MRPL18

Summary

MRPL18 (mitochondrial ribosomal protein L18, HGNC:14477) is a protein-coding gene on chromosome 6q25.3, encoding Large ribosomal subunit protein uL18m (Q9H0U6). Together with thiosulfate sulfurtransferase (TST), acts as a mitochondrial import factor for the cytosolic 5S rRNA. It is a selective cancer dependency (DepMap: 52.2% of cell lines).

This nuclear gene encodes a protein component of the larger 39S subunit of mitochondrial ribosome. This protein may also aid in the import of nuclear-encoded 5S rRNA into mitochondria. Alternative splicing results in multiple transcript variants, most of which are not predicted to encode a protein. A pseudogene of this gene is found on chromosome 16.

Source: NCBI Gene 29074 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 38 total — 1 pathogenic
• Cancer dependency (DepMap): dependent in 52.2% of screened cell lines
• MANE Select transcript: NM_014161

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:14477
Approved symbol	MRPL18
Name	mitochondrial ribosomal protein L18
Location	6q25.3
Locus type	gene with protein product
Status	Approved
Aliases	HSPC071, uL18m
Ensembl gene	ENSG00000112110
Ensembl biotype	protein_coding
OMIM	611831
Entrez	29074

Gene structure

Transcript identifiers

Ensembl transcripts: 6 — 3 protein_coding, 3 protein_coding_CDS_not_defined

ENST00000367034, ENST00000476826, ENST00000479638, ENST00000480842, ENST00000857674, ENST00000953331

RefSeq mRNA: 2 — MANE Select: NM_014161 NM_001318817, NM_014161

CCDS: CCDS5270

Canonical transcript exons

ENST00000367034 — 4 exons

Exon	Start	End
ENSE00001443299	159790467	159790639
ENSE00003649410	159798052	159798429
ENSE00003652170	159797287	159797518
ENSE00003657521	159790940	159791126

Expression profiles

Bgee: expression breadth ubiquitous, 287 present calls, max score 99.33.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 60.7445 / max 709.1135, expressed in 1823 samples.

FANTOM5 promoters (8 alternative TSS)

Promoter ID	TPM avg	Samples expressed
70997	41.3143	1820
70993	8.7788	1779
70995	3.9010	1315
70996	2.0786	1307
70990	2.0431	1028
70991	1.2219	759
70992	1.0676	789
70994	0.3390	149

Top tissues by expression

288 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
oocyte	CL:0000023	99.33	gold quality
secondary oocyte	CL:0000655	98.63	gold quality
olfactory bulb	UBERON:0002264	96.61	gold quality
palpebral conjunctiva	UBERON:0001812	96.50	gold quality
adult organism	UBERON:0007023	96.39	gold quality
hindlimb stylopod muscle	UBERON:0004252	96.32	gold quality
adrenal tissue	UBERON:0018303	96.20	gold quality
cingulate cortex	UBERON:0003027	96.11	gold quality
anterior cingulate cortex	UBERON:0009835	96.11	gold quality
mucosa of transverse colon	UBERON:0004991	95.98	gold quality
smooth muscle tissue	UBERON:0001135	95.93	gold quality
prefrontal cortex	UBERON:0000451	95.87	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	95.84	gold quality
type B pancreatic cell	CL:0000169	95.83	gold quality
rectum	UBERON:0001052	95.65	gold quality
amygdala	UBERON:0001876	95.65	gold quality
mucosa of sigmoid colon	UBERON:0004993	95.65	gold quality
caudate nucleus	UBERON:0001873	95.64	gold quality
gingiva	UBERON:0001828	95.61	gold quality
muscle layer of sigmoid colon	UBERON:0035805	95.57	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	95.55	gold quality
Brodmann (1909) area 9	UBERON:0013540	95.55	gold quality
right adrenal gland	UBERON:0001233	95.51	gold quality
popliteal artery	UBERON:0002250	95.47	gold quality
colonic mucosa	UBERON:0000317	95.46	gold quality
tibial artery	UBERON:0007610	95.46	gold quality
epithelium of nasopharynx	UBERON:0001951	95.45	gold quality
right coronary artery	UBERON:0001625	95.42	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	95.41	gold quality
islet of Langerhans	UBERON:0000006	95.38	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-MTAB-10137	no	668.16
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

14 targeting MRPL18, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-627-3P	99.90	71.42	3316
HSA-MIR-3140-3P	99.88	68.47	2069
HSA-MIR-137-3P	99.87	74.74	2401
HSA-MIR-3660	99.68	67.33	1149
HSA-MIR-486-3P	99.51	66.82	1901
HSA-MIR-4687-3P	99.48	66.41	968
HSA-MIR-4666A-5P	99.41	69.72	1887
HSA-MIR-130A-5P	99.33	70.26	2623
HSA-MIR-324-3P	99.26	66.31	1034
HSA-MIR-5584-3P	99.23	68.79	1351
HSA-MIR-1537-5P	98.70	68.33	999
HSA-MIR-532-5P	98.43	67.53	760
HSA-MIR-6509-3P	98.32	67.33	1343
HSA-MIR-4772-3P	98.04	65.60	1203

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 52.2% of screened cell lines.

