MROH7

Summary

MROH7 (maestro heat like repeat family member 7, HGNC:24802) is a protein-coding gene on chromosome 1p32.3, encoding Maestro heat-like repeat-containing protein family member 7 (Q68CQ1).

Located in extracellular space.

Source: NCBI Gene 374977 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 228 total
• MANE Select transcript: NM_001039464

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:24802
Approved symbol	MROH7
Name	maestro heat like repeat family member 7
Location	1p32.3
Locus type	gene with protein product
Status	Approved
Aliases	FLJ46354
Ensembl gene	ENSG00000184313
Ensembl biotype	protein_coding
Entrez	374977

Gene structure

Transcript identifiers

Ensembl transcripts: 14 — 5 protein_coding, 5 nonsense_mediated_decay, 2 retained_intron, 2 protein_coding_CDS_not_defined

ENST00000339553, ENST00000371287, ENST00000395690, ENST00000409996, ENST00000413188, ENST00000421030, ENST00000422659, ENST00000438846, ENST00000440047, ENST00000440217, ENST00000472987, ENST00000478097, ENST00000493533, ENST00000857672

RefSeq mRNA: 2 — MANE Select: NM_001039464 NM_001039464, NM_001291332

CCDS: CCDS41342

Canonical transcript exons

ENST00000421030 — 24 exons

Exon	Start	End
ENSE00001893474	54709946	54710266
ENSE00001958219	54641786	54641968
ENSE00003474633	54678742	54678854
ENSE00003489561	54674016	54674151
ENSE00003532786	54700321	54700461
ENSE00003554239	54679891	54680045
ENSE00003567012	54692424	54692561
ENSE00003580866	54679263	54679439
ENSE00003595454	54695376	54695490
ENSE00003661714	54682656	54682794
ENSE00003685397	54686258	54686448
ENSE00003695030	54665167	54665240
ENSE00003697896	54652853	54654157
ENSE00003698194	54668854	54668937
ENSE00003698555	54709014	54709076
ENSE00003698675	54670497	54670576
ENSE00003698749	54702623	54702745
ENSE00003698791	54706435	54706537
ENSE00003699361	54673701	54673805
ENSE00003699515	54673091	54673186
ENSE00003699770	54702090	54702245
ENSE00003700525	54701143	54701322
ENSE00003701420	54651949	54651983
ENSE00003701579	54670800	54670929

Expression profiles

Bgee: expression breadth ubiquitous, 137 present calls, max score 96.09.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0157 / max 9.0217, expressed in 5 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
2958	0.0905	3
2960	0.0121	5
2957	0.0072	4
2959	0.0036	3

Top tissues by expression

152 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right testis	UBERON:0004534	96.09	gold quality
left testis	UBERON:0004533	95.99	gold quality
testis	UBERON:0000473	94.77	gold quality
pituitary gland	UBERON:0000007	88.96	gold quality
adenohypophysis	UBERON:0002196	87.70	gold quality
apex of heart	UBERON:0002098	87.45	gold quality
left lobe of thyroid gland	UBERON:0001120	86.44	gold quality
thyroid gland	UBERON:0002046	86.38	gold quality
right lobe of thyroid gland	UBERON:0001119	85.13	gold quality
lower esophagus muscularis layer	UBERON:0035833	81.95	gold quality
lower esophagus	UBERON:0013473	81.89	gold quality
heart left ventricle	UBERON:0002084	81.60	gold quality
right uterine tube	UBERON:0001302	81.18	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	81.06	gold quality
muscle layer of sigmoid colon	UBERON:0035805	80.70	gold quality
sigmoid colon	UBERON:0001159	80.66	gold quality
right atrium auricular region	UBERON:0006631	80.39	gold quality
hindlimb stylopod muscle	UBERON:0004252	80.07	gold quality
heart	UBERON:0000948	79.76	gold quality
left ovary	UBERON:0002119	79.59	gold quality
mucosa of transverse colon	UBERON:0004991	79.56	gold quality
right ovary	UBERON:0002118	79.36	gold quality
fundus of stomach	UBERON:0001160	79.26	gold quality
transverse colon	UBERON:0001157	78.99	gold quality
ovary	UBERON:0000992	78.56	gold quality
colon	UBERON:0001155	78.47	gold quality
caudate nucleus	UBERON:0001873	78.14	gold quality
ascending aorta	UBERON:0001496	77.70	gold quality
prostate gland	UBERON:0002367	77.56	gold quality
thoracic aorta	UBERON:0001515	77.51	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	3.67

Regulation

Is transcription factor: no

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Mroh7	ENSMUSG00000047502
rattus_norvegicus	Mroh7	ENSRNOG00000058870

Paralogs (8): MROH8 (ENSG00000101353), MROH9 (ENSG00000117501), MRO (ENSG00000134042), MROH2B (ENSG00000171495), MROH1 (ENSG00000179832), MROH2A (ENSG00000185038), MROH6 (ENSG00000204839), MROH5 (ENSG00000226807)

Protein

Protein identifiers

Maestro heat-like repeat-containing protein family member 7 — Q68CQ1 (reviewed: Q68CQ1)

Alternative names: HEAT repeat-containing protein 8

All UniProt accessions (5): B7ZBM2, F8W8P2, F8WE25, F8WFA2, Q68CQ1

UniProt curated annotations — full annotation on UniProt →

Subcellular location. Membrane.

