MPRIP

Summary

MPRIP (myosin phosphatase Rho interacting protein, HGNC:30321) is a protein-coding gene on chromosome 17p11.2, encoding Myosin phosphatase Rho-interacting protein (Q6WCQ1). Targets myosin phosphatase to the actin cytoskeleton.

Enables cadherin binding activity. Located in actin cytoskeleton and cytosol.

Source: NCBI Gene 23164 — RefSeq curated summary.

At a glance

• GWAS associations: 5
• Clinical variants (ClinVar): 204 total
• MANE Select transcript: NM_001364716

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:30321
Approved symbol	MPRIP
Name	myosin phosphatase Rho interacting protein
Location	17p11.2
Locus type	gene with protein product
Status	Approved
Aliases	RHOIP3, M-RIP, p116Rip
Ensembl gene	ENSG00000133030
Ensembl biotype	protein_coding
OMIM	612935
Entrez	23164

Gene structure

Transcript identifiers

Ensembl transcripts: 23 — 16 protein_coding, 6 protein_coding_CDS_not_defined, 1 retained_intron

ENST00000313485, ENST00000341712, ENST00000395806, ENST00000395807, ENST00000395811, ENST00000414263, ENST00000429184, ENST00000462033, ENST00000466186, ENST00000577514, ENST00000578209, ENST00000578521, ENST00000578548, ENST00000579361, ENST00000579832, ENST00000581855, ENST00000581955, ENST00000581989, ENST00000584067, ENST00000584936, ENST00000651222, ENST00000948254, ENST00000948255

RefSeq mRNA: 3 — MANE Select: NM_001364716 NM_001364716, NM_015134, NM_201274

CCDS: CCDS32578, CCDS42268, CCDS92265

Canonical transcript exons

ENST00000651222 — 24 exons

Exon	Start	End
ENSE00000907786	17173916	17174075
ENSE00000907787	17175293	17175412
ENSE00000907789	17177250	17177412
ENSE00000907790	17180003	17180088
ENSE00001606225	17150144	17150233
ENSE00001609181	17172698	17172815
ENSE00001618716	17171718	17171865
ENSE00001622527	17161240	17161356
ENSE00001625403	17147319	17147387
ENSE00001639709	17158432	17159002
ENSE00001646598	17164109	17167915
ENSE00001659433	17146036	17146092
ENSE00001699629	17142627	17142765
ENSE00001756678	17143556	17143669
ENSE00001822722	17137916	17138429
ENSE00003528138	17176426	17176512
ENSE00003538212	17078011	17078076
ENSE00003577150	17154306	17154415
ENSE00003606301	17075710	17075787
ENSE00003646061	17131617	17131701
ENSE00003672465	17136219	17136450
ENSE00003788093	17126702	17126853
ENSE00003843892	17042457	17042971
ENSE00003847382	17184823	17192643

Expression profiles

Bgee: expression breadth ubiquitous, 300 present calls, max score 99.06.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 45.6271 / max 624.7259, expressed in 1814 samples.

FANTOM5 promoters (10 alternative TSS)

Promoter ID	TPM avg	Samples expressed
159719	24.0737	1808
159720	18.2855	1771
159721	1.2964	749
159718	0.9248	641
159730	0.4957	67
159724	0.3480	176
159729	0.1116	41
159726	0.0379	12
159731	0.0305	18
159732	0.0230	18

