MRPL10

Summary

MRPL10 (mitochondrial ribosomal protein L10, HGNC:14055) is a protein-coding gene on chromosome 17q21.32, encoding Large ribosomal subunit protein uL10m (Q7Z7H8). It is a common-essential gene (DepMap: required in 92.9% of cancer cell lines).

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Sequence analysis identified three transcript variants that encode two different isoforms. A pseudogene corresponding to this gene is found on chromosome 5q.

Source: NCBI Gene 124995 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• Clinical variants (ClinVar): 47 total
• Cancer dependency (DepMap): dependent in 92.9% of screened cell lines (common-essential)
• MANE Select transcript: NM_145255

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:14055
Approved symbol	MRPL10
Name	mitochondrial ribosomal protein L10
Location	17q21.32
Locus type	gene with protein product
Status	Approved
Aliases	RPML8, MRP-L8, L10MT, MRP-L10, MRPL8, MGC17973, uL10m
Ensembl gene	ENSG00000159111
Ensembl biotype	protein_coding
OMIM	611825
Entrez	124995

Gene structure

Transcript identifiers

Ensembl transcripts: 9 — 5 protein_coding, 2 nonsense_mediated_decay, 2 retained_intron

ENST00000290208, ENST00000351111, ENST00000414011, ENST00000421763, ENST00000423147, ENST00000466016, ENST00000480901, ENST00000928398, ENST00000959995

RefSeq mRNA: 2 — MANE Select: NM_145255 NM_145255, NM_148887

CCDS: CCDS11516, CCDS11517

Canonical transcript exons

ENST00000351111 — 5 exons

Exon	Start	End
ENSE00001349129	47823272	47824458
ENSE00001926566	47831460	47831541
ENSE00003458817	47828501	47828670
ENSE00003464328	47827040	47827204
ENSE00003549461	47826637	47826781

Expression profiles

Bgee: expression breadth ubiquitous, 253 present calls, max score 95.54.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 64.1604 / max 286.7567, expressed in 1822 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
166610	64.1080	1822
166609	0.0524	18

Top tissues by expression

260 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
apex of heart	UBERON:0002098	95.54	gold quality
heart left ventricle	UBERON:0002084	94.55	gold quality
hindlimb stylopod muscle	UBERON:0004252	94.55	gold quality
cardiac ventricle	UBERON:0002082	94.44	gold quality
left ventricle myocardium	UBERON:0006566	94.42	gold quality
gastrocnemius	UBERON:0001388	94.20	gold quality
muscle of leg	UBERON:0001383	93.86	gold quality
cardiac muscle of right atrium	UBERON:0003379	93.78	gold quality
deltoid	UBERON:0001476	93.64	gold quality
lower esophagus muscularis layer	UBERON:0035833	93.63	gold quality
lower esophagus	UBERON:0013473	93.62	gold quality
skeletal muscle organ	UBERON:0014892	93.52	gold quality
heart	UBERON:0000948	93.42	gold quality
tibialis anterior	UBERON:0001385	93.37	silver quality
muscle layer of sigmoid colon	UBERON:0035805	93.28	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	93.20	gold quality
granulocyte	CL:0000094	93.15	gold quality
popliteal artery	UBERON:0002250	93.15	gold quality
mucosa of stomach	UBERON:0001199	93.14	gold quality
right atrium auricular region	UBERON:0006631	93.14	gold quality
tibial artery	UBERON:0007610	93.14	gold quality
cardiac atrium	UBERON:0002081	93.11	gold quality
quadriceps femoris	UBERON:0001377	93.04	gold quality
myocardium	UBERON:0002349	92.82	gold quality
vastus lateralis	UBERON:0001379	92.80	gold quality
mucosa of transverse colon	UBERON:0004991	92.55	gold quality
left ovary	UBERON:0002119	92.54	gold quality
adult organism	UBERON:0007023	92.48	gold quality
body of stomach	UBERON:0001161	92.46	gold quality
body of pancreas	UBERON:0001150	92.42	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	6.09
E-GEOD-106540	no	792.57

