MORN5

Summary

MORN5 (MORN repeat containing 5, HGNC:17841) is a protein-coding gene on chromosome 9q33.2, encoding MORN repeat-containing protein 5 (Q5VZ52).

Predicted to be located in sperm flagellum.

Source: NCBI Gene 254956 — RefSeq curated summary.

At a glance

• Gene–disease (curated): isolated cleft palate (No Known Disease Relationship, GenCC)
• GWAS associations: 3
• Clinical variants (ClinVar): 31 total
• MANE Select transcript: NM_198469

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:17841
Approved symbol	MORN5
Name	MORN repeat containing 5
Location	9q33.2
Locus type	gene with protein product
Status	Approved
Aliases	FLJ46909
Ensembl gene	ENSG00000185681
Ensembl biotype	protein_coding
OMIM	619837
Entrez	254956

Gene structure

Transcript identifiers

Ensembl transcripts: 6 — 4 protein_coding, 2 protein_coding_CDS_not_defined

ENST00000373764, ENST00000418632, ENST00000477017, ENST00000486801, ENST00000536616, ENST00000918677

RefSeq mRNA: 2 — MANE Select: NM_198469 NM_001286828, NM_198469

CCDS: CCDS6836, CCDS75894

Canonical transcript exons

ENST00000373764 — 5 exons

Exon	Start	End
ENSE00001302917	122169645	122169756
ENSE00001461480	122199885	122200083
ENSE00002213915	122159908	122160019
ENSE00003508038	122174496	122174627
ENSE00003666188	122166768	122166915

Expression profiles

Bgee: expression breadth ubiquitous, 159 present calls, max score 99.02.

FANTOM5 (CAGE): breadth broad, TPM avg 0.7191 / max 138.9342, expressed in 201 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
98399	0.6743	192
98400	0.0448	18

Top tissues by expression

248 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bronchial epithelial cell	CL:0002328	99.02	gold quality
right uterine tube	UBERON:0001302	98.42	gold quality
bronchus	UBERON:0002185	98.02	gold quality
left testis	UBERON:0004533	95.84	gold quality
right testis	UBERON:0004534	95.71	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	94.29	gold quality
testis	UBERON:0000473	92.94	gold quality
muscle layer of sigmoid colon	UBERON:0035805	91.57	gold quality
mucosa of paranasal sinus	UBERON:0005030	91.47	gold quality
smooth muscle tissue	UBERON:0001135	91.45	gold quality
adult organism	UBERON:0007023	89.64	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	89.26	gold quality
fallopian tube	UBERON:0003889	87.97	gold quality
sperm	CL:0000019	86.07	gold quality
epithelium of nasopharynx	UBERON:0001951	83.57	gold quality
oviduct epithelium	UBERON:0004804	83.47	gold quality
left uterine tube	UBERON:0001303	80.59	gold quality
pancreatic ductal cell	CL:0002079	76.61	silver quality
nasal cavity epithelium	UBERON:0005384	76.12	silver quality
body of uterus	UBERON:0009853	75.33	gold quality
hypothalamus	UBERON:0001898	74.01	gold quality
caudate nucleus	UBERON:0001873	73.88	gold quality
nasal cavity mucosa	UBERON:0001826	73.65	gold quality
right lung	UBERON:0002167	73.28	gold quality
lower esophagus	UBERON:0013473	72.52	gold quality
lower esophagus muscularis layer	UBERON:0035833	72.51	gold quality
nucleus accumbens	UBERON:0001882	72.45	gold quality
myometrium	UBERON:0001296	72.27	gold quality
trachea	UBERON:0003126	72.13	gold quality
caput epididymis	UBERON:0004358	72.11	gold quality

Single-cell (SCXA)

Detected in 4 experiment(s), a significant marker in 4.