Miscellaneous. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.

Isoforms (6)

UniProt ID	Names	Canonical?
Q68CQ1-7	1	yes
Q68CQ1-2	2
Q68CQ1-8	3
Q68CQ1-4	4
Q68CQ1-9	5
Q68CQ1-1	6

RefSeq proteins (2): NP_001034553, NP_001278261 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR011989	ARM-like	Homologous_superfamily
IPR016024	ARM-type_fold	Homologous_superfamily
IPR045206	Maestro_heat-like_prot	Family
IPR048465	Maestro-like_HEAT	Domain
IPR055406	HEAT_Maestro	Domain
IPR055408	HEAT_MROH2B-like	Domain

Pfam: PF21047, PF23210, PF23227

UniProt features (37 total): splice variant 10, sequence variant 10, repeat 4, glycosylation site 3, sequence conflict 3, region of interest 3, transmembrane region 2, chain 1, compositionally biased region 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q68CQ1-F1	66.69	0.33

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Glycosylation sites (3): 318, 438, 586

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 40 (showing top): GGTGTGT_MIR329, TGACCTY_ERR1_Q2, GNF2_CCNA1, ATCATGA_MIR433, GGTGAAG_MIR412, MULLIGHAN_MLL_SIGNATURE_2_DN, LEIN_CHOROID_PLEXUS_MARKERS, ER_Q6_02, MULLIGHAN_MLL_SIGNATURE_1_DN, ER_Q6_01, ZWANG_EGF_INTERVAL_UP, JAK2_DN.V1_DN, NFKBIA_TARGET_GENES, SRPK2_TARGET_GENES, ZNF22_TARGET_GENES

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (3): obsolete extracellular space (GO:0005615), cytoplasm (GO:0005737), membrane (GO:0016020)

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cellular anatomical structure	2
intracellular anatomical structure	1

Protein interactions and networks

STRING

330 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
MROH7	CDCP2	Q5VXM1	541
MROH7	WDR27	A2RRH5	457
MROH7	SMIM21	Q3B7S5	447
MROH7	LDLRAD1	Q5T700	434
MROH7	HEATR4	Q86WZ0	433
MROH7	MROH2B	Q7Z745	429
MROH7	TMEM178B	H3BS89	416
MROH7	ARRDC2	Q8TBH0	414
MROH7	TTC4	O95801	408
MROH7	RSPH14	Q9UHP6	405
MROH7	TANGO6	Q9C0B7	397
MROH7	REXO2	Q9Y3B8	396
MROH7	A8MUN0	A8MUN0	394
MROH7	SLC35F6	Q8N357	379
MROH7	CAPN7	Q9Y6W3	375

IntAct

0 interactions, top by confidence:

BioGRID (5): MROH7 (Affinity Capture-MS), MROH7 (Affinity Capture-MS), MROH7 (Affinity Capture-MS), MROH7 (Cross-Linking-MS (XL-MS)), MROH7 (Protein-peptide)

ESM2 similar proteins: A1A5P9, A2AVR2, A6QPT6, B2KFW1, O14978, P17029, P17040, P17098, P25233, P70503, Q13342, Q14D33, Q3SYK4, Q3V3Q4, Q4KLI1, Q4R8H9, Q4V8E9, Q5PPP4, Q5R670, Q5R7U0, Q5VWK0, Q61066, Q63HK3, Q68CQ1, Q6PCZ4, Q7TS72, Q80ZG2, Q8BGS3, Q8CF60, Q8IWY8, Q8N660, Q8NDZ0, Q8TD17, Q921B4, Q923B3, Q96D09, Q96GC6, Q96JL9, Q96M43, Q99608

Diamond homologs: A2AVR2, A2RUW0, Q68CQ1, A6NGR9, A7E2Y6

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

228 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	206
Likely benign	21
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

5606 predictions. Top by Δscore:

Variant	Effect	Δscore
1:54670572:C:G	donor_gain	1.0000
1:54670786:T:A	acceptor_gain	1.0000
1:54670786:T:TA	acceptor_gain	1.0000
1:54670798:A:AG	acceptor_gain	1.0000
1:54670799:G:GA	acceptor_gain	1.0000
1:54670799:G:GG	acceptor_gain	1.0000
1:54670799:GC:G	acceptor_gain	1.0000
1:54670799:GCC:G	acceptor_gain	1.0000
1:54670799:GCCA:G	acceptor_gain	1.0000
1:54670799:GCCAC:G	acceptor_gain	1.0000
1:54670926:CCAG:C	donor_loss	1.0000
1:54670926:CCAGG:C	donor_loss	1.0000
1:54670927:CAGGT:C	donor_loss	1.0000
1:54670930:GTGAG:G	donor_loss	1.0000
1:54670931:T:A	donor_loss	1.0000
1:54678738:GCAGG:G	acceptor_loss	1.0000
1:54678739:CA:C	acceptor_loss	1.0000
1:54678740:A:AG	acceptor_gain	1.0000
1:54678741:G:GG	acceptor_gain	1.0000
1:54678741:G:GT	acceptor_loss	1.0000
1:54678741:GGA:G	acceptor_gain	1.0000
1:54679257:TTTCA:T	acceptor_loss	1.0000
1:54679259:TCA:T	acceptor_loss	1.0000
1:54679260:CA:C	acceptor_loss	1.0000
1:54679260:CAG:C	acceptor_loss	1.0000
1:54679261:AG:A	acceptor_gain	1.0000
1:54679262:G:A	acceptor_loss	1.0000
1:54679262:GG:G	acceptor_gain	1.0000
1:54679262:GGA:G	acceptor_gain	1.0000
1:54679405:TGCTG:T	donor_gain	1.0000

AlphaMissense

8651 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:54682672:T:A	W800R	0.998
1:54682672:T:C	W800R	0.998
1:54692506:T:A	W932R	0.996
1:54692506:T:C	W932R	0.996
1:54700322:T:C	L989P	0.996
1:54682674:G:C	W800C	0.995
1:54682674:G:T	W800C	0.995
1:54692508:G:C	W932C	0.995
1:54692508:G:T	W932C	0.995
1:54695426:T:C	L967P	0.995
1:54686331:T:C	L865P	0.994
1:54692542:G:A	G944R	0.994
1:54692542:G:C	G944R	0.994
1:54695377:G:C	A951P	0.994
1:54695477:C:A	A984D	0.994
1:54692543:G:A	G944E	0.993
1:54692558:C:A	A949E	0.993
1:54695468:C:A	T981K	0.993
1:54695471:C:A	A982D	0.993
1:54700430:G:A	G1025D	0.993
1:54682673:G:C	W800S	0.992
1:54686334:T:C	L866P	0.992
1:54692450:T:C	L913P	0.992
1:54695470:G:C	A982P	0.992
1:54700360:T:C	Y1002H	0.992
1:54700429:G:C	G1025R	0.992
1:54686321:T:G	Y862D	0.991
1:54700349:T:C	I998T	0.991
1:54686262:C:A	A842D	0.990
1:54686268:G:A	G844D	0.990

dbSNP variants (sampled 300 via entrez): RS1000000936 (1:54657579 G>A), RS1000011373 (1:54708862 C>G,T), RS1000074963 (1:54654612 A>G), RS1000110360 (1:54703185 C>A), RS1000240504 (1:54679737 C>T), RS1000263189 (1:54710571 G>A), RS1000312737 (1:54645530 C>G), RS1000321661 (1:54689830 C>T), RS1000350964 (1:54685495 C>T), RS1000366590 (1:54645279 T>G), RS1000423852 (1:54691891 C>T), RS1000566167 (1:54700983 G>A), RS1000584967 (1:54662167 C>A), RS1000615167 (1:54707427 T>C), RS1000621425 (1:54643636 CAG>C)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST003833_20	Adult asthma	9.000000e-07
GCST003833_9	Adult asthma	2.000000e-06

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

17 total (human), top 17 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
terbufos	increases methylation	1
benzo(e)pyrene	increases methylation	1
(+)-JQ1 compound	increases expression	1
Resveratrol	affects cotreatment, decreases expression	1
Sunitinib	increases expression	1
Benzo(a)pyrene	affects methylation	1
Fonofos	increases methylation	1
Formaldehyde	decreases expression	1
Methapyrilene	increases methylation	1
Oxygen	increases expression	1
Parathion	increases methylation	1
Plant Extracts	affects cotreatment, decreases expression	1
Silicon Dioxide	decreases expression	1
Tobacco Smoke Pollution	decreases expression	1
Triclosan	decreases expression	1
Aflatoxin B1	decreases methylation	1
S-Nitrosoglutathione	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.