MRPL16

Summary

MRPL16 (mitochondrial ribosomal protein L16, HGNC:14476) is a protein-coding gene on chromosome 11q12.1, encoding Large ribosomal subunit protein uL16m (Q9NX20). It is a selective cancer dependency (DepMap: 56.7% of cell lines).

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein.

Source: NCBI Gene 54948 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 47 total
• Cancer dependency (DepMap): dependent in 56.7% of screened cell lines
• MANE Select transcript: NM_017840

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:14476
Approved symbol	MRPL16
Name	mitochondrial ribosomal protein L16
Location	11q12.1
Locus type	gene with protein product
Status	Approved
Aliases	FLJ20484, PNAS-111, uL16m
Ensembl gene	ENSG00000166902
Ensembl biotype	protein_coding
OMIM	611829
Entrez	54948

Gene structure

Transcript identifiers

Ensembl transcripts: 7 — 5 protein_coding, 2 retained_intron

ENST00000300151, ENST00000525470, ENST00000531802, ENST00000534340, ENST00000884381, ENST00000923616, ENST00000923617

RefSeq mRNA: 1 — MANE Select: NM_017840 NM_017840

CCDS: CCDS7976

Canonical transcript exons

ENST00000300151 — 4 exons

Exon	Start	End
ENSE00001107615	59806140	59806832
ENSE00001107620	59810604	59810778
ENSE00003583764	59807701	59807849
ENSE00003669119	59809855	59809920

Expression profiles

Bgee: expression breadth ubiquitous, 278 present calls, max score 96.99.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 65.9732 / max 350.5138, expressed in 1822 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
119881	65.9732	1822

Top tissues by expression

287 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
apex of heart	UBERON:0002098	96.99	gold quality
right adrenal gland	UBERON:0001233	96.42	gold quality
heart left ventricle	UBERON:0002084	96.26	gold quality
cardiac ventricle	UBERON:0002082	96.23	gold quality
mucosa of transverse colon	UBERON:0004991	96.21	gold quality
right adrenal gland cortex	UBERON:0035827	96.11	gold quality
left adrenal gland	UBERON:0001234	96.01	gold quality
left adrenal gland cortex	UBERON:0035825	95.91	gold quality
hindlimb stylopod muscle	UBERON:0004252	95.90	gold quality
right atrium auricular region	UBERON:0006631	95.83	gold quality
adrenal cortex	UBERON:0001235	95.77	gold quality
heart right ventricle	UBERON:0002080	95.74	gold quality
heart	UBERON:0000948	95.43	gold quality
cardiac atrium	UBERON:0002081	95.22	gold quality
rectum	UBERON:0001052	95.13	gold quality
adrenal gland	UBERON:0002369	95.11	gold quality
body of tongue	UBERON:0011876	94.78	gold quality
transverse colon	UBERON:0001157	94.58	gold quality
right lobe of liver	UBERON:0001114	94.56	gold quality
body of pancreas	UBERON:0001150	94.56	gold quality
body of stomach	UBERON:0001161	94.54	gold quality
muscle of leg	UBERON:0001383	94.31	gold quality
lower esophagus muscularis layer	UBERON:0035833	94.31	gold quality
lower esophagus	UBERON:0013473	94.30	gold quality
biceps brachii	UBERON:0001507	94.17	gold quality
gastrocnemius	UBERON:0001388	94.13	gold quality
vena cava	UBERON:0004087	94.02	silver quality
renal medulla	UBERON:0000362	94.01	gold quality
muscle layer of sigmoid colon	UBERON:0035805	93.96	gold quality
muscle organ	UBERON:0001630	93.95	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-MTAB-7606	no	244.38
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

22 targeting MRPL16, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3065-5P	99.97	71.56	3281
HSA-MIR-551B-5P	99.96	71.28	3493
HSA-MIR-3942-3P	99.57	69.03	2854
HSA-MIR-4328	99.57	71.06	4094
HSA-MIR-3616-5P	99.55	67.02	989
HSA-MIR-573	99.55	67.44	955
HSA-MIR-7159-5P	99.53	72.12	2472
HSA-MIR-582-5P	99.47	70.79	2635
HSA-MIR-513A-3P	99.39	70.63	3620
HSA-MIR-513C-3P	99.39	70.63	3620
HSA-MIR-3140-5P	99.39	69.04	1136
HSA-MIR-135A-5P	99.36	71.85	1601
HSA-MIR-135B-5P	99.36	71.63	1613
HSA-MIR-3606-3P	99.11	69.84	3254
HSA-MIR-4478	99.07	65.16	2320
HSA-MIR-222-5P	98.75	69.17	1242
HSA-MIR-6868-3P	98.63	69.64	2259
HSA-MIR-1248	98.47	67.54	1314
HSA-MIR-6783-5P	97.67	67.21	1528
HSA-MIR-194-3P	97.36	65.96	1027
HSA-MIR-4448	97.04	66.22	752
HSA-MIR-6734-5P	95.70	65.56	950

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 56.7% of screened cell lines.

