MRPL17

Summary

MRPL17 (mitochondrial ribosomal protein L17, HGNC:14053) is a protein-coding gene on chromosome 11p15.4, encoding Large ribosomal subunit protein bL17m (Q9NRX2). It is a selective cancer dependency (DepMap: 49.7% of cell lines).

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein.

Source: NCBI Gene 63875 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• Clinical variants (ClinVar): 39 total
• Cancer dependency (DepMap): dependent in 49.7% of screened cell lines
• MANE Select transcript: NM_022061

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:14053
Approved symbol	MRPL17
Name	mitochondrial ribosomal protein L17
Location	11p15.4
Locus type	gene with protein product
Status	Approved
Aliases	RPML26, MRP-L26, bL17m
Ensembl gene	ENSG00000158042
Ensembl biotype	protein_coding
OMIM	611830
Entrez	63875

Gene structure

Transcript identifiers

Ensembl transcripts: 7 — 5 protein_coding, 1 retained_intron, 1 protein_coding_CDS_not_defined

ENST00000288937, ENST00000529958, ENST00000532203, ENST00000532676, ENST00000921844, ENST00000921845, ENST00000921846

RefSeq mRNA: 1 — MANE Select: NM_022061 NM_022061

CCDS: CCDS31412

Canonical transcript exons

ENST00000288937 — 3 exons

Exon	Start	End
ENSE00001036733	6682747	6682815
ENSE00001188391	6680385	6682402
ENSE00001220106	6683123	6683340

Expression profiles

Bgee: expression breadth ubiquitous, 260 present calls, max score 96.48.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 49.6270 / max 178.9909, expressed in 1821 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
118458	49.6270	1821

Top tissues by expression

279 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
stromal cell of endometrium	CL:0002255	96.48	gold quality
apex of heart	UBERON:0002098	95.02	gold quality
adenohypophysis	UBERON:0002196	94.21	gold quality
left adrenal gland	UBERON:0001234	94.00	gold quality
heart right ventricle	UBERON:0002080	93.82	gold quality
right adrenal gland	UBERON:0001233	93.75	gold quality
left adrenal gland cortex	UBERON:0035825	93.66	gold quality
pituitary gland	UBERON:0000007	93.57	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	93.47	gold quality
right adrenal gland cortex	UBERON:0035827	93.35	gold quality
hindlimb stylopod muscle	UBERON:0004252	93.17	gold quality
periodontal ligament	UBERON:0008266	93.07	gold quality
heart left ventricle	UBERON:0002084	92.75	gold quality
adrenal gland	UBERON:0002369	92.74	gold quality
adrenal cortex	UBERON:0001235	92.70	gold quality
cardiac ventricle	UBERON:0002082	92.63	gold quality
mucosa of transverse colon	UBERON:0004991	92.15	gold quality
prefrontal cortex	UBERON:0000451	92.10	gold quality
ventricular zone	UBERON:0003053	91.89	gold quality
islet of Langerhans	UBERON:0000006	91.76	gold quality
parotid gland	UBERON:0001831	91.68	silver quality
heart	UBERON:0000948	91.46	gold quality
adult mammalian kidney	UBERON:0000082	91.38	gold quality
right atrium auricular region	UBERON:0006631	91.35	gold quality
cartilage tissue	UBERON:0002418	91.33	gold quality
gall bladder	UBERON:0002110	91.27	gold quality
ganglionic eminence	UBERON:0004023	91.14	gold quality
body of pancreas	UBERON:0001150	90.47	gold quality
cardiac atrium	UBERON:0002081	90.28	gold quality
gastrocnemius	UBERON:0001388	90.24	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	7.71

Regulation

Is transcription factor: no

Upstream regulators (CollecTRI, top): CTCF

miRNA regulators (miRDB)

