MROH9

Summary

MROH9 (maestro heat like repeat family member 9, HGNC:26287) is a protein-coding gene on chromosome 1q24.3, encoding Maestro heat-like repeat-containing protein family member 9 (Q5TGP6).

At a glance

• GWAS associations: 23
• Clinical variants (ClinVar): 90 total
• MANE Select transcript: NM_001163629

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:26287
Approved symbol	MROH9
Name	maestro heat like repeat family member 9
Location	1q24.3
Locus type	gene with protein product
Status	Approved
Aliases	FLJ23550, ARMC11
Ensembl gene	ENSG00000117501
Ensembl biotype	protein_coding
Entrez	80133

Gene structure

Transcript identifiers

Ensembl transcripts: 4 — 4 protein_coding

ENST00000367758, ENST00000367759, ENST00000426136, ENST00000864982

RefSeq mRNA: 2 — MANE Select: NM_001163629 NM_001163629, NM_025063

CCDS: CCDS41436, CCDS53429

Canonical transcript exons

ENST00000367759 — 22 exons

Exon	Start	End
ENSE00000814534	170996507	170996644
ENSE00001334212	170995389	170995531
ENSE00001445565	171014117	171014254
ENSE00001445566	170998154	170998274
ENSE00001628945	170945520	170945581
ENSE00001794090	170947527	170947573
ENSE00002209730	171024649	171024765
ENSE00002216322	170983422	170983534
ENSE00002218330	171024395	171024547
ENSE00002232985	171062132	171062194
ENSE00002234756	170965151	170965255
ENSE00002247407	170971748	170971883
ENSE00002247438	170986561	170986710
ENSE00002255155	171025318	171025420
ENSE00002270042	170989855	170990003
ENSE00002276155	170935534	170935587
ENSE00002276931	170961890	170961976
ENSE00002283655	171016163	171016336
ENSE00002284058	171064099	171064765
ENSE00002290450	170992164	170992329
ENSE00002305622	170959462	170959597
ENSE00002316232	170958461	170958540

Expression profiles

Bgee: expression breadth broad, 48 present calls, max score 79.70.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.0045 / max 6.5644, expressed in 1 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
6586	0.0045	1

Top tissues by expression

251 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	79.70	silver quality
olfactory segment of nasal mucosa	UBERON:0005386	73.39	gold quality
right uterine tube	UBERON:0001302	69.74	gold quality
bronchial epithelial cell	CL:0002328	68.08	gold quality
epithelium of bronchus	UBERON:0002031	65.30	gold quality
bronchus	UBERON:0002185	64.41	gold quality
mucosa of paranasal sinus	UBERON:0005030	57.56	gold quality
right lung	UBERON:0002167	56.60	gold quality
nasal cavity mucosa	UBERON:0001826	56.03	gold quality
lower lobe of lung	UBERON:0008949	55.39	silver quality
bone marrow cell	CL:0002092	54.50	gold quality
fallopian tube	UBERON:0003889	53.75	gold quality
pancreatic ductal cell	CL:0002079	52.17	silver quality
left testis	UBERON:0004533	51.24	gold quality
testis	UBERON:0000473	50.84	gold quality
cranial nerve II	UBERON:0000941	50.14	silver quality
right testis	UBERON:0004534	50.12	gold quality
epithelial cell of pancreas	CL:0000083	49.84	gold quality
Brodmann (1909) area 46	UBERON:0006483	49.30	gold quality
blood vessel layer	UBERON:0004797	49.29	gold quality
cervix squamous epithelium	UBERON:0006922	49.20	gold quality
hair follicle	UBERON:0002073	49.18	gold quality
endometrium	UBERON:0001295	49.12	gold quality
olfactory bulb	UBERON:0002264	48.92	gold quality
choroid plexus epithelium	UBERON:0003911	48.89	gold quality
myocardium	UBERON:0002349	48.87	gold quality
type B pancreatic cell	CL:0000169	48.83	gold quality
quadriceps femoris	UBERON:0001377	48.81	gold quality
cardiac muscle of right atrium	UBERON:0003379	48.55	gold quality
CA1 field of hippocampus	UBERON:0003881	48.50	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.16

