MPP1

Summary

MPP1 (MAGUK p55 scaffold protein 1, HGNC:7219) is a protein-coding gene on chromosome Xq28, encoding 55 kDa erythrocyte membrane protein (Q00013). Essential regulator of neutrophil polarity.

This gene encodes the prototype of the membrane-associated guanylate kinase (MAGUK) family proteins. MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intercellular junctions. The encoded protein is an extensively palmitoylated membrane phosphoprotein containing a PDZ domain, a Src homology 3 (SH3) motif, and a guanylate kinase domain. This gene product interacts with various cytoskeletal proteins and cell junctional proteins in different tissue and cell types, and may be involved in the regulation of cell shape, hair cell development, neural patterning of the retina, and apico-basal polarity and tumor suppression pathways in non-erythroid cells. Multiple transcript variants encoding different isoforms have been found for this gene.

Source: NCBI Gene 4354 — RefSeq curated summary.

At a glance

• GWAS associations: 6
• Clinical variants (ClinVar): 170 total
• MANE Select transcript: NM_002436

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:7219
Approved symbol	MPP1
Name	MAGUK p55 scaffold protein 1
Location	Xq28
Locus type	gene with protein product
Status	Approved
Aliases	PEMP
Ensembl gene	ENSG00000130830
Ensembl biotype	protein_coding
OMIM	305360
Entrez	4354

Gene structure

Transcript identifiers

Ensembl transcripts: 26 — 15 protein_coding, 5 retained_intron, 4 protein_coding_CDS_not_defined, 2 nonsense_mediated_decay

ENST00000369531, ENST00000369534, ENST00000393529, ENST00000393531, ENST00000413259, ENST00000417435, ENST00000428488, ENST00000439370, ENST00000453245, ENST00000462825, ENST00000471821, ENST00000475943, ENST00000482757, ENST00000488694, ENST00000488754, ENST00000491955, ENST00000493871, ENST00000494170, ENST00000907097, ENST00000907098, ENST00000907099, ENST00000907100, ENST00000934478, ENST00000955645, ENST00000955646, ENST00000955647

RefSeq mRNA: 4 — MANE Select: NM_002436 NM_001166460, NM_001166461, NM_001166462, NM_002436

CCDS: CCDS14762, CCDS55544, CCDS55545

Canonical transcript exons

ENST00000369534 — 12 exons

Exon	Start	End
ENSE00001696815	154805272	154805485
ENSE00001863406	154778684	154779353
ENSE00003492827	154791769	154791847
ENSE00003516788	154790983	154791068
ENSE00003531049	154785051	154785157
ENSE00003533989	154781239	154781313
ENSE00003568212	154784028	154784108
ENSE00003627769	154789954	154790022
ENSE00003635533	154792142	154792285
ENSE00003637682	154781600	154781802
ENSE00003641614	154783427	154783507
ENSE00003644786	154786204	154786400

Expression profiles

Bgee: expression breadth ubiquitous, 285 present calls, max score 98.46.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 44.8755 / max 2647.6399, expressed in 1634 samples.

FANTOM5 promoters (10 alternative TSS)

Promoter ID	TPM avg	Samples expressed
201069	38.7370	1618
201067	3.0590	841
201066	1.2521	578
201065	0.7524	349
201068	0.2708	115
201071	0.2678	41
201070	0.2591	94
201062	0.2159	40
201063	0.0525	18
201061	0.0089	5

