MRPL11

Summary

MRPL11 (mitochondrial ribosomal protein L11, HGNC:14042) is a protein-coding gene on chromosome 11q13.2, encoding Large ribosomal subunit protein uL11m (Q9Y3B7).

This nuclear gene encodes a 39S subunit component of the mitochondial ribosome. Alternative splicing results in multiple transcript variants. Pseudogenes for this gene are found on chromosomes 5 and 12.

Source: NCBI Gene 65003 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• Clinical variants (ClinVar): 27 total
• Druggable target: yes
• MANE Select transcript: NM_016050

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:14042
Approved symbol	MRPL11
Name	mitochondrial ribosomal protein L11
Location	11q13.2
Locus type	gene with protein product
Status	Approved
Aliases	uL11m
Ensembl gene	ENSG00000174547
Ensembl biotype	protein_coding
OMIM	611826
Entrez	65003

Gene structure

Transcript identifiers

Ensembl transcripts: 13 — 11 protein_coding, 1 protein_coding_CDS_not_defined, 1 nonsense_mediated_decay

ENST00000310999, ENST00000329819, ENST00000430466, ENST00000524576, ENST00000528272, ENST00000534488, ENST00000901138, ENST00000901139, ENST00000916481, ENST00000916482, ENST00000916483, ENST00000916484, ENST00000943610

RefSeq mRNA: 3 — MANE Select: NM_016050 NM_016050, NM_170738, NM_170739

CCDS: CCDS44655, CCDS8139, CCDS8140

Canonical transcript exons

ENST00000310999 — 5 exons

Exon	Start	End
ENSE00001676168	66435075	66436112
ENSE00002177786	66438632	66438848
ENSE00003551268	66437350	66437443
ENSE00003585913	66437104	66437263
ENSE00003644681	66438164	66438259

Expression profiles

Bgee: expression breadth ubiquitous, 245 present calls, max score 96.80.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 96.0371 / max 681.0244, expressed in 1822 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
120807	96.0371	1822

Top tissues by expression

275 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
mucosa of transverse colon	UBERON:0004991	96.80	gold quality
hindlimb stylopod muscle	UBERON:0004252	95.95	gold quality
apex of heart	UBERON:0002098	95.87	gold quality
gastrocnemius	UBERON:0001388	94.51	gold quality
transverse colon	UBERON:0001157	94.32	gold quality
muscle of leg	UBERON:0001383	94.29	gold quality
muscle layer of sigmoid colon	UBERON:0035805	94.17	gold quality
right lobe of liver	UBERON:0001114	93.97	gold quality
lower esophagus	UBERON:0013473	93.92	gold quality
lower esophagus muscularis layer	UBERON:0035833	93.92	gold quality
rectum	UBERON:0001052	93.91	gold quality
right atrium auricular region	UBERON:0006631	93.88	gold quality
lower esophagus mucosa	UBERON:0035834	93.85	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	93.73	gold quality
heart left ventricle	UBERON:0002084	93.70	gold quality
body of stomach	UBERON:0001161	93.60	gold quality
body of pancreas	UBERON:0001150	93.48	gold quality
cardiac ventricle	UBERON:0002082	93.43	gold quality
esophagus	UBERON:0001043	93.41	gold quality
muscle organ	UBERON:0001630	93.23	gold quality
granulocyte	CL:0000094	93.20	gold quality
esophagus mucosa	UBERON:0002469	93.17	gold quality
left ovary	UBERON:0002119	92.90	gold quality
cardiac atrium	UBERON:0002081	92.86	gold quality
small intestine Peyer’s patch	UBERON:0003454	92.81	gold quality
heart	UBERON:0000948	92.76	gold quality
left coronary artery	UBERON:0001626	92.67	gold quality
right ovary	UBERON:0002118	92.45	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	92.37	gold quality
popliteal artery	UBERON:0002250	92.36	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-CURD-112	yes	10.04
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

