MIR-892C-3P	99.65	69.38	1745
HSA-MIR-6757-3P	99.63	66.88	1089

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	morn4	ENSDARG00000039062
mus_musculus	Morn4	ENSMUSG00000049670
rattus_norvegicus	Morn4	ENSRNOG00000027156

Protein

Protein identifiers

MORN repeat-containing protein 4 — Q8NDC4 (reviewed: Q8NDC4)

Alternative names: Protein 44050, Retinophilin

All UniProt accessions (4): A6XB87, Q8NDC4, G3V1L7, Q8WVZ3

UniProt curated annotations — full annotation on UniProt →

Function. Plays a role in promoting axonal degeneration following neuronal injury by toxic insult or trauma.

Subunit / interactions. Interacts with MYO3A.

Subcellular location. Cytoplasm. Cell projection. Filopodium tip. Stereocilium.

Isoforms (2)

UniProt ID	Names	Canonical?
Q8NDC4-1	1	yes
Q8NDC4-2	2

RefSeq proteins (2): NP_001092301, NP_849154* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR003409	MORN	Repeat
IPR052315	MORN4	Family

Pfam: PF02493

UniProt features (6 total): repeat 4, chain 1, splice variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q8NDC4-F1	97.33	0.97

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 97 (showing top): MYAATNNNNNNNGGC_UNKNOWN, GOBP_RESPONSE_TO_AXON_INJURY, YY1_Q6, BEIER_GLIOMA_STEM_CELL_DN, NF1_Q6_01, CCCNNNNNNAAGWT_UNKNOWN, LASTOWSKA_NEUROBLASTOMA_COPY_NUMBER_DN, GOCC_NEURON_PROJECTION, TGTYNNNNNRGCARM_UNKNOWN, GATGKMRGCG_UNKNOWN, GOCC_FILOPODIUM, GOCC_STEREOCILIUM_BUNDLE, GOCC_CLUSTER_OF_ACTIN_BASED_CELL_PROJECTIONS, GOCC_FILOPODIUM_TIP, GOCC_ACTIN_BASED_CELL_PROJECTION

GO Biological Process (1): response to axon injury (GO:0048678)

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (6): cytoplasm (GO:0005737), stereocilium tip (GO:0032426), filopodium tip (GO:0032433), cell projection (GO:0042995), stereocilium (GO:0032420), actin-based cell projection (GO:0098858)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	4
response to wounding	1
binding	1
intracellular anatomical structure	1
stereocilium	1
filopodium	1
stereocilium bundle	1
neuron projection	1
actin-based cell projection	1
actin cytoskeleton	1
plasma membrane bounded cell projection	1

Protein interactions and networks

STRING

602 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
MORN4	MYO3A	Q8NEV4	731
MORN4	MYO3B	Q8WXR4	703
MORN4	MORN5	Q5VZ52	642
MORN4	MFAP3	P55082	536
MORN4	ESPNL	Q6ZVH7	523
MORN4	NOL6	Q9H6R4	474
MORN4	SARM1	Q6SZW1	474
MORN4	ESPN	B1AK53	463
MORN4	COMMD9	Q9P000	454
MORN4	MORN2	Q502X0	435
MORN4	TMEM184B	Q9Y519	435
MORN4	ZWINT	O95229	369
MORN4	PCDHGB1	Q9Y5G3	348
MORN4	FMNL1	O95466	336
MORN4	AJAP1	Q9UKB5	330

IntAct

130 interactions, top by confidence:

A	B	Type	Score
FAM22F	MORN4	psi-mi:“MI:0915”(physical association)	0.720
MORN4		psi-mi:“MI:0915”(physical association)	0.720
MORN4	TRIM23	psi-mi:“MI:0915”(physical association)	0.720
MORN4	SEPTIN6	psi-mi:“MI:0915”(physical association)	0.720
MORN4	BEND3	psi-mi:“MI:0915”(physical association)	0.720
MORN4	SSX2IP	psi-mi:“MI:0915”(physical association)	0.720
MORN4	FAM22F	psi-mi:“MI:0915”(physical association)	0.720
TRIM23	MORN4	psi-mi:“MI:0915”(physical association)	0.720
BEND3	MORN4	psi-mi:“MI:0915”(physical association)	0.720
	MORN4	psi-mi:“MI:0915”(physical association)	0.720
SNCB	MORN4	psi-mi:“MI:0915”(physical association)	0.720
SEPTIN6	MORN4	psi-mi:“MI:0915”(physical association)	0.720
MORN4	SNCB	psi-mi:“MI:0915”(physical association)	0.720
HMMR	MORN4	psi-mi:“MI:0915”(physical association)	0.670
MORN4	NYAP2	psi-mi:“MI:0915”(physical association)	0.670

BioGRID (47): MORN4 (Two-hybrid), MORN4 (Two-hybrid), MORN4 (Two-hybrid), MORN4 (Two-hybrid), MORN4 (Two-hybrid), MORN4 (Two-hybrid), MORN4 (Two-hybrid), MORN4 (Two-hybrid), MORN4 (Two-hybrid), MORN4 (Two-hybrid), MORN4 (Two-hybrid), MORN4 (Two-hybrid), MORN4 (Two-hybrid), NUTM1 (Two-hybrid), INO80E (Two-hybrid)

