MOV10L1

Summary

MOV10L1 (Mov10 like RNA helicase 1, HGNC:7201) is a protein-coding gene on chromosome 22q13.33, encoding RNA helicase Mov10l1 (Q9BXT6). ATP-dependent RNA helicase required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for germline integrity.

This gene is similar to a mouse gene that encodes a putative RNA helicase and shows testis-specific expression. Multiple transcript variants encoding different isoforms have been found for this gene.

Source: NCBI Gene 54456 — RefSeq curated summary.

At a glance

• Gene–disease (curated): spermatogenic failure 73 (Moderate, GenCC)
• GWAS associations: 7
• Clinical variants (ClinVar): 215 total — 3 pathogenic, 2 likely-pathogenic
• Phenotypes (HPO): 11
• MANE Select transcript: NM_018995

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:7201
Approved symbol	MOV10L1
Name	Mov10 like RNA helicase 1
Location	22q13.33
Locus type	gene with protein product
Status	Approved
Aliases	DJ402G11.8, DKFZp434B0717, CHAMP
Ensembl gene	ENSG00000073146
Ensembl biotype	protein_coding
OMIM	605794
Entrez	54456

Gene structure

Transcript identifiers

Ensembl transcripts: 9 — 5 protein_coding, 3 nonsense_mediated_decay, 1 protein_coding_CDS_not_defined

ENST00000262794, ENST00000354853, ENST00000395852, ENST00000395854, ENST00000395858, ENST00000419054, ENST00000434497, ENST00000475190, ENST00000540615

RefSeq mRNA: 4 — MANE Select: NM_018995 NM_001164104, NM_001164105, NM_001164106, NM_018995

CCDS: CCDS14084, CCDS54541, CCDS54542, CCDS54543

Canonical transcript exons

ENST00000262794 — 27 exons

Exon	Start	End
ENSE00001869377	50090006	50090185
ENSE00003841515	50161368	50161687
ENSE00004013878	50158057	50158206
ENSE00004013879	50145689	50145810
ENSE00004013880	50113648	50113788
ENSE00004013881	50108136	50108248
ENSE00004013882	50149615	50149714
ENSE00004013883	50143043	50143221
ENSE00004013884	50153045	50153218
ENSE00004013885	50142081	50142189
ENSE00004013886	50134007	50134065
ENSE00004013887	50126202	50126272
ENSE00004013888	50099443	50099602
ENSE00004013889	50134530	50134630
ENSE00004013890	50160688	50160825
ENSE00004013891	50115114	50115246
ENSE00004013892	50159678	50159785
ENSE00004013893	50128416	50128507
ENSE00004013894	50092001	50092185
ENSE00004013895	50120502	50120616
ENSE00004013896	50114381	50114622
ENSE00004013897	50108657	50108844
ENSE00004013898	50160964	50161055
ENSE00004013899	50150735	50150899
ENSE00004013900	50125392	50125569
ENSE00004013901	50117157	50117351
ENSE00004013902	50144097	50144243

Expression profiles

Bgee: expression breadth ubiquitous, 153 present calls, max score 93.22.

FANTOM5 (CAGE): breadth broad, TPM avg 0.7194 / max 28.9734, expressed in 287 samples.

FANTOM5 promoters (5 alternative TSS)

Promoter ID	TPM avg	Samples expressed
192956	0.3193	202
192958	0.3000	128
192955	0.0436	13
192957	0.0388	17
192954	0.0178	7