35 targeting MRPL11, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-4534	99.99	66.58	1907
HSA-LET-7C-3P	99.95	73.42	2862
HSA-MIR-4302	99.89	67.94	1187
HSA-MIR-10395-5P	99.86	67.35	676
HSA-MIR-544A	99.84	68.66	1965
HSA-MIR-8080	99.82	67.52	1342
HSA-MIR-545-5P	99.66	70.18	2308
HSA-MIR-587	99.64	70.86	2611
HSA-MIR-9851-3P	99.63	69.68	1110
HSA-MIR-4756-3P	99.62	66.30	1319
HSA-MIR-3915	99.45	68.49	1905
HSA-MIR-942-5P	99.41	68.40	1977
HSA-MIR-4251	99.40	69.19	3363
HSA-MIR-593-5P	99.34	69.50	965
HSA-MIR-6791-5P	99.16	65.92	1844
HSA-MIR-6749-3P	99.00	65.73	1443
HSA-MIR-939-3P	98.97	65.07	2347
HSA-MIR-6770-5P	98.97	66.76	1853
HSA-MIR-382-3P	98.83	67.10	1074
HSA-MIR-3187-5P	98.36	65.74	1776
HSA-MIR-1265	98.36	66.46	598
HSA-MIR-506-5P	98.02	67.41	1065
HSA-MIR-876-5P	97.99	68.49	1345
HSA-MIR-1279	97.83	67.50	1898
HSA-MIR-1285-3P	97.72	67.02	1932
HSA-MIR-5189-5P	97.72	66.96	1814
HSA-MIR-194-3P	97.36	65.96	1027
HSA-MIR-612	97.26	65.95	1597
HSA-MIR-6860	97.21	66.31	1656

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	mrpl11	ENSDARG00000013075
mus_musculus	Mrpl11	ENSMUSG00000024902
rattus_norvegicus	mrpl11	ENSRNOG00000019970
drosophila_melanogaster	mRpL11	FBGN0038234
caenorhabditis_elegans		WBGENE00015133

Paralogs (1): RPL12 (ENSG00000197958)

Protein

Protein identifiers

Large ribosomal subunit protein uL11m — Q9Y3B7 (reviewed: Q9Y3B7)

Alternative names: 39S ribosomal protein L11, mitochondrial

All UniProt accessions (3): Q9Y3B7, E9PQB6, H0YCD5

UniProt curated annotations — full annotation on UniProt →

Subunit / interactions. Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.

Subcellular location. Mitochondrion.

Similarity. Belongs to the universal ribosomal protein uL11 family.

Isoforms (3)

UniProt ID	Names	Canonical?
Q9Y3B7-1	1	yes
Q9Y3B7-2	2
Q9Y3B7-3	3

RefSeq proteins (3): NP_057134, NP_733934, NP_733935 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000911	Ribosomal_uL11	Family
IPR006519	Ribosomal_uL11_bact	Family
IPR020783	Ribosomal_uL11_C	Domain
IPR020784	Ribosomal_uL11_N	Domain
IPR036769	Ribosomal_uL11_C_sf	Homologous_superfamily
IPR036796	Ribosomal_uL11_N_sf	Homologous_superfamily

Pfam: PF00298, PF03946

UniProt features (22 total): strand 9, helix 5, turn 2, splice variant 2, sequence conflict 2, transit peptide 1, chain 1

Structure

Experimental structures (PDB)

84 structures, top 30 by resolution.

