MRPL15

Summary

MRPL15 (mitochondrial ribosomal protein L15, HGNC:14054) is a protein-coding gene on chromosome 8q11.23, encoding Large ribosomal subunit protein uL15m (Q9P015). It is a selective cancer dependency (DepMap: 47.8% of cell lines).

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the EcoL15 ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome 15q.

Source: NCBI Gene 29088 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 58 total
• Cancer dependency (DepMap): dependent in 47.8% of screened cell lines
• MANE Select transcript: NM_014175

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:14054
Approved symbol	MRPL15
Name	mitochondrial ribosomal protein L15
Location	8q11.23
Locus type	gene with protein product
Status	Approved
Aliases	RPML7, MRP-L7, HSPC145, L15mt, MRP-L15, uL15m
Ensembl gene	ENSG00000137547
Ensembl biotype	protein_coding
OMIM	611828
Entrez	29088

Gene structure

Transcript identifiers

Ensembl transcripts: 7 — 7 protein_coding

ENST00000260102, ENST00000519831, ENST00000522521, ENST00000867845, ENST00000938846, ENST00000938847, ENST00000938848

RefSeq mRNA: 1 — MANE Select: NM_014175 NM_014175

CCDS: CCDS6158

Canonical transcript exons

ENST00000260102 — 5 exons

Exon	Start	End
ENSE00000693950	54136511	54136665
ENSE00000928386	54147382	54148514
ENSE00001192002	54135241	54135391
ENSE00003743315	54142663	54142786
ENSE00003753157	54137268	54137433

Expression profiles

Bgee: expression breadth ubiquitous, 286 present calls, max score 98.35.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 62.6533 / max 325.4950, expressed in 1822 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
88861	62.6533	1822

Top tissues by expression

290 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
heart right ventricle	UBERON:0002080	98.35	gold quality
vastus lateralis	UBERON:0001379	98.15	gold quality
biceps brachii	UBERON:0001507	98.10	gold quality
quadriceps femoris	UBERON:0001377	98.04	gold quality
hindlimb stylopod muscle	UBERON:0004252	97.97	gold quality
gastrocnemius	UBERON:0001388	97.86	gold quality
deltoid	UBERON:0001476	97.63	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	97.63	gold quality
triceps brachii	UBERON:0001509	97.57	gold quality
muscle organ	UBERON:0001630	97.56	gold quality
skeletal muscle organ	UBERON:0014892	97.56	gold quality
heart left ventricle	UBERON:0002084	97.52	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	97.51	gold quality
cardiac ventricle	UBERON:0002082	97.48	gold quality
skeletal muscle tissue	UBERON:0001134	97.46	gold quality
muscle of leg	UBERON:0001383	97.46	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	97.17	gold quality
right atrium auricular region	UBERON:0006631	97.08	gold quality
body of tongue	UBERON:0011876	96.99	gold quality
cardiac atrium	UBERON:0002081	96.95	gold quality
myocardium	UBERON:0002349	96.94	gold quality
apex of heart	UBERON:0002098	96.86	gold quality
muscle tissue	UBERON:0002385	96.84	gold quality
diaphragm	UBERON:0001103	96.83	gold quality
rectum	UBERON:0001052	96.73	gold quality
heart	UBERON:0000948	96.67	gold quality
left ventricle myocardium	UBERON:0006566	96.49	gold quality
tibialis anterior	UBERON:0001385	96.30	gold quality
mucosa of transverse colon	UBERON:0004991	95.94	gold quality
cardiac muscle of right atrium	UBERON:0003379	95.30	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-CURD-112	no	3.76
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