Experiment	Marker?	Max mean expression
E-CURD-114	yes	62.62
E-HCAD-1	yes	30.43
E-MTAB-10287	yes	26.33
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

9 targeting MORN5, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-1200	99.71	70.42	1838
HSA-MIR-4424	98.91	70.33	1145
HSA-MIR-4436B-3P	98.25	65.26	1494
HSA-MIR-6735-5P	98.24	65.36	1488
HSA-MIR-7843-5P	98.12	65.26	1421
HSA-MIR-4632-5P	97.82	65.38	1470
HSA-MIR-6879-5P	97.77	65.52	1521
HSA-MIR-4456	97.50	64.88	1678
HSA-MIR-7973	96.48	65.54	502

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	morn5	ENSDARG00000033610
mus_musculus	Morn5	ENSMUSG00000026894
rattus_norvegicus	Morn5	ENSRNOG00000026111

Protein

Protein identifiers

MORN repeat-containing protein 5 — Q5VZ52 (reviewed: Q5VZ52)

All UniProt accessions (3): A0A0A0MTF6, Q5VZ52, Q5T7S4

UniProt curated annotations — full annotation on UniProt →

Subcellular location. Cell projection. Cilium. Flagellum.

Tissue specificity. Expressed in sperm (at protein level).

Isoforms (2)

UniProt ID	Names	Canonical?
Q5VZ52-1	1	yes
Q5VZ52-2	2

RefSeq proteins (2): NP_001273757, NP_940871* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR003409	MORN	Repeat
IPR042814	Morn5	Family

Pfam: PF02493

UniProt features (6 total): repeat 3, chain 1, splice variant 1, sequence conflict 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q5VZ52-F1	91.19	0.69

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 50 (showing top): DARWICHE_SKIN_TUMOR_PROMOTER_DN, DARWICHE_PAPILLOMA_RISK_LOW_DN, DARWICHE_PAPILLOMA_RISK_HIGH_UP, DARWICHE_SQUAMOUS_CELL_CARCINOMA_UP, DARWICHE_PAPILLOMA_PROGRESSION_RISK, SENGUPTA_NASOPHARYNGEAL_CARCINOMA_DN, GOCC_MOTILE_CILIUM, GOCC_CILIUM, DODD_NASOPHARYNGEAL_CARCINOMA_DN, BRUINS_UVC_RESPONSE_VIA_TP53_GROUP_B, GOCC_9PLUS2_MOTILE_CILIUM, CBX5_TARGET_GENES, HMG20B_TARGET_GENES, NPAT_TARGET_GENES, TEAD2_TARGET_GENES

GO Biological Process (0):

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (4): sperm flagellum (GO:0036126), cilium (GO:0005929), motile cilium (GO:0031514), cell projection (GO:0042995)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
binding	1
9+2 motile cilium	1
intraciliary transport particle	1
membrane-bounded organelle	1
plasma membrane bounded cell projection	1
cilium	1
cellular anatomical structure	1

Protein interactions and networks

STRING

790 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
MORN5	MORN3	Q6PF18	709
MORN5	MORN4	Q8NDC4	642
MORN5	CFAP95	Q5VTT2	639
MORN5	CCER1	Q8TC90	594
MORN5	CIMIP4	O43247	591
MORN5	RIBC1	Q8N443	530
MORN5	PEBP4	Q96S96	525
MORN5	GARIN3	Q8TC56	519
MORN5	GARIN5A	Q6IPT2	519
MORN5	MORN1	Q5T089	514
MORN5	GARIN4	Q8IYT1	509
MORN5	NDUFA8	P51970	482
MORN5	CFAP161	Q6P656	477
MORN5	SCNM1	Q9BWG6	477
MORN5	VSIG10L	Q86VR7	464

IntAct

32 interactions, top by confidence:

A	B	Type	Score
AGXT	MORN5	psi-mi:“MI:0915”(physical association)	0.560
HAT1	MORN5	psi-mi:“MI:0915”(physical association)	0.560
MORN5	STAMBPL1	psi-mi:“MI:0915”(physical association)	0.560
MORN5	MISP	psi-mi:“MI:0915”(physical association)	0.560
MORN5	POM121	psi-mi:“MI:0915”(physical association)	0.560
TLX3	MORN5	psi-mi:“MI:0915”(physical association)	0.560
MORN5	ENKD1	psi-mi:“MI:0915”(physical association)	0.560
MORN5	GAS2L2	psi-mi:“MI:0915”(physical association)	0.560
USP2	MORN5	psi-mi:“MI:0915”(physical association)	0.560
MORN5	BCAT1	psi-mi:“MI:0914”(association)	0.530
AGXT	MORN5	psi-mi:“MI:0915”(physical association)	0.000
HAT1	MORN5	psi-mi:“MI:0915”(physical association)	0.000
STAMBPL1	MORN5	psi-mi:“MI:0915”(physical association)	0.000
MISP	MORN5	psi-mi:“MI:0915”(physical association)	0.000
POM121	MORN5	psi-mi:“MI:0915”(physical association)	0.000
USP2	MORN5	psi-mi:“MI:0915”(physical association)	0.000
TLX3	MORN5	psi-mi:“MI:0915”(physical association)	0.000
ENKD1	MORN5	psi-mi:“MI:0915”(physical association)	0.000
GAS2L2	MORN5	psi-mi:“MI:0915”(physical association)	0.000

BioGRID (14): BCAT1 (Affinity Capture-MS), CHST15 (Affinity Capture-MS), DHTKD1 (Affinity Capture-MS), MORN5 (Two-hybrid), MORN5 (Two-hybrid), MORN5 (Two-hybrid), MORN5 (Two-hybrid), MORN5 (Two-hybrid), MORN5 (Two-hybrid), MORN5 (Two-hybrid), POM121 (Two-hybrid), GAS2L2 (Two-hybrid), CHST15 (Affinity Capture-MS), BCAT1 (Affinity Capture-MS)

ESM2 similar proteins: A0A3Q1N1R0, A0JMQ0, A2VE39, A2VEI2, A4IHS2, A7YT82, B3MHX6, B3NLK7, B4GIU9, B4HN85, B4J9K1, B4KQU8, B4LKS9, B4MYI5, B4P528, D2HRF1, E9Q5M6, O42131, O46374, O60551, O70311, P11388, Q02880, Q28FE4, Q28XF0, Q32LL6, Q32TF8, Q32TG3, Q4VBJ9, Q5JST6, Q5R981, Q5RAF3, Q5U2Z5, Q5VZ52, Q60HE5, Q64511, Q6GQ76, Q7K0Y1, Q7SXS8, Q7T0W1

Diamond homologs: Q28FE4, Q32LL6, Q4VBJ9, Q5VZ52, Q9DAI9

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

31 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	27
Likely benign	0
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

747 predictions. Top by Δscore:

Variant	Effect	Δscore
9:122159986:G:GT	donor_gain	1.0000
9:122166766:AG:A	acceptor_gain	1.0000
9:122166767:GG:G	acceptor_gain	1.0000
9:122174490:TTCAA:T	acceptor_loss	1.0000
9:122174491:TCAAG:T	acceptor_loss	1.0000
9:122174492:CAAG:C	acceptor_loss	1.0000
9:122174493:AAG:A	acceptor_gain	1.0000
9:122174493:AAGGT:A	acceptor_loss	1.0000
9:122174495:G:GA	acceptor_loss	1.0000
9:122174629:T:A	donor_loss	1.0000
9:122160001:GGGAA:G	donor_gain	0.9900
9:122160002:GGAA:G	donor_gain	0.9900
9:122160015:GGGAG:G	donor_gain	0.9900
9:122160016:GGAGG:G	donor_gain	0.9900
9:122160017:G:T	donor_gain	0.9900
9:122160017:GAGGT:G	donor_loss	0.9900
9:122160018:AGG:A	donor_loss	0.9900
9:122160020:G:GC	donor_loss	0.9900
9:122160021:T:G	donor_loss	0.9900
9:122166762:TTACA:T	acceptor_loss	0.9900
9:122166763:TACA:T	acceptor_loss	0.9900
9:122166764:ACAGG:A	acceptor_loss	0.9900
9:122166765:CA:C	acceptor_loss	0.9900
9:122166766:A:AG	acceptor_gain	0.9900
9:122166766:AGGAT:A	acceptor_gain	0.9900
9:122166767:G:GC	acceptor_loss	0.9900
9:122166767:G:GG	acceptor_gain	0.9900
9:122166767:GGAT:G	acceptor_gain	0.9900
9:122166767:GGATG:G	acceptor_gain	0.9900
9:122171491:T:G	acceptor_gain	0.9900

