MRPL14

Summary

MRPL14 (mitochondrial ribosomal protein L14, HGNC:14279) is a protein-coding gene on chromosome 6p21.1, encoding Large ribosomal subunit protein uL14m (Q6P1L8). Forms part of 2 intersubunit bridges in the assembled ribosome. It is a selective cancer dependency (DepMap: 45.5% of cell lines).

This nuclear gene encodes a protein component of the 39S subunit of the mitochondrial ribosome. A pseudogene of this gene is found on chromosome 17.

Source: NCBI Gene 64928 — RefSeq curated summary.

At a glance

• GWAS associations: 6
• Clinical variants (ClinVar): 45 total
• Cancer dependency (DepMap): dependent in 45.5% of screened cell lines
• MANE Select transcript: NM_032111

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:14279
Approved symbol	MRPL14
Name	mitochondrial ribosomal protein L14
Location	6p21.1
Locus type	gene with protein product
Status	Approved
Aliases	RPML32, MRP-L32, uL14m
Ensembl gene	ENSG00000180992
Ensembl biotype	protein_coding
OMIM	611827
Entrez	64928

Gene structure

Transcript identifiers

Ensembl transcripts: 24 — 24 protein_coding

ENST00000372014, ENST00000872326, ENST00000872327, ENST00000872328, ENST00000872329, ENST00000872330, ENST00000872331, ENST00000872332, ENST00000872333, ENST00000872334, ENST00000872335, ENST00000872336, ENST00000872337, ENST00000930436, ENST00000930437, ENST00000930438, ENST00000930439, ENST00000930440, ENST00000930441, ENST00000930442, ENST00000930443, ENST00000930444, ENST00000967823, ENST00000967824

RefSeq mRNA: 6 — MANE Select: NM_032111 NM_001318767, NM_001318768, NM_001318769, NM_001318770, NM_001318771, NM_032111

CCDS: CCDS34460

Canonical transcript exons

ENST00000372014 — 3 exons

Exon	Start	End
ENSE00001456702	44113451	44114209
ENSE00001456711	44116541	44116629
ENSE00001456714	44127344	44127452

Expression profiles

Bgee: expression breadth ubiquitous, 252 present calls, max score 97.99.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 28.9830 / max 120.1378, expressed in 1817 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
73738	21.6184	1814
73739	5.5764	1668
73737	1.7883	675

Top tissues by expression

255 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
tibialis anterior	UBERON:0001385	97.99	gold quality
quadriceps femoris	UBERON:0001377	97.79	gold quality
biceps brachii	UBERON:0001507	97.78	gold quality
vastus lateralis	UBERON:0001379	97.70	gold quality
deltoid	UBERON:0001476	97.68	gold quality
upper arm skin	UBERON:0004263	97.62	gold quality
gastrocnemius	UBERON:0001388	97.61	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	97.45	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	97.23	gold quality
skeletal muscle tissue	UBERON:0001134	97.01	gold quality
muscle of leg	UBERON:0001383	96.96	gold quality
gingival epithelium	UBERON:0001949	96.84	gold quality
hindlimb stylopod muscle	UBERON:0004252	96.49	gold quality
adult organism	UBERON:0007023	96.38	gold quality
mucosa of transverse colon	UBERON:0004991	96.30	gold quality
body of tongue	UBERON:0011876	96.03	gold quality
cartilage tissue	UBERON:0002418	95.93	gold quality
gingiva	UBERON:0001828	95.83	gold quality
muscle tissue	UBERON:0002385	95.72	gold quality
nasal cavity epithelium	UBERON:0005384	95.63	gold quality
left ventricle myocardium	UBERON:0006566	95.27	gold quality
mammalian vulva	UBERON:0000997	95.20	gold quality
upper lobe of lung	UBERON:0008948	94.82	gold quality
upper lobe of left lung	UBERON:0008952	94.81	gold quality
tongue	UBERON:0001723	94.80	gold quality
islet of Langerhans	UBERON:0000006	94.70	gold quality
lower lobe of lung	UBERON:0008949	94.33	gold quality
apex of heart	UBERON:0002098	94.24	gold quality
palpebral conjunctiva	UBERON:0001812	94.21	gold quality
right lobe of liver	UBERON:0001114	94.15	gold quality

Single-cell (SCXA)

Detected in 7 experiment(s), a significant marker in 6.