41 targeting MRPL15, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-6833-3P	100.00	70.63	3197
HSA-MIR-4768-5P	100.00	69.49	2861
HSA-MIR-4775	99.98	75.00	6394
HSA-MIR-23B-5P	99.98	66.07	587
HSA-MIR-590-3P	99.96	74.34	6478
HSA-MIR-651-3P	99.94	73.48	5177
HSA-MIR-23A-5P	99.94	65.39	468
HSA-MIR-141-3P	99.94	72.79	2421
HSA-MIR-200A-3P	99.94	72.68	2420
HSA-MIR-6809-3P	99.91	71.45	3814
HSA-MIR-3919	99.87	69.45	2489
HSA-MIR-579-3P	99.86	71.66	3628
HSA-MIR-664B-3P	99.84	71.65	3590
HSA-MIR-4420	99.82	70.08	1624
HSA-MIR-181B-2-3P	99.81	70.06	1646
HSA-MIR-181B-3P	99.81	70.06	1646
HSA-MIR-1299	99.77	71.24	2389
HSA-MIR-4524A-3P	99.72	66.85	2406
HSA-MIR-4470	99.66	69.35	1767
HSA-MIR-875-3P	99.63	69.47	2548
HSA-MIR-6757-3P	99.63	66.88	1089
HSA-MIR-1252-3P	99.55	67.71	2862
HSA-MIR-6727-3P	99.49	65.92	1333
HSA-MIR-4441	99.49	66.56	3216
HSA-MIR-4722-3P	99.35	65.22	1099
HSA-MIR-6505-3P	99.34	67.39	1071
HSA-MIR-140-3P	99.04	67.69	1324
HSA-MIR-4270	99.02	66.26	1987
HSA-MIR-194-5P	99.01	69.65	1465
HSA-MIR-6754-5P	98.60	65.54	1627

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 47.8% of screened cell lines.

Literature-anchored findings (GeneRIF, showing 2)

• MRPL15 is a novel prognostic biomarker and therapeutic target for epithelial ovarian cancer. (PMID:33934540)
• Methylation factor MRPL15 identified as a potential biological target in Alzheimer’s disease. (PMID:34016794)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	mrpl15	ENSDARG00000101306
mus_musculus	Mrpl15	ENSMUSG00000033845
rattus_norvegicus	Mrpl15	ENSRNOG00000008566
drosophila_melanogaster	mRpL15	FBGN0036990
caenorhabditis_elegans	mrpl-15	WBGENE00022373

Protein

Protein identifiers

Large ribosomal subunit protein uL15m — Q9P015 (reviewed: Q9P015)

Alternative names: 39S ribosomal protein L15, mitochondrial

All UniProt accessions (3): Q9P015, E5RHF4, E5RIZ4

UniProt curated annotations — full annotation on UniProt →

Subunit / interactions. Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.

Subcellular location. Mitochondrion.

Similarity. Belongs to the universal ribosomal protein uL15 family.

RefSeq proteins (1): NP_054894* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR005749	Ribosomal_uL15_bact	Family
IPR021131	Ribosomal_uL15/eL18	Domain
IPR030878	Ribosomal_uL15	Family
IPR036227	Ribosomal_uL15/eL18_sf	Homologous_superfamily

Pfam: PF00828

UniProt features (43 total): helix 17, strand 12, turn 8, sequence conflict 2, transit peptide 1, chain 1, region of interest 1, compositionally biased region 1

Structure

Experimental structures (PDB)

86 structures, top 30 by resolution.