Top tissues by expression

252 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right testis	UBERON:0004534	93.22	gold quality
left testis	UBERON:0004533	93.19	gold quality
testis	UBERON:0000473	90.33	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	87.58	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	86.13	gold quality
sperm	CL:0000019	84.21	gold quality
stromal cell of endometrium	CL:0002255	78.72	gold quality
right hemisphere of cerebellum	UBERON:0014890	71.81	gold quality
buccal mucosa cell	CL:0002336	71.47	silver quality
pancreatic ductal cell	CL:0002079	71.02	silver quality
cerebellar hemisphere	UBERON:0002245	70.96	gold quality
cerebellar cortex	UBERON:0002129	70.89	gold quality
ascending aorta	UBERON:0001496	70.44	gold quality
left ovary	UBERON:0002119	70.37	gold quality
thoracic aorta	UBERON:0001515	70.26	gold quality
cerebellum	UBERON:0002037	69.51	gold quality
right ovary	UBERON:0002118	69.23	gold quality
right frontal lobe	UBERON:0002810	69.17	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	68.36	gold quality
kidney epithelium	UBERON:0004819	68.24	gold quality
adult organism	UBERON:0007023	67.70	gold quality
Brodmann (1909) area 9	UBERON:0013540	67.56	gold quality
prefrontal cortex	UBERON:0000451	67.30	gold quality
upper arm skin	UBERON:0004263	67.15	gold quality
left uterine tube	UBERON:0001303	67.12	gold quality
anterior cingulate cortex	UBERON:0009835	66.77	gold quality
ovary	UBERON:0000992	66.68	gold quality
muscle layer of sigmoid colon	UBERON:0035805	66.29	gold quality
descending thoracic aorta	UBERON:0002345	66.18	gold quality
body of uterus	UBERON:0009853	65.92	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.36

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): NKX2-5

miRNA regulators (miRDB)

3 targeting MOV10L1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-6735-5P	98.24	65.36	1488
HSA-MIR-7843-5P	98.12	65.26	1421
HSA-MIR-604	93.13	64.42	299

Literature-anchored findings (GeneRIF, showing 1)

• Our results suggest that MOV10L1 gene polymorphisms in the studied infertile males with complete maturation arrest are linked to infertility. (PMID:24817005)

Cross-species orthologs

8 orthologs

Organism	Symbol	Gene ID
danio_rerio	setx	ENSDARG00000022996
mus_musculus	Mov10l1	ENSMUSG00000015365
rattus_norvegicus	Mov10l1	ENSRNOG00000031093
drosophila_melanogaster	CG6701	FBGN0033889
drosophila_melanogaster	Mov10	FBGN0034187
caenorhabditis_elegans	Y106G6D.5	WBGENE00014965
caenorhabditis_elegans	sosi-1	WBGENE00016565
caenorhabditis_elegans	eri-7	WBGENE00016566

Paralogs (10): UPF1 (ENSG00000005007), AQR (ENSG00000021776), SETX (ENSG00000107290), ZNFX1 (ENSG00000124201), HELZ2 (ENSG00000130589), IGHMBP2 (ENSG00000132740), DNA2 (ENSG00000138346), MOV10 (ENSG00000155363), CT55 (ENSG00000169551), HELZ (ENSG00000198265)

Protein

Protein identifiers

RNA helicase Mov10l1 — Q9BXT6 (reviewed: Q9BXT6)

Alternative names: Moloney leukemia virus 10-like protein 1

All UniProt accessions (3): Q9BXT6, F2Z2H1, H7C1D5

UniProt curated annotations — full annotation on UniProt →

Function. ATP-dependent RNA helicase required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Involved in the primary piRNA metabolic process. Specifically binds to piRNA precursors and promotes the generation of intermediate piRNA processing fragments that are subsequently loaded to Piwi proteins. Acts via its ATP-dependent RNA helicase activity: displays 5’-3’ RNA unwinding activity and probably mediates unwinding and funneling of single-stranded piRNA precursor transcripts to the endonuclease that catalyzes the first cleavage step of piRNA processing to generate piRNA intermediate fragments that are subsequently loaded to Piwi proteins.

Subunit / interactions. Interacts with PIWIL1. Interacts with PIWIL2. Interacts with PIWIL4. Interacts with HSPA2. Interacts with PLD6.

Subcellular location. Cytoplasm.

Tissue specificity. Specifically expressed in testis.

Disease relevance. Spermatogenic failure 73 (SPGF73) [MIM:619878] An autosomal recessive male infertility disorder characterized by non-obstructive azoospermia due to meiotic arrest. The disease is caused by variants affecting the gene represented in this entry.

Similarity. Belongs to the DNA2/NAM7 helicase family. SDE3 subfamily.