Literature-anchored findings (GeneRIF, showing 1)

• Results from a study on gene expression variability markers in early-stage human embryos shows that MRPL16 is a putative variability and gene expression level marker for the 3-day, 8-cell embryo stage. (PMID:26288249)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	mrpl16	ENSDARG00000075325
mus_musculus	Mrpl16	ENSMUSG00000024683
rattus_norvegicus	Mrpl16	ENSRNOG00000021005
drosophila_melanogaster	mRpL16	FBGN0023519
caenorhabditis_elegans		WBGENE00011412

Protein

Protein identifiers

Large ribosomal subunit protein uL16m — Q9NX20 (reviewed: Q9NX20)

Alternative names: 39S ribosomal protein L16, mitochondrial

All UniProt accessions (2): Q9NX20, E9PI14

UniProt curated annotations — full annotation on UniProt →

Subunit / interactions. Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.

Subcellular location. Mitochondrion.

Similarity. Belongs to the universal ribosomal protein uL16 family.

RefSeq proteins (1): NP_060310* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000114	Ribosomal_uL16_bact	Family
IPR016180	Ribosomal_uL16_dom	Domain
IPR036920	Ribosomal_uL16_sf	Homologous_superfamily
IPR047873	Ribosomal_uL16	Family

Pfam: PF00252

UniProt features (26 total): strand 11, helix 7, sequence variant 3, turn 2, transit peptide 1, chain 1, sequence conflict 1

Structure

Experimental structures (PDB)

87 structures, top 30 by resolution.

PDB	Method	Resolution (Å)
7OF0	ELECTRON MICROSCOPY	2.2
7QI4	ELECTRON MICROSCOPY	2.21
8RRI	ELECTRON MICROSCOPY	2.4
8QU5	ELECTRON MICROSCOPY	2.42
9OLF	ELECTRON MICROSCOPY	2.46
7OF7	ELECTRON MICROSCOPY	2.5
7PO4	ELECTRON MICROSCOPY	2.56
6ZM6	ELECTRON MICROSCOPY	2.59
7O9M	ELECTRON MICROSCOPY	2.6
7OF6	ELECTRON MICROSCOPY	2.6
9CN3	ELECTRON MICROSCOPY	2.62
7QI5	ELECTRON MICROSCOPY	2.63
7OF2	ELECTRON MICROSCOPY	2.7
7OF3	ELECTRON MICROSCOPY	2.7
7OF4	ELECTRON MICROSCOPY	2.7
8QU1	ELECTRON MICROSCOPY	2.74
9PR4	ELECTRON MICROSCOPY	2.77
9PRA	ELECTRON MICROSCOPY	2.83
8ANY	ELECTRON MICROSCOPY	2.85
6ZM5	ELECTRON MICROSCOPY	2.89
7QH7	ELECTRON MICROSCOPY	2.89
7ODR	ELECTRON MICROSCOPY	2.9
7OF5	ELECTRON MICROSCOPY	2.9
8K2A	ELECTRON MICROSCOPY	2.9
8OIT	ELECTRON MICROSCOPY	2.9
9PGL	ELECTRON MICROSCOPY	2.9
9PGF	ELECTRON MICROSCOPY	2.93
6VMI	ELECTRON MICROSCOPY	2.96
6VLZ	ELECTRON MICROSCOPY	2.97
7QI6	ELECTRON MICROSCOPY	2.98

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9NX20-F1	88.97	0.83

Function

Pathways and Gene Ontology

Reactome pathways

7 pathways

ID	Pathway
R-HSA-5368286	Mitochondrial translation initiation
R-HSA-5389840	Mitochondrial translation elongation
R-HSA-5419276	Mitochondrial translation termination
R-HSA-9937383	Mitochondrial ribosome-associated quality control
R-HSA-392499	Metabolism of proteins
R-HSA-5368287	Mitochondrial translation
R-HSA-72766	Translation