78 targeting MRPL17, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4533	100.00	69.48	2758
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-4476	100.00	68.18	2030
HSA-MIR-6876-5P	100.00	67.68	2126
HSA-MIR-1252-5P	100.00	69.80	2774
HSA-MIR-4682	100.00	68.89	1258
HSA-MIR-4768-5P	100.00	69.49	2861
HSA-MIR-6798-5P	100.00	65.77	699
HSA-MIR-4425	100.00	67.59	1049
HSA-MIR-6833-3P	100.00	70.63	3197
HSA-MIR-5696	99.98	72.36	4487
HSA-MIR-3148	99.97	75.06	6478
HSA-MIR-3658	99.96	73.87	4379
HSA-MIR-651-3P	99.94	73.48	5177
HSA-MIR-205-3P	99.92	69.92	3165
HSA-MIR-5682	99.89	72.56	1005
HSA-MIR-6715A-3P	99.83	68.05	1473
HSA-MIR-4639-5P	99.81	67.37	1028
HSA-MIR-4658	99.77	64.94	514
HSA-MIR-6790-5P	99.77	65.24	505
HSA-MIR-7856-5P	99.75	69.99	2901
HSA-MIR-6505-5P	99.73	69.25	1595
HSA-MIR-4699-3P	99.71	70.15	3142
HSA-MIR-548BA	99.69	69.14	1514
HSA-MIR-7161-5P	99.68	68.92	1592
HSA-MIR-548U	99.65	67.78	1463
HSA-MIR-4499	99.62	67.29	1470
HSA-MIR-6513-3P	99.59	69.77	1102
HSA-MIR-6832-5P	99.58	64.82	1132

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 49.7% of screened cell lines.

Literature-anchored findings (GeneRIF, showing 1)

• High levels of LIP2 were found in serum and synovial fluid of rheumatoid arthritis patients, providing evidence for a cytokine-like role. (PMID:18162190)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	mrpl17	ENSDARG00000075677
mus_musculus	Mrpl17	ENSMUSG00000030879
rattus_norvegicus	Mrpl17	ENSRNOG00000019497
caenorhabditis_elegans	mrpl-17	WBGENE00021829

Protein

Protein identifiers

Large ribosomal subunit protein bL17m — Q9NRX2 (reviewed: Q9NRX2)

Alternative names: 39S ribosomal protein L17, mitochondrial, LYST-interacting protein 2

All UniProt accessions (2): E9PKV2, Q9NRX2

UniProt curated annotations — full annotation on UniProt →

Subunit / interactions. Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.

Subcellular location. Mitochondrion.

Tissue specificity. Detected in adrenal gland, mammary gland and adipose tissue.

Similarity. Belongs to the bacterial ribosomal protein bL17 family.

RefSeq proteins (1): NP_071344* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR000456	Ribosomal_bL17	Family
IPR036373	Ribosomal_bL17_sf	Homologous_superfamily

Pfam: PF01196

UniProt features (17 total): helix 6, strand 5, transit peptide 1, chain 1, turn 1, region of interest 1, compositionally biased region 1, sequence conflict 1

Structure

Experimental structures (PDB)

87 structures, top 30 by resolution.

PDB	Method	Resolution (Å)
7OF0	ELECTRON MICROSCOPY	2.2
7QI4	ELECTRON MICROSCOPY	2.21
8RRI	ELECTRON MICROSCOPY	2.4
8QU5	ELECTRON MICROSCOPY	2.42
9OLF	ELECTRON MICROSCOPY	2.46
7OF7	ELECTRON MICROSCOPY	2.5
7PO4	ELECTRON MICROSCOPY	2.56
6ZM6	ELECTRON MICROSCOPY	2.59
7O9M	ELECTRON MICROSCOPY	2.6
7OF6	ELECTRON MICROSCOPY	2.6
9CN3	ELECTRON MICROSCOPY	2.62
7QI5	ELECTRON MICROSCOPY	2.63
7OF2	ELECTRON MICROSCOPY	2.7
7OF3	ELECTRON MICROSCOPY	2.7
7OF4	ELECTRON MICROSCOPY	2.7
8QU1	ELECTRON MICROSCOPY	2.74
9PR4	ELECTRON MICROSCOPY	2.77
9PRA	ELECTRON MICROSCOPY	2.83
8ANY	ELECTRON MICROSCOPY	2.85
6ZM5	ELECTRON MICROSCOPY	2.89
7QH7	ELECTRON MICROSCOPY	2.89
7ODR	ELECTRON MICROSCOPY	2.9
7OF5	ELECTRON MICROSCOPY	2.9
8K2A	ELECTRON MICROSCOPY	2.9
8OIT	ELECTRON MICROSCOPY	2.9
9PGL	ELECTRON MICROSCOPY	2.9
9PGF	ELECTRON MICROSCOPY	2.93
6VMI	ELECTRON MICROSCOPY	2.96
6VLZ	ELECTRON MICROSCOPY	2.97
7QI6	ELECTRON MICROSCOPY	2.98

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9NRX2-F1	93.51	0.87

Function

Pathways and Gene Ontology

Reactome pathways

7 pathways

ID	Pathway
R-HSA-5368286	Mitochondrial translation initiation
R-HSA-5389840	Mitochondrial translation elongation
R-HSA-5419276	Mitochondrial translation termination
R-HSA-9937383	Mitochondrial ribosome-associated quality control
R-HSA-392499	Metabolism of proteins
R-HSA-5368287	Mitochondrial translation
R-HSA-72766	Translation