Isoforms (5)

UniProt ID	Names	Canonical?
Q9BXT6-1	1	yes
Q9BXT6-2	2
Q9BXT6-3	3
Q9BXT6-4	4
Q9BXT6-5	5

RefSeq proteins (4): NP_001157576, NP_001157577, NP_001157578, NP_061868* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR027417	P-loop_NTPase	Homologous_superfamily
IPR041677	DNA2/NAM7_AAA_11	Domain
IPR041679	DNA2/NAM7-like_C	Domain
IPR047187	SF1_C_Upf1	Domain
IPR049080	MOV-10-like_beta-barrel	Domain

Pfam: PF13086, PF13087, PF21634

Catalyzed reactions (Rhea), 1 shown:

• ATP + H2O = ADP + phosphate + H(+) (RHEA:13065)

UniProt features (32 total): sequence variant 10, splice variant 9, sequence conflict 4, region of interest 3, compositionally biased region 3, chain 1, short sequence motif 1, binding site 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9BXT6-F1	74.79	0.30

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (1): 770–777

Function

Pathways and Gene Ontology

Reactome pathways

3 pathways

ID	Pathway
R-HSA-5601884	PIWI-interacting RNA (piRNA) biogenesis
R-HSA-211000	Gene Silencing by RNA
R-HSA-74160	Gene expression (Transcription)

MSigDB gene sets: 115 (showing top): GSE45365_NK_CELL_VS_CD11B_DC_UP, GOBP_MALE_GAMETE_GENERATION, NIKOLSKY_BREAST_CANCER_22Q13_AMPLICON, GOBP_POST_TRANSCRIPTIONAL_REGULATION_OF_GENE_EXPRESSION, GOBP_NEGATIVE_REGULATION_OF_GENE_EXPRESSION_EPIGENETIC, GOBP_DNA_METHYLATION_DEPENDENT_CONSTITUTIVE_HETEROCHROMATIN_FORMATION, GOBP_ORGANELLE_FISSION, GOBP_MALE_MEIOSIS_I, GOBP_CELLULAR_PROCESS_INVOLVED_IN_REPRODUCTION_IN_MULTICELLULAR_ORGANISM, GOBP_PIRNA_PROCESSING, GOBP_DEVELOPMENTAL_PROCESS_INVOLVED_IN_REPRODUCTION, GOBP_MEIOTIC_CELL_CYCLE_PROCESS, WEBER_METHYLATED_HCP_IN_SPERM_UP, GOBP_CHROMATIN_REMODELING, GOBP_HETEROCHROMATIN_ORGANIZATION

GO Biological Process (6): male meiosis I (GO:0007141), germ cell development (GO:0007281), spermatogenesis (GO:0007283), piRNA processing (GO:0034587), regulatory ncRNA-mediated post-transcriptional gene silencing (GO:0035194), transposable element silencing by piRNA-mediated DNA methylation (GO:0141196)

GO Molecular Function (8): magnesium ion binding (GO:0000287), RNA binding (GO:0003723), RNA helicase activity (GO:0003724), ATP binding (GO:0005524), ATP hydrolysis activity (GO:0016887), nucleotide binding (GO:0000166), helicase activity (GO:0004386), hydrolase activity (GO:0016787)

GO Cellular Component (4): cytosol (GO:0005829), P granule (GO:0043186), pi-body (GO:0071546), cytoplasm (GO:0005737)

Reactome top-level categories

Rollup of top-2 pathways:

Category	Pathways
Gene Silencing by RNA	1
Gene expression (Transcription)	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
male gamete generation	2
developmental process involved in reproduction	2
ATP-dependent activity	2
cellular anatomical structure	2
meiosis I	1
male meiotic nuclear division	1
meiotic cell cycle	1
gamete generation	1
cellular process involved in reproduction in multicellular organism	1
cell development	1
regulatory ncRNA processing	1
post-transcriptional gene silencing	1
regulatory ncRNA-mediated gene silencing	1
transposable element silencing by heterochromatin formation	1
gene silencing by piRNA-directed DNA methylation	1
metal ion binding	1
nucleic acid binding	1
helicase activity	1
ATP-dependent activity, acting on RNA	1
catalytic activity, acting on RNA	1
adenyl ribonucleotide binding	1
purine ribonucleoside triphosphate binding	1
ribonucleoside triphosphate phosphatase activity	1
nucleoside phosphate binding	1
heterocyclic compound binding	1
nucleic acid conformation isomerase activity	1
catalytic activity, acting on a nucleic acid	1
catalytic activity	1
cytoplasm	1
cytoplasmic ribonucleoprotein granule	1
germ plasm	1
P granule	1
intracellular anatomical structure	1