Experiment	Marker?	Max mean expression
E-MTAB-8410	yes	660.71
E-HCAD-1	yes	92.69
E-MTAB-7316	yes	19.72
E-MTAB-8271	yes	7.61
E-GEOD-130148	yes	7.01
E-MTAB-10137	no	318.45
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

16 targeting MRPL14, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-4768-5P	100.00	69.49	2861
HSA-MIR-6833-3P	100.00	70.63	3197
HSA-MIR-4789-3P	99.99	70.75	2484
HSA-MIR-4302	99.89	67.94	1187
HSA-MIR-9902	99.89	69.15	2250
HSA-MIR-4729	99.69	72.18	4233
HSA-MIR-875-3P	99.63	69.47	2548
HSA-MIR-150-3P	99.43	70.51	920
HSA-MIR-12125	98.59	67.54	1044
HSA-MIR-3130-5P	98.14	66.00	711
HSA-MIR-4483	98.09	64.12	1642
HSA-MIR-4482-5P	97.53	65.68	598
HSA-MIR-7106-3P	97.33	65.33	644
HSA-MIR-10398-5P	97.12	64.94	1051
HSA-MIR-5579-5P	96.32	68.54	730

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 45.5% of screened cell lines.

Literature-anchored findings (GeneRIF, showing 1)

• C7orf30 promotes incorporation of MRPL14 into the mitochondrial large ribosomal subunit. (PMID:23171548)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	mrpl14	ENSDARG00000068886
mus_musculus	Mrpl14	ENSMUSG00000023939
rattus_norvegicus	Mrpl14	ENSRNOG00000019734
drosophila_melanogaster	mRpL14	FBGN0040389

Paralogs (1): C1orf53 (ENSG00000203724)

Protein

Protein identifiers

Large ribosomal subunit protein uL14m — Q6P1L8 (reviewed: Q6P1L8)

Alternative names: 39S ribosomal protein L14, mitochondrial, 39S ribosomal protein L32, mitochondrial

All UniProt accessions (1): Q6P1L8

UniProt curated annotations — full annotation on UniProt →

Function. Forms part of 2 intersubunit bridges in the assembled ribosome. Upon binding to MALSU1 intersubunit bridge formation is blocked, preventing ribosome formation and repressing translation.

Subunit / interactions. Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins. Interacts with MALSU1.

Subcellular location. Mitochondrion.

Similarity. Belongs to the universal ribosomal protein uL14 family.

RefSeq proteins (6): NP_001305696, NP_001305697, NP_001305698, NP_001305699, NP_001305700, NP_115487* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000218	Ribosomal_uL14	Family
IPR036853	Ribosomal_uL14_sf	Homologous_superfamily

Pfam: PF00238

UniProt features (15 total): strand 10, helix 3, transit peptide 1, chain 1

Structure

Experimental structures (PDB)

86 structures, top 30 by resolution.