Top tissues by expression

301 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
lower esophagus mucosa	UBERON:0035834	99.06	gold quality
popliteal artery	UBERON:0002250	99.00	gold quality
tibial artery	UBERON:0007610	99.00	gold quality
sural nerve	UBERON:0015488	98.85	gold quality
right coronary artery	UBERON:0001625	98.81	gold quality
amniotic fluid	UBERON:0000173	98.78	gold quality
peripheral nervous system	UBERON:0000010	98.76	gold quality
aorta	UBERON:0000947	98.76	gold quality
nerve	UBERON:0001021	98.76	gold quality
tibial nerve	UBERON:0001323	98.76	gold quality
olfactory bulb	UBERON:0002264	98.75	gold quality
saphenous vein	UBERON:0007318	98.71	gold quality
body of uterus	UBERON:0009853	98.60	gold quality
ganglionic eminence	UBERON:0004023	98.57	gold quality
buccal mucosa cell	CL:0002336	98.56	gold quality
ascending aorta	UBERON:0001496	98.49	gold quality
thoracic aorta	UBERON:0001515	98.47	gold quality
left coronary artery	UBERON:0001626	98.47	gold quality
coronary artery	UBERON:0001621	98.46	gold quality
inferior olivary complex	UBERON:0002127	98.45	gold quality
right lobe of thyroid gland	UBERON:0001119	98.43	gold quality
ventricular zone	UBERON:0003053	98.41	gold quality
apex of heart	UBERON:0002098	98.40	gold quality
left lobe of thyroid gland	UBERON:0001120	98.35	gold quality
right frontal lobe	UBERON:0002810	98.33	gold quality
descending thoracic aorta	UBERON:0002345	98.32	gold quality
upper lobe of left lung	UBERON:0008952	98.26	gold quality
myometrium	UBERON:0001296	98.25	gold quality
heart left ventricle	UBERON:0002084	98.25	gold quality
putamen	UBERON:0001874	98.24	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	10.06
E-MTAB-6678	yes	4.39

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

264 targeting MPRIP, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4476	100.00	68.18	2030
HSA-MIR-6876-5P	100.00	67.68	2126
HSA-MIR-4533	100.00	69.48	2758
HSA-MIR-200B-3P	100.00	73.31	2693
HSA-MIR-200C-3P	100.00	73.35	2685
HSA-MIR-429	100.00	73.44	2698
HSA-MIR-4668-3P	100.00	68.74	2635
HSA-MIR-1252-5P	100.00	69.80	2774
HSA-MIR-4747-5P	100.00	67.90	2681
HSA-MIR-5196-5P	100.00	67.98	2761
HSA-MIR-6867-5P	100.00	82.21	3464
HSA-MIR-5193	100.00	67.26	1744
HSA-MIR-4283	100.00	66.42	2097
HSA-MIR-5692A	100.00	74.40	6850
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-548AW	99.99	72.57	3559
HSA-MIR-548C-3P	99.99	74.01	7587
HSA-MIR-524-5P	99.98	73.43	4882
HSA-MIR-19A-3P	99.98	75.33	2762
HSA-MIR-19B-3P	99.98	75.44	2754
HSA-MIR-520D-5P	99.98	73.34	4883
HSA-MIR-4775	99.98	75.00	6394
HSA-MIR-8068	99.98	73.85	2376
HSA-MIR-570-3P	99.96	72.41	4910
HSA-MIR-1250-3P	99.96	70.04	4038
HSA-MIR-495-3P	99.96	72.81	4197
HSA-MIR-5688	99.96	73.23	4504
HSA-MIR-548AA	99.96	70.64	3753
HSA-MIR-548AP-3P	99.96	70.64	3753
HSA-MIR-548T-3P	99.96	70.64	3753

Literature-anchored findings (GeneRIF, showing 9)

• p116Rip is an important regulatory component that controls the RhoA signaling pathway, thus regulating MLCP activity and myosin phosphorylation in cells (PMID:15545284)
• M-RIP-dependent targeting of myosin phosphatase to stress fibers has an important role in regulating myosin light chain phosphorylation state and morphology in human vascular smooth muscle cells (PMID:16257966)
• A functional analysis of JNK1 and M-RIP with RNA interference reveals a critical role for this cascade in the invasive behavior of cancer cells. (PMID:18636174)
• MLCP (myosin light chain phosphatase) activation is counteracted by a previously unrecognized association between MRIP and the inducible kinase NUAK2 (PMID:21242312)
• Our data identify M-RIP as a crucial local regulator of the Rho-Rac balance during chemotaxis and antigen recognition. (PMID:22349701)
• The B-Raf(V600E) inhibitor dabrafenib selectively inhibits RIP3 and alleviates acetaminophen-induced liver injury. (PMID:24901049)
• The F-Actin-Binding MPRIP Forms Phase-Separated Condensates and Associates with PI(4,5)P2 and Active RNA Polymerase II in the Cell Nucleus. (PMID:33918018)
• PIP2-Effector Protein MPRIP Regulates RNA Polymerase II Condensation and Transcription. (PMID:36979361)
• [circDDX17 targets miR-223-3p / RIP3 to regulate the proliferation and apoptosis of non-small cell lung cancer cells]. (PMID:38494770)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	si:ch73-103b11.2	ENSDARG00000105209
mus_musculus	Mprip	ENSMUSG00000005417
rattus_norvegicus	Mprip	ENSRNOG00000003226
drosophila_melanogaster	osp	FBGN0003016
caenorhabditis_elegans	F10G8.8	WBGENE00008666