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

27 targeting MROH9, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-30A-5P	100.00	76.31	3233
HSA-MIR-30B-5P	100.00	76.29	3248
HSA-MIR-30C-5P	100.00	76.29	3248
HSA-MIR-30D-5P	100.00	76.32	3233
HSA-MIR-30E-5P	100.00	76.32	3242
HSA-LET-7A-3P	100.00	74.03	3932
HSA-LET-7B-3P	100.00	74.08	3913
HSA-LET-7F-1-3P	100.00	74.02	3928
HSA-MIR-98-3P	100.00	74.08	3907
HSA-MIR-520D-5P	99.98	73.34	4883
HSA-MIR-524-5P	99.98	73.43	4882
HSA-MIR-7152-3P	99.97	67.47	849
HSA-LET-7C-3P	99.95	73.42	2862
HSA-MIR-1236-3P	99.94	68.04	1695
HSA-MIR-4731-5P	99.89	67.23	2537
HSA-MIR-629-3P	99.85	67.99	1875
HSA-MIR-10393-3P	99.72	66.56	961
HSA-MIR-6801-5P	99.72	66.50	981
HSA-MIR-302B-5P	99.50	69.49	1857
HSA-MIR-302D-5P	99.50	69.34	1863
HSA-MIR-183-5P	99.31	72.27	1164
HSA-MIR-3973	99.20	69.19	1990
HSA-MIR-1228-3P	99.00	66.53	857
HSA-MIR-942-3P	98.81	69.04	876
HSA-MIR-6867-3P	98.12	66.07	1305
HSA-MIR-4469	97.93	65.81	1319
HSA-MIR-4667-5P	97.61	66.67	1683

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Mroh9	ENSMUSG00000071890
rattus_norvegicus	Mroh9	ENSRNOG00000003698

Paralogs (8): MROH8 (ENSG00000101353), MRO (ENSG00000134042), MROH2B (ENSG00000171495), MROH1 (ENSG00000179832), MROH7 (ENSG00000184313), MROH2A (ENSG00000185038), MROH6 (ENSG00000204839), MROH5 (ENSG00000226807)

Protein

Protein identifiers

Maestro heat-like repeat-containing protein family member 9 — Q5TGP6 (reviewed: Q5TGP6)

All UniProt accessions (2): H0Y687, Q5TGP6

Isoforms (2)

UniProt ID	Names	Canonical?
Q5TGP6-1	1	yes
Q5TGP6-2	2

RefSeq proteins (2): NP_001157101, NP_079339 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR016024	ARM-type_fold	Homologous_superfamily
IPR045206	Maestro_heat-like_prot	Family
IPR048465	Maestro-like_HEAT	Domain

Pfam: PF21047

UniProt features (11 total): repeat 5, sequence variant 3, chain 1, sequence conflict 1, splice variant 1

Structure

Experimental structures (PDB)

0 structures.

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q5TGP6-F1	76.95	0.34

Function

Pathways and Gene Ontology

Reactome pathways

0 pathways

MSigDB gene sets: 37 (showing top): DODD_NASOPHARYNGEAL_CARCINOMA_DN, HMGA1_TARGET_GENES, MIR30B_5P_MIR30C_5P, MIR30D_5P, MIR30E_5P, MIR30A_5P, MIR4778_3P, MIR3123, MIR6797_5P, MIR1249_5P, MIR873_5P, MIR5585_3P, MIR4460, MIR140_5P, GSE13229_IMM_VS_MATURE_NKCELL_UP

GO Biological Process (0):

GO Molecular Function (0):

GO Cellular Component (0):