PDB	Method	Resolution (Å)
7OF0	ELECTRON MICROSCOPY	2.2
7QI4	ELECTRON MICROSCOPY	2.21
8RRI	ELECTRON MICROSCOPY	2.4
8QU5	ELECTRON MICROSCOPY	2.42
9OLF	ELECTRON MICROSCOPY	2.46
7OF7	ELECTRON MICROSCOPY	2.5
7PO4	ELECTRON MICROSCOPY	2.56
6ZM6	ELECTRON MICROSCOPY	2.59
7O9M	ELECTRON MICROSCOPY	2.6
7OF6	ELECTRON MICROSCOPY	2.6
9CN3	ELECTRON MICROSCOPY	2.62
7QI5	ELECTRON MICROSCOPY	2.63
7OF2	ELECTRON MICROSCOPY	2.7
7OF3	ELECTRON MICROSCOPY	2.7
7OF4	ELECTRON MICROSCOPY	2.7
8QU1	ELECTRON MICROSCOPY	2.74
9PR4	ELECTRON MICROSCOPY	2.77
9PRA	ELECTRON MICROSCOPY	2.83
8ANY	ELECTRON MICROSCOPY	2.85
6ZM5	ELECTRON MICROSCOPY	2.89
7QH7	ELECTRON MICROSCOPY	2.89
7ODR	ELECTRON MICROSCOPY	2.9
7OF5	ELECTRON MICROSCOPY	2.9
8K2A	ELECTRON MICROSCOPY	2.9
8OIT	ELECTRON MICROSCOPY	2.9
9PGL	ELECTRON MICROSCOPY	2.9
9PGF	ELECTRON MICROSCOPY	2.93
6VMI	ELECTRON MICROSCOPY	2.96
6VLZ	ELECTRON MICROSCOPY	2.97
7QI6	ELECTRON MICROSCOPY	2.98

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q6P1L8-F1	85.38	0.76

Function

Pathways and Gene Ontology

Reactome pathways

7 pathways

ID	Pathway
R-HSA-5368286	Mitochondrial translation initiation
R-HSA-5389840	Mitochondrial translation elongation
R-HSA-5419276	Mitochondrial translation termination
R-HSA-9937383	Mitochondrial ribosome-associated quality control
R-HSA-392499	Metabolism of proteins
R-HSA-5368287	Mitochondrial translation
R-HSA-72766	Translation

MSigDB gene sets: 104 (showing top): AREB6_03, GOBP_MITOCHONDRIAL_TRANSLATION, TGACCTY_ERR1_Q2, CAGCTG_AP4_Q5, GOBP_TRANSLATION, WEI_MYCN_TARGETS_WITH_E_BOX, GOMF_STRUCTURAL_CONSTITUENT_OF_RIBOSOME, HEN1_01, GOCC_MITOCHONDRIAL_ENVELOPE, GOCC_LARGE_RIBOSOMAL_SUBUNIT, GOCC_RIBOSOME, GOCC_ORGANELLAR_RIBOSOME, GOCC_MITOCHONDRIAL_MATRIX, GOCC_ORGANELLE_INNER_MEMBRANE, YGCGYRCGC_UNKNOWN

GO Biological Process (2): mitochondrial translation (GO:0032543), translation (GO:0006412)

GO Molecular Function (2): RNA binding (GO:0003723), structural constituent of ribosome (GO:0003735)

GO Cellular Component (5): mitochondrion (GO:0005739), mitochondrial inner membrane (GO:0005743), mitochondrial large ribosomal subunit (GO:0005762), ribosome (GO:0005840), ribonucleoprotein complex (GO:1990904)

Reactome top-level categories

Rollup of top-3 pathways:

Category	Pathways
Mitochondrial translation	4
Translation	1
Metabolism of proteins	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
mitochondrion	1
translation	1
mitochondrial gene expression	1
peptidyltransferase activity	1
translational initiation	1
translational elongation	1
translational termination	1
macromolecule biosynthetic process	1
protein metabolic process	1
protein biosynthetic process	1
nucleic acid binding	1
structural molecule activity	1
ribosome	1
cytoplasm	1
intracellular membrane-bounded organelle	1
organelle inner membrane	1
mitochondrial membrane	1
organellar large ribosomal subunit	1
mitochondrial ribosome	1
mitochondrial protein-containing complex	1
intracellular membraneless organelle	1
protein-containing complex	1