ESM2 similar proteins: A5D7C1, B9EHT4, G5EC24, O48709, O80673, P25027, P80197, P84737, Q0J3D9, Q0VD26, Q3SX00, Q4IEV4, Q4KM33, Q56YP2, Q5BJS9, Q5R578, Q5R686, Q5R8C8, Q5U243, Q6C710, Q6PGF2, Q6TNT2, Q76K24, Q76L34, Q7S9B6, Q86W74, Q8BTZ5, Q8CIE6, Q8L796, Q8NDC4, Q8RY89, Q94A40, Q94C27, Q96DZ5, Q9AUR7, Q9AUR8, Q9FIM9, Q9FNP4, Q9FX86, Q9JHK5

Diamond homologs: Q0VD26, Q5BJS9, Q5R578, Q6PGF2, Q8NDC4, Q9VN91

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

21 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	18
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

828 predictions. Top by Δscore:

Variant	Effect	Δscore
10:97616424:C:CT	acceptor_gain	1.0000
10:97616784:ATACC:A	acceptor_loss	1.0000
10:97616786:ACCTG:A	acceptor_loss	1.0000
10:97616788:CTGCA:C	acceptor_loss	1.0000
10:97616789:T:A	acceptor_loss	1.0000
10:97617205:CA:C	donor_loss	1.0000
10:97617207:C:G	donor_loss	1.0000
10:97617323:C:CC	acceptor_gain	1.0000
10:97619476:AAAT:A	donor_gain	1.0000
10:97619479:T:TA	donor_gain	1.0000
10:97619520:T:TA	donor_gain	1.0000
10:97619568:C:CA	donor_gain	1.0000
10:97619569:C:A	donor_gain	1.0000
10:97616411:CC:C	acceptor_loss	0.9900
10:97616411:CCTT:C	acceptor_gain	0.9900
10:97616412:C:CC	acceptor_gain	0.9900
10:97616413:T:C	acceptor_gain	0.9900
10:97616414:T:C	acceptor_gain	0.9900
10:97616414:T:TC	acceptor_gain	0.9900
10:97616425:A:T	acceptor_gain	0.9900
10:97616673:CT:C	donor_loss	0.9900
10:97616674:TTACC:T	donor_loss	0.9900
10:97616675:TACC:T	donor_loss	0.9900
10:97616676:A:AG	donor_loss	0.9900
10:97616783:CATAC:C	acceptor_gain	0.9900
10:97617319:CGGC:C	acceptor_gain	0.9900
10:97617320:GGC:G	acceptor_gain	0.9900
10:97617321:GC:G	acceptor_gain	0.9900
10:97617322:CC:C	acceptor_gain	0.9900
10:97617328:C:CT	acceptor_gain	0.9900

AlphaMissense

954 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
10:97616780:C:A	G64W	0.996
10:97616710:C:T	G87E	0.995
10:97616711:C:A	G87W	0.995
10:97616779:C:T	G64E	0.995
10:97616411:C:T	G98D	0.994
10:97616703:A:C	F89L	0.994
10:97616703:A:T	F89L	0.994
10:97616704:A:G	F89S	0.994
10:97616705:A:G	F89L	0.994
10:97616405:A:G	L100P	0.993
10:97616746:C:T	G75E	0.993
10:97616772:A:C	F66L	0.993
10:97616772:A:T	F66L	0.993
10:97616774:A:G	F66L	0.993
10:97616780:C:G	G64R	0.993
10:97616780:C:T	G64R	0.993
10:97617236:C:A	G52W	0.993
10:97616786:A:C	Y62D	0.992
10:97616711:C:G	G87R	0.991
10:97616711:C:T	G87R	0.991
10:97617275:A:C	Y39D	0.991
10:97617298:A:G	L31P	0.991
10:97617304:C:T	G29D	0.991
10:97616773:A:G	F66S	0.990
10:97617235:C:T	G52E	0.990
10:97617261:A:C	F43L	0.990
10:97617261:A:T	F43L	0.990
10:97617263:A:G	F43L	0.990
10:97617269:C:G	G41R	0.990
10:97616357:A:G	F116S	0.989

dbSNP variants (sampled 300 via entrez): RS1000059700 (10:97617777 T>C), RS1000182648 (10:97635913 C>G), RS1000365068 (10:97622342 C>G), RS1000639820 (10:97628008 T>C,G), RS1000669596 (10:97634429 C>T), RS1000756225 (10:97615523 C>A,T), RS1000783845 (10:97634143 A>C), RS1000926560 (10:97631287 C>G), RS1001000177 (10:97630915 C>A), RS1001238935 (10:97633204 C>A,T), RS1001561989 (10:97621186 C>G), RS1001593811 (10:97634464 C>T), RS1001906857 (10:97622854 C>G,T), RS1001946427 (10:97622259 G>A,C), RS1001969043 (10:97622461 G>A)

Disease associations

OMIM: gene MIM:617736 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST011354_35	Bell’s palsy	1.000000e-07

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

22 total (human), top 22 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects expression, affects cotreatment, decreases expression	5
Benzo(a)pyrene	decreases expression, affects methylation	2
Nickel	decreases expression	2
Phenylmercuric Acetate	decreases expression, affects cotreatment	2
aristolochic acid I	increases expression	1
bisphenol A	increases expression	1
tris(1,3-dichloro-2-propyl)phosphate	increases expression	1
sodium arsenite	increases expression	1
polyhexamethyleneguanidine	affects expression	1
perfluorooctane sulfonic acid	increases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
ICG 001	increases expression	1
dorsomorphin	affects cotreatment, decreases expression	1
jinfukang	increases expression, affects cotreatment	1
(+)-JQ1 compound	decreases expression	1
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	increases expression	1
Temozolomide	decreases expression	1
Sunitinib	increases expression	1
Cisplatin	affects cotreatment, increases expression	1
Cyclosporine	increases expression	1
Antirheumatic Agents	increases expression	1
Cadmium Chloride	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.