Protein interactions and networks

STRING

326 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
MROH9	MROH2A	A6NES4	600
MROH9	FAM217A	Q8IXS0	512
MROH9	OR6M1	Q8NGM8	507
MROH9	OR8H3	Q8N146	479
MROH9	RSPH10B2	B2RC85	447
MROH9	OR9G1	Q8NH87	444
MROH9	MROH2B	Q7Z745	415
MROH9	RSPH10B	P0C881	404
MROH9	POPDC3	Q9HBV1	403
MROH9	ANKRD29	Q8N6D5	401
MROH9	CCDC81	Q6ZN84	398
MROH9	MFSD6L	Q8IWD5	396
MROH9	MIPOL1	Q8TD10	391
MROH9	ARMC12	Q5T9G4	377
MROH9	TMPRSS12	Q86WS5	377

IntAct

2 interactions, top by confidence:

A	B	Type	Score
GLO1	MROH9	psi-mi:“MI:0915”(physical association)	0.400

BioGRID (3): MROH9 (Affinity Capture-MS), MROH9 (Affinity Capture-MS), MROH9 (Affinity Capture-MS)

ESM2 similar proteins: A0A0M3U1B0, A1A5Q6, A2AFS9, A2AVR2, A2CI98, A2CJ06, A2RTY3, A2RUW0, O70167, O70173, P0C2Y1, P15304, P59729, Q08EC4, Q3SYK4, Q3TYG6, Q3U1D0, Q4R744, Q4R9E9, Q5R4B2, Q5T4T6, Q5TGP6, Q5VWK0, Q68CQ1, Q6AYJ3, Q6IFT4, Q6IRU7, Q6REY9, Q6ZUA9, Q7Z572, Q80VH0, Q86WZ0, Q86XG9, Q8C0X8, Q8CCC3, Q8ND61, Q8NDZ2, Q8TB24, Q96M43, Q96QP1

SIGNOR signaling

0 interactions.

Disease & clinical

Clinical variants and AI predictions

ClinVar

90 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	71
Likely benign	13
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

2435 predictions. Top by Δscore:

Variant	Effect	Δscore
1:170958447:A:AG	acceptor_gain	1.0000
1:170958447:AACAT:A	acceptor_gain	1.0000
1:170958448:A:G	acceptor_gain	1.0000
1:170958448:ACAT:A	acceptor_gain	1.0000
1:170958450:AT:A	acceptor_gain	1.0000
1:170958451:T:G	acceptor_gain	1.0000
1:170958451:T:TA	acceptor_gain	1.0000
1:170959460:A:AG	acceptor_gain	1.0000
1:170959460:AG:A	acceptor_loss	1.0000
1:170959461:G:GG	acceptor_gain	1.0000
1:170959461:GC:G	acceptor_gain	1.0000
1:170959461:GCTTT:G	acceptor_gain	1.0000
1:170959595:G:GT	donor_gain	1.0000
1:170961985:GAAA:G	donor_gain	1.0000
1:170961988:A:G	donor_gain	1.0000
1:170971747:GATAA:G	acceptor_gain	1.0000
1:170989999:GACGA:G	donor_gain	1.0000
1:170990002:GA:G	donor_gain	1.0000
1:170990004:G:GG	donor_gain	1.0000
1:170992282:G:GT	donor_gain	1.0000
1:170992287:G:T	donor_gain	1.0000
1:170992341:GA:G	donor_gain	1.0000
1:170995498:G:GG	donor_gain	1.0000
1:170995527:GCTTT:G	donor_gain	1.0000
1:170995532:G:GG	donor_gain	1.0000
1:170996640:GC:G	donor_gain	1.0000
1:170996640:GCTAA:G	donor_gain	1.0000
1:170996641:C:CG	donor_gain	1.0000
1:170996641:C:G	donor_gain	1.0000
1:170996645:G:GG	donor_gain	1.0000