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

47 targeting MRPL10, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4425	100.00	67.59	1049
HSA-MIR-4476	100.00	68.18	2030
HSA-MIR-6876-5P	100.00	67.68	2126
HSA-MIR-34A-5P	99.99	71.21	1784
HSA-MIR-449A	99.99	71.05	1776
HSA-MIR-4531	99.99	69.70	3181
HSA-MIR-34C-5P	99.97	70.45	1577
HSA-MIR-449B-5P	99.97	70.26	1580
HSA-MIR-4668-5P	99.79	70.58	3782
HSA-MIR-4306	99.72	70.50	3630
HSA-MIR-3202	99.66	67.70	2737
HSA-MIR-497-3P	99.61	69.71	1990
HSA-MIR-4516	99.61	67.78	3390
HSA-MIR-4437	99.52	65.29	1266
HSA-MIR-3915	99.45	68.49	1905
HSA-MIR-185-5P	99.35	68.60	2497
HSA-MIR-4644	99.35	69.12	2514
HSA-MIR-6797-3P	99.17	66.94	668
HSA-MIR-4254	99.11	65.15	1315
HSA-MIR-3619-5P	99.00	68.87	2308
HSA-MIR-384	98.71	67.34	1229
HSA-MIR-214-3P	98.71	68.12	2128
HSA-MIR-761	98.71	68.07	2051
HSA-MIR-6728-3P	98.63	67.63	1534
HSA-MIR-6076	98.61	65.69	637
HSA-MIR-210-5P	98.57	64.37	832
HSA-MIR-6882-3P	98.23	67.01	1119
HSA-MIR-6834-3P	98.16	65.77	551
HSA-MIR-4769-3P	97.95	68.17	1002
HSA-MIR-6817-5P	97.95	67.86	1026

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 92.9% of screened cell lines, common-essential.

Literature-anchored findings (GeneRIF, showing 1)

• Analyzes the RNA binding properties of orthologous bovine 39S ribosomal subunit proteins, including MRPL10. (PMID:3129699)

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	mrpl10	ENSDARG00000045091
mus_musculus	Mrpl10	ENSMUSG00000001445
rattus_norvegicus	Mrpl10	ENSRNOG00000009567

Protein

Protein identifiers

Large ribosomal subunit protein uL10m — Q7Z7H8 (reviewed: Q7Z7H8)

Alternative names: 39S ribosomal protein L10, mitochondrial, 39S ribosomal protein L8, mitochondrial

All UniProt accessions (2): Q7Z7H8, F2Z2K7

UniProt curated annotations — full annotation on UniProt →

Subunit / interactions. Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins. uL10m contributes a single cysteine residue to a zinc-binding site with mL66.

Subcellular location. Mitochondrion.

Similarity. Belongs to the universal ribosomal protein uL10 family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q7Z7H8-1	1	yes
Q7Z7H8-2	2

RefSeq proteins (2): NP_660298, NP_683685 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001790	Ribosomal_uL10_N	Domain
IPR043141	Ribosomal_uL10-like_sf	Homologous_superfamily
IPR047865	Ribosomal_uL10_bact_orga	Family

Pfam: PF00466

UniProt features (23 total): strand 7, helix 7, turn 3, sequence variant 2, transit peptide 1, chain 1, region of interest 1, splice variant 1

Structure

Experimental structures (PDB)

84 structures, top 30 by resolution.

PDB	Method	Resolution (Å)
7OF0	ELECTRON MICROSCOPY	2.2
7QI4	ELECTRON MICROSCOPY	2.21
8QU5	ELECTRON MICROSCOPY	2.42
9OLF	ELECTRON MICROSCOPY	2.46
7OF7	ELECTRON MICROSCOPY	2.5
7PO4	ELECTRON MICROSCOPY	2.56
6ZM6	ELECTRON MICROSCOPY	2.59
7O9M	ELECTRON MICROSCOPY	2.6
7OF6	ELECTRON MICROSCOPY	2.6
9CN3	ELECTRON MICROSCOPY	2.62
7QI5	ELECTRON MICROSCOPY	2.63
7OF2	ELECTRON MICROSCOPY	2.7
7OF3	ELECTRON MICROSCOPY	2.7
7OF4	ELECTRON MICROSCOPY	2.7
8QU1	ELECTRON MICROSCOPY	2.74
9PR4	ELECTRON MICROSCOPY	2.77
9PRA	ELECTRON MICROSCOPY	2.83
8ANY	ELECTRON MICROSCOPY	2.85
6ZM5	ELECTRON MICROSCOPY	2.89
7QH7	ELECTRON MICROSCOPY	2.89
7ODR	ELECTRON MICROSCOPY	2.9
7OF5	ELECTRON MICROSCOPY	2.9
8K2A	ELECTRON MICROSCOPY	2.9
8OIT	ELECTRON MICROSCOPY	2.9
9PGL	ELECTRON MICROSCOPY	2.9
9PGF	ELECTRON MICROSCOPY	2.93
6VMI	ELECTRON MICROSCOPY	2.96
6VLZ	ELECTRON MICROSCOPY	2.97
7QI6	ELECTRON MICROSCOPY	2.98
9PSM	ELECTRON MICROSCOPY	2.98