Protein interactions and networks

STRING

738 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
MOV10L1	PIWIL2	Q8TC59	896
MOV10L1	PIWIL1	Q96J94	883
MOV10L1	PLD6	Q8N2A8	827
MOV10L1	TDRD9	Q8NDG6	775
MOV10L1	TDRD1	Q9BXT4	719
MOV10L1	TDRD5	Q8NAT2	703
MOV10L1	PIWIL4	Q7Z3Z4	677
MOV10L1	MAEL	Q96JY0	677
MOV10L1	TDRKH	Q9Y2W6	670
MOV10L1	GTSF1	Q8WW33	667
MOV10L1	ASZ1	Q8WWH4	656
MOV10L1	RNF17	Q9BXT8	603
MOV10L1	HENMT1	Q5T8I9	599
MOV10L1	FKBP6	O75344	598
MOV10L1	DDX4	Q9NQI0	589

IntAct

3 interactions, top by confidence:

A	B	Type	Score
MOV10L1	AGXT2	psi-mi:“MI:0915”(physical association)	0.400
rep	PTCD3	psi-mi:“MI:0914”(association)	0.350

BioGRID (8): AASDHPPT (Co-fractionation), MOV10L1 (Proximity Label-MS), MOV10L1 (Affinity Capture-MS), AGXT2 (Affinity Capture-MS), MOV10L1 (Affinity Capture-MS), MOV10L1 (Protein-RNA), MOV10L1 (Protein-peptide), MOV10L1 (Co-fractionation)

ESM2 similar proteins: A0JPF9, A1A5Q7, A2RT67, A2RUS2, A4D126, A5PKL6, A6NCI4, A6QPR9, D4ACE5, E9PYK3, F1ND48, Q05AA6, Q09M05, Q13474, Q15061, Q32PJ3, Q3TTL0, Q3UMR0, Q3UVV9, Q3UY96, Q498D5, Q49MI3, Q4R6Y8, Q4U2V3, Q502W6, Q5F204, Q5JPI3, Q5M8J0, Q5REW9, Q5RL51, Q5XIJ6, Q6DJG6, Q6RI63, Q7TNH6, Q7TPQ3, Q80V94, Q8BSE0, Q8CEL2, Q8IZC4, Q8N392

Diamond homologs: B6SFA4, D3ZG52, E1BMP7, F1RCY6, K0E4D9, O76512, O94247, P30771, P39369, P51530, Q00416, Q0VGT4, Q54I89, Q5ZKG3, Q6ZQJ5, Q86AS0, Q86YA3, Q8GYD9, Q8QHA5, Q92355, Q92900, Q98TR3, Q9BXT6, Q9EPU0, Q9FJR0, Q9HEH1, Q9URU2, Q9VYS3, E9P860, E9QAM5, O74465, O94387, P32644, P38935, Q09820, Q57568, Q5ZKD7, Q60560, Q9BYK8, A0A1P8ASY1

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

215 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	3
Likely pathogenic	2
Uncertain significance	175
Likely benign	16
Benign	5

Top pathogenic / likely-pathogenic (5)

Variant ID	HGVS	Classification
1328947	NM_018995.3(MOV10L1):c.743+5G>A	Pathogenic
1344502	NM_018995.3(MOV10L1):c.3095_3098del (p.Pro1032fs)	Pathogenic
57944	GRCh38/hg38 22q13.2-13.33(chr22:42599757-50725241)x3	Pathogenic
1344500	NM_018995.3(MOV10L1):c.2447G>T (p.Ser816Ile)	Likely pathogenic
3024485	NM_018995.3(MOV10L1):c.2179+3A>G	Likely pathogenic

SpliceAI

5548 predictions. Top by Δscore:

Variant	Effect	Δscore
22:50090152:G:GT	donor_gain	1.0000
22:50090182:G:GT	donor_gain	1.0000
22:50090183:A:T	donor_gain	1.0000
22:50092184:GG:G	donor_gain	1.0000
22:50092185:GG:G	donor_gain	1.0000
22:50092186:G:GG	donor_gain	1.0000
22:50092186:GT:G	donor_loss	1.0000
22:50092187:T:A	donor_loss	1.0000
22:50099588:A:T	donor_gain	1.0000
22:50099603:G:GC	donor_loss	1.0000
22:50099604:T:G	donor_loss	1.0000
22:50108124:T:TA	acceptor_gain	1.0000
22:50115166:G:GT	donor_gain	1.0000
22:50115242:GGAAA:G	donor_gain	1.0000
22:50115243:GAAA:G	donor_gain	1.0000
22:50115243:GAAAG:G	donor_gain	1.0000
22:50115244:A:T	donor_gain	1.0000
22:50115247:G:GG	donor_gain	1.0000
22:50117155:A:G	acceptor_gain	1.0000
22:50143042:GTA:G	acceptor_gain	1.0000
22:50144089:T:A	acceptor_gain	1.0000
22:50144089:T:TA	acceptor_loss	1.0000
22:50144092:TGAA:T	acceptor_loss	1.0000
22:50144093:GAAG:G	acceptor_loss	1.0000
22:50144094:AAG:A	acceptor_loss	1.0000
22:50144096:G:GC	acceptor_loss	1.0000
22:50144240:GGAG:G	donor_gain	1.0000
22:50144241:GAGG:G	donor_gain	1.0000
22:50144243:GGTGA:G	donor_loss	1.0000
22:50144245:T:A	donor_loss	1.0000

AlphaMissense

7940 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
22:50143172:G:A	G770E	0.999
22:50149649:G:C	A888P	0.999
22:50150751:A:G	D915G	0.999
22:50125441:T:C	L540P	0.998
22:50134021:G:C	R642P	0.998
22:50143171:G:A	G770R	0.998
22:50143171:G:C	G770R	0.998
22:50143210:G:C	A783P	0.998
22:50144215:G:C	R826P	0.998
22:50149647:A:T	E887V	0.998
22:50149650:C:A	A888D	0.998
22:50149658:G:C	A891P	0.998
22:50150748:G:A	G914E	0.998
22:50150751:A:C	D915A	0.998
22:50150751:A:T	D915V	0.998
22:50150826:G:C	R940P	0.998
22:50153065:C:A	N971K	0.998
22:50153065:C:G	N971K	0.998
22:50153108:T:C	F986L	0.998
22:50153110:C:A	F986L	0.998
22:50153110:C:G	F986L	0.998
22:50160736:T:C	F1125L	0.998
22:50160738:C:A	F1125L	0.998
22:50160738:C:G	F1125L	0.998
22:50160762:T:A	N1133K	0.998
22:50160762:T:G	N1133K	0.998
22:50160818:T:C	L1152P	0.998
22:50143121:T:A	V753D	0.997
22:50143181:G:A	G773D	0.997
22:50144147:C:A	N803K	0.997

dbSNP variants (sampled 300 via entrez): RS1000026658 (22:50119809 G>A), RS1000057140 (22:50150441 C>G,T), RS1000120304 (22:50121040 C>T), RS1000138946 (22:50152681 T>G), RS1000142987 (22:50154186 G>C), RS1000163636 (22:50099047 C>A,T), RS1000196349 (22:50153883 A>C), RS1000208560 (22:50159458 C>T), RS1000362338 (22:50158894 G>A), RS1000374033 (22:50104467 C>T), RS1000389436 (22:50139282 A>G), RS1000409928 (22:50131491 A>C), RS1000420063 (22:50153637 G>A), RS1000441784 (22:50139777 G>A), RS1000457194 (22:50097100 A>G)

Disease associations

OMIM: gene MIM:605794 | disease phenotypes: MIM:619878

GenCC curated gene-disease

Disease	Classification	Inheritance
spermatogenic failure 73	Moderate	Autosomal recessive

Mondo (3): azoospermia (MONDO:0100459), spermatogenic failure 73 (MONDO:0030818), male infertility (MONDO:0005372)

Orphanet (0):

HPO phenotypes

11 total (11 of 11 shown, HPO-id order):