PDB	Method	Resolution (Å)
7OF0	ELECTRON MICROSCOPY	2.2
7QI4	ELECTRON MICROSCOPY	2.21
8RRI	ELECTRON MICROSCOPY	2.4
8QU5	ELECTRON MICROSCOPY	2.42
9OLF	ELECTRON MICROSCOPY	2.46
7OF7	ELECTRON MICROSCOPY	2.5
7PO4	ELECTRON MICROSCOPY	2.56
6ZM6	ELECTRON MICROSCOPY	2.59
7O9M	ELECTRON MICROSCOPY	2.6
7OF6	ELECTRON MICROSCOPY	2.6
9CN3	ELECTRON MICROSCOPY	2.62
7QI5	ELECTRON MICROSCOPY	2.63
7OF2	ELECTRON MICROSCOPY	2.7
7OF3	ELECTRON MICROSCOPY	2.7
7OF4	ELECTRON MICROSCOPY	2.7
8QU1	ELECTRON MICROSCOPY	2.74
9PR4	ELECTRON MICROSCOPY	2.77
9PRA	ELECTRON MICROSCOPY	2.83
8ANY	ELECTRON MICROSCOPY	2.85
6ZM5	ELECTRON MICROSCOPY	2.89
7QH7	ELECTRON MICROSCOPY	2.89
7ODR	ELECTRON MICROSCOPY	2.9
7OF5	ELECTRON MICROSCOPY	2.9
8K2A	ELECTRON MICROSCOPY	2.9
8OIT	ELECTRON MICROSCOPY	2.9
9PGL	ELECTRON MICROSCOPY	2.9
9PGF	ELECTRON MICROSCOPY	2.93
6VMI	ELECTRON MICROSCOPY	2.96
6VLZ	ELECTRON MICROSCOPY	2.97
7QI6	ELECTRON MICROSCOPY	2.98

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9P015-F1	91.15	0.75

Function

Pathways and Gene Ontology

Reactome pathways

7 pathways

ID	Pathway
R-HSA-5368286	Mitochondrial translation initiation
R-HSA-5389840	Mitochondrial translation elongation
R-HSA-5419276	Mitochondrial translation termination
R-HSA-9937383	Mitochondrial ribosome-associated quality control
R-HSA-392499	Metabolism of proteins
R-HSA-5368287	Mitochondrial translation
R-HSA-72766	Translation

MSigDB gene sets: 178 (showing top): GSE18804_BRAIN_VS_COLON_TUMORAL_MACROPHAGE_DN, GSE18804_SPLEEN_MACROPHAGE_VS_TUMORAL_MACROPHAGE_DN, GSE45365_CTRL_VS_MCMV_INFECTION_NK_CELL_DN, GOBP_RESPONSE_TO_PEPTIDE, STARK_PREFRONTAL_CORTEX_22Q11_DELETION_DN, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN, GOBP_MITOCHONDRIAL_TRANSLATION, MONNIER_POSTRADIATION_TUMOR_ESCAPE_UP, GOBP_TRANSLATION, WEI_MYCN_TARGETS_WITH_E_BOX, ONKEN_UVEAL_MELANOMA_UP, GOMF_STRUCTURAL_CONSTITUENT_OF_RIBOSOME, HESS_TARGETS_OF_HOXA9_AND_MEIS1_UP, GOCC_MITOCHONDRIAL_ENVELOPE, GARY_CD5_TARGETS_DN

GO Biological Process (3): mitochondrial translation (GO:0032543), cellular response to leukemia inhibitory factor (GO:1990830), translation (GO:0006412)

GO Molecular Function (3): RNA binding (GO:0003723), structural constituent of ribosome (GO:0003735), protein binding (GO:0005515)

GO Cellular Component (6): mitochondrion (GO:0005739), mitochondrial inner membrane (GO:0005743), mitochondrial large ribosomal subunit (GO:0005762), ribosome (GO:0005840), large ribosomal subunit (GO:0015934), ribonucleoprotein complex (GO:1990904)

Reactome top-level categories

Rollup of top-3 pathways:

Category	Pathways
Mitochondrial translation	4
Translation	1
Metabolism of proteins	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
mitochondrion	1
translation	1
mitochondrial gene expression	1
cellular response to cytokine stimulus	1
response to leukemia inhibitory factor	1
peptidyltransferase activity	1
translational initiation	1
translational elongation	1
translational termination	1
macromolecule biosynthetic process	1
protein metabolic process	1
protein biosynthetic process	1
nucleic acid binding	1
structural molecule activity	1
ribosome	1
binding	1
cytoplasm	1
intracellular membrane-bounded organelle	1
organelle inner membrane	1
mitochondrial membrane	1
organellar large ribosomal subunit	1
mitochondrial ribosome	1
mitochondrial protein-containing complex	1
intracellular membraneless organelle	1
ribosomal subunit	1
protein-containing complex	1