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	mrpl18	ENSDARG00000060199
mus_musculus	Mrpl18	ENSMUSG00000057388
rattus_norvegicus	Mrpl18	ENSRNOG00000014582
drosophila_melanogaster	mRpL18	FBGN0026741
caenorhabditis_elegans		WBGENE00017044

Protein

Protein identifiers

Large ribosomal subunit protein uL18m — Q9H0U6 (reviewed: Q9H0U6)

Alternative names: 39S ribosomal protein L18, mitochondrial

All UniProt accessions (1): Q9H0U6

UniProt curated annotations — full annotation on UniProt →

Function. Together with thiosulfate sulfurtransferase (TST), acts as a mitochondrial import factor for the cytosolic 5S rRNA. The precursor form shows RNA chaperone activity; is able to fold the 5S rRNA into an import-competent conformation that is recognized by rhodanese (TST). Both the cytoplasmic and mitochondrial forms are able to bind to the helix IV-loop D in the gamma domain of the 5S rRNA.

Subunit / interactions. Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.

Subcellular location. Mitochondrion.

Similarity. Belongs to the universal ribosomal protein uL18 family.

RefSeq proteins (2): NP_001305746, NP_054880* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR005484	Ribosomal_uL18_bac/plant/anim	Family
IPR036967	Ribosomal_uS11_sf	Homologous_superfamily
IPR057268	Ribosomal_L18	Family

Pfam: PF00861

UniProt features (19 total): strand 8, helix 7, transit peptide 1, chain 1, sequence variant 1, sequence conflict 1

Structure

Experimental structures (PDB)

75 structures, top 30 by resolution.

PDB	Method	Resolution (Å)
7OF0	ELECTRON MICROSCOPY	2.2
7QI4	ELECTRON MICROSCOPY	2.21
8RRI	ELECTRON MICROSCOPY	2.4
8QU5	ELECTRON MICROSCOPY	2.42
9OLF	ELECTRON MICROSCOPY	2.46
7OF7	ELECTRON MICROSCOPY	2.5
7PO4	ELECTRON MICROSCOPY	2.56
6ZM6	ELECTRON MICROSCOPY	2.59
7OF6	ELECTRON MICROSCOPY	2.6
9CN3	ELECTRON MICROSCOPY	2.62
7QI5	ELECTRON MICROSCOPY	2.63
7OF2	ELECTRON MICROSCOPY	2.7
7OF3	ELECTRON MICROSCOPY	2.7
7OF4	ELECTRON MICROSCOPY	2.7
8QU1	ELECTRON MICROSCOPY	2.74
9PR4	ELECTRON MICROSCOPY	2.77
9PRA	ELECTRON MICROSCOPY	2.83
8ANY	ELECTRON MICROSCOPY	2.85
6ZM5	ELECTRON MICROSCOPY	2.89
7QH7	ELECTRON MICROSCOPY	2.89
7ODR	ELECTRON MICROSCOPY	2.9
7OF5	ELECTRON MICROSCOPY	2.9
8K2A	ELECTRON MICROSCOPY	2.9
8OIT	ELECTRON MICROSCOPY	2.9
9PGL	ELECTRON MICROSCOPY	2.9
9PGF	ELECTRON MICROSCOPY	2.93
7QI6	ELECTRON MICROSCOPY	2.98
9PSM	ELECTRON MICROSCOPY	2.98
8QSJ	ELECTRON MICROSCOPY	3
9UWH	ELECTRON MICROSCOPY	3

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9H0U6-F1	86.86	0.75

Function

Pathways and Gene Ontology

Reactome pathways

11 pathways

ID	Pathway
R-HSA-5368286	Mitochondrial translation initiation
R-HSA-5389840	Mitochondrial translation elongation
R-HSA-5419276	Mitochondrial translation termination
R-HSA-9937383	Mitochondrial ribosome-associated quality control
R-HSA-3371453	Regulation of HSF1-mediated heat shock response
R-HSA-3371511	HSF1 activation
R-HSA-3371568	Attenuation phase
R-HSA-3371571	HSF1-dependent transactivation
R-HSA-392499	Metabolism of proteins
R-HSA-5368287	Mitochondrial translation
R-HSA-72766	Translation