PDB	Method	Resolution (Å)
7OF0	ELECTRON MICROSCOPY	2.2
7QI4	ELECTRON MICROSCOPY	2.21
8RRI	ELECTRON MICROSCOPY	2.4
8QU5	ELECTRON MICROSCOPY	2.42
9OLF	ELECTRON MICROSCOPY	2.46
7OF7	ELECTRON MICROSCOPY	2.5
7PO4	ELECTRON MICROSCOPY	2.56
6ZM6	ELECTRON MICROSCOPY	2.59
7O9M	ELECTRON MICROSCOPY	2.6
7OF6	ELECTRON MICROSCOPY	2.6
9CN3	ELECTRON MICROSCOPY	2.62
7QI5	ELECTRON MICROSCOPY	2.63
7OF2	ELECTRON MICROSCOPY	2.7
7OF3	ELECTRON MICROSCOPY	2.7
7OF4	ELECTRON MICROSCOPY	2.7
8QU1	ELECTRON MICROSCOPY	2.74
9PR4	ELECTRON MICROSCOPY	2.77
9PRA	ELECTRON MICROSCOPY	2.83
8ANY	ELECTRON MICROSCOPY	2.85
6ZM5	ELECTRON MICROSCOPY	2.89
7ODR	ELECTRON MICROSCOPY	2.9
7OF5	ELECTRON MICROSCOPY	2.9
8K2A	ELECTRON MICROSCOPY	2.9
8OIT	ELECTRON MICROSCOPY	2.9
9PGL	ELECTRON MICROSCOPY	2.9
9PGF	ELECTRON MICROSCOPY	2.93
6VMI	ELECTRON MICROSCOPY	2.96
6VLZ	ELECTRON MICROSCOPY	2.97
7QI6	ELECTRON MICROSCOPY	2.98
9PSM	ELECTRON MICROSCOPY	2.98

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9Y3B7-F1	83.87	0.33

Function

Pathways and Gene Ontology

Reactome pathways

7 pathways

ID	Pathway
R-HSA-5368286	Mitochondrial translation initiation
R-HSA-5389840	Mitochondrial translation elongation
R-HSA-5419276	Mitochondrial translation termination
R-HSA-9937383	Mitochondrial ribosome-associated quality control
R-HSA-392499	Metabolism of proteins
R-HSA-5368287	Mitochondrial translation
R-HSA-72766	Translation

MSigDB gene sets: 173 (showing top): STARK_PREFRONTAL_CORTEX_22Q11_DELETION_DN, GOBP_MITOCHONDRIAL_TRANSLATION, TAL1ALPHAE47_01, chr11q13, GOBP_TRANSLATION, GOMF_STRUCTURAL_CONSTITUENT_OF_RIBOSOME, HNF4_DR1_Q3, GOCC_MITOCHONDRIAL_ENVELOPE, YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_13, GARCIA_TARGETS_OF_FLI1_AND_DAX1_DN, PPAR_DR1_Q2, WANG_TARGETS_OF_MLL_CBP_FUSION_UP, NIKOLSKY_BREAST_CANCER_11Q12_Q14_AMPLICON, WONG_MITOCHONDRIA_GENE_MODULE, GOCC_LARGE_RIBOSOMAL_SUBUNIT

GO Biological Process (2): translation (GO:0006412), mitochondrial translation (GO:0032543)

GO Molecular Function (4): RNA binding (GO:0003723), structural constituent of ribosome (GO:0003735), large ribosomal subunit rRNA binding (GO:0070180), protein binding (GO:0005515)

GO Cellular Component (6): mitochondrion (GO:0005739), mitochondrial inner membrane (GO:0005743), mitochondrial ribosome (GO:0005761), mitochondrial large ribosomal subunit (GO:0005762), ribosome (GO:0005840), ribonucleoprotein complex (GO:1990904)

Reactome top-level categories

Rollup of top-3 pathways:

Category	Pathways
Mitochondrial translation	4
Translation	1
Metabolism of proteins	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
peptidyltransferase activity	1
translational initiation	1
translational elongation	1
translational termination	1
macromolecule biosynthetic process	1
protein metabolic process	1
protein biosynthetic process	1
mitochondrion	1
translation	1
mitochondrial gene expression	1
nucleic acid binding	1
structural molecule activity	1
ribosome	1
rRNA binding	1
binding	1
cytoplasm	1
intracellular membrane-bounded organelle	1
organelle inner membrane	1
mitochondrial membrane	1
organellar ribosome	1
mitochondrial matrix	1
organellar large ribosomal subunit	1
mitochondrial ribosome	1
mitochondrial protein-containing complex	1
intracellular membraneless organelle	1
protein-containing complex	1

