MRM3

Summary

MRM3 (mitochondrial rRNA methyltransferase 3, HGNC:18485) is a protein-coding gene on chromosome 17p13.3, encoding rRNA methyltransferase 3, mitochondrial (Q9HC36). S-adenosyl-L-methionine-dependent 2’-O-ribose methyltransferase that catalyzes the formation of 2’-O-methylguanosine at position 1370 (Gm1370) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a conserved modification in the peptidyl transferase domain of the mt…. It is a selective cancer dependency (DepMap: 11.6% of cell lines).

Efficient translation of mitochondrial-derived transcripts requires proper assembly of the large subunit of the mitochondrial ribosome. Central to the biogenesis of this large subunit is the A-loop of mitochondrial 16S rRNA, which is modified by three rRNA methyltransferases located near mtDNA nucleoids. The protein encoded by this gene methylates G(1370) of 16S rRNA, and this modification is necessary for proper ribosomal large subnit assembly. Two transcript variants encoding different isoforms have been found for this gene.

Source: NCBI Gene 55178 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 12 total
• Cancer dependency (DepMap): dependent in 11.6% of screened cell lines
• MANE Select transcript: NM_018146

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:18485
Approved symbol	MRM3
Name	mitochondrial rRNA methyltransferase 3
Location	17p13.3
Locus type	gene with protein product
Status	Approved
Aliases	FLJ10581, HC90, RMTL1
Ensembl gene	ENSG00000171861
Ensembl biotype	protein_coding
OMIM	612600
Entrez	55178

Gene structure

Transcript identifiers

Ensembl transcripts: 8 — 6 protein_coding, 1 nonsense_mediated_decay, 1 retained_intron

ENST00000304478, ENST00000571157, ENST00000574509, ENST00000574916, ENST00000872466, ENST00000872467, ENST00000938389, ENST00000938390

RefSeq mRNA: 2 — MANE Select: NM_018146 NM_001317947, NM_018146

CCDS: CCDS10997

Canonical transcript exons

ENST00000304478 — 4 exons

Exon	Start	End
ENSE00001130996	783083	783327
ENSE00001199338	782353	782692
ENSE00001265741	791534	792509
ENSE00003507601	787965	788132

Expression profiles

Bgee: expression breadth ubiquitous, 263 present calls, max score 92.31.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 14.9915 / max 124.8042, expressed in 1810 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
158691	14.8547	1810
158692	0.1368	56

Top tissues by expression

282 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
endothelial cell	CL:0000115	92.31	gold quality
gastrocnemius	UBERON:0001388	89.93	gold quality
muscle of leg	UBERON:0001383	89.37	gold quality
apex of heart	UBERON:0002098	88.67	gold quality
hindlimb stylopod muscle	UBERON:0004252	87.76	gold quality
muscle organ	UBERON:0001630	87.27	gold quality
gluteal muscle	UBERON:0002000	87.00	gold quality
gingival epithelium	UBERON:0001949	86.78	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	86.73	gold quality
body of pancreas	UBERON:0001150	86.55	gold quality
sperm	CL:0000019	86.37	gold quality
deltoid	UBERON:0001476	85.67	silver quality
right lobe of liver	UBERON:0001114	85.63	gold quality
heart left ventricle	UBERON:0002084	85.38	gold quality
cardiac ventricle	UBERON:0002082	85.06	gold quality
mucosa of transverse colon	UBERON:0004991	85.00	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	84.79	gold quality
left testis	UBERON:0004533	84.54	gold quality
pancreas	UBERON:0001264	84.44	gold quality
right adrenal gland	UBERON:0001233	84.29	gold quality
right adrenal gland cortex	UBERON:0035827	84.29	gold quality
testis	UBERON:0000473	84.23	gold quality
body of stomach	UBERON:0001161	84.23	gold quality
male germ cell	CL:0000015	84.21	gold quality
right testis	UBERON:0004534	84.15	gold quality
left adrenal gland	UBERON:0001234	83.98	gold quality
gingiva	UBERON:0001828	83.92	gold quality
cervix squamous epithelium	UBERON:0006922	83.90	gold quality
skin of leg	UBERON:0001511	83.87	gold quality
lower esophagus muscularis layer	UBERON:0035833	83.84	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.72

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): CREB1

miRNA regulators (miRDB)