Paralogs (1): TRIOBP (ENSG00000100106)

Protein

Protein identifiers

Myosin phosphatase Rho-interacting protein — Q6WCQ1 (reviewed: Q6WCQ1)

Alternative names: Rho-interacting protein 3, p116Rip

All UniProt accessions (13): A0A1W2PPU9, A0A494BZV2, A8MZF8, Q6WCQ1, H0Y2S9, H0Y7E2, H7C3G6, J3KSK7, J3KSW8, J3QL44, J3QRL2, K7EJ14, K7EL39

UniProt curated annotations — full annotation on UniProt →

Function. Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells.

Subunit / interactions. Binds F-actin through its N-terminus. Interacts with MYZAP. Binds RHOA, PPP1R12A/MBS and PPP1R12C/MBS85 through adjacent coiled coil domains.

Subcellular location. Cytoplasm. Cytoskeleton.

Isoforms (3)

UniProt ID	Names	Canonical?
Q6WCQ1-1	1	yes
Q6WCQ1-2	2
Q6WCQ1-3	3

RefSeq proteins (3): NP_001351645, NP_055949, NP_958431 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001849	PH_domain	Domain
IPR011993	PH-like_dom_sf	Homologous_superfamily
IPR039597	M-RIP_PH	Domain
IPR052223	Actin_Cytoskeleton_Reg	Family

Pfam: PF00169

UniProt features (57 total): modified residue 25, sequence conflict 9, compositionally biased region 8, region of interest 7, domain 2, splice variant 2, initiator methionine 1, chain 1, coiled-coil region 1, sequence variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q6WCQ1-F1	65.71	0.31

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (25): 192, 217, 218, 220, 224, 226, 265, 269, 289, 292, 295, 326, 348, 362, 365, 493, 619, 646, 663, 800 …

Function

Pathways and Gene Ontology

Reactome pathways

4 pathways

ID	Pathway
R-HSA-6802952	Signaling by BRAF and RAF1 fusions
R-HSA-1643685	Disease
R-HSA-5663202	Diseases of signal transduction by growth factor receptors and second messengers
R-HSA-6802957	Oncogenic MAPK signaling

MSigDB gene sets: 219 (showing top): HORIUCHI_WTAP_TARGETS_DN, BERTUCCI_MEDULLARY_VS_DUCTAL_BREAST_CANCER_DN, MODULE_255, RORA1_01, GCANCTGNY_MYOD_Q6, MODULE_317, HSIAO_HOUSEKEEPING_GENES, HNF1_Q6, CAGCTG_AP4_Q5, SCHAEFFER_PROSTATE_DEVELOPMENT_6HR_DN, HP1SITEFACTOR_Q6, TGANTCA_AP1_C, FOURNIER_ACINAR_DEVELOPMENT_EARLY_DN, LYF1_01, GOMF_ACTIN_BINDING

GO Biological Process (0):

GO Molecular Function (4): cadherin binding (GO:0045296), actin filament binding (GO:0051015), actin binding (GO:0003779), protein binding (GO:0005515)

GO Cellular Component (5): cytosol (GO:0005829), focal adhesion (GO:0005925), actin cytoskeleton (GO:0015629), cytoplasm (GO:0005737), cytoskeleton (GO:0005856)

Reactome top-level categories

Rollup of top-3 pathways:

Category	Pathways
Oncogenic MAPK signaling	1
Disease	1
Diseases of signal transduction by growth factor receptors and second messengers	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	2
cell adhesion molecule binding	1
actin binding	1
protein-containing complex binding	1
cytoskeletal protein binding	1
binding	1
cytoplasm	1
cell-substrate junction	1
cytoskeleton	1
intracellular anatomical structure	1
intracellular membraneless organelle	1