Protein interactions and networks

STRING

3662 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
MRPL11	MRPL21	Q7Z2W9	825
MRPL11	MRPL13	Q9BYD1	773
MRPL11	MRPL17	Q9NRX2	745
MRPL11	MRPL45	Q9BRJ2	742
MRPL11	MRPL12	P52815	719
MRPL11	MRPL19	P49406	700
MRPL11	MRPL24	Q96A35	689
MRPL11	MRPL4	Q9BYD3	686
MRPL11	MRPL44	Q9H9J2	681
MRPL11	MRPS18B	Q9Y676	671
MRPL11	MRPS22	P82650	651
MRPL11	MRPS23	Q9Y3D9	637
MRPL11	MRPL36	Q9P0J6	626
MRPL11	MRPL41	Q8IXM3	625
MRPL11	MRPS16	Q9Y3D3	625

IntAct

267 interactions, top by confidence:

A	B	Type	Score
N	HNRNPR	psi-mi:“MI:0914”(association)	0.730
MRPL11	FSD2	psi-mi:“MI:0915”(physical association)	0.720
TAX1BP1	MRPL11	psi-mi:“MI:0915”(physical association)	0.720
PNMA1	MRPL11	psi-mi:“MI:0915”(physical association)	0.720
MRPL11	PNMA1	psi-mi:“MI:0915”(physical association)	0.720
FSD2	MRPL11	psi-mi:“MI:0915”(physical association)	0.720
CFTR	ESYT2	psi-mi:“MI:0914”(association)	0.710
MRPL11	MTUS2	psi-mi:“MI:0915”(physical association)	0.700
MTUS2	MRPL11	psi-mi:“MI:0915”(physical association)	0.700
MRPL11	CAMK2D	psi-mi:“MI:0915”(physical association)	0.670
MRPL11	THAP1	psi-mi:“MI:0915”(physical association)	0.670
THAP1	MRPL11	psi-mi:“MI:0915”(physical association)	0.670
CAMK2D	MRPL11	psi-mi:“MI:0915”(physical association)	0.670
MRPS30	GTPBP10	psi-mi:“MI:0914”(association)	0.640
CFTR	HAX1	psi-mi:“MI:0914”(association)	0.610

BioGRID (505): MRPL11 (Two-hybrid), MRPL11 (Two-hybrid), MRPL11 (Two-hybrid), MRPL11 (Two-hybrid), MRPL11 (Two-hybrid), MRPL11 (Two-hybrid), MRPL11 (Two-hybrid), MRPL11 (Two-hybrid), MRPL11 (Two-hybrid), MRPL11 (Two-hybrid), HMBOX1 (Two-hybrid), FSD2 (Two-hybrid), KRT40 (Two-hybrid), SLC16A9 (Two-hybrid), MRPL11 (Affinity Capture-RNA)

ESM2 similar proteins: A0A1S4BZI5, A0A1S4CB73, A1AX79, A1B011, A9GRA1, C4LBV6, O04603, O82234, P02398, P24929, P27793, P30956, P31164, P36212, P36428, P36688, P41348, P42732, P57720, P82163, P82191, P82192, P82195, Q01908, Q0BYA0, Q2YDI0, Q42884, Q5FTX3, Q5XF75, Q5XIE3, Q6FF94, Q6K471, Q8RXX5, Q8VYL1, Q8VYN6, Q93WI0, Q949U7, Q9CQF0, Q9FGS4, Q9LE95

Diamond homologs: A0B923, A0LRK9, A2BN63, A2STU0, A3CSJ5, A4FW91, A4YH87, A5UKV0, A5UYI4, A6Q1L9, A6UQ78, A6UVR5, A6VH19, A7IAK5, A7NRZ8, A8F4F6, A9A582, A9A9N0, A9BF37, B0R4W3, B0S061, B1L6L2, B1L939, B2A4C6, B4U733, B6YSX7, B7JWT8, B7KJM5, B8D5P9, B8GIY2, B8J1A4, B9L7J2, B9LQE0, C0QQL2, C3MR83, C3MXH2, C3MZB8, C3N7D9, C3NG95, C4KIJ7