Protein interactions and networks

STRING

1186 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
MRPL14	MALSU1	Q96EH3	621
MRPL14	MRPL11	Q9Y3B7	522
MRPL14	C2orf15	Q8WU43	480
MRPL14	DAP3	P51398	467
MRPL14	ZNF239	Q16600	447
MRPL14	MRPL44	Q9H9J2	434
MRPL14	MRPS18B	Q9Y676	418
MRPL14	MRPS27	Q92552	418
MRPL14	LINC03040	Q8N319	398
MRPL14	TMEM217	Q8N7C4	391
MRPL14	MTG1	Q9BT17	390
MRPL14	TMEM217B	A0A494BZU4	383
MRPL14	MTERF4	Q7Z6M4	380
MRPL14	MRPS22	P82650	373
MRPL14	MRPL36	Q9P0J6	371

IntAct

70 interactions, top by confidence:

A	B	Type	Score
CFTR	ESYT2	psi-mi:“MI:2364”(proximity)	0.710
MALSU1	NDUFAB1	psi-mi:“MI:0914”(association)	0.710
MRPS30	GTPBP10	psi-mi:“MI:0914”(association)	0.640
NP	KPNA6	psi-mi:“MI:0914”(association)	0.550
MRPL50	GTPBP10	psi-mi:“MI:0914”(association)	0.530
MRPL10	ZZEF1	psi-mi:“MI:0914”(association)	0.530
MRPL41	MRPL3	psi-mi:“MI:0914”(association)	0.530
MRPL18	GTPBP10	psi-mi:“MI:0914”(association)	0.530
MRPL2	GTPBP10	psi-mi:“MI:0914”(association)	0.530
COX15	SLC25A3	psi-mi:“MI:0914”(association)	0.530
NDUFAB1	MIEF1	psi-mi:“MI:0915”(physical association)	0.490
SDC1	ILVBL	psi-mi:“MI:0915”(physical association)	0.400
Brwd3	WDR91	psi-mi:“MI:0914”(association)	0.350
ETS2	ANKS6	psi-mi:“MI:0914”(association)	0.350
WRAP53	STK24	psi-mi:“MI:0914”(association)	0.350
MRPL50	MRPL43	psi-mi:“MI:0914”(association)	0.350
MRPL9	MRPL43	psi-mi:“MI:0914”(association)	0.350
GOLT1B		psi-mi:“MI:0914”(association)	0.350
MRPL1	MRPL43	psi-mi:“MI:0914”(association)	0.350
NP	HNRNPDL	psi-mi:“MI:0914”(association)	0.350
NP	KPNA6	psi-mi:“MI:0914”(association)	0.350
NP	TRIM66	psi-mi:“MI:0914”(association)	0.350
PDHA1		psi-mi:“MI:0914”(association)	0.350
CUL3	PXDNL	psi-mi:“MI:0914”(association)	0.350
LRRK2		psi-mi:“MI:0914”(association)	0.350
MRPL39	PTCD1	psi-mi:“MI:0914”(association)	0.350
MRPL47	MRPL33	psi-mi:“MI:0914”(association)	0.350

BioGRID (163): MRPL14 (Affinity Capture-MS), MRPL14 (Affinity Capture-MS), MRPL14 (Affinity Capture-MS), MRPL14 (Affinity Capture-MS), MRPL14 (Affinity Capture-MS), MRPL14 (Affinity Capture-MS), MRPL14 (Affinity Capture-MS), MRPL14 (Affinity Capture-MS), MRPL14 (Co-fractionation), MRPL14 (Co-fractionation), MRPL14 (Affinity Capture-MS), MRPL14 (Affinity Capture-MS), MRPL14 (Affinity Capture-MS), MRPL14 (Affinity Capture-MS), MRPL14 (Affinity Capture-MS)

ESM2 similar proteins: A0A1D8PFG4, A1XQU5, G1TXF6, O14388, O74538, P02412, P0C2H6, P0C2H7, P0CX29, P0CX30, P0CY39, P0CY40, P36105, P38754, P46222, P55844, P61353, P61354, P61355, P61356, P61357, P61358, P61359, P62251, P69090, P69091, P91914, Q02753, Q02984, Q12672, Q1JQ99, Q43291, Q4R8Z4, Q6FLA8, Q6P1L8, Q6YIA3, Q7M0E7, Q7ZTZ2, Q7ZV82, Q8LJU5