MSigDB gene sets: 130 (showing top): GOBP_MITOCHONDRIAL_TRANSLATION, IVANOVA_HEMATOPOIESIS_LATE_PROGENITOR, GOBP_TRANSLATION, GOMF_STRUCTURAL_CONSTITUENT_OF_RIBOSOME, GNF2_FBL, GOCC_MITOCHONDRIAL_ENVELOPE, BERENJENO_TRANSFORMED_BY_RHOA_UP, GOCC_LARGE_RIBOSOMAL_SUBUNIT, GOCC_RIBOSOME, GOCC_ORGANELLAR_RIBOSOME, GOCC_MITOCHONDRIAL_MATRIX, GOCC_ORGANELLE_INNER_MEMBRANE, GOCC_RIBOSOMAL_SUBUNIT, BLALOCK_ALZHEIMERS_DISEASE_DN, GOCC_RIBONUCLEOPROTEIN_COMPLEX

GO Biological Process (2): mitochondrial translation (GO:0032543), translation (GO:0006412)

GO Molecular Function (2): structural constituent of ribosome (GO:0003735), rRNA binding (GO:0019843)

GO Cellular Component (6): mitochondrion (GO:0005739), mitochondrial inner membrane (GO:0005743), mitochondrial large ribosomal subunit (GO:0005762), ribosome (GO:0005840), large ribosomal subunit (GO:0015934), ribonucleoprotein complex (GO:1990904)

Reactome top-level categories

Rollup of top-3 pathways:

Category	Pathways
Mitochondrial translation	4
Translation	1
Metabolism of proteins	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
mitochondrion	1
translation	1
mitochondrial gene expression	1
peptidyltransferase activity	1
translational initiation	1
translational elongation	1
translational termination	1
macromolecule biosynthetic process	1
protein metabolic process	1
protein biosynthetic process	1
structural molecule activity	1
ribosome	1
RNA binding	1
cytoplasm	1
intracellular membrane-bounded organelle	1
organelle inner membrane	1
mitochondrial membrane	1
organellar large ribosomal subunit	1
mitochondrial ribosome	1
mitochondrial protein-containing complex	1
intracellular membraneless organelle	1
ribosomal subunit	1
protein-containing complex	1

Protein interactions and networks

STRING

4303 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
MRPL16	MRPL24	Q96A35	717
MRPL16	MRPL21	Q7Z2W9	709
MRPL16	MRPL17	Q9NRX2	666
MRPL16	MRPL2	Q5T653	662
MRPL16	MRPS16	Q9Y3D3	595
MRPL16	MRPL30	Q8TCC3	591
MRPL16	MRPS11	P82912	575
MRPL16	MRPL11	Q9Y3B7	561
MRPL16	MRPL33	O75394	552
MRPL16	MRPS2	Q9Y399	551
MRPL16	MRPS18C	Q9Y3D5	534
MRPL16	MRPS18A	Q9NVS2	529
MRPL16	MRPL20	Q9BYC9	522
MRPL16	MRPS5	P82675	507
MRPL16	KGD4	P82909	492

IntAct

179 interactions, top by confidence:

A	B	Type	Score
YBX1	HNRNPR	psi-mi:“MI:0914”(association)	0.770
NDUFS3	NDUFS8	psi-mi:“MI:0914”(association)	0.730
MRPL37	HSPD1	psi-mi:“MI:0914”(association)	0.710
CFTR	ESYT2	psi-mi:“MI:2364”(proximity)	0.710
MRPS30	GTPBP10	psi-mi:“MI:0914”(association)	0.640
LIN28A	IGF2BP3	psi-mi:“MI:0914”(association)	0.640
NP	KPNA6	psi-mi:“MI:0914”(association)	0.550
MRPL50	GTPBP10	psi-mi:“MI:0914”(association)	0.530
DHX32	POLRMT	psi-mi:“MI:0914”(association)	0.530
RPL18	NOP56	psi-mi:“MI:0914”(association)	0.530
MRPL10	ZZEF1	psi-mi:“MI:0914”(association)	0.530
MRPL42	GATC	psi-mi:“MI:0914”(association)	0.530
MRPL28	MRPL3	psi-mi:“MI:0914”(association)	0.530
MRPL41	MRPL3	psi-mi:“MI:0914”(association)	0.530
MRPL16	HSPD1	psi-mi:“MI:0914”(association)	0.530
MRPL2	GTPBP10	psi-mi:“MI:0914”(association)	0.530
MRPL13	GTPBP10	psi-mi:“MI:0914”(association)	0.530
MRPL18	GTPBP10	psi-mi:“MI:0914”(association)	0.530
MRPL16	MRPL2	psi-mi:“MI:0914”(association)	0.530
ABT1	ZNF316	psi-mi:“MI:0914”(association)	0.530
MRPL27	MRPL33	psi-mi:“MI:0914”(association)	0.530
NDUFAB1	MIEF1	psi-mi:“MI:0915”(physical association)	0.490
DDX21	MED19	psi-mi:“MI:2364”(proximity)	0.480