Top tissues by expression

294 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
monocyte	CL:0000576	98.46	gold quality
mononuclear cell	CL:0000842	98.28	gold quality
leukocyte	CL:0000738	98.06	gold quality
blood	UBERON:0000178	97.92	gold quality
jejunal mucosa	UBERON:0000399	97.76	gold quality
trabecular bone tissue	UBERON:0002483	97.53	gold quality
bone marrow	UBERON:0002371	96.98	gold quality
bone marrow cell	CL:0002092	96.12	gold quality
duodenum	UBERON:0002114	95.63	gold quality
right lung	UBERON:0002167	95.27	gold quality
spleen	UBERON:0002106	95.07	gold quality
granulocyte	CL:0000094	94.51	gold quality
thymus	UBERON:0002370	94.49	gold quality
cerebellar hemisphere	UBERON:0002245	94.45	gold quality
cerebellar cortex	UBERON:0002129	94.42	gold quality
right hemisphere of cerebellum	UBERON:0014890	94.39	gold quality
upper lobe of left lung	UBERON:0008952	94.36	gold quality
gall bladder	UBERON:0002110	94.27	gold quality
left adrenal gland cortex	UBERON:0035825	94.13	gold quality
left adrenal gland	UBERON:0001234	94.08	gold quality
right frontal lobe	UBERON:0002810	94.06	gold quality
right adrenal gland cortex	UBERON:0035827	94.05	gold quality
upper lobe of lung	UBERON:0008948	93.94	gold quality
Brodmann (1909) area 9	UBERON:0013540	93.78	gold quality
cerebellum	UBERON:0002037	93.59	gold quality
right adrenal gland	UBERON:0001233	93.57	gold quality
placenta	UBERON:0001987	93.53	gold quality
pons	UBERON:0000988	93.44	gold quality
prefrontal cortex	UBERON:0000451	93.42	gold quality
adrenal cortex	UBERON:0001235	93.31	gold quality

Single-cell (SCXA)

Detected in 13 experiment(s), a significant marker in 13.

Experiment	Marker?	Max mean expression
E-HCAD-4	yes	155.19
E-MTAB-6701	yes	124.49
E-MTAB-10042	yes	33.22
E-MTAB-9221	yes	23.98
E-CURD-122	yes	23.47
E-HCAD-10	yes	16.85
E-MTAB-9067	yes	12.98
E-MTAB-6678	yes	12.04
E-MTAB-9388	yes	10.31
E-HCAD-1	yes	7.83
E-HCAD-9	yes	7.60
E-MTAB-9467	yes	5.25
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

39 targeting MPP1, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-32-5P	99.98	75.21	1964
HSA-MIR-92A-3P	99.98	75.21	1960
HSA-MIR-92B-3P	99.98	75.25	1955
HSA-MIR-25-3P	99.98	74.60	1817
HSA-MIR-363-3P	99.98	74.72	1821
HSA-MIR-367-3P	99.98	74.83	1819
HSA-MIR-607	99.97	73.62	5593
HSA-MIR-515-5P	99.92	69.82	2343
HSA-MIR-519E-5P	99.92	69.62	2358
HSA-MIR-1305	99.91	71.43	3443
HSA-MIR-153-5P	99.89	73.86	6317
HSA-MIR-3140-3P	99.88	68.47	2069
HSA-MIR-605-3P	99.88	69.22	1833
HSA-MIR-137-3P	99.87	74.74	2401
HSA-MIR-4446-5P	99.72	69.19	2544
HSA-MIR-4755-5P	99.71	70.34	2716
HSA-MIR-5006-3P	99.71	70.26	2728
HSA-MIR-6126	99.62	68.09	996
HSA-MIR-519D-5P	99.41	69.30	2057
HSA-MIR-5695	99.41	67.48	1047
HSA-MIR-1912-3P	99.32	67.40	936
HSA-MIR-3064-5P	99.26	66.13	1497
HSA-MIR-3085-3P	99.26	66.16	1490
HSA-MIR-6504-5P	99.26	65.95	1487
HSA-MIR-1295B-5P	99.03	67.50	810
HSA-MIR-423-5P	98.69	67.48	1522
HSA-MIR-3135B	98.61	65.33	1470
HSA-MIR-3184-5P	98.56	67.13	1491
HSA-MIR-6873-5P	98.45	66.14	1417
HSA-MIR-6864-5P	98.38	66.59	1079

Literature-anchored findings (GeneRIF, showing 10)