Diamond homologs: A0L5Y3, A0PXV6, A1BJ24, A2C4Y9, A3PGM1, A4SCR9, A4WVJ8, A4XBN6, A5CCK2, A5GVX0, A5I7J6, A6LPS1, A6X0C8, A7FZ59, A7GJ64, A8IAQ6, A8LM67, A8M519, A9B421, A9BCN7, A9IW13, A9M5P0, B0B892, B0BCF7, B0SA37, B0SSG7, B1IGE4, B1KSL5, B1WQS0, B1X4Z8, B1XJS9, B2S2E6, B2S669, B3CN36, B3EGY0, B3EP51, B3EUL3, B3QR72, B3QYD4, B4S5B8

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
MRPL14	“form complex”	“39S mitochondrial large ribosomal subunit”	binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 83 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Mitochondrial ribosome-associated quality control	20	39.0×	8e-25
Mitochondrial translation initiation	17	34.2×	4e-20
Mitochondrial translation elongation	17	34.2×	4e-20
Mitochondrial translation	15	32.8×	2e-17
Mitochondrial translation termination	17	29.6×	4e-19
Translation	15	14.8×	3e-12

GO biological processes:

GO term	Partners	Fold	FDR
mitochondrial translation	18	42.3×	3e-22
negative regulation of translation	5	13.2×	4e-03
protein autophosphorylation	6	11.8×	1e-03
translation	8	11.1×	1e-04
MAPK cascade	5	10.3×	9e-03
protein phosphorylation	8	7.3×	1e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

45 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	32
Likely benign	1
Benign	2

Top pathogenic / likely-pathogenic (0)

SpliceAI

634 predictions. Top by Δscore:

Variant	Effect	Δscore
6:44114205:TGGTG:T	acceptor_gain	1.0000
6:44114207:GTG:G	acceptor_gain	1.0000
6:44114208:TG:T	acceptor_gain	1.0000
6:44114206:GGTG:G	acceptor_gain	0.9900
6:44114208:TGC:T	acceptor_loss	0.9900
6:44114209:GCT:G	acceptor_loss	0.9900
6:44114210:C:CC	acceptor_gain	0.9900
6:44114210:CTG:C	acceptor_loss	0.9900
6:44114211:T:G	acceptor_loss	0.9900
6:44114213:G:GC	acceptor_gain	0.9900
6:44116536:GTTA:G	donor_loss	0.9900
6:44116537:TTAC:T	donor_loss	0.9900
6:44116538:TA:T	donor_loss	0.9900
6:44116539:ACC:A	donor_loss	0.9900
6:44116540:C:CA	donor_loss	0.9900
6:44116626:GATCC:G	acceptor_loss	0.9900
6:44116628:TC:T	acceptor_gain	0.9900
6:44116629:CC:C	acceptor_gain	0.9900
6:44116629:CCTG:C	acceptor_loss	0.9900
6:44116630:C:CG	acceptor_loss	0.9900
6:44116631:T:A	acceptor_loss	0.9900
6:44127068:AGCAG:A	donor_loss	0.9900
6:44127069:GCAGG:G	donor_loss	0.9900
6:44127070:CAG:C	donor_loss	0.9900
6:44127071:AGG:A	donor_loss	0.9900
6:44127072:GGTG:G	donor_loss	0.9900
6:44127073:GTGA:G	donor_loss	0.9900
6:44127074:T:G	donor_loss	0.9900
6:44114213:G:C	acceptor_gain	0.9800
6:44116630:C:CC	acceptor_gain	0.9800