Protein interactions and networks

STRING

3097 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
MRPL15	RPL15	P39030	531
MRPL15	NEURL1B	A8MQ27	487
MRPL15	PMPCB	O75439	480
MRPL15	RITA1	Q96K30	470
MRPL15	MRPL16	Q9NX20	462
MRPL15	GSAP	A4D1B5	455
MRPL15	MRPL2	Q5T653	443
MRPL15	RPL7L1	Q6DKI1	442
MRPL15	MRPL9	Q9BYD2	432
MRPL15	PCMT1	P22061	427
MRPL15	THOC7	Q6I9Y2	394
MRPL15	ATP6V1H	Q9UI12	374
MRPL15	MRPS16	Q9Y3D3	364
MRPL15	HYPK	Q9NX55	360
MRPL15	MRPS2	Q9Y399	359

IntAct

185 interactions, top by confidence:

A	B	Type	Score
MRPL15	CCNDBP1	psi-mi:“MI:0915”(physical association)	0.780
CCNDBP1	MRPL15	psi-mi:“MI:0915”(physical association)	0.780
YBX1	HNRNPR	psi-mi:“MI:0914”(association)	0.770
MRPS30	GTPBP10	psi-mi:“MI:0914”(association)	0.640
LIN28A	IGF2BP3	psi-mi:“MI:0914”(association)	0.640
MRPL15	RUNDC3A	psi-mi:“MI:0915”(physical association)	0.560
RUNDC3A	MRPL15	psi-mi:“MI:0915”(physical association)	0.560
SNRPA	MRPL15	psi-mi:“MI:0915”(physical association)	0.560
U2AF2	MRPL15	psi-mi:“MI:0915”(physical association)	0.560
TEFM	POLRMT	psi-mi:“MI:0914”(association)	0.560
Zfp36	CNOT1	psi-mi:“MI:0914”(association)	0.560
NP	KPNA6	psi-mi:“MI:0914”(association)	0.550
MRPL50	GTPBP10	psi-mi:“MI:0914”(association)	0.530
MRPL10	ZZEF1	psi-mi:“MI:0914”(association)	0.530
MRPL42	GATC	psi-mi:“MI:0914”(association)	0.530
MRPL28	MRPL3	psi-mi:“MI:0914”(association)	0.530
MRPL41	MRPL3	psi-mi:“MI:0914”(association)	0.530
MRPL2	GTPBP10	psi-mi:“MI:0914”(association)	0.530
IGF2BP3	PTCD1	psi-mi:“MI:0914”(association)	0.530
MRPL13	GTPBP10	psi-mi:“MI:0914”(association)	0.530
MRPL18	GTPBP10	psi-mi:“MI:0914”(association)	0.530

BioGRID (280): MRPL15 (Two-hybrid), MRPL15 (Two-hybrid), MRPL15 (Affinity Capture-RNA), MRPL15 (Affinity Capture-RNA), MRPL15 (Affinity Capture-MS), MRPL15 (Affinity Capture-MS), MRPL15 (Affinity Capture-MS), MRPL15 (Affinity Capture-MS), MRPL15 (Affinity Capture-MS), MRPL15 (Affinity Capture-MS), MRPL15 (Affinity Capture-MS), MRPL15 (Affinity Capture-MS), MRPL15 (Affinity Capture-MS), MRPL15 (Affinity Capture-MS), MRPL15 (Affinity Capture-MS)