AlphaMissense

1073 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
9:122166892:T:A	W58R	0.991
9:122166892:T:C	W58R	0.991
9:122169657:T:C	F70L	0.988
9:122169659:C:A	F70L	0.988
9:122169659:C:G	F70L	0.988
9:122174570:T:G	Y128D	0.986
9:122174620:A:C	R144S	0.986
9:122174620:A:T	R144S	0.986
9:122166886:G:C	A56P	0.983
9:122174565:G:A	G126D	0.983
9:122174592:T:A	V135D	0.983
9:122169701:C:G	C84W	0.982
9:122166811:T:G	Y31D	0.981
9:122166857:T:C	L46P	0.981
9:122169670:T:C	L74P	0.980
9:122169720:T:C	F91L	0.980
9:122169722:T:A	F91L	0.980
9:122169722:T:G	F91L	0.980
9:122166817:G:T	G33W	0.979
9:122166894:G:C	W58C	0.978
9:122166894:G:T	W58C	0.978
9:122166893:G:C	W58S	0.977
9:122169690:T:A	W81R	0.977
9:122169690:T:C	W81R	0.977
9:122169715:G:C	R89P	0.976
9:122174619:G:C	R144T	0.976
9:122199919:T:G	C158W	0.976
9:122166818:G:A	G33E	0.975
9:122169700:G:A	C84Y	0.974
9:122166850:G:A	G44R	0.971

dbSNP variants (sampled 300 via entrez): RS1000009326 (9:122163490 A>G), RS1000038008 (9:122169919 G>C), RS1000278827 (9:122159820 A>C,G,T), RS1000479076 (9:122168252 C>G), RS1000638754 (9:122172667 C>T), RS1000768900 (9:122180411 G>A), RS1000882575 (9:122184595 G>T), RS1000987076 (9:122191846 T>G), RS1001018020 (9:122192005 T>A), RS1001023394 (9:122174316 G>C), RS1001070746 (9:122190720 A>G), RS1001176118 (9:122163194 A>G), RS1001207124 (9:122162876 G>A,T), RS1001217877 (9:122177322 C>G), RS1001248858 (9:122177080 C>A,T)

Disease associations

OMIM: gene MIM:619837 | disease phenotypes:

GenCC curated gene-disease

Disease	Classification	Inheritance
isolated cleft palate	No Known Disease Relationship	Unknown

Mondo (1): isolated cleft palate (MONDO:0007336)

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST010725_17	Malaria	5.000000e-06
GCST010725_29	Malaria	1.000000e-06
GCST010725_96	Malaria	9.000000e-07

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

15 total (human), top 15 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	decreases methylation, increases expression	3
Air Pollutants	increases expression, increases abundance	2
propionaldehyde	increases expression	1
ethyl-p-hydroxybenzoate	decreases expression	1
butyraldehyde	increases expression	1
pentanal	increases expression	1
entinostat	increases expression	1
Vorinostat	increases expression	1
Aldehydes	increases expression	1
Amiodarone	increases expression	1
Fenfluramine	increases expression	1
Silicon Dioxide	decreases expression	1
Smoke	increases abundance, increases expression	1
Tobacco Smoke Pollution	decreases expression	1
Cadmium Chloride	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.