MSigDB gene sets: 154 (showing top): TONKS_TARGETS_OF_RUNX1_RUNX1T1_FUSION_MONOCYTE_UP, HONMA_DOCETAXEL_RESISTANCE, STARK_PREFRONTAL_CORTEX_22Q11_DELETION_DN, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN, GOBP_MITOCHONDRIAL_TRANSLATION, GOBP_TRANSLATION, GOMF_STRUCTURAL_CONSTITUENT_OF_RIBOSOME, GOCC_MITOCHONDRIAL_ENVELOPE, PU1_Q6, FISCHER_DREAM_TARGETS, RASHI_RESPONSE_TO_IONIZING_RADIATION_5, GRADE_COLON_AND_RECTAL_CANCER_UP, GOCC_LARGE_RIBOSOMAL_SUBUNIT, GOCC_RIBOSOME, GOCC_ORGANELLAR_RIBOSOME

GO Biological Process (2): mitochondrial translation (GO:0032543), translation (GO:0006412)

GO Molecular Function (3): structural constituent of ribosome (GO:0003735), protein domain specific binding (GO:0019904), protein binding (GO:0005515)

GO Cellular Component (5): mitochondrion (GO:0005739), mitochondrial inner membrane (GO:0005743), mitochondrial large ribosomal subunit (GO:0005762), ribosome (GO:0005840), ribonucleoprotein complex (GO:1990904)

Reactome top-level categories

Rollup of top-3 pathways:

Category	Pathways
Mitochondrial translation	4
Translation	1
Metabolism of proteins	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
mitochondrion	1
translation	1
mitochondrial gene expression	1
peptidyltransferase activity	1
translational initiation	1
translational elongation	1
translational termination	1
macromolecule biosynthetic process	1
protein metabolic process	1
protein biosynthetic process	1
structural molecule activity	1
ribosome	1
protein binding	1
binding	1
cytoplasm	1
intracellular membrane-bounded organelle	1
organelle inner membrane	1
mitochondrial membrane	1
organellar large ribosomal subunit	1
mitochondrial ribosome	1
mitochondrial protein-containing complex	1
intracellular membraneless organelle	1
protein-containing complex	1

Protein interactions and networks

STRING

2995 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
MRPL17	MRPL24	Q96A35	753
MRPL17	MRPL11	Q9Y3B7	745
MRPL17	MRPL4	Q9BYD3	708
MRPL17	MRPL21	Q7Z2W9	704
MRPL17	MRPL16	Q9NX20	666
MRPL17	MRPL36	Q9P0J6	647
MRPL17	MRPL12	P52815	645
MRPL17	MRPL13	Q9BYD1	644
MRPL17	MRPL19	P49406	627
MRPL17	MRPS12	O15235	607
MRPL17	MRPL32	Q9BYC8	593
MRPL17	MRPL33	O75394	578
MRPL17	MRPL45	Q9BRJ2	555
MRPL17	MRPL9	Q9BYD2	542
MRPL17	MRPS16	Q9Y3D3	542

IntAct

139 interactions, top by confidence:

A	B	Type	Score
MIS12	ZWINT	psi-mi:“MI:0914”(association)	0.900
YBX1	SSB	psi-mi:“MI:0914”(association)	0.710
MRPS30	GTPBP10	psi-mi:“MI:0914”(association)	0.640
LIN28A	IGF2BP3	psi-mi:“MI:0914”(association)	0.640
HNRNPF	MRPL17	psi-mi:“MI:0915”(physical association)	0.560
UBTD2	MRPL17	psi-mi:“MI:0915”(physical association)	0.560
NP	KPNA6	psi-mi:“MI:0914”(association)	0.550
MRPL50	GTPBP10	psi-mi:“MI:0914”(association)	0.530
ZNF324B	ZNF316	psi-mi:“MI:0914”(association)	0.530
RPL18	NOP56	psi-mi:“MI:0914”(association)	0.530
MRPL10	ZZEF1	psi-mi:“MI:0914”(association)	0.530
MRPL42	GATC	psi-mi:“MI:0914”(association)	0.530
RSPRY1	NEFL	psi-mi:“MI:0914”(association)	0.530
MRPL28	MRPL3	psi-mi:“MI:0914”(association)	0.530
MRPL41	MRPL3	psi-mi:“MI:0914”(association)	0.530
MRPL2	GTPBP10	psi-mi:“MI:0914”(association)	0.530
NGRN	RPL7	psi-mi:“MI:0914”(association)	0.530
MRPL13	GTPBP10	psi-mi:“MI:0914”(association)	0.530
MRPL18	GTPBP10	psi-mi:“MI:0914”(association)	0.530
MRPL27	MRPL33	psi-mi:“MI:0914”(association)	0.530
NDUFAB1	MIEF1	psi-mi:“MI:0915”(physical association)	0.490
HCCS	MROH1	psi-mi:“MI:0914”(association)	0.350
UBA5	P4HA1	psi-mi:“MI:0914”(association)	0.350
BAG6	CNOT1	psi-mi:“MI:0914”(association)	0.350
MRPL50	MRPL43	psi-mi:“MI:0914”(association)	0.350