ESM2 similar proteins: A0A1D8PFV1, G1SVW5, G1TVS8, O02056, O15594, O65729, P02385, P05426, P08429, P09180, P09897, P0DJ55, P10664, P14148, P18124, P19253, P35427, P35679, P36578, P40429, P42791, P49165, P49626, P49669, P49691, P50878, Q0VC21, Q28346, Q3SZ90, Q4PM04, Q4R506, Q4R5P9, Q4R8Z2, Q54Z69, Q58DT1, Q58DW0, Q5R9R4, Q5RA38, Q5RCR3, Q5ZJ56

Diamond homologs: A0M579, A0PXW5, A1B047, A1USR3, A3PGN0, A4IJK7, A4WVI9, A4YSL1, A5ELK8, A5FN02, A5FZU6, A5V5Y3, A5VQY7, A6GZ80, A6U878, A6X0D7, A7HWT0, A7IPQ1, A8LM76, A9H3K5, A9IW02, A9KJH5, A9M5N1, A9VP96, A9W4S1, B0CH13, B0T2E1, B0UHV0, B1LWQ7, B1Z774, B2IK81, B2S660, B3PWU0, B3QBW1, B3QR90, B4R8N6, B5ZYV4, B6IRS5, B6JEY4, B7GJ86

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
MRPL15	“form complex”	“39S mitochondrial large ribosomal subunit”	binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 158 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Mitochondrial ribosome-associated quality control	39	42.8×	2e-53
Mitochondrial translation	34	41.8×	3e-46
Mitochondrial translation initiation	36	40.8×	1e-48
Mitochondrial translation elongation	36	40.8×	1e-48
Mitochondrial translation termination	36	35.3×	5e-46
Translation	36	19.9×	5e-36
Transport of Mature Transcript to Cytoplasm	5	17.0×	1e-04
Peptide chain elongation	10	11.3×	4e-07

GO biological processes:

GO term	Partners	Fold	FDR
mitochondrial translation	39	48.4×	2e-54
translation	30	22.0×	1e-29
cytoplasmic translation	10	13.2×	8e-07
negative regulation of translation	8	11.2×	9e-05
regulation of alternative mRNA splicing, via spliceosome	6	10.5×	2e-03
mRNA processing	11	6.2×	2e-04

Disease & clinical

Clinical variants and AI predictions

ClinVar

58 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	50
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

470 predictions. Top by Δscore:

Variant	Effect	Δscore
8:54135391:GGTAA:G	donor_loss	1.0000
8:54135392:G:GA	donor_loss	1.0000
8:54135392:G:GG	donor_gain	1.0000
8:54135393:T:A	donor_loss	1.0000
8:54136506:T:TA	acceptor_gain	1.0000
8:54136508:CAGG:C	acceptor_gain	1.0000
8:54136509:A:AG	acceptor_gain	1.0000
8:54136509:A:C	acceptor_loss	1.0000
8:54136509:AG:A	acceptor_gain	1.0000
8:54136509:AGGA:A	acceptor_gain	1.0000
8:54136510:G:GA	acceptor_gain	1.0000
8:54136510:GG:G	acceptor_gain	1.0000
8:54136510:GGA:G	acceptor_gain	1.0000
8:54136510:GGAG:G	acceptor_gain	1.0000
8:54136510:GGAGA:G	acceptor_gain	1.0000
8:54136659:GACA:G	donor_gain	1.0000
8:54136665:GGTAA:G	donor_loss	1.0000
8:54136666:G:GA	donor_loss	1.0000
8:54136666:G:GG	donor_gain	1.0000
8:54137266:A:AG	acceptor_gain	1.0000
8:54137267:G:GA	acceptor_gain	1.0000
8:54137267:GTTTC:G	acceptor_gain	1.0000
8:54137430:GGAG:G	donor_gain	1.0000
8:54137431:GAGG:G	donor_gain	1.0000
8:54137431:GAGGT:G	donor_loss	1.0000
8:54137433:GGTA:G	donor_loss	1.0000
8:54137434:G:T	donor_loss	1.0000
8:54137435:T:G	donor_loss	1.0000
8:54142661:AG:A	acceptor_gain	1.0000
8:54142662:GG:G	acceptor_gain	1.0000