20 targeting MRM3, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-6778-3P	99.96	67.29	2693
HSA-MIR-8063	99.91	69.76	3146
HSA-MIR-12119	99.87	68.35	1653
HSA-MIR-6752-3P	99.72	66.71	1587
HSA-MIR-7152-5P	99.60	69.33	2094
HSA-MIR-4276	99.56	67.66	2514
HSA-MIR-2116-5P	99.32	69.34	1273
HSA-MIR-7974	99.24	65.48	1137
HSA-MIR-767-3P	98.61	67.69	1192
HSA-MIR-138-5P	98.43	70.49	1292
HSA-MIR-3138	98.41	67.53	744
HSA-MIR-3187-5P	98.36	65.74	1776
HSA-MIR-660-3P	98.14	66.04	1434
HSA-MIR-1285-3P	97.72	67.02	1932
HSA-MIR-5189-5P	97.72	66.96	1814
HSA-MIR-612	97.26	65.95	1597
HSA-MIR-6860	97.21	66.31	1656
HSA-MIR-8071	95.69	64.93	484
HSA-MIR-4765	93.11	66.17	737
HSA-MIR-8053	92.82	66.12	79

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 11.6% of screened cell lines.

Literature-anchored findings (GeneRIF, showing 3)

• The ATF/CREB site is the key element for transcription of this protein found on human chromosome 17. (PMID:12296377)
• MRM2 and MRM3 are human mitochondrial methyltransferases involved in the modification of 16S rRNA and are important factors for the biogenesis and function of the large subunit of the mitochondrial ribosome. (PMID:25009282)
• Data show that 2’-O-methyltransferases MRM1, MRM2, and RNMTL1 are responsible for modification of large subunit rRNA at residues G1145, U1369, and G1370, respectively. (PMID:25074936)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
mus_musculus	Mrm3	ENSMUSG00000038046
rattus_norvegicus	Mrm3	ENSRNOG00000037238
caenorhabditis_elegans		WBGENE00020498

Paralogs (2): TARBP1 (ENSG00000059588), MRM1 (ENSG00000278619)

Protein

Protein identifiers

rRNA methyltransferase 3, mitochondrial — Q9HC36 (reviewed: Q9HC36)

Alternative names: 16S rRNA (guanosine(1370)-2’-O)-methyltransferase, 16S rRNA [Gm1370] 2’-O-methyltransferase, RNA methyltransferase-like protein 1

All UniProt accessions (3): Q9HC36, I3L0T6, I3L443

UniProt curated annotations — full annotation on UniProt →

Function. S-adenosyl-L-methionine-dependent 2’-O-ribose methyltransferase that catalyzes the formation of 2’-O-methylguanosine at position 1370 (Gm1370) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a conserved modification in the peptidyl transferase domain of the mtLSU rRNA. Also required for formation of 2’-O-methyluridine at position 1369 (Um1369) mediated by MRM2.

Subcellular location. Mitochondrion.

Tissue specificity. Expressed at same level in normal liver and hepatocarcinoma.

Similarity. Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family.

RefSeq proteins (2): NP_001304876, NP_060616* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001537	SpoU_MeTrfase	Domain
IPR013123	SpoU_subst-bd	Domain
IPR029026	tRNA_m1G_MTases_N	Homologous_superfamily
IPR029028	Alpha/beta_knot_MTases	Homologous_superfamily
IPR029064	Ribosomal_eL30-like_sf	Homologous_superfamily
IPR051259	rRNA_Methyltransferase	Family
IPR053888	MRM3-like_sub_bind	Domain

Pfam: PF00588, PF22435

Enzyme classification (BRENDA):

• EC 2.1.1.B124 — (BRENDA: organisms, substrates, inhibitors, Km, kcat entries)

Catalyzed reactions (Rhea), 1 shown:

• guanosine(1370) in 16S rRNA + S-adenosyl-L-methionine = 2’-O-methylguanosine(1370) in 16S rRNA + S-adenosyl-L-homocysteine + H(+) (RHEA:47756)

UniProt features (12 total): sequence variant 4, binding site 3, transit peptide 1, chain 1, sequence conflict 1, region of interest 1, compositionally biased region 1

Structure

Experimental structures (PDB)

1 structures.