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q7Z7H8-F1	83.63	0.50

Function

Pathways and Gene Ontology

Reactome pathways

7 pathways

ID	Pathway
R-HSA-5368286	Mitochondrial translation initiation
R-HSA-5389840	Mitochondrial translation elongation
R-HSA-5419276	Mitochondrial translation termination
R-HSA-9937383	Mitochondrial ribosome-associated quality control
R-HSA-392499	Metabolism of proteins
R-HSA-5368287	Mitochondrial translation
R-HSA-72766	Translation

MSigDB gene sets: 85 (showing top): GOBP_MITOCHONDRIAL_TRANSLATION, GOBP_TRANSLATION, GOMF_STRUCTURAL_CONSTITUENT_OF_RIBOSOME, GOCC_MITOCHONDRIAL_ENVELOPE, CYTAGCAAY_UNKNOWN, NAKAMURA_TUMOR_ZONE_PERIPHERAL_VS_CENTRAL_DN, GCM_NF2, GOCC_LARGE_RIBOSOMAL_SUBUNIT, GOCC_RIBOSOME, GOCC_ORGANELLAR_RIBOSOME, GOCC_MITOCHONDRIAL_MATRIX, GOCC_ORGANELLE_INNER_MEMBRANE, RFX1_01, GOCC_RIBOSOMAL_SUBUNIT, GOCC_RIBONUCLEOPROTEIN_COMPLEX

GO Biological Process (2): translation (GO:0006412), mitochondrial translation (GO:0032543)

GO Molecular Function (3): RNA binding (GO:0003723), structural constituent of ribosome (GO:0003735), protein binding (GO:0005515)

GO Cellular Component (6): nucleoplasm (GO:0005654), mitochondrion (GO:0005739), mitochondrial inner membrane (GO:0005743), mitochondrial large ribosomal subunit (GO:0005762), ribonucleoprotein complex (GO:1990904), ribosome (GO:0005840)

Reactome top-level categories

Rollup of top-3 pathways:

Category	Pathways
Mitochondrial translation	4
Translation	1
Metabolism of proteins	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
peptidyltransferase activity	1
translational initiation	1
translational elongation	1
translational termination	1
macromolecule biosynthetic process	1
protein metabolic process	1
protein biosynthetic process	1
mitochondrion	1
translation	1
mitochondrial gene expression	1
nucleic acid binding	1
structural molecule activity	1
ribosome	1
binding	1
nuclear lumen	1
cellular anatomical structure	1
cytoplasm	1
intracellular membrane-bounded organelle	1
organelle inner membrane	1
mitochondrial membrane	1
organellar large ribosomal subunit	1
mitochondrial ribosome	1
mitochondrial protein-containing complex	1
protein-containing complex	1
intracellular membraneless organelle	1

Protein interactions and networks

STRING

1506 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
MRPL10	MRPL11	Q9Y3B7	601
MRPL10	UBXN11	Q5T124	573
MRPL10	MRPL38	Q96DV4	566
MRPL10	MRPS27	Q92552	559
MRPL10	MRPL12	P52815	554
MRPL10	ANKRD27	Q96NW4	545
MRPL10	MRPS21	P82921	510
MRPL10	SIRT3	Q9NTG7	479
MRPL10	ACSS1	Q9NUB1	476
MRPL10	MRPL45	Q9BRJ2	449
MRPL10	NDUFA9	Q16795	439
MRPL10	MRPL13	Q9BYD1	438
MRPL10	ANKRD49	Q8WVL7	417
MRPL10	MRPL21	Q7Z2W9	409
MRPL10	DAP3	P51398	404

IntAct

122 interactions, top by confidence:

A	B	Type	Score
CFTR	ESYT2	psi-mi:“MI:2364”(proximity)	0.710
KLHL22	METTL15	psi-mi:“MI:0914”(association)	0.640
MRPL10	TCF4	psi-mi:“MI:0915”(physical association)	0.560
MRPL10	REL	psi-mi:“MI:0915”(physical association)	0.560
KLHL12	MRPL10	psi-mi:“MI:0915”(physical association)	0.560
FAM9B	MRPL10	psi-mi:“MI:0915”(physical association)	0.560
MRPL10	PNMA1	psi-mi:“MI:0915”(physical association)	0.560
TCF4	MRPL10	psi-mi:“MI:0915”(physical association)	0.560
REL	MRPL10	psi-mi:“MI:0915”(physical association)	0.560
PNMA1	MRPL10	psi-mi:“MI:0915”(physical association)	0.560
MRPL10	KLHL12	psi-mi:“MI:0915”(physical association)	0.560
MRPL10	FAM9B	psi-mi:“MI:0915”(physical association)	0.560
ACTN2	MRPL10	psi-mi:“MI:0915”(physical association)	0.560
MRPL50	GTPBP10	psi-mi:“MI:0914”(association)	0.530
MRPL10	ZZEF1	psi-mi:“MI:0914”(association)	0.530
MRPL42	GATC	psi-mi:“MI:0914”(association)	0.530
MRPL28	MRPL3	psi-mi:“MI:0914”(association)	0.530
MRPL2	GTPBP10	psi-mi:“MI:0914”(association)	0.530
MRPL13	GTPBP10	psi-mi:“MI:0914”(association)	0.530
MRPL18	GTPBP10	psi-mi:“MI:0914”(association)	0.530
MRPL23	BCKDHA	psi-mi:“MI:0914”(association)	0.530

BioGRID (288): MRPL10 (Two-hybrid), MRPL10 (Two-hybrid), MRPL10 (Two-hybrid), MRPL10 (Two-hybrid), FAM9B (Two-hybrid), MRPL10 (Affinity Capture-MS), MRPL10 (Affinity Capture-MS), MRPL10 (Affinity Capture-MS), MRPL10 (Affinity Capture-MS), MRPL10 (Affinity Capture-MS), MRPL10 (Affinity Capture-MS), MRPL10 (Affinity Capture-MS), MRPL10 (Co-fractionation), MRPL15 (Co-fractionation), MRPL10 (Affinity Capture-MS)

ESM2 similar proteins: A6QPQ5, A9X1A9, O95707, P0C2C1, P82664, P82670, P82675, P82915, P82919, P82933, Q08BI9, Q0P5E7, Q0VFH6, Q2KIB9, Q2KID9, Q2KIJ6, Q2TBK2, Q2TBR2, Q3MHY7, Q3SYS0, Q3T040, Q58DQ5, Q58DV5, Q5C9Z4, Q5R7B0, Q5REJ1, Q5REY4, Q5RFM3, Q641X9, Q7Z2W9, Q7Z7H8, Q8N3Z3, Q8TCC3, Q924T2, Q99N85, Q99N87, Q99N94, Q9BSH4, Q9BYD2, Q9BYD6

Diamond homologs: A5FZX3, P0C2C4, Q3MHY7, Q3TBW2, Q5BJB7, Q7Z7H8, A9H3S7, A9W8N6, B0UHX8, B1ZGR8, B7KN43, B8IS75, Q98N68

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
MRPL10	“form complex”	“39S mitochondrial large ribosomal subunit”	binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 111 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Mitochondrial ribosome-associated quality control	31	45.3×	2e-42
Mitochondrial translation	27	44.2×	9e-37
Mitochondrial translation initiation	29	43.8×	2e-39
Mitochondrial translation elongation	29	43.8×	2e-39
Mitochondrial translation termination	29	37.9×	2e-37
Translation	28	20.7×	5e-28

GO biological processes:

GO term	Partners	Fold	FDR
mitochondrial translation	31	52.3×	2e-43
translation	19	19.0×	1e-16

Disease & clinical

Clinical variants and AI predictions

ClinVar

47 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	33
Likely benign	3
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

747 predictions. Top by Δscore:

Variant	Effect	Δscore
17:47824455:CCAC:C	acceptor_gain	1.0000
17:47824456:CAC:C	acceptor_gain	1.0000
17:47824456:CACC:C	acceptor_gain	1.0000
17:47824459:C:CC	acceptor_gain	1.0000
17:47824459:CT:C	acceptor_loss	1.0000
17:47826634:CACCT:C	donor_loss	1.0000
17:47826636:CCTAG:C	donor_gain	1.0000
17:47826779:GAC:G	acceptor_gain	1.0000
17:47826779:GACC:G	acceptor_loss	1.0000
17:47826780:ACC:A	acceptor_loss	1.0000
17:47826781:CCTGG:C	acceptor_loss	1.0000
17:47826782:C:CA	acceptor_loss	1.0000
17:47826782:C:CC	acceptor_gain	1.0000
17:47826789:C:CT	acceptor_gain	1.0000
17:47826790:A:T	acceptor_gain	1.0000
17:47827035:CCTAC:C	donor_loss	1.0000
17:47827037:TA:T	donor_loss	1.0000
17:47827038:A:AT	donor_loss	1.0000
17:47827039:C:G	donor_loss	1.0000
17:47827211:T:C	acceptor_gain	1.0000
17:47827211:T:TC	acceptor_gain	1.0000
17:47827307:G:GC	acceptor_gain	1.0000
17:47828496:CTTA:C	donor_loss	1.0000
17:47828497:TTACC:T	donor_loss	1.0000
17:47828498:TA:T	donor_loss	1.0000
17:47828499:ACCT:A	donor_gain	1.0000
17:47828500:CCTC:C	donor_gain	1.0000
17:47828502:T:TA	donor_gain	1.0000
17:47828666:CCGGC:C	acceptor_gain	1.0000
17:47828667:CGGC:C	acceptor_gain	1.0000