AlphaMissense

1907 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
8:54136601:T:C	F67L	0.995
8:54136603:T:A	F67L	0.995
8:54136603:T:G	F67L	0.995
8:54142780:A:C	S183R	0.994
8:54142782:T:A	S183R	0.994
8:54142782:T:G	S183R	0.994
8:54147487:G:C	R220P	0.994
8:54142754:T:A	V174D	0.993
8:54137423:T:A	L140Q	0.992
8:54147486:C:A	R220S	0.992
8:54147490:G:A	G221E	0.992
8:54137330:G:C	R109P	0.990
8:54137417:T:A	V138D	0.990
8:54142694:T:A	I154N	0.990
8:54137297:T:A	L98H	0.989
8:54142700:T:A	V156E	0.989
8:54147643:G:A	G272E	0.989
8:54147645:T:A	W273R	0.989
8:54147645:T:C	W273R	0.989
8:54137423:T:G	L140R	0.988
8:54137306:T:A	L101Q	0.987
8:54137315:T:C	L104P	0.987
8:54137414:G:A	G137D	0.987
8:54142676:T:C	F148S	0.987
8:54142765:T:C	F178L	0.987
8:54142767:C:A	F178L	0.987
8:54142767:C:G	F178L	0.987
8:54136649:T:C	F83L	0.986
8:54136651:T:A	F83L	0.986
8:54136651:T:G	F83L	0.986

dbSNP variants (sampled 300 via entrez): RS1000272980 (8:54146819 T>C), RS1000347964 (8:54148492 G>A), RS1000376196 (8:54134601 A>G), RS1000409496 (8:54141571 G>A), RS1000425801 (8:54141233 T>C), RS1000597306 (8:54146698 T>A,C), RS1000667305 (8:54148220 G>A), RS1000707102 (8:54142338 T>C), RS1000752747 (8:54140221 G>A,C,T), RS1000885369 (8:54133271 C>T), RS1001094808 (8:54147015 C>T), RS1001205344 (8:54135697 G>C), RS1001419227 (8:54139610 A>G), RS1001477347 (8:54148901 C>T), RS1001804762 (8:54147425 C>A,G,T)

Disease associations

OMIM: gene MIM:611828 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST011741_56	LDL cholesterol levels in HIV infection	7.000000e-06

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0004611	low density lipoprotein cholesterol measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

36 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects cotreatment, increases expression, decreases expression	4
sodium arsenite	decreases expression, affects cotreatment, increases abundance, increases expression	3
Acetaminophen	decreases expression	3
Cadmium Chloride	decreases expression, increases abundance, increases expression	3
Tretinoin	decreases expression	2
dicrotophos	decreases expression	1
bisphenol A	increases expression	1
trichostatin A	affects expression	1
manganese chloride	increases abundance, increases expression, affects cotreatment	1
gossypol acetic acid	decreases expression	1
di-n-butylphosphoric acid	affects expression	1
perfluorooctane sulfonic acid	increases expression	1
2,3,5-(triglutathion-S-yl)hydroquinone	increases ADP-ribosylation	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, increases expression	1
ICG 001	decreases expression	1
dorsomorphin	affects cotreatment, increases expression	1
bisphenol S	affects expression	1
(+)-JQ1 compound	decreases expression	1
bisphenol AF	increases expression	1
Resveratrol	affects cotreatment, increases expression	1
Air Pollutants	increases abundance, decreases expression	1
Arsenic	affects cotreatment, increases abundance, increases expression	1
Atrazine	decreases expression	1
Benzo(a)pyrene	decreases methylation	1
Cadmium	increases expression, increases abundance	1
Dichlorodiphenyl Dichloroethylene	increases expression	1
Ivermectin	decreases expression	1
Lead	affects expression	1
Manganese	increases abundance, increases expression, affects cotreatment	1
Plant Extracts	affects cotreatment, increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.