MROCKI

Summary

MROCKI (MARCKS cis regulating lncRNA promoter of cytokines and inflammation, HGNC:50323) is a long non-coding RNA gene on chromosome 6q21.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:50323
Approved symbol	MROCKI
Name	MARCKS cis regulating lncRNA promoter of cytokines and inflammation
Location	6q21
Locus type	RNA, long non-coding
Status	Approved
Aliases	LOC285758, ROCKI
Ensembl gene	ENSG00000227502
Ensembl biotype	lncRNA
Entrez	285758
RNAcentral	URS000075A16D — lncRNA, 2764 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 12 — 12 lncRNA

ENST00000434296, ENST00000670411, ENST00000692726, ENST00000693460, ENST00000747029, ENST00000747030, ENST00000747031, ENST00000747032, ENST00000747033, ENST00000747034, ENST00000747035, ENST00000747036

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000434296 — 3 exons

Exon	Start	End
ENSE00001747346	113870669	113870734
ENSE00004088548	113868013	113870343
ENSE00004088555	113872994	113873380

Expression profiles

Bgee: expression breadth ubiquitous, 160 present calls, max score 78.06.

FANTOM5 (CAGE): breadth broad, TPM avg 1.0821 / max 69.0127, expressed in 282 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
75216	0.6435	226
75217	0.2491	123
75218	0.1895	98

Top tissues by expression

237 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	78.06	silver quality
bone marrow cell	CL:0002092	75.99	gold quality
right lobe of liver	UBERON:0001114	74.20	gold quality
mucosa of transverse colon	UBERON:0004991	72.93	gold quality
rectum	UBERON:0001052	71.86	gold quality
jejunal mucosa	UBERON:0000399	71.59	gold quality
duodenum	UBERON:0002114	68.98	gold quality
right lung	UBERON:0002167	68.79	gold quality
small intestine	UBERON:0002108	67.77	gold quality
small intestine Peyer’s patch	UBERON:0003454	67.69	gold quality
upper lobe of left lung	UBERON:0008952	67.41	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	66.63	gold quality
transverse colon	UBERON:0001157	66.42	gold quality
sural nerve	UBERON:0015488	66.42	silver quality
upper lobe of lung	UBERON:0008948	66.35	gold quality
bone marrow	UBERON:0002371	65.83	gold quality
calcaneal tendon	UBERON:0003701	65.75	gold quality
colonic epithelium	UBERON:0000397	65.69	silver quality
liver	UBERON:0002107	65.14	gold quality
spinal cord	UBERON:0002240	64.97	gold quality
tibial nerve	UBERON:0001323	63.98	gold quality
endocervix	UBERON:0000458	63.50	gold quality
intestine	UBERON:0000160	63.25	gold quality
hypothalamus	UBERON:0001898	63.13	gold quality
trabecular bone tissue	UBERON:0002483	62.75	silver quality
metanephros cortex	UBERON:0010533	62.60	gold quality
colon	UBERON:0001155	62.06	gold quality
large intestine	UBERON:0000059	61.72	gold quality
smooth muscle tissue	UBERON:0001135	61.70	gold quality
substantia nigra	UBERON:0002038	61.11	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.03

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• [Effect of Long Non-Coding RNA LINC01268 on the Malignant Biological Behaviors of Acute Myeloid Leukemia Cells]. (PMID:38071035)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.