AlphaMissense

5716 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:170992180:T:A	W349R	0.988
1:170992180:T:C	W349R	0.988
1:170995462:T:C	L423P	0.978
1:170995452:T:C	F420L	0.969
1:170995454:C:A	F420L	0.969
1:170995454:C:G	F420L	0.969
1:170998173:T:C	F499L	0.969
1:170998175:T:A	F499L	0.969
1:170998175:T:G	F499L	0.969
1:170992182:G:C	W349C	0.967
1:170992182:G:T	W349C	0.967
1:170996641:C:A	A491D	0.967
1:170992244:T:C	L370P	0.965
1:170996551:T:C	L461P	0.963
1:170989969:T:C	F332L	0.962
1:170989971:T:A	F332L	0.962
1:170989971:T:G	F332L	0.962
1:170971791:T:C	L175P	0.960
1:170989976:T:C	L334P	0.960
1:170995474:T:C	L427P	0.959
1:170996533:T:C	L455P	0.955
1:170971772:G:C	G169R	0.953
1:170986600:T:C	F257L	0.953
1:170986602:T:A	F257L	0.953
1:170986602:T:G	F257L	0.953
1:170995390:C:A	A399E	0.953
1:170995453:T:C	F420S	0.953
1:170995465:T:C	L424S	0.953
1:170996536:T:C	L456P	0.951
1:170971784:G:C	A173P	0.950

dbSNP variants (sampled 300 via entrez): RS1000044245 (1:171054289 C>T), RS1000053600 (1:171005916 T>C), RS1000105914 (1:171017009 T>G), RS1000121490 (1:171002202 C>T), RS1000194456 (1:171063991 T>C,G), RS1000226289 (1:170989084 A>G), RS1000236354 (1:171008609 A>C), RS1000241693 (1:171041469 C>T), RS1000251141 (1:170967758 T>C), RS1000338236 (1:170996436 G>T), RS1000362462 (1:171014294 T>A,C), RS1000369166 (1:171054724 T>C), RS1000379877 (1:171060454 A>G), RS1000415430 (1:171042302 T>C), RS1000448246 (1:171019567 C>G,T)

Disease associations

OMIM: gene `` | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

23 associations (top):

Study	Trait	p-value
GCST005580_163	Intraocular pressure	1.000000e-08
GCST005580_267	Intraocular pressure	4.000000e-10
GCST010002_370	Refractive error	3.000000e-11
GCST011011_3	Youthful appearance (self-reported)	3.000000e-08
GCST012020_36	Serum metabolite levels	2.000000e-15
GCST012094_6	Major depressive disorder and major depressive episode treated with electroconvulsive therapy	4.000000e-06
GCST012095_6	Major depressive episode treated with electroconvulsive therapy	5.000000e-07
GCST012226_589	Waist circumference adjusted for body mass index	1.000000e-09
GCST012226_590	Waist circumference adjusted for body mass index	6.000000e-11
GCST012231_159	A body shape index	2.000000e-08
GCST90011866_7	Systemic lupus erythematosus	7.000000e-08
GCST90020026_644	Hip index	2.000000e-13
GCST90020026_648	Hip index	2.000000e-12
GCST90020026_650	Hip index	5.000000e-09
GCST90020026_651	Hip index	1.000000e-08
GCST90020028_225	Hip circumference adjusted for BMI	7.000000e-10
GCST90020028_252	Hip circumference adjusted for BMI	4.000000e-13
GCST90020028_253	Hip circumference adjusted for BMI	8.000000e-14
GCST90020028_254	Hip circumference adjusted for BMI	2.000000e-08
GCST90020028_255	Hip circumference adjusted for BMI	1.000000e-09
GCST90020028_256	Hip circumference adjusted for BMI	8.000000e-10
GCST90020028_257	Hip circumference adjusted for BMI	5.000000e-09
GCST90020029_1098	Waist circumference adjusted for body mass index	3.000000e-08

EFO canonical traits (4, from GWAS)

EFO ID	Trait name
EFO:0004695	intraocular pressure measurement
EFO:0007634	major depressive episode
EFO:0007789	BMI-adjusted waist circumference
EFO:0008039	BMI-adjusted hip circumference

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

8 total (human), top 8 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	affects methylation, increases expression	2
bisphenol A	affects cotreatment, decreases methylation	1
S-(1,2-dichlorovinyl)cysteine	affects cotreatment, increases expression	1
Fulvestrant	affects cotreatment, decreases methylation	1
Acetaminophen	decreases expression	1
Cadmium	decreases expression	1
Lipopolysaccharides	affects cotreatment, increases expression	1
Tobacco Smoke Pollution	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.