HPO	Term
HP:0000007	Autosomal recessive inheritance
HP:0000027	Azoospermia
HP:0000118	Phenotypic abnormality
HP:0000837	Increased circulating gonadotropin level
HP:0003251	Male infertility
HP:0008669	Abnormal spermatogenesis
HP:0008734	Decreased testicular size
HP:0011462	Young adult onset
HP:0011961	Non-obstructive azoospermia
HP:0011962	Obstructive azoospermia
HP:0031038	Spermatogenesis maturation arrest

GWAS associations

7 associations (top):

Study	Trait	p-value
GCST001762_608	Obesity-related traits	1.000000e-06
GCST002481_12	Acne (severe)	4.000000e-06
GCST004616_180	Platelet distribution width	1.000000e-09
GCST006101_10	Cardiometabolic and hematological traits	8.000000e-32
GCST009259_10	Amygdala volume	5.000000e-06
GCST012490_397	Femur bone mineral density x serum urate levels interaction	1.000000e-08
GCST90002401_284	Platelet distribution width	4.000000e-12

EFO canonical traits (4, from GWAS)

EFO ID	Trait name
EFO:0005190	urinary nitrogen measurement
EFO:0007984	platelet component distribution width
EFO:0004309	platelet count
EFO:0004531	urate measurement

MeSH disease descriptors (2)

Descriptor	Name	Tree numbers
D053713	Azoospermia	C12.100.500.430.380; C12.100.750.700.380; C12.200.294.430.380
D007248	Infertility, Male	C12.100.500.430; C12.100.750.700; C12.200.294.430

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

17 total (human), top 17 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	increases expression	2
Aflatoxin B1	increases methylation	2
propionaldehyde	decreases expression	1
bisphenol A	decreases methylation	1
tris(1,3-dichloro-2-propyl)phosphate	increases expression	1
cobaltous chloride	decreases expression	1
aflatoxin B2	increases methylation	1
Azacitidine	increases expression	1
Benzo(a)pyrene	affects methylation	1
Estradiol	affects cotreatment, increases expression	1
Phthalic Acids	decreases methylation	1
Smoke	decreases expression	1
Thiram	increases expression	1
Tobacco Smoke Pollution	increases expression	1
Triclosan	increases expression	1
Cadmium Chloride	increases expression	1
Okadaic Acid	decreases expression	1

Clinical trials (associated diseases)

150 trials via MONDO — disease-level, not drug-specific.