Protein interactions and networks

STRING

1184 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
MPRIP	RHOA	P06749	985
MPRIP	PPP1R12A	O14974	913
MPRIP	PPA1	Q15181	842
MPRIP	PRKG1	P14619	755
MPRIP	NTRK1	P04629	551
MPRIP	CDC42BPB	Q9Y5S2	515
MPRIP	NUAK2	Q9H093	498
MPRIP	NT5M	Q9NPB1	471
MPRIP	PLEK2	Q9NYT0	469
MPRIP	PLEK	P08567	465
MPRIP	NOC3L	Q8WTT2	464
MPRIP	INO80D	Q53TQ3	450
MPRIP	TPM3	P06753	447
MPRIP	POLR2F	P41584	445
MPRIP	SEPTIN9	Q9UHD8	444

IntAct

216 interactions, top by confidence:

A	B	Type	Score
GRB2	EGFR	psi-mi:“MI:0914”(association)	0.980
PSMC3	PSMD9	psi-mi:“MI:0914”(association)	0.940
MPRIP	YWHAQ	psi-mi:“MI:0915”(physical association)	0.910
SGF29	NDC80	psi-mi:“MI:0914”(association)	0.840
CAPN1	CAPNS1	psi-mi:“MI:0914”(association)	0.840
YWHAQ	WDR62	psi-mi:“MI:0914”(association)	0.830
PLK1	SPAG9	psi-mi:“MI:0914”(association)	0.790
PACSIN1	COBL	psi-mi:“MI:0914”(association)	0.750
PACSIN2	COBL	psi-mi:“MI:0914”(association)	0.740
VAPB	FAM83G	psi-mi:“MI:0914”(association)	0.730
CFTR	ESYT2	psi-mi:“MI:0914”(association)	0.710
CFTR	ESYT2	psi-mi:“MI:2364”(proximity)	0.710
YWHAG	BLTP3B	psi-mi:“MI:2364”(proximity)	0.640
VAPA	FAM83G	psi-mi:“MI:0914”(association)	0.640
PSMC3	PSMD12	psi-mi:“MI:0914”(association)	0.640
VAPA	PITPNM1	psi-mi:“MI:0914”(association)	0.640
NUAK2	PPP1R12A	psi-mi:“MI:0914”(association)	0.640
YWHAH	PLEKHG3	psi-mi:“MI:0914”(association)	0.610
CFTR	HAX1	psi-mi:“MI:0914”(association)	0.610
YWHAB	BLTP3B	psi-mi:“MI:2364”(proximity)	0.610
MPRIP	Ppp1r12a	psi-mi:“MI:0915”(physical association)	0.580

BioGRID (343): MPRIP (Affinity Capture-MS), MPRIP (Affinity Capture-MS), MPRIP (Affinity Capture-MS), MPRIP (Affinity Capture-MS), MPRIP (Affinity Capture-MS), MPRIP (Affinity Capture-MS), MPRIP (Affinity Capture-MS), MPRIP (Affinity Capture-MS), MPRIP (Reconstituted Complex), MPRIP (Affinity Capture-MS), MPRIP (Affinity Capture-MS), MPRIP (Proximity Label-MS), MPRIP (Affinity Capture-MS), MPRIP (Affinity Capture-MS), MPRIP (Affinity Capture-MS)

ESM2 similar proteins: A0A0G2JUG7, A1L390, A2AHC3, B2RWW0, O14924, O43182, O54834, O54960, O94885, P59808, P80192, P97434, Q13009, Q17R10, Q3U1V8, Q3U214, Q4VAC9, Q5DTU0, Q5DU25, Q5JU85, Q5RBI7, Q5SXA9, Q60610, Q6DN90, Q6NXJ0, Q6P0Q8, Q6P1I6, Q6P720, Q6P9R4, Q6WCQ1, Q6XZF7, Q76G19, Q76LL6, Q7T2V3, Q80Z38, Q810W7, Q8IX03, Q8N103, Q8R0S2, Q8R4H2