AlphaMissense

1685 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
17:47827137:G:T	A97D	0.989
17:47826701:A:C	S156R	0.987
17:47826701:A:T	S156R	0.987
17:47826703:T:G	S156R	0.987
17:47827132:A:G	C99R	0.980
17:47827134:A:T	V98D	0.979
17:47827065:A:G	I121T	0.977
17:47824430:G:C	S187R	0.974
17:47824430:G:T	S187R	0.974
17:47824432:T:G	S187R	0.974
17:47824455:C:T	G179D	0.968
17:47826705:A:T	V155D	0.967
17:47827138:C:G	A97P	0.966
17:47827158:A:G	F90S	0.961
17:47827143:A:G	M95T	0.958
17:47826678:A:C	M164R	0.957
17:47826741:A:G	L143P	0.955
17:47827049:G:C	F126L	0.955
17:47827049:G:T	F126L	0.955
17:47827051:A:G	F126L	0.955
17:47826708:A:C	L154R	0.954
17:47827080:A:G	L116P	0.954
17:47828578:C:G	A49P	0.954
17:47827143:A:C	M95R	0.953
17:47824458:C:T	G178D	0.951
17:47826702:C:A	S156I	0.950
17:47827143:A:T	M95K	0.950
17:47826708:A:T	L154Q	0.947
17:47827140:A:T	I96K	0.946
17:47826678:A:T	M164K	0.944

dbSNP variants (sampled 300 via entrez): RS1000162850 (17:47832104 G>A), RS1000915323 (17:47823033 C>T), RS1001292335 (17:47828931 A>G), RS1003140256 (17:47832569 G>A), RS1003257863 (17:47831953 T>C), RS1003412882 (17:47832045 G>A,C), RS1004285207 (17:47833209 A>G), RS1004720991 (17:47832972 A>C), RS1004977530 (17:47829782 A>G,T), RS1005095181 (17:47823344 G>A), RS1005146384 (17:47827630 C>T), RS1005319751 (17:47831343 G>A), RS1005489877 (17:47833362 C>T), RS1005699927 (17:47831653 C>A,G,T), RS1006393651 (17:47828332 T>C)

Disease associations

OMIM: gene MIM:611825 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST001915_38	Alzheimer’s disease (cognitive decline)	8.000000e-08
GCST005951_17	Body mass index	3.000000e-09
GCST008916_117	Asthma	1.000000e-09

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0004340	body mass index

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

24 total (human), top 24 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Acetaminophen	increases expression, affects cotreatment	2
aristolochic acid I	increases expression	1
bisphenol A	increases expression	1
mono-(2-ethylhexyl)phthalate	decreases methylation, increases abundance	1
ochratoxin A	decreases expression	1
beta-methylcholine	affects expression	1
perfluorooctane sulfonic acid	increases expression	1
abrine	increases expression	1
bisphenol S	increases expression	1
jinfukang	increases expression	1
Sunitinib	increases expression	1
Amiodarone	increases expression	1
Copper	affects binding, decreases expression	1
Diethylhexyl Phthalate	decreases methylation, increases abundance	1
Disulfiram	affects binding, decreases expression	1
Enzyme Inhibitors	decreases activity, increases O-linked glycosylation	1
Lipopolysaccharides	affects cotreatment, increases expression	1
Methyl Methanesulfonate	increases expression	1
Ribonucleotides	affects binding	1
Thimerosal	decreases expression	1
Tobacco Smoke Pollution	increases expression	1
Valproic Acid	affects expression	1
1-Methyl-4-phenylpyridinium	decreases expression	1
Cadmium Chloride	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.