BioGRID (237): MRPL16 (Affinity Capture-MS), HNRNPA1 (Affinity Capture-MS), MRPL16 (Affinity Capture-MS), MRPL16 (Affinity Capture-MS), MRPL16 (Affinity Capture-MS), MRPL16 (Affinity Capture-MS), MRPL16 (Affinity Capture-MS), MRPL16 (Affinity Capture-MS), MRPL16 (Affinity Capture-MS), MRPL16 (Co-fractionation), MRPL16 (Co-fractionation), MRPL16 (Co-fractionation), MRPS7 (Co-fractionation), MRPL16 (Affinity Capture-MS), MRPL16 (Affinity Capture-MS)

ESM2 similar proteins: A0A1D8PDL6, A1CJS8, A1D7P0, A3LQ06, A5DCN7, A5DZE1, A6R3Q6, A6S4J2, A6ZR80, A7TIZ1, O01802, O60143, P05737, P0CQ60, P0CQ61, P0CU36, P11874, P25457, P40078, P60039, P60040, Q0UV95, Q12213, Q1DQ27, Q4P3S7, Q4WX36, Q54GN8, Q54J69, Q5A2Y7, Q5AIB8, Q5B954, Q5M818, Q5R7L3, Q5ZKT8, Q6AZN4, Q6BTA4, Q6BU14, Q6C603, Q6C6D1, Q6CNC5

Diamond homologs: A0ALW1, A0RM18, A0T0I6, A0T0Y0, A1A076, A1W1V3, A2RC21, A3CK70, A4XLS3, A5USI2, A5VLJ8, A6MW08, A6QCQ5, A7H105, A7H649, A7HBM5, A7NR56, A7ZG05, A8AZL8, A8FP14, A8Z675, A9B419, A9KJI7, A9NEE0, A9WH73, B0RZU7, B1I8K5, B1MW07, B2G8X1, B2IS47, B2RLY5, B3DQC1, B4U507, B5E6G2, B5XJ43, B7GND3, B8DB15, B8G6R8, B8ZKG4, B9DSV7

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
MRPL16	“form complex”	“39S mitochondrial large ribosomal subunit”	binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 161 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Mitochondrial ribosome-associated quality control	37	37.5×	6e-48
Mitochondrial translation	31	35.2×	4e-39
Mitochondrial translation initiation	33	34.6×	2e-41
Mitochondrial translation elongation	33	34.6×	2e-41
Mitochondrial translation termination	33	29.9×	4e-39
Translation	34	17.4×	1e-31
Peptide chain elongation	11	11.5×	1e-07
Viral mRNA Translation	11	11.5×	1e-07

GO biological processes:

GO term	Partners	Fold	FDR
mitochondrial translation	35	41.4×	2e-45
mitochondrial large ribosomal subunit assembly	5	33.7×	4e-05
translation	31	21.7×	2e-30
cytoplasmic translation	12	15.1×	6e-09
negative regulation of translation	9	12.0×	1e-05
rRNA processing	8	7.7×	1e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

47 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	41
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

523 predictions. Top by Δscore:

Variant	Effect	Δscore
11:59806829:ATGCC:A	acceptor_loss	1.0000
11:59806831:GCC:G	acceptor_loss	1.0000
11:59806833:CTAAA:C	acceptor_loss	1.0000
11:59807694:CACT:C	donor_loss	1.0000
11:59807695:ACTC:A	donor_loss	1.0000
11:59807696:CTCA:C	donor_loss	1.0000
11:59807697:TCA:T	donor_loss	1.0000
11:59807698:CACC:C	donor_loss	1.0000
11:59807699:A:AC	donor_gain	1.0000
11:59807699:A:AG	donor_loss	1.0000
11:59807700:C:CC	donor_gain	1.0000
11:59807700:C:CG	donor_loss	1.0000
11:59807847:CAT:C	acceptor_gain	1.0000
11:59807849:TCT:T	acceptor_loss	1.0000
11:59807850:C:CC	acceptor_gain	1.0000
11:59807850:CTAAA:C	acceptor_loss	1.0000
11:59807851:T:C	acceptor_loss	1.0000
11:59809850:CTCA:C	donor_loss	1.0000
11:59809851:TCAC:T	donor_loss	1.0000
11:59809853:A:AG	donor_loss	1.0000
11:59809854:CCTTC:C	donor_loss	1.0000
11:59809918:AATC:A	acceptor_loss	1.0000
11:59809919:ATC:A	acceptor_loss	1.0000
11:59809920:TCTA:T	acceptor_loss	1.0000
11:59809921:C:CC	acceptor_gain	1.0000
11:59809921:CT:C	acceptor_loss	1.0000
11:59806830:TGC:T	acceptor_gain	0.9900
11:59806833:C:CC	acceptor_gain	0.9900
11:59806834:T:A	acceptor_loss	0.9900
11:59806839:G:C	acceptor_gain	0.9900