Diamond homologs: B6RSP1, D3ZL52, G9CGD6, O08967, O43739, P54644, P60669, P97434, P97696, Q3UIL6, Q5DU31, Q6IQ23, Q6WCQ1, Q6ZNL6, Q7TQG1, Q80UZ0, Q80VL0, Q80YA9, Q86IV4, Q8BH49, Q8C4V1, Q8N264, Q8N4B1, Q8VC98, Q8WWN9, Q8WXI2, Q99KW3, Q9ERE6, Q9ERS5, Q9H4M7, Q9HAU0, Q9HB19, Q9Y2H5, Q9Z1T4, Q9H2D6, Q27421, P34512, Q1ZXL0, Q86I31, Q91VS8

SIGNOR signaling

3 interactions.

A	Effect	B	Mechanism
ROCK1	down-regulates	MPRIP	phosphorylation
PPM1B	“down-regulates activity”	MPRIP	dephosphorylation
RIPK1	“up-regulates activity”	MPRIP	phosphorylation

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 205 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex	9	40.0×	2e-10
Activation of BAD and translocation to mitochondria	7	35.3×	1e-07
SARS-CoV-1 targets host intracellular signalling and regulatory pathways	7	31.1×	2e-07
Activation of BH3-only proteins	7	23.0×	1e-06
RHO GTPases activate PKNs	9	18.9×	2e-07
Intrinsic Pathway for Apoptosis	9	17.4×	2e-07
Apoptosis	11	12.2×	2e-07
FOXO-mediated transcription	5	11.1×	2e-03

GO biological processes:

GO term	Partners	Fold	FDR
positive regulation of ubiquitin-dependent protein catabolic process	7	21.6×	5e-05
cellular response to glucose starvation	6	11.1×	9e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

204 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	158
Likely benign	15
Benign	5

Top pathogenic / likely-pathogenic (0)

SpliceAI

6741 predictions. Top by Δscore:

Variant	Effect	Δscore
17:17042968:GCAG:G	donor_gain	1.0000
17:17042970:AGGT:A	donor_loss	1.0000
17:17042971:GGT:G	donor_loss	1.0000
17:17042972:G:GG	donor_gain	1.0000
17:17042972:GTGA:G	donor_loss	1.0000
17:17075706:CTAGG:C	acceptor_loss	1.0000
17:17075707:TAGG:T	acceptor_loss	1.0000
17:17075708:A:AG	acceptor_gain	1.0000
17:17075708:A:C	acceptor_loss	1.0000
17:17075709:G:GA	acceptor_loss	1.0000
17:17075709:G:GG	acceptor_gain	1.0000
17:17075709:GGCAA:G	acceptor_gain	1.0000
17:17078072:AGATG:A	donor_gain	1.0000
17:17078073:GATG:G	donor_gain	1.0000
17:17078073:GATGG:G	donor_gain	1.0000
17:17078074:ATG:A	donor_gain	1.0000
17:17078074:ATGGT:A	donor_loss	1.0000
17:17078075:TG:T	donor_gain	1.0000
17:17078075:TGG:T	donor_loss	1.0000
17:17078076:GG:G	donor_gain	1.0000
17:17078077:G:GA	donor_loss	1.0000
17:17078077:G:GG	donor_gain	1.0000
17:17078078:T:A	donor_loss	1.0000
17:17126850:GTGG:G	donor_gain	1.0000
17:17126854:G:GG	donor_gain	1.0000
17:17126854:GTGA:G	donor_loss	1.0000
17:17126855:TGAG:T	donor_loss	1.0000
17:17131613:CCAG:C	acceptor_loss	1.0000
17:17131614:CAGG:C	acceptor_loss	1.0000
17:17131615:A:AC	acceptor_loss	1.0000