PDB	Method	Resolution (Å)
7OI6	ELECTRON MICROSCOPY	5.7

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9HC36-F1	74.54	0.51

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Ligand- & substrate-binding residues (3): 356; 380; 389

Function

Pathways and Gene Ontology

Reactome pathways

4 pathways

ID	Pathway
R-HSA-6793080	rRNA modification in the mitochondrion
R-HSA-72312	rRNA processing
R-HSA-8868766	rRNA processing in the mitochondrion
R-HSA-8953854	Metabolism of RNA

MSigDB gene sets: 151 (showing top): GOBP_RIBOSOME_BIOGENESIS, GOBP_RIBOSOME_ASSEMBLY, GOBP_RNA_METHYLATION, MUELLER_PLURINET, GOBP_RNA_MODIFICATION, GOBP_RIBOSOMAL_LARGE_SUBUNIT_ASSEMBLY, BLALOCK_ALZHEIMERS_DISEASE_UP, E4F1_Q6, GOBP_PROTEIN_RNA_COMPLEX_ORGANIZATION, GOBP_ORGANELLE_ASSEMBLY, MCCLUNG_COCAINE_REWARD_5D, RICKMAN_TUMOR_DIFFERENTIATED_MODERATELY_VS_POORLY_UP, GOBP_RRNA_MODIFICATION, GOBP_METHYLATION, GOBP_RIBONUCLEOPROTEIN_COMPLEX_BIOGENESIS

GO Biological Process (5): rRNA 2’-O-methylation (GO:0000451), rRNA processing (GO:0006364), mitochondrial large ribosomal subunit assembly (GO:1902775), RNA processing (GO:0006396), methylation (GO:0032259)

GO Molecular Function (7): RNA binding (GO:0003723), identical protein binding (GO:0042802), rRNA (guanosine-2’-O-ribose)-methyltransferase activity (GO:0070039), protein binding (GO:0005515), methyltransferase activity (GO:0008168), RNA methyltransferase activity (GO:0008173), transferase activity (GO:0016740)

GO Cellular Component (3): mitochondrion (GO:0005739), mitochondrial matrix (GO:0005759), cytoplasm (GO:0005737)

Reactome top-level categories

Rollup of top-3 pathways:

Category	Pathways
rRNA processing in the mitochondrion	1
Metabolism of RNA	1
rRNA processing	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
rRNA methylation	1
RNA processing	1
rRNA metabolic process	1
ribosome biogenesis	1
ribosomal large subunit assembly	1
mitochondrial ribosome assembly	1
gene expression	1
RNA biosynthetic process	1
primary metabolic process	1
metabolic process	1
nucleic acid binding	1
protein binding	1
rRNA 2’-O-methylation	1
rRNA (guanine) methyltransferase activity	1
RNA 2’-O-methyltransferase activity	1
binding	1
transferase activity, transferring one-carbon groups	1
methyltransferase activity	1
catalytic activity, acting on RNA	1
catalytic activity	1
cytoplasm	1
intracellular membrane-bounded organelle	1
mitochondrion	1
intracellular organelle lumen	1
intracellular anatomical structure	1
cellular anatomical structure	1

Protein interactions and networks

STRING

2159 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
MRM3	MRM2	Q9UI43	830
MRM3	MRM1	Q6IN84	807
MRM3	DDX28	Q9NUL7	802
MRM3	MALSU1	Q96EH3	761
MRM3	MTERF3	Q96E29	752
MRM3	NSUN4	Q96CB9	710
MRM3	RPUSD4	Q96CM3	701
MRM3	METTL15	A6NJ78	693
MRM3	METTL1	Q9UBP6	685
MRM3	NGRN	Q9NPE2	676
MRM3	GTPBP10	A4D1E9	661
MRM3	FASTKD2	Q9NYY8	654
MRM3	MTERF4	Q7Z6M4	652
MRM3	MTG2	Q9H4K7	650
MRM3	TFB1M	Q8WVM0	630

IntAct

169 interactions, top by confidence:

A	B	Type	Score
N	MRM3	psi-mi:“MI:0915”(physical association)	0.770
N	HNRNPR	psi-mi:“MI:0914”(association)	0.730
FHL3	MRM3	psi-mi:“MI:0915”(physical association)	0.720
CFTR	ESYT2	psi-mi:“MI:2364”(proximity)	0.710
MRPS30	GTPBP10	psi-mi:“MI:0914”(association)	0.640
SCARF1	MRM3	psi-mi:“MI:0915”(physical association)	0.560
TNF	MRM3	psi-mi:“MI:0915”(physical association)	0.560
MIP	MRM3	psi-mi:“MI:0915”(physical association)	0.560
MRM3	AIG1	psi-mi:“MI:0915”(physical association)	0.560
BTN2A2	MRM3	psi-mi:“MI:0915”(physical association)	0.560
MRM3	MRM3	psi-mi:“MI:0915”(physical association)	0.560
GAD2	MRM3	psi-mi:“MI:0915”(physical association)	0.560
ARLN	MRM3	psi-mi:“MI:0915”(physical association)	0.560
ZFPL1	MRM3	psi-mi:“MI:0915”(physical association)	0.560
JAGN1	MRM3	psi-mi:“MI:0915”(physical association)	0.560
GALNT2	MRM3	psi-mi:“MI:0915”(physical association)	0.560
MRM3	UBIAD1	psi-mi:“MI:0915”(physical association)	0.560
MRPL50	GTPBP10	psi-mi:“MI:0914”(association)	0.530
ZNF512	ZNF724	psi-mi:“MI:0914”(association)	0.530
MRPL42	GATC	psi-mi:“MI:0914”(association)	0.530
MRM3	NDUFS6	psi-mi:“MI:0914”(association)	0.530
MRPL28	MRPL3	psi-mi:“MI:0914”(association)	0.530
N	HNRNPDL	psi-mi:“MI:0914”(association)	0.530