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
MRPL11	“form complex”	“39S mitochondrial large ribosomal subunit”	binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 141 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Mitochondrial ribosome-associated quality control	14	20.2×	2e-12
HSF1-dependent transactivation	5	18.7×	3e-04
Transcriptional Regulation by MECP2	5	18.7×	3e-04
Mitochondrial translation initiation	11	16.4×	8e-09
Mitochondrial translation elongation	11	16.4×	8e-09
Oncogenic MAPK signaling	5	14.6×	6e-04
Mitochondrial translation	9	14.6×	8e-07
Mitochondrial translation termination	11	14.2×	3e-08

GO biological processes:

GO term	Partners	Fold	FDR
mitochondrial translation	10	15.0×	8e-07

Disease & clinical

Clinical variants and AI predictions

ClinVar

27 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	22
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1035 predictions. Top by Δscore:

Variant	Effect	Δscore
11:66436108:TGAGG:T	acceptor_gain	1.0000
11:66436109:GAGG:G	acceptor_gain	1.0000
11:66436110:AGG:A	acceptor_gain	1.0000
11:66436111:GG:G	acceptor_gain	1.0000
11:66436113:C:CC	acceptor_gain	1.0000
11:66436116:CAAG:C	acceptor_gain	1.0000
11:66436119:G:C	acceptor_gain	1.0000
11:66436119:G:GC	acceptor_gain	1.0000
11:66437098:ACTT:A	donor_loss	1.0000
11:66437100:TTACT:T	donor_loss	1.0000
11:66437101:TACT:T	donor_loss	1.0000
11:66437102:A:AC	donor_gain	1.0000
11:66437102:ACT:A	donor_gain	1.0000
11:66437102:ACTC:A	donor_gain	1.0000
11:66437103:C:CA	donor_gain	1.0000
11:66437103:CT:C	donor_gain	1.0000
11:66437103:CTC:C	donor_gain	1.0000
11:66437103:CTCC:C	donor_gain	1.0000
11:66437176:T:TA	donor_gain	1.0000
11:66437262:CC:C	acceptor_gain	1.0000
11:66437263:CC:C	acceptor_gain	1.0000
11:66437264:C:CA	acceptor_loss	1.0000
11:66437264:C:CC	acceptor_gain	1.0000
11:66437265:T:A	acceptor_loss	1.0000
11:66437344:CCTCA:C	donor_loss	1.0000
11:66437346:TCA:T	donor_loss	1.0000
11:66437347:CACCT:C	donor_loss	1.0000
11:66437348:ACC:A	donor_loss	1.0000
11:66437444:C:CC	acceptor_gain	1.0000
11:66437445:T:C	acceptor_gain	1.0000

AlphaMissense

1220 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:66438224:G:C	F53L	0.997
11:66438224:G:T	F53L	0.997
11:66438226:A:G	F53L	0.997
11:66437205:T:A	K124N	0.996
11:66437205:T:G	K124N	0.996
11:66437134:G:T	A148D	0.995
11:66438225:A:G	F53S	0.995
11:66438236:A:C	F49L	0.995
11:66438236:A:T	F49L	0.995
11:66438238:A:G	F49L	0.995
11:66437215:G:T	A121D	0.994
11:66437379:G:T	A95D	0.994
11:66438237:A:G	F49S	0.994
11:66437216:C:G	A121P	0.993
11:66437135:C:G	A148P	0.992
11:66437380:C:G	A95P	0.992
11:66437391:A:G	L91P	0.992
11:66438186:A:G	L66P	0.992
11:66438636:C:T	G40D	0.991
11:66437391:A:T	L91Q	0.989
11:66437429:A:C	F78L	0.989
11:66437429:A:T	F78L	0.989
11:66437431:A:G	F78L	0.989
11:66438174:A:G	I70T	0.988
11:66438252:A:T	V44D	0.988
11:66438649:C:G	G36R	0.988
11:66437119:A:G	I153T	0.987
11:66437387:C:A	K92N	0.987
11:66437387:C:G	K92N	0.987
11:66438639:A:T	L39Q	0.987

