MRGPRG

Summary

MRGPRG (MAS related GPR family member G, HGNC:24829) is a protein-coding gene on chromosome 11p15.4, encoding Mas-related G-protein coupled receptor member G (Q86SM5). Orphan receptor.

Predicted to enable G protein-coupled receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway. Predicted to be located in membrane. Predicted to be active in plasma membrane.

Source: NCBI Gene 386746 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• Clinical variants (ClinVar): 57 total
• Druggable target: yes
• MANE Select transcript: NM_001164377

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:24829
Approved symbol	MRGPRG
Name	MAS related GPR family member G
Location	11p15.4
Locus type	gene with protein product
Status	Approved
Aliases	mrgG
Ensembl gene	ENSG00000182170
Ensembl biotype	protein_coding
OMIM	607234
Entrez	386746

Gene structure

Transcript identifiers

Ensembl transcripts: 1 — 1 protein_coding

ENST00000332314

RefSeq mRNA: 1 — MANE Select: NM_001164377 NM_001164377

CCDS: CCDS44520

Canonical transcript exons

ENST00000332314 — 1 exons

Exon	Start	End
ENSE00001330298	3217944	3218813

Expression profiles

Bgee: expression breadth tissue_specific, 4 present calls, max score 38.68.

Top tissues by expression

125 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
bone marrow cell	CL:0002092	38.68	gold quality
colonic epithelium	UBERON:0000397	37.20	gold quality
ventricular zone	UBERON:0003053	36.48	gold quality
cortical plate	UBERON:0005343	36.47	gold quality
ganglionic eminence	UBERON:0004023	35.49	gold quality
skeletal muscle tissue	UBERON:0001134	33.38	gold quality
bone marrow	UBERON:0002371	33.03	gold quality
hindlimb stylopod muscle	UBERON:0004252	32.15	gold quality
testis	UBERON:0000473	31.69	silver quality
left testis	UBERON:0004533	31.47	silver quality
muscle tissue	UBERON:0002385	31.06	gold quality
sural nerve	UBERON:0015488	30.93	gold quality
right testis	UBERON:0004534	30.60	gold quality
stromal cell of endometrium	CL:0002255	29.87	gold quality
prefrontal cortex	UBERON:0000451	29.22	gold quality
placenta	UBERON:0001987	28.59	gold quality
liver	UBERON:0002107	28.27	gold quality
duodenum	UBERON:0002114	28.14	gold quality
monocyte	CL:0000576	28.09	gold quality
leukocyte	CL:0000738	28.05	gold quality
endocervix	UBERON:0000458	27.71	silver quality
olfactory segment of nasal mucosa	UBERON:0005386	27.65	silver quality
lymph node	UBERON:0000029	27.57	gold quality
tonsil	UBERON:0002372	27.05	gold quality
islet of Langerhans	UBERON:0000006	26.97	gold quality
vermiform appendix	UBERON:0001154	26.42	gold quality
blood	UBERON:0000178	26.17	gold quality
gall bladder	UBERON:0002110	25.98	gold quality
urinary bladder	UBERON:0001255	25.72	gold quality
muscle of leg	UBERON:0001383	24.93	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.33

Regulation

Is transcription factor: no

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
mus_musculus	Mrgprg	ENSMUSG00000050276
rattus_norvegicus	Mrgprgl1	ENSRNOG00000061525
rattus_norvegicus	Mrgprg	ENSRNOG00000069807

Paralogs (10): MAS1 (ENSG00000130368), MRGPRX1 (ENSG00000170255), MRGPRF (ENSG00000172935), MRGPRD (ENSG00000172938), GPR152 (ENSG00000175514), MRGPRX4 (ENSG00000179817), MRGPRX3 (ENSG00000179826), MRGPRX2 (ENSG00000183695), MRGPRE (ENSG00000184350), MAS1L (ENSG00000204687)

Protein

Protein identifiers

Mas-related G-protein coupled receptor member G — Q86SM5 (reviewed: Q86SM5)

Alternative names: G-protein coupled receptor 169

All UniProt accessions (1): Q86SM5

UniProt curated annotations — full annotation on UniProt →

Function. Orphan receptor. May regulate nociceptor function and/or development, including the sensation or modulation of pain.

Subcellular location. Cell membrane.

Similarity. Belongs to the G-protein coupled receptor 1 family. Mas subfamily.