AlphaMissense

949 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
6:44113964:A:T	V106D	0.984
6:44113981:G:C	F100L	0.984
6:44113981:G:T	F100L	0.984
6:44113983:A:G	F100L	0.984
6:44114063:A:T	I73K	0.979
6:44114063:A:C	I73R	0.969
6:44113928:C:G	R118P	0.967
6:44113977:A:G	S102P	0.967
6:44114024:A:T	I86N	0.967
6:44114027:A:G	L85P	0.966
6:44114149:A:C	S44R	0.966
6:44114149:A:T	S44R	0.966
6:44114151:T:G	S44R	0.966
6:44113859:G:T	A141D	0.965
6:44114112:A:G	C57R	0.965
6:44113972:G:C	N103K	0.964
6:44113972:G:T	N103K	0.964
6:44113967:A:T	V105E	0.962
6:44114110:G:C	C57W	0.962
6:44114063:A:G	I73T	0.961
6:44113961:A:T	L107H	0.957
6:44114072:C:A	G70V	0.957
6:44114021:A:T	V87E	0.956
6:44114157:C:G	D42H	0.954
6:44113873:C:A	K136N	0.953
6:44113873:C:G	K136N	0.953
6:44113913:A:T	I123N	0.953
6:44113925:A:G	I119T	0.953
6:44113935:C:A	G116W	0.953
6:44114030:G:T	A84E	0.953

dbSNP variants (sampled 300 via entrez): RS1000098100 (6:44115374 T>C), RS1000277610 (6:44121774 T>C), RS1000339022 (6:44128132 T>C), RS1000770792 (6:44126696 A>T), RS1001018520 (6:44120523 T>C), RS1001795351 (6:44117846 T>G), RS1002114455 (6:44114504 C>T), RS1002162612 (6:44128296 G>T), RS1002448631 (6:44125093 T>C), RS1002835070 (6:44114089 A>C,G), RS1002910005 (6:44114264 A>C), RS1003133131 (6:44128445 C>G,T), RS1003244079 (6:44113197 G>T), RS1003560906 (6:44124888 C>T), RS1003591869 (6:44125232 T>C)

Disease associations

OMIM: gene MIM:611827 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

6 associations (top):

Study	Trait	p-value
GCST001155_1	Vascular endothelial growth factor levels	0.000000e+00
GCST001850_17	Major depressive disorder	9.000000e-06
GCST002942_11	Percentage gas trapping	9.000000e-07
GCST009144_30	Disease progression in age-related macular degeneration (adjusted for baseline)	9.000000e-07
GCST010867_63	Coronary artery disease	4.000000e-08
GCST012048_5	Triglyceride levels	9.000000e-07

EFO canonical traits (3, from GWAS)

EFO ID	Trait name
EFO:0007628	gas trapping measurement
EFO:0008336	disease progression measurement
EFO:0004530	triglyceride measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

34 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	affects expression, decreases expression	2
ginger extract	decreases expression, increases abundance	1
bisphenol A	decreases methylation	1
arsenite	affects binding, increases reaction	1
manganese chloride	increases expression, increases abundance	1
ochratoxin A	decreases expression	1
gossypol acetic acid	decreases expression	1
pinosylvin	decreases expression	1
di-n-butylphosphoric acid	affects expression	1
CGP 52608	affects binding, increases reaction	1
K 7174	decreases expression	1
4-chloro-N-((4-(1,1-dimethylethyl)phenyl)methyl)-3-ethyl-1-methyl-1H-pyrazole-5-carboxamide	increases expression	1
pyrimidifen	increases expression	1
ICG 001	decreases expression	1
2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine	decreases expression, increases response to substance	1
Acetaminophen	affects cotreatment, decreases expression	1
Air Pollutants	decreases expression, increases abundance	1
Ethyl Methanesulfonate	decreases expression	1
Hydrogen Peroxide	affects expression	1
Lipopolysaccharides	affects cotreatment, decreases expression	1
Manganese	increases abundance, increases expression	1
Methyl Methanesulfonate	decreases expression	1
Oils, Volatile	decreases expression, increases abundance	1
Ribonucleotides	affects binding	1
Rotenone	increases expression	1
Smoke	decreases expression	1
Dronabinol	decreases expression	1
Thiram	decreases expression	1
Tobacco Smoke Pollution	increases expression	1
Valproic Acid	decreases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.