BioGRID (223): RNMTL1 (Two-hybrid), RNMTL1 (Affinity Capture-MS), RNMTL1 (Affinity Capture-MS), RNMTL1 (Affinity Capture-MS), RNMTL1 (Affinity Capture-MS), RNMTL1 (Affinity Capture-MS), RNMTL1 (Affinity Capture-MS), PMPCB (Affinity Capture-MS), SPTY2D1 (Affinity Capture-MS), RNMTL1 (Affinity Capture-MS), RNMTL1 (Affinity Capture-MS), RNMTL1 (Reconstituted Complex), RNMTL1 (Affinity Capture-MS), RNMTL1 (Affinity Capture-MS), RNMTL1 (Affinity Capture-MS)

ESM2 similar proteins: A0JPF9, A4D126, A5PKL6, A6QP81, B2GUS6, D2H8V8, E1BCH6, E1BVR9, E9PYK3, F1ND48, G5E8F4, P79106, Q28CZ7, Q32PY6, Q3U269, Q3U3W5, Q3U5Q7, Q3UVV9, Q49MI3, Q4R3W5, Q5F3V0, Q5ND52, Q5R5X9, Q5RCP1, Q5RFM7, Q5RJG7, Q5RL51, Q5S6T3, Q5T8I9, Q5VZV1, Q6AYG3, Q8BIW1, Q8BK58, Q8BQJ6, Q8BTK5, Q8BZ20, Q8C5V5, Q8CAE2, Q8IXQ6, Q8IYR2

Diamond homologs: A1L2E4, A4QNL8, P94538, Q566V3, Q5ND52, Q5SM16, Q6GPJ4, Q72GI1, Q7VQP0, Q9HC36, Q9VW14, A0R557, A1TG08, A1UMF4, A3Q6V9, A4T5L0, D7A3L6, O30272, O51081, O51468, O67577, P0AGJ2, P0AGJ3, P0AGJ4, P44906, P47494, P52393, P63177, P63178, P63179, P63180, P75424, Q06753, Q1B2P4, Q49V41, Q6D127, Q6FF50, Q6LM40, Q7MH13, Q7MYU6

SIGNOR signaling

0 interactions.

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 151 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Mitochondrial ribosome-associated quality control	20	23.6×	6e-20
Mitochondrial translation	17	22.5×	7e-17
Mitochondrial translation initiation	18	22.0×	1e-17
Mitochondrial translation elongation	18	22.0×	1e-17
Mitochondrial translation termination	18	19.0×	1e-16
Translation	20	11.9×	1e-14
rRNA modification in the nucleus and cytosol	5	9.0×	3e-03
Peptide chain elongation	7	8.5×	6e-04

GO biological processes:

GO term	Partners	Fold	FDR
mitochondrial translation	21	26.4×	1e-21
cytoplasmic translation	8	10.7×	2e-04
translation	14	10.4×	3e-08
ribosomal small subunit biogenesis	6	9.9×	4e-03
RNA processing	6	9.5×	5e-03
rRNA processing	8	8.2×	1e-03
RNA splicing	10	6.4×	8e-04
mRNA processing	9	5.1×	7e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

12 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	6
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

484 predictions. Top by Δscore:

Variant	Effect	Δscore
17:782640:G:GT	donor_gain	1.0000
17:782640:G:T	donor_gain	1.0000
17:783082:GCAGT:G	acceptor_gain	1.0000
17:791526:T:G	acceptor_gain	1.0000
17:791528:TTCCA:T	acceptor_loss	1.0000
17:791529:TCCA:T	acceptor_loss	1.0000
17:791530:CCA:C	acceptor_loss	1.0000
17:791531:CAG:C	acceptor_loss	1.0000
17:791532:A:AG	acceptor_gain	1.0000
17:791533:G:GA	acceptor_loss	1.0000
17:791533:G:GG	acceptor_gain	1.0000
17:791533:GGCT:G	acceptor_gain	1.0000
17:782684:GAGGC:G	donor_gain	0.9900
17:782687:GC:G	donor_gain	0.9900
17:783082:GCA:G	acceptor_gain	0.9900
17:783319:GAA:G	donor_gain	0.9900
17:791525:A:AG	acceptor_gain	0.9900
17:791532:AG:A	acceptor_gain	0.9900
17:791532:AGGCT:A	acceptor_gain	0.9900
17:791533:GG:G	acceptor_gain	0.9900
17:791533:GGC:G	acceptor_gain	0.9900
17:791533:GGCTG:G	acceptor_gain	0.9900
17:782785:G:GG	donor_gain	0.9800
17:783326:GG:G	donor_gain	0.9800
17:783327:GG:G	donor_gain	0.9800
17:782609:G:GT	donor_gain	0.9700
17:782662:A:G	donor_gain	0.9700
17:783076:T:G	acceptor_gain	0.9700
17:783255:GTC:G	donor_gain	0.9700
17:787963:A:AG	acceptor_gain	0.9700

AlphaMissense

2739 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
17:791992:A:C	S396R	0.996
17:791994:C:A	S396R	0.996
17:791994:C:G	S396R	0.996
17:791548:T:A	W248R	0.994
17:791548:T:C	W248R	0.994
17:783327:G:A	G187R	0.993
17:783327:G:C	G187R	0.993
17:787965:G:A	G187E	0.993
17:788075:G:T	G224W	0.993
17:783169:C:A	A134D	0.992
17:783147:G:C	G127R	0.991
17:783168:G:C	A134P	0.991
17:783327:G:T	G187W	0.991
17:788045:T:C	C214R	0.991
17:788073:T:C	L223P	0.991
17:791842:T:A	W346R	0.991
17:791842:T:C	W346R	0.991
17:792004:T:C	F400L	0.991
17:792006:C:A	F400L	0.991
17:792006:C:G	F400L	0.991
17:783118:G:C	R117P	0.990
17:783207:A:C	S147R	0.990
17:783209:C:A	S147R	0.990
17:783209:C:G	S147R	0.990
17:791617:T:A	W271R	0.990
17:791617:T:C	W271R	0.990
17:791588:T:C	F261S	0.989
17:788075:G:A	G224R	0.988
17:788075:G:C	G224R	0.988
17:791976:C:A	N390K	0.988

dbSNP variants (sampled 300 via entrez): RS1000189619 (17:789463 G>T), RS1000192306 (17:786700 C>T), RS1000224066 (17:787468 G>T), RS1000291531 (17:792436 A>C,G), RS1000387183 (17:782045 T>G), RS1000635563 (17:780861 A>C), RS1000719775 (17:781078 G>T), RS1000855903 (17:786924 C>G), RS1000933558 (17:787840 C>T), RS1000936512 (17:781164 A>C,T), RS1000969347 (17:786381 C>T), RS1001047437 (17:792430 C>T), RS1001080305 (17:792129 G>A), RS1001467371 (17:785838 T>A), RS1001606920 (17:785430 T>C)

Disease associations

OMIM: gene MIM:612600 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST001942_3	Prostate cancer	5.000000e-15

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

32 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	increases expression, increases methylation	4
sodium arsenite	increases abundance, increases expression, decreases expression, affects cotreatment	2
Air Pollutants	affects expression, increases abundance, decreases expression	2
aristolochic acid I	increases expression	1
urushiol	decreases expression	1
trichostatin A	affects expression, decreases reaction	1
tobacco tar	increases expression	1
manganese chloride	affects cotreatment, increases abundance, increases expression	1
benzo(e)pyrene	decreases methylation	1
aflatoxin B2	decreases methylation	1
di-n-butylphosphoric acid	affects expression	1
cylindrospermopsin	increases expression	1
monomethylarsonous acid	decreases expression	1
abrine	decreases expression, increases expression	1
bisphenol S	increases expression	1
Temozolomide	increases expression	1
Arsenic	increases abundance, increases expression, affects cotreatment	1
Atrazine	decreases expression	1
Carbamazepine	affects expression	1
Enzyme Inhibitors	decreases activity, increases O-linked glycosylation	1
Manganese	increases expression, affects cotreatment, increases abundance	1
Methapyrilene	decreases methylation	1
Nickel	affects expression, decreases reaction	1
Ozone	affects expression, increases abundance	1
Ribonucleotides	affects binding	1
Smoke	decreases expression	1
Tobacco Smoke Pollution	increases expression	1
Vitamin E	increases expression	1
Cyclosporine	decreases expression	1
Aflatoxin B1	increases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.