RefSeq proteins (1): NP_001157849* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000276	GPCR_Rhodpsn	Family
IPR017452	GPCR_Rhodpsn_7TM	Domain
IPR026234	MRGPCRFAMILY	Family
IPR027336	MRGPCRG	Family

UniProt features (16 total): topological domain 8, transmembrane region 7, chain 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q86SM5-F1	86.34	0.52

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 20 (showing top): GOMF_TRANSMEMBRANE_SIGNALING_RECEPTOR_ACTIVITY, GOMF_G_PROTEIN_COUPLED_RECEPTOR_ACTIVITY, MIKKELSEN_MCV6_LCP_WITH_H3K27ME3, MIKKELSEN_MEF_LCP_WITH_H3K27ME3, MIKKELSEN_ES_LCP_WITH_H3K27ME3, GOBP_G_PROTEIN_COUPLED_RECEPTOR_SIGNALING_PATHWAY, KUMAR_PATHOGEN_LOAD_BY_MACROPHAGES, GSE13547_WT_VS_ZFX_KO_BCELL_ANTI_IGM_STIM_12H_UP, GSE11924_TFH_VS_TH17_CD4_TCELL_UP, GOMF_MOLECULAR_TRANSDUCER_ACTIVITY, GSE39820_IL1B_IL6_VS_IL1B_IL6_IL23A_TREATED_CD4_TCELL_DN, GSE8921_UNSTIM_VS_TLR1_2_STIM_MONOCYTE_24H_DN, GSE5542_IFNG_VS_IFNA_TREATED_EPITHELIAL_CELLS_24H_DN, GSE5099_MONOCYTE_VS_CLASSICAL_M1_MACROPHAGE_UP, GSE6674_UNSTIM_VS_ANTI_IGM_STIM_BCELL_DN

GO Biological Process (2): G protein-coupled receptor signaling pathway (GO:0007186), signal transduction (GO:0007165)

GO Molecular Function (1): G protein-coupled receptor activity (GO:0004930)

GO Cellular Component (2): plasma membrane (GO:0005886), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
G protein-coupled receptor activity	1
signal transduction	1
cell communication	1
cellular process	1
signaling	1
regulation of cellular process	1
cellular response to stimulus	1
transmembrane signaling receptor activity	1
G protein-coupled receptor signaling pathway	1
membrane	1
cell periphery	1
cellular anatomical structure	1

Protein interactions and networks

STRING

280 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
MRGPRG	NPFF	O15130	721
MRGPRG	ZDHHC13	Q8IUH4	474
MRGPRG	OR3A2	P47893	447
MRGPRG	OR10AD1	Q8NGE0	419
MRGPRG	OR52L1	Q8NGH7	419
MRGPRG	PPP1R26	Q5T8A7	411
MRGPRG	TMEM134	Q9H6X4	400
MRGPRG	OR6B2	Q6IFH4	396
MRGPRG	TOR2A	Q5JU69	388
MRGPRG	PTRH1	Q86Y79	381
MRGPRG	SAAL1	Q96ER3	375
MRGPRG	GPR152	Q8TDT2	368
MRGPRG	GPR82	Q96P67	357
MRGPRG	PGGHG	Q32M88	353
MRGPRG	GPR148	Q8TDV2	351
MRGPRG	MORF4L2	Q15014	351

IntAct

2 interactions, top by confidence:

A	B	Type	Score
RAMP1	MRGPRG	psi-mi:“MI:0915”(physical association)	0.400
MRGPRG	RAMP3	psi-mi:“MI:0915”(physical association)	0.400

BioGRID (1): MRGPRG (Protein-peptide)

ESM2 similar proteins: A6NGC4, A6NKX4, A6NM10, D3YZZ2, O35595, O46547, O60391, O77808, O95528, P30518, P43119, P46092, P46095, P48044, P48748, Q14626, Q3SYU3, Q3ZAV1, Q4U2R8, Q4W8A3, Q5RF19, Q5U419, Q64385, Q684M3, Q6UXD7, Q6UXT9, Q6YNI2, Q863Y8, Q86SM5, Q8CFZ5, Q8IXF9, Q8WUG5, Q91X56, Q924U0, Q96S37, Q99MF4, Q9BGL8, Q9BZ11, Q9H1Z9, Q9H228

Diamond homologs: B9VR26, O55197, O88680, P04201, P12526, P23749, P30554, P35410, Q16581, Q2LL16, Q3KNA1, Q3UG50, Q3UG61, Q4QXU0, Q4QXU2, Q4QXU3, Q4QXU4, Q4QXU5, Q4QXU6, Q4QXX9, Q5REI5, Q5U9D9, Q6L786, Q6TAC8, Q6XKD3, Q7TN38, Q7TN39, Q7TN40, Q7TN41, Q7TN44, Q7TN45, Q7TN49, Q7TN50, Q7TN51, Q86SM5, Q8CIP3, Q8NGA4, Q8R4G1, Q8TDS7, Q8VCJ6

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

57 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	53
Likely benign	4
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

45 predictions. Top by Δscore:

Variant	Effect	Δscore
11:3218040:C:A	donor_gain	0.4900
11:3218113:A:T	acceptor_gain	0.4600
11:3218112:C:CT	acceptor_gain	0.4500
11:3218619:C:CT	acceptor_gain	0.3700
11:3218020:GACCT:G	donor_loss	0.3600
11:3218022:C:CA	donor_loss	0.3600
11:3218619:C:T	acceptor_gain	0.3600
11:3218019:CGACC:C	donor_gain	0.3500
11:3218039:T:TA	donor_gain	0.3500
11:3218014:A:AC	donor_gain	0.3200
11:3218234:GCCGC:G	acceptor_gain	0.3100
11:3218236:C:CT	acceptor_gain	0.3100
11:3218263:C:T	acceptor_gain	0.3100
11:3218550:C:CT	donor_gain	0.3000
11:3218020:GACC:G	donor_gain	0.2900
11:3218021:A:T	donor_gain	0.2900
11:3218022:C:T	donor_gain	0.2900
11:3218624:G:T	acceptor_gain	0.2900
11:3218115:C:CT	acceptor_gain	0.2800
11:3218225:AGAG:A	acceptor_gain	0.2800
11:3218257:G:C	donor_gain	0.2800
11:3218254:CAGG:C	donor_gain	0.2600
11:3218276:C:CT	donor_gain	0.2600
11:3218581:T:TA	donor_gain	0.2600
11:3218018:CCGA:C	donor_gain	0.2500
11:3218023:C:G	donor_gain	0.2500
11:3218544:C:CT	acceptor_gain	0.2500
11:3218015:GTACC:G	donor_loss	0.2400
11:3218016:TAC:T	donor_loss	0.2400
11:3218116:G:T	acceptor_gain	0.2400

AlphaMissense

1807 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:3218547:G:C	F89L	0.858
11:3218547:G:T	F89L	0.858
11:3218549:A:G	F89L	0.858
11:3218634:G:C	F60L	0.816
11:3218634:G:T	F60L	0.816
11:3218636:A:G	F60L	0.816
11:3218556:G:C	F86L	0.809
11:3218556:G:T	F86L	0.809
11:3218558:A:G	F86L	0.809
11:3218613:G:C	F67L	0.786
11:3218613:G:T	F67L	0.786
11:3218615:A:G	F67L	0.786
11:3218082:G:C	S244R	0.723
11:3218082:G:T	S244R	0.723
11:3218084:T:G	S244R	0.723
11:3218766:G:C	F16L	0.712
11:3218766:G:T	F16L	0.712
11:3218768:A:G	F16L	0.712
11:3218092:A:T	V241D	0.689
11:3218676:G:C	F46L	0.657
11:3218676:G:T	F46L	0.657
11:3218678:A:G	F46L	0.657
11:3218157:G:C	S219R	0.631
11:3218157:G:T	S219R	0.631
11:3218159:T:G	S219R	0.631
11:3218085:G:C	S243R	0.629
11:3218085:G:T	S243R	0.629
11:3218087:T:G	S243R	0.629
11:3218121:A:C	F231L	0.607
11:3218121:A:T	F231L	0.607

dbSNP variants (sampled 300 via entrez): RS1000180807 (11:3219204 T>C), RS1000262710 (11:3220431 A>C,G), RS1000554484 (11:3218968 C>T), RS1000621812 (11:3219174 A>C,G), RS1000922769 (11:3220437 G>A), RS1000992525 (11:3219376 C>T), RS1001787327 (11:3219921 T>C,G), RS1001830217 (11:3220226 G>T), RS1002093598 (11:3219059 G>T), RS1003762888 (11:3217935 C>A), RS1003836681 (11:3217630 C>A,T), RS1004154834 (11:3218207 C>A,T), RS1005788449 (11:3220697 C>G,T), RS1007088189 (11:3219286 C>T), RS1007509661 (11:3220478 G>A,T)

Disease associations

OMIM: gene MIM:607234 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST010725_20	Malaria	4.000000e-69
GCST010725_33	Malaria	2.000000e-67
GCST010725_51	Malaria	1.000000e-55

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL4523881 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

GtoPdb / IUPHAR curated pharmacology

(IUPHAR/BPS Guide to Pharmacology — expert-curated)

Target class: gpcr — Class A Orphans with no pharmacology

CTD chemical–gene interactions

6 total (human), top 6 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
propionaldehyde	decreases expression	1
bisphenol A	affects cotreatment, increases methylation	1
Fulvestrant	affects cotreatment, increases methylation	1
Benzo(a)pyrene	affects methylation, decreases methylation	1
Valproic Acid	increases methylation	1
Aflatoxin B1	increases methylation	1

ChEMBL screening assays

2 unique, capped per target: 2 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL4883534	Binding	PRESTO-Tango GPCRome screening (MRGPRG)	Data for DCP probe UCSF924

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.