AlphaMissense

1645 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:59806739:A:G	W122R	0.989
11:59806739:A:T	W122R	0.989
11:59806746:A:C	F119L	0.984
11:59806746:A:T	F119L	0.984
11:59806748:A:G	F119L	0.984
11:59806716:C:A	K129N	0.983
11:59806716:C:G	K129N	0.983
11:59806786:C:G	R106P	0.983
11:59807705:A:T	I89N	0.979
11:59807708:G:T	A88E	0.977
11:59806744:G:T	A120D	0.975
11:59806771:C:G	R111P	0.975
11:59806466:A:G	W213R	0.974
11:59806466:A:T	W213R	0.974
11:59806642:A:T	V154E	0.974
11:59806787:G:T	R106S	0.973
11:59806543:G:T	A187E	0.971
11:59806548:G:C	F185L	0.968
11:59806548:G:T	F185L	0.968
11:59806550:A:G	F185L	0.968
11:59806470:G:C	N211K	0.967
11:59806470:G:T	N211K	0.967
11:59806831:G:T	A91E	0.966
11:59806624:A:T	V160D	0.965
11:59807753:C:G	R73P	0.965
11:59807705:A:G	I89T	0.964
11:59807709:C:G	A88P	0.964
11:59807726:A:G	F82S	0.964
11:59806630:C:G	R158P	0.963
11:59806813:A:G	L97P	0.962

dbSNP variants (sampled 300 via entrez): RS1000040802 (11:59809292 C>T), RS1000207020 (11:59805730 C>A), RS1000661079 (11:59807372 A>G), RS1000730486 (11:59806013 G>A), RS1000948304 (11:59807027 C>T), RS1001936686 (11:59806478 T>C,G), RS1002041672 (11:59812334 T>G), RS1002237202 (11:59809643 C>A), RS1002561490 (11:59807965 G>A), RS1003457207 (11:59806093 A>G), RS1004030231 (11:59807587 G>A,T), RS1004347763 (11:59812455 G>A), RS1004392815 (11:59806118 G>A,T), RS1004709835 (11:59807483 C>G,T), RS1005582911 (11:59812400 G>A)

Disease associations

OMIM: gene MIM:611829 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

36 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Acetaminophen	affects cotreatment, decreases expression	4
sodium arsenite	increases expression, decreases expression	2
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	decreases expression	2
Cyclosporine	decreases expression	2
aristolochic acid I	decreases expression	1
triphenyl phosphate	affects expression	1
arsenite	affects binding, increases reaction	1
tris(1,3-dichloro-2-propyl)phosphate	decreases expression	1
potassium chromate(VI)	affects cotreatment, decreases expression	1
epigallocatechin gallate	affects cotreatment, decreases expression	1
corosolic acid	decreases expression	1
K 7174	decreases expression	1
bisphenol B	increases expression	1
abrine	decreases expression	1
Grape Seed Proanthocyanidins	affects cotreatment, decreases expression	1
NSC 689534	affects binding, decreases expression	1
bisphenol AF	increases expression	1
Resveratrol	affects cotreatment, increases expression	1
Air Pollutants	decreases expression, increases abundance	1
Arsenic	affects methylation	1
Benzo(a)pyrene	increases methylation	1
Carbamazepine	affects expression	1
Catechin	affects cotreatment, decreases expression	1
Copper	affects binding, decreases expression	1
Dimethyl Sulfoxide	increases expression	1
Drugs, Chinese Herbal	decreases expression	1
Lipopolysaccharides	affects cotreatment, decreases expression	1
Piroxicam	decreases expression	1
Plant Extracts	affects cotreatment, increases expression	1
Ribonucleotides	affects binding	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.