BioGRID (205): MRPL17 (Affinity Capture-MS), MRPL17 (Affinity Capture-MS), MRPL17 (Affinity Capture-MS), MRPL17 (Affinity Capture-MS), MRPL17 (Affinity Capture-MS), MRPL17 (Affinity Capture-MS), MRPL17 (Affinity Capture-MS), MRPL17 (Affinity Capture-MS), MRPL17 (Co-fractionation), MRPL17 (Co-fractionation), MRPL17 (Co-fractionation), MRPL17 (Co-fractionation), MRPL17 (Co-fractionation), MRPL17 (Co-fractionation), MRPL17 (Co-fractionation)

ESM2 similar proteins: A0BD73, A0CEY2, A3DJK2, A5GFQ0, B3CT30, B6YQ59, O14006, O42991, O43004, O49885, O65055, O74464, O94150, O94345, P0DJ15, P22353, P26785, P38064, P38120, P47150, Q04PW6, Q10129, Q1K8C8, Q27389, Q3T0L3, Q54TY5, Q5AB87, Q5RAH8, Q5RCA3, Q60R52, Q6BIJ5, Q6CFK6, Q6CJ65, Q6FL25, Q6PDW6, Q72NI9, Q7S5N0, Q95Q11, Q9D8P4, Q9FKC0

Diamond homologs: A0LIL8, A0PXX6, A1ALW8, A1USR9, A1W1J8, A3PGN6, A4IJL5, A4J140, A4XLQ1, A4YSL7, A5D5F0, A5ELK2, A5FZU0, A5GAU7, A5I7H6, A5N4S6, A6LPU1, A6Q1K5, A6TWF2, A7FZ43, A7GJ44, A7HBP6, A7HWT6, A7IPP5, A8FNQ8, A8LM82, A8MLH0, B0K5S2, B0KCM9, B1I1B4, B1IGC4, B1KSJ5, B2IF97, B2TIK5, B2UYE0, B3E858, B3QB18, B4R8P2, B4U773, B5YG21

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
MRPL17	“form complex”	“39S mitochondrial large ribosomal subunit”	binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 129 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Mitochondrial ribosome-associated quality control	35	45.2×	2e-48
Mitochondrial translation	30	43.5×	4e-41
Mitochondrial translation initiation	32	42.7×	2e-43
Mitochondrial translation elongation	32	42.7×	2e-43
Mitochondrial translation termination	32	37.0×	3e-41
Translation	32	20.9×	1e-32
Peptide chain elongation	11	14.7×	7e-09
Viral mRNA Translation	11	14.7×	7e-09

GO biological processes:

GO term	Partners	Fold	FDR
mitochondrial translation	35	53.3×	4e-50
translation	26	23.4×	3e-26
cytoplasmic translation	11	17.9×	4e-09
negative regulation of translation	8	13.8×	1e-05

Disease & clinical

Clinical variants and AI predictions

ClinVar

39 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	32
Likely benign	3
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

194 predictions. Top by Δscore:

Variant	Effect	Δscore
11:6682400:CTC:C	acceptor_gain	1.0000
11:6682403:CTA:C	acceptor_loss	1.0000
11:6682742:CTCA:C	donor_gain	1.0000
11:6682743:TCA:T	donor_loss	1.0000
11:6682744:CACTG:C	donor_loss	1.0000
11:6682745:A:AC	donor_gain	1.0000
11:6682745:AC:A	donor_loss	1.0000
11:6682746:C:CC	donor_gain	1.0000
11:6682746:CT:C	donor_gain	1.0000
11:6682746:CTG:C	donor_gain	1.0000
11:6683117:CCTCA:C	donor_loss	1.0000
11:6683118:CTCA:C	donor_loss	1.0000
11:6683119:TCA:T	donor_loss	1.0000
11:6683120:CA:C	donor_loss	1.0000
11:6683121:ACCTT:A	donor_loss	1.0000
11:6682401:TC:T	acceptor_gain	0.9900
11:6682402:CC:C	acceptor_gain	0.9900
11:6682403:C:CC	acceptor_gain	0.9900
11:6682404:T:A	acceptor_loss	0.9900
11:6682740:CACT:C	donor_loss	0.9900
11:6682741:A:AC	donor_gain	0.9900
11:6682742:C:CC	donor_gain	0.9900
11:6682746:CTGT:C	donor_gain	0.9900
11:6682746:CTGTG:C	donor_gain	0.9900
11:6682845:C:CT	acceptor_gain	0.9900
11:6682846:G:T	acceptor_gain	0.9900
11:6683121:A:AC	donor_gain	0.9900
11:6683122:C:CC	donor_gain	0.9900
11:6683122:CCTT:C	donor_gain	0.9900
11:6683134:AGCC:A	donor_gain	0.9900

AlphaMissense

1135 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:6682376:A:C	F90L	0.989
11:6682376:A:T	F90L	0.989
11:6682378:A:G	F90L	0.989
11:6682756:G:C	F78L	0.986
11:6682756:G:T	F78L	0.986
11:6682758:A:G	F78L	0.986
11:6683178:T:A	E40V	0.986
11:6682802:C:T	G63E	0.984
11:6682751:A:G	L80P	0.982
11:6682803:C:A	G63W	0.982
11:6683208:C:G	R30P	0.980
11:6682382:C:A	K88N	0.979
11:6682382:C:G	K88N	0.979
11:6682755:A:G	W79R	0.979
11:6682755:A:T	W79R	0.979
11:6683131:C:G	A56P	0.979
11:6683130:G:T	A56E	0.978
11:6682284:G:T	A121E	0.977
11:6682763:G:T	A76D	0.977
11:6682814:A:G	L59P	0.977
11:6682285:C:G	A121P	0.976
11:6682751:A:T	L80H	0.976
11:6683175:C:G	R41P	0.976
11:6682814:A:T	L59H	0.974
11:6683142:A:C	M52R	0.971
11:6683176:G:T	R41S	0.970
11:6682377:A:G	F90S	0.967
11:6682278:A:T	I123N	0.966
11:6682764:C:G	A76P	0.966
11:6683142:A:T	M52K	0.966

dbSNP variants (sampled 300 via entrez): RS1000018626 (11:6681222 C>T), RS1000046549 (11:6681463 T>A,C), RS1001069451 (11:6682366 CCAGT>C), RS1001473790 (11:6680455 G>T), RS1001631815 (11:6680780 C>A,G), RS1003233793 (11:6683737 G>A), RS1003266776 (11:6684034 T>C), RS1003298026 (11:6684317 C>T), RS1004169316 (11:6681647 T>TC), RS1004263215 (11:6681911 G>A,C), RS1004586642 (11:6682017 C>G,T), RS1005546082 (11:6681814 C>G,T), RS1005553707 (11:6683046 G>A,C), RS1005976124 (11:6680735 G>T), RS1006046341 (11:6685223 G>T)

Disease associations

OMIM: gene MIM:611830 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST010725_20	Malaria	4.000000e-69
GCST010725_33	Malaria	2.000000e-67
GCST010725_51	Malaria	1.000000e-55

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

27 total (human), top 27 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	affects splicing, decreases expression, increases expression	3
cobaltous chloride	decreases expression	2
arsenite	affects binding, increases reaction	1
di-n-butylphosphoric acid	affects expression	1
K 7174	decreases expression	1
ICG 001	increases expression	1
2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine	decreases expression, increases response to substance	1
3-(2-hydroxy-4-(2-methylnonan-2-yl)phenyl)cyclohexan-1-ol	decreases expression	1
bisphenol AF	increases expression	1
Resveratrol	affects cotreatment, increases expression	1
Sunitinib	increases expression	1
Arsenic Trioxide	increases expression	1
Acetaminophen	affects cotreatment, affects expression, decreases expression	1
Ivermectin	decreases expression	1
Lipopolysaccharides	affects cotreatment, affects expression	1
Plant Extracts	affects cotreatment, increases expression	1
Ribonucleotides	affects binding	1
Smoke	decreases expression	1
Tetrachlorodibenzodioxin	affects expression	1
Dronabinol	decreases expression	1
Thiram	decreases expression	1
Tobacco Smoke Pollution	increases expression	1
Urethane	decreases expression	1
7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide	decreases expression	1
Cyclosporine	decreases expression	1
Sodium Selenite	increases expression	1
Copper Sulfate	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.