AlphaMissense

15892 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
17:17042873:T:A	C9S	1.000
17:17042873:T:C	C9R	1.000
17:17042874:G:A	C9Y	1.000
17:17042874:G:C	C9S	1.000
17:17042875:C:G	C9W	1.000
17:17042882:T:C	F12L	1.000
17:17042883:T:C	F12S	1.000
17:17042883:T:G	F12C	1.000
17:17042884:C:A	F12L	1.000
17:17042884:C:G	F12L	1.000
17:17042893:C:A	N15K	1.000
17:17042893:C:G	N15K	1.000
17:17042895:T:C	I16T	1.000
17:17042897:T:A	F17I	1.000
17:17042897:T:C	F17L	1.000
17:17042897:T:G	F17V	1.000
17:17042898:T:C	F17S	1.000
17:17042898:T:G	F17C	1.000
17:17042899:C:A	F17L	1.000
17:17042899:C:G	F17L	1.000
17:17042909:A:G	K21E	1.000
17:17042911:G:C	K21N	1.000
17:17042911:G:T	K21N	1.000
17:17042912:T:A	C22S	1.000
17:17042912:T:C	C22R	1.000
17:17042913:G:A	C22Y	1.000
17:17042913:G:C	C22S	1.000
17:17042913:G:T	C22F	1.000
17:17042914:T:G	C22W	1.000
17:17042921:T:A	C25S	1.000

dbSNP variants (sampled 300 via entrez): RS1000019674 (17:17050782 G>A), RS1000040759 (17:17093064 T>C), RS1000054640 (17:17110431 T>G), RS1000075510 (17:17070790 T>A), RS1000086848 (17:17110205 G>T), RS1000096340 (17:17051960 G>A), RS1000104456 (17:17092545 C>G), RS1000104969 (17:17133123 C>G), RS1000106052 (17:17170489 C>T), RS1000114895 (17:17187949 A>G), RS1000130928 (17:17176338 G>A), RS1000140096 (17:17095336 C>G,T), RS1000164556 (17:17115943 T>C), RS1000212309 (17:17058626 C>T), RS1000244493 (17:17155155 T>G)

Disease associations

OMIM: gene MIM:612935 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

5 associations (top):

Study	Trait	p-value
GCST001017_7	Diabetic retinopathy	7.000000e-06
GCST001762_467	Obesity-related traits	7.000000e-08
GCST008058_260	Estimated glomerular filtration rate	2.000000e-08
GCST90002383_64	Hematocrit	5.000000e-09
GCST90002384_406	Hemoglobin	2.000000e-09

EFO canonical traits (3, from GWAS)

EFO ID	Trait name
EFO:0004626	IGFBP-3 measurement
EFO:0004348	hematocrit
EFO:0004509	hemoglobin measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

73 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects cotreatment, increases expression, affects expression	5
trichostatin A	affects cotreatment, increases expression	3
bisphenol F	increases expression	2
bisphenol A	decreases methylation, increases expression	2
bisphenol S	increases expression, affects cotreatment, increases methylation	2
Benzo(a)pyrene	affects methylation, increases expression	2
Testosterone	affects cotreatment, decreases expression, increases expression	2
Aflatoxin B1	increases expression, increases methylation	2
FR900359	affects phosphorylation	1
moringin	affects cotreatment, decreases expression	1
dicrotophos	increases expression	1
2,4,6-tribromophenol	decreases expression	1
triphenyl phosphate	affects expression	1
alpha-pinene	affects cotreatment, increases oxidation, increases abundance	1
propylparaben	increases expression	1
lead acetate	increases expression	1
pyrogallol 1,3-dimethyl ether	increases expression, affects cotreatment, affects localization, decreases expression	1
decabromobiphenyl ether	decreases expression	1
terbufos	increases methylation	1
2-butenal	decreases expression	1
beta-lapachone	decreases expression, increases expression	1
methylparaben	increases expression	1
sodium arsenite	decreases expression, increases abundance	1
cobaltous chloride	decreases expression	1
tetrabromobisphenol A	decreases expression	1
perfluorooctanoic acid	decreases expression	1
ochratoxin A	decreases expression	1
benzo(e)pyrene	increases methylation	1
aflatoxin B2	increases methylation	1
cupric chloride	increases expression	1

Cellosaurus cell lines

3 cell lines: 3 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_B1XG	Abcam HeLa MPRIP KO	Cancer cell line	Female
CVCL_C8TE	CUTO-3	Cancer cell line	Female
CVCL_UJ35	CUTO-3.29	Cancer cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.