• Results show the NMR-derived structure of the human erythroid p55 PDZ domain and propose a possible interaction mode with the C-terminus of glycophorin C. (PMID:16741958)
• MPP1 links the Usher protein network and the Crumbs protein complex in the retina (PMID:17584769)
• p55 binds to two distinct sites within the FERM domain, and the alternatively spliced exon 5 is necessary for the membrane targeting of protein 4.1R in epithelial cells. (PMID:18952129)
• p55-NF2 protein interaction may play a functional role in the regulation of apico-basal polarity and tumor suppression pathways in non-erythroid cells. (PMID:19144871)
• MPP1 gene expression is decreased in both classic and follicular variants of papillary thyroid carcinoma. (PMID:21509594)
• MPP1 knockdown significantly affects the activation of MAP-kinase signaling. (PMID:23507198)
• Studies indicate that palmitoylated erythrocyte membrane protein p55 (MPP1) and its palmitoylation play a crucial role in lateral membrane organization in erythroid cells. (PMID:25408337)
• conclusion, the data demonstrates that MPP1 interacts with lipid mixtures in two different model membrane systems. (PMID:28653654)
• A new perspective on the role of MPP1 in erythroid cells suggests that direct MPP1-flotillins interactions could be the major driving-force behind the formation of raft domains in red blood cells. (PMID:28865798)
• Data suggest that targeting the ATP binding cassette subfamily C member 4 (ABCC4)-membrane palmitoylated protein 1 (MPP1) protein complex can lead to new therapies to improve treatment outcome of acute myeloid leukemia (AML). (PMID:29146910)

Cross-species orthologs

8 orthologs

Organism	Symbol	Gene ID
danio_rerio	mpp1	ENSDARG00000105287
mus_musculus	Mpp1	ENSMUSG00000031402
drosophila_melanogaster	CASK	FBGN0013759
drosophila_melanogaster	metro	FBGN0050021
drosophila_melanogaster	vari	FBGN0250785
caenorhabditis_elegans		WBGENE00002991
caenorhabditis_elegans	magu-3	WBGENE00016841
caenorhabditis_elegans		WBGENE00021914

Paralogs (7): PALS1 (ENSG00000072415), MPP4 (ENSG00000082126), PALS2 (ENSG00000105926), MPP2 (ENSG00000108852), CASK (ENSG00000147044), MPP7 (ENSG00000150054), MPP3 (ENSG00000161647)

Protein

Protein identifiers

55 kDa erythrocyte membrane protein — Q00013 (reviewed: Q00013)

Alternative names: Membrane protein, palmitoylated 1

All UniProt accessions (7): Q00013, A6NFY0, A8MTH1, C9J9J4, C9JB34, F8WC84, F8WDV6

UniProt curated annotations — full annotation on UniProt →

Function. Essential regulator of neutrophil polarity. Regulates neutrophil polarization by regulating AKT1 phosphorylation through a mechanism that is independent of PIK3CG activity.

Subunit / interactions. Heterodimer with PALS1. Interacts with DLG5 and NF2. Interacts (via guanylate kinase-like domain) with WHRN (via third PDZ domain).

Subcellular location. Cell membrane. Cell projection. Stereocilium.

Tissue specificity. Ubiquitous.

Post-translational modifications. Palmitoylated.

Similarity. Belongs to the MAGUK family.

Isoforms (3)

UniProt ID	Names	Canonical?
Q00013-1	1	yes
Q00013-2	2
Q00013-3	3

RefSeq proteins (4): NP_001159932, NP_001159933, NP_001159934, NP_002427* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001452	SH3_domain	Domain
IPR001478	PDZ	Domain
IPR008144	Guanylate_kin-like_dom	Domain
IPR008145	GK/Ca_channel_bsu	Domain
IPR020590	Guanylate_kinase_CS	Conserved_site
IPR027417	P-loop_NTPase	Homologous_superfamily
IPR035475	MPP1_SH3	Domain
IPR036028	SH3-like_dom_sf	Homologous_superfamily
IPR036034	PDZ_sf	Homologous_superfamily
IPR050716	MAGUK	Family

Pfam: PF00018, PF00595, PF00625

UniProt features (45 total): strand 14, helix 10, modified residue 8, domain 3, turn 3, splice variant 2, initiator methionine 1, chain 1, sequence variant 1, sequence conflict 1, region of interest 1

Structure

Experimental structures (PDB)

3 structures.