Trial	Phase	Status	Title
NCT02307994	PHASE4	UNKNOWN	Clinical Research on Effectiveness and Safety of Treatment of Severe Oligospermia or Azoospermia With uFSH
NCT02202382	PHASE4	COMPLETED	Effects of Korean Red Ginseng on Male Infertility
NCT02204826	PHASE4	COMPLETED	Effects of Korean Red Ginseng on Semen Parameters in Male Infertility Patients: a Randomized, Placebo-controlled, Double-blind Clinical Study
NCT03802864	PHASE4	COMPLETED	Post-operative Pain Control of Testicular Sperm Extraction Using Liposomal Bupivacaine
NCT06100432	PHASE4	ACTIVE_NOT_RECRUITING	Effect of Eurycoma Longifolia (DLBS5055) and Multivitamins (Vitamin C+Vitamin E+ β-carotene) for Infertile Males
NCT07523022	PHASE4	ENROLLING_BY_INVITATION	Comparison of the Effect of Gonadotropin and Clomiphene Citrate Treatment on Sperm Parameters and the Outcome of Assisted Reproductive Procedures in Subfertile Men Based on the APHRODITE Groups
NCT02275169	PHASE3	UNKNOWN	FSH Treatment for Non-obstructive Azoospermic Patients
NCT00975117	PHASE3	COMPLETED	Spermotrend in the Treatment of Male Infertility
NCT01407432	PHASE3	COMPLETED	Impact of Folates in the Care of the Male Infertility
NCT01895816	PHASE3	COMPLETED	Herbal Tonic Fertile Supplement(ZO2C5)
NCT02605070	PHASE3	TERMINATED	Pilot Study on the Effects of FSH Treatment on the Epigenetic Characteristics of Spermatozoa in Infertile Patients With Severe Oligozoospermia
NCT07402759	PHASE3	ACTIVE_NOT_RECRUITING	Impact of tdrd9 Gene Mutations in the Therapeutic Response to L-carnitine in Oligoasthenozoospermic Men
NCT02544191	PHASE2	UNKNOWN	GnRHa Combined With hCG and hMG for Treatment of Patients With Non-obstructive Azoospermia
NCT03762967	PHASE2	UNKNOWN	Autologous Adipose-Derived Adult Stromal Vascular Cell Administration for Male Patients With Infertility
NCT01880086	PHASE2	COMPLETED	Clomiphene Citrate for the Treatment of Low Testosterone Associated With Chronic Opioid Pain Medication Administration
NCT02061384	PHASE2	COMPLETED	RA-2 13-cis Retinoic Acid (Isotretinoin)
NCT02421887	PHASE2	COMPLETED	Males, Antioxidants, and Infertility Trial
NCT05200663	PHASE2	UNKNOWN	Efficacy Comparison of Tamoxifen and Tamoxifen With Antioxidants on Semen Quality of Male With Idiopathic Infertility
NCT05290558	PHASE2	ACTIVE_NOT_RECRUITING	The Therapeutic Effects of Bu Shen Yi Jing Pill on Semen Quality in Sub Fertile Males: a Randomized Controlled Trial
NCT06091969	PHASE2	NOT_YET_RECRUITING	Supplementation for Male Subfertility
NCT01595308	PHASE1	COMPLETED	A Pilot Study to Evaluate the Effect of Pomegranate Juice on Semen Parameters in Healthy Male Volunteers
NCT02122211	PHASE1	COMPLETED	Choline Dehydrogenase and Sperm Function: Effects of Betaine
NCT02575924	PHASE1	UNKNOWN	Influence of Culture Media on Clinical Outcomes in Poor Responders or Severe Male Infertility
NCT02041910	PHASE1/PHASE2	UNKNOWN	Testicular Injection of Autologous Stem Cells for Treatment of Patients With Azoospermia
NCT00282477	Not specified	UNKNOWN	Trial to Evaluate Erectile Function, Fertility and Sperm Count in Male Cyclists Compared to Age Matched Controls
NCT00484081	Not specified	COMPLETED	Microdissection Testicular Sperm Extraction (MicroTESE) and IVF-ICSI Outcome in Non-Obstructive Azoospermia (NOA)
NCT00548977	Not specified	COMPLETED	Genetic Studies Spermatogenic Failure
NCT01375062	Not specified	COMPLETED	Obtaining Undifferentiated Cells From Testis Biopsy
NCT01509482	Not specified	COMPLETED	Insulin Resistance in Idiopathic Oligospermia and Azoospermia
NCT02008799	Not specified	UNKNOWN	Intra Testicular Artery Injection of Bone Marrow Stem Cell in Management of Azoospermia
NCT02339272	Not specified	COMPLETED	Study of Synapsis and Recombination in Male Meiosis and the Implications in Infertility
NCT02414295	Not specified	COMPLETED	Sperm Production in Kleinfelter Syndrome Patients After Mesenchymal Stem Cell Injection
NCT02418832	Not specified	RECRUITING	Testis Needle Aspiration of Sperm in Men With Azoospermia
NCT02617173	Not specified	UNKNOWN	The Effect of Low Electrical Current on Testicular Spermatocyte Count
NCT02773498	Not specified	TERMINATED	Comparison of Medical Results of Testicular Sperm Extraction by Conventional Surgery and Microsurgical Track
NCT03497728	Not specified	TERMINATED	Detection of Microdeletions in the Azoospermia Factor (AZF) Regions in Infertile Male Patients
NCT04675164	Not specified	COMPLETED	Laser Assisted Sperm Selection of Viable Immotile Testicular Sperm in Azoospermic Infertile Men
NCT05479474	Not specified	RECRUITING	Platelet Rich Plasma Testis Treatment for Infertile Men
NCT05628987	Not specified	RECRUITING	The Association of Gut Microbiota and Spermatogenic Dysfunction
NCT05866484	Not specified	COMPLETED	Testicular Sperm Aspiration (TESA) vs. Microfluidic Sperm Separation (MSS)