dbSNP variants (sampled 300 via entrez): RS1000105874 (11:66439966 T>A,C), RS1000237913 (11:66438998 C>T), RS1000476721 (11:66436570 T>C), RS1001080073 (11:66440770 G>A), RS1001795683 (11:66439355 G>A), RS1002111114 (11:66437276 A>G), RS1002342383 (11:66434764 G>A), RS1002402179 (11:66434616 G>T), RS1003089127 (11:66438374 C>A,T), RS1003568907 (11:66435665 A>G), RS1003911165 (11:66435759 T>C), RS1005141480 (11:66436368 C>T), RS1005190881 (11:66438326 CG>C), RS1005474889 (11:66437878 A>C), RS1006287739 (11:66437650 A>G)

Disease associations

OMIM: gene MIM:611826 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST001241_12	Bipolar disorder	2.000000e-07
GCST010204_155	Low density lipoprotein cholesterol levels	2.000000e-10
GCST90020028_1911	Hip circumference adjusted for BMI	6.000000e-09

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0004611	low density lipoprotein cholesterol measurement
EFO:0008039	BMI-adjusted hip circumference

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL6067214 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

ChEMBL bioactivities

2 potent at pChembl≥5 of 2 total, top 2 by pChembl (potency: 10 = 0.1 nM, 6 = 1 µM).

pChembl	Type	Value	Unit	Molecule
7.12	Kd	76	nM	CHEMBL5653589
7.12	ED50	76	nM	CHEMBL5653589

PubChem BioAssay actives

1 with measured affinity, of 2 total; 1 most potent distinct compounds. Largely complementary to BindingDB; screening values are coarse (µM, 4 dp), so sub-nM hits tie at the floor.

Compound	Assay	Type	Value	Unit
4-methyl-3-[(2-methyl-6-pyridin-3-ylpyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-[3-(trifluoromethyl)phenyl]benzamide	2148769: Binding affinity to human MRPL11 incubated for 45 mins by Kinobead based pull down assay	kd	0.0760	uM

CTD chemical–gene interactions

31 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
(+)-JQ1 compound	decreases expression	3
Acetaminophen	affects cotreatment, decreases expression	3
bisphenol A	affects expression, decreases expression	2
sodium arsenite	affects binding, increases reaction, decreases expression	2
Tretinoin	decreases expression	2
arsenite	affects binding, increases reaction	1
K 7174	decreases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
Grape Seed Proanthocyanidins	affects cotreatment, increases expression	1
bisphenol S	increases expression	1
LDN 193189	affects cotreatment, decreases expression	1
Temozolomide	decreases expression	1
Air Pollutants	affects expression, increases abundance	1
Atrazine	decreases expression	1
Benzo(a)pyrene	increases methylation	1
Catechin	affects cotreatment, increases expression	1
Dichlorodiphenyl Dichloroethylene	increases expression	1
Hydralazine	affects cotreatment, increases expression	1
Ivermectin	decreases expression	1
Ketoconazole	decreases expression	1
Lipopolysaccharides	affects cotreatment, decreases expression	1
Ozone	increases abundance, affects expression	1
Ribonucleotides	affects binding	1
Rotenone	increases expression	1
Smoke	decreases expression	1
Tunicamycin	decreases expression	1
Valproic Acid	affects cotreatment, increases expression	1
Vitamin E	increases expression	1
Cyclosporine	decreases expression	1
Copper Sulfate	decreases expression	1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL5651811	Binding	Binding affinity to human MRPL11 incubated for 45 mins by Kinobead based pull down assay	NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family. — ChemMedChem

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.