PDB	Method	Resolution (Å)
3NEY	X-RAY DIFFRACTION	2.26
2EJY	SOLUTION NMR
2EV8	SOLUTION NMR

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q00013-F1	78.77	0.51

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (8): 52, 57, 110, 243, 2, 13, 19, 49

Function

Pathways and Gene Ontology

Reactome pathways

1 pathways

ID	Pathway
R-HSA-9662361	Sensory processing of sound by outer hair cells of the cochlea

MSigDB gene sets: 364 (showing top): SHEPARD_BMYB_MORPHOLINO_UP, GOBP_NUCLEOSIDE_DIPHOSPHATE_METABOLIC_PROCESS, GOBP_MYELOID_LEUKOCYTE_MIGRATION, GOBP_CELL_CHEMOTAXIS, KAAB_FAILED_HEART_ATRIUM_DN, GOBP_RESPONSE_TO_FLUID_SHEAR_STRESS, MODULE_45, IVANOVA_HEMATOPOIESIS_MATURE_CELL, GOBP_ORGANOPHOSPHATE_METABOLIC_PROCESS, LUCAS_HNF4A_TARGETS_UP, ACEVEDO_LIVER_CANCER_WITH_H3K27ME3_UP, GOBP_REGULATION_OF_LEUKOCYTE_MIGRATION, GOBP_CARBOHYDRATE_DERIVATIVE_METABOLIC_PROCESS, GNF2_ANK1, GOBP_LEUKOCYTE_CHEMOTAXIS

GO Biological Process (4): signal transduction (GO:0007165), regulation of neutrophil chemotaxis (GO:0090022), GMP metabolic process (GO:0046037), GDP metabolic process (GO:0046710)

GO Molecular Function (3): GMP kinase activity (GO:0004385), signaling receptor binding (GO:0005102), protein binding (GO:0005515)

GO Cellular Component (10): plasma membrane (GO:0005886), cell-cell junction (GO:0005911), membrane (GO:0016020), cortical cytoskeleton (GO:0030863), stereocilium (GO:0032420), centriolar satellite (GO:0034451), cytoskeleton (GO:0005856), cell projection (GO:0042995), organelle (GO:0043226), cell periphery (GO:0071944)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Sensory processing of sound	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	5
purine ribonucleotide metabolic process	2
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
neutrophil chemotaxis	1
regulation of granulocyte chemotaxis	1
regulation of neutrophil migration	1
purine ribonucleoside monophosphate metabolic process	1
purine ribonucleoside diphosphate metabolic process	1
GMP metabolic process	1
GDP metabolic process	1
nucleoside monophosphate kinase activity	1
protein binding	1
binding	1
membrane	1
cell periphery	1
anchoring junction	1
cytoskeleton	1
cell cortex	1
stereocilium bundle	1
neuron projection	1
actin-based cell projection	1
centrosome	1
intracellular membraneless organelle	1

Protein interactions and networks

STRING

1738 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
MPP1	EPB41	P11171	871
MPP1	KIF13B	Q9NQT8	769
MPP1	GYPC	P04921	735
MPP1	WHRN	Q9P202	701
MPP1	LIN7A	O14910	663
MPP1	LRRC4C	Q9HCJ2	649
MPP1	SORBS3	O60504	648
MPP1	EPB41L2	O43491	592
MPP1	DMTN	Q08495	585
MPP1	DLG5	Q8TDM6	566
MPP1	MYO15A	Q9UKN7	565
MPP1	G6PD	P11413	564
MPP1	TJP1	Q07157	560
MPP1	USH1G	Q495M9	543
MPP1	ADGRV1	Q8WXG9	533

IntAct

174 interactions, top by confidence:

A	B	Type	Score
MPP1	ABCC4	psi-mi:“MI:0407”(direct interaction)	0.780
MPP1	ABCC4	psi-mi:“MI:0915”(physical association)	0.780
ABCC4	MPP1	psi-mi:“MI:0915”(physical association)	0.780
MPP1	ABCC4	psi-mi:“MI:2364”(proximity)	0.780
ABCC4	MPP1	psi-mi:“MI:0407”(direct interaction)	0.780
KLHL12	MPP1	psi-mi:“MI:0915”(physical association)	0.720
MPP1	DNPEP	psi-mi:“MI:0915”(physical association)	0.720
DNPEP	MPP1	psi-mi:“MI:0915”(physical association)	0.720
MPP1	KLHL12	psi-mi:“MI:0915”(physical association)	0.720
CFTR	ESYT2	psi-mi:“MI:2364”(proximity)	0.710
MPP1	GYPC	psi-mi:“MI:0407”(direct interaction)	0.680
GYPC	MPP1	psi-mi:“MI:0407”(direct interaction)	0.680
MPP1	GYPC	psi-mi:“MI:0915”(physical association)	0.680
SRSF10	MPP1	psi-mi:“MI:0915”(physical association)	0.560
MPP1	MEOX2	psi-mi:“MI:0915”(physical association)	0.560
MPP1	ZNF639	psi-mi:“MI:0915”(physical association)	0.560

BioGRID (137): DNPEP (Two-hybrid), KLHL12 (Two-hybrid), AMOTL2 (Two-hybrid), MPP1 (Co-fractionation), MPP1 (Proximity Label-MS), DKC1 (Affinity Capture-MS), HDAC2 (Affinity Capture-MS), AGFG1 (Affinity Capture-MS), MPP1 (Affinity Capture-MS), MPP1 (Affinity Capture-MS), NCBP1 (Affinity Capture-MS), PRDX1 (Affinity Capture-MS), PRDX2 (Affinity Capture-MS), TAF1B (Affinity Capture-MS), FAM13A (Affinity Capture-MS)

ESM2 similar proteins: A1A5G4, A2ALK8, A8MUH7, A9CB74, F1M386, F1MSG6, F1PBJ0, O14745, O14907, O14936, O70589, P19878, P26045, P70290, P70441, P70600, Q00013, Q09506, Q14289, Q17QN6, Q28619, Q3SZK8, Q3T0X8, Q4L1J4, Q4R6G4, Q570Y9, Q5F488, Q5RCF7, Q5RDW4, Q5T2W1, Q5TCQ9, Q5ZIJ9, Q5ZJ00, Q60629, Q62915, Q69ZS7, Q6RHR9, Q865P3, Q8CHG7, Q8TB45

Diamond homologs: A6QQZ7, A8KBF6, A9CB74, B4F7E7, D3ZAA9, E2QY99, G5ECY0, O14936, O34328, O70589, O88910, O88954, P0C0M9, P15454, P31006, P31007, P44310, P46195, P49697, P54936, P65219, P65220, P65221, P70175, P70290, P72648, P93757, P99176, Q00013, Q13368, Q14168, Q15700, Q16774, Q17QN6, Q182S8, Q24210, Q2FHM9, Q2G1U0, Q2QPW1, Q2S8R2

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

170 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	40
Likely benign	4
Benign	3

Top pathogenic / likely-pathogenic (0)

SpliceAI

0 predictions. Top by Δscore:

AlphaMissense

3088 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
X:154786277:A:G	W202R	1.000
X:154786277:A:T	W202R	1.000
X:154786274:A:G	W203R	0.999
X:154786274:A:T	W203R	0.999
X:154786275:C:A	W202C	0.999
X:154786275:C:G	W202C	0.999
X:154786213:A:G	L223P	0.998
X:154786225:G:T	P219H	0.998
X:154786231:A:G	L217S	0.998
X:154786276:C:G	W202S	0.998
X:154786324:A:G	F186S	0.998
X:154791800:T:A	R98S	0.998
X:154791800:T:G	R98S	0.998
X:154791801:C:A	R98I	0.998
X:154791801:C:G	R98T	0.998
X:154791847:C:G	G83R	0.998
X:154791847:C:T	G83R	0.998
X:154784082:A:C	Y271D	0.997
X:154786222:G:A	S220F	0.997
X:154786225:G:C	P219R	0.997
X:154786267:C:T	G205E	0.997
X:154786268:C:G	G205R	0.997
X:154786268:C:T	G205R	0.997
X:154786269:C:A	Q204H	0.997
X:154786269:C:G	Q204H	0.997
X:154786272:C:A	W203C	0.997
X:154786272:C:G	W203C	0.997
X:154786323:A:C	F186L	0.997
X:154786323:A:T	F186L	0.997
X:154786325:A:G	F186L	0.997

dbSNP variants (sampled 300 via entrez): RS1000267506 (X:154785303 G>A), RS1000631793 (X:154803983 A>T), RS1000707631 (X:154795582 T>C), RS1000982646 (X:154804776 C>T), RS1001306546 (X:154799794 G>C), RS1001382541 (X:154790430 T>C), RS1001436360 (X:154789795 G>A,T), RS1002254102 (X:154802225 T>A), RS1002349838 (X:154783063 A>G), RS1002388764 (X:154793058 T>C), RS1002664863 (X:154778458 C>T), RS1002933468 (X:154798404 C>T), RS1003020689 (X:154778896 C>T), RS1003115060 (X:154787534 T>A), RS1003396534 (X:154797810 C>A)

Disease associations

OMIM: gene MIM:305360 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

6 associations (top):

Study	Trait	p-value
GCST001779_11	Hematology traits	1.000000e-11
GCST001781_2	Mean corpuscular volume	4.000000e-10
GCST001873_1	Red blood cell traits	2.000000e-16
GCST001873_11	Red blood cell traits	4.000000e-19
GCST001873_4	Red blood cell traits	4.000000e-18
GCST001873_9	Red blood cell traits	4.000000e-14

EFO canonical traits (3, from GWAS)

EFO ID	Trait name
EFO:0004305	erythrocyte count
EFO:0004348	hematocrit
EFO:0004509	hemoglobin measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

43 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	increases expression, affects cotreatment	4
Benzo(a)pyrene	decreases expression, increases methylation, affects methylation	3
Tretinoin	affects cotreatment, decreases reaction, increases expression	3
bisphenol A	affects expression, decreases methylation	2
sodium arsenite	affects expression, increases expression	2
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases reaction, increases expression	2
Air Pollutants	decreases expression, affects cotreatment, increases abundance, increases oxidation	2
Phenylmercuric Acetate	affects cotreatment, increases expression	2
Cyclosporine	increases expression	2
FR900359	affects phosphorylation	1
bisphenol F	increases expression	1
alpha-pinene	affects cotreatment, increases oxidation, increases abundance	1
propionaldehyde	increases expression	1
glycidyl methacrylate	decreases expression	1
arsenite	affects binding, increases reaction	1
tris(1,3-dichloro-2-propyl)phosphate	increases expression	1
butyraldehyde	increases expression	1
potassium chromate(VI)	decreases expression	1
methacrylaldehyde	affects cotreatment, increases oxidation, increases abundance	1
Chir 99021	affects cotreatment, decreases reaction, increases expression	1
ICG 001	decreases expression	1
dorsomorphin	affects cotreatment, increases expression	1
jinfukang	decreases expression, increases expression, affects cotreatment	1
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	decreases expression	1
Temozolomide	decreases expression	1
Sunitinib	decreases expression	1
Acetaminophen	increases expression	1
Acrolein	affects cotreatment, increases oxidation, increases abundance	1
Cisplatin	affects cotreatment, decreases expression	1
Diethylhexyl Phthalate	increases expression	1

Cellosaurus cell lines

1 cell lines: 1 transformed cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_B3B5	Abcam HEK293T MPP1 KO	Transformed cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.