MSigDB gene sets: 185 (showing top): MODULE_255, PAL_PRMT5_TARGETS_UP, GOBP_MITOCHONDRIAL_TRANSLATION, MODULE_317, GOLDRATH_ANTIGEN_RESPONSE, GOBP_TRANSLATION, WEI_MYCN_TARGETS_WITH_E_BOX, chr6q25, E2F_Q3, GOMF_STRUCTURAL_CONSTITUENT_OF_RIBOSOME, GOBP_NUCLEOBASE_CONTAINING_COMPOUND_TRANSPORT, GOCC_MITOCHONDRIAL_ENVELOPE, YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_13, ZHOU_INFLAMMATORY_RESPONSE_LIVE_DN, E2F1_Q3

GO Biological Process (3): translation (GO:0006412), mitochondrial translation (GO:0032543), rRNA import into mitochondrion (GO:0035928)

GO Molecular Function (4): structural constituent of ribosome (GO:0003735), 5S rRNA binding (GO:0008097), RNA binding (GO:0003723), protein binding (GO:0005515)

GO Cellular Component (7): obsolete extracellular space (GO:0005615), mitochondrion (GO:0005739), mitochondrial inner membrane (GO:0005743), mitochondrial ribosome (GO:0005761), mitochondrial large ribosomal subunit (GO:0005762), ribosome (GO:0005840), ribonucleoprotein complex (GO:1990904)

Reactome top-level categories

Rollup of top-5 pathways:

Category	Pathways
Mitochondrial translation	4
Cellular response to heat stress	3
HSF1-dependent transactivation	1
Translation	1
Metabolism of proteins	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
peptidyltransferase activity	1
translational initiation	1
translational elongation	1
translational termination	1
macromolecule biosynthetic process	1
protein metabolic process	1
protein biosynthetic process	1
mitochondrion	1
translation	1
mitochondrial gene expression	1
RNA import into mitochondrion	1
rRNA transport	1
structural molecule activity	1
ribosome	1
rRNA binding	1
nucleic acid binding	1
binding	1
cytoplasm	1
intracellular membrane-bounded organelle	1
organelle inner membrane	1
mitochondrial membrane	1
organellar ribosome	1
mitochondrial matrix	1
organellar large ribosomal subunit	1
mitochondrial ribosome	1
mitochondrial protein-containing complex	1
intracellular membraneless organelle	1
protein-containing complex	1

Protein interactions and networks

STRING

1170 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
MRPL18	TST	Q16762	580
MRPL18	MRPS25	P82663	523
MRPL18	MRPL44	Q9H9J2	493
MRPL18	FAM151B	Q6UXP7	474
MRPL18	ACTN3	Q08043	423
MRPL18	GUCY1A1	Q02108	396
MRPL18	GTF3A	Q92664	390
MRPL18	TIMM10	P62072	378
MRPL18	CABP7	Q86V35	364
MRPL18	RPS9	P46781	352
MRPL18	MYL6	P16475	329
MRPL18	TMEM243	Q9BU79	328
MRPL18	MRPS10	P82664	325
MRPL18	CCS	O14618	316
MRPL18	RPL5	P46777	305

IntAct

104 interactions, top by confidence:

A	B	Type	Score
MRPL18	MRPL38	psi-mi:“MI:0915”(physical association)	0.800
MRPL38	MRPL18	psi-mi:“MI:0915”(physical association)	0.800
RPS6	RPL4	psi-mi:“MI:0914”(association)	0.710
YBX1	SSB	psi-mi:“MI:0914”(association)	0.710
MALSU1	NDUFAB1	psi-mi:“MI:0914”(association)	0.710
MRPS30	GTPBP10	psi-mi:“MI:0914”(association)	0.640
RPL4	RPS20	psi-mi:“MI:0914”(association)	0.620
ERH	SNRPD3	psi-mi:“MI:0914”(association)	0.580
MRPL18	LAPTM5	psi-mi:“MI:0915”(physical association)	0.560
LAPTM5	MRPL18	psi-mi:“MI:0915”(physical association)	0.560
RPL4	RPL5	psi-mi:“MI:0914”(association)	0.530
MRPL50	GTPBP10	psi-mi:“MI:0914”(association)	0.530
MRPL10	ZZEF1	psi-mi:“MI:0914”(association)	0.530
MRPL42	GATC	psi-mi:“MI:0914”(association)	0.530
MRPL38	DUSP14	psi-mi:“MI:0914”(association)	0.530
MRPL41	MRPL3	psi-mi:“MI:0914”(association)	0.530
MRPL13	GTPBP10	psi-mi:“MI:0914”(association)	0.530
MRPL18	GTPBP10	psi-mi:“MI:0914”(association)	0.530
MRPL23	BCKDHA	psi-mi:“MI:0914”(association)	0.530
MRPL27	MRPL33	psi-mi:“MI:0914”(association)	0.530
NDUFAB1	MIEF1	psi-mi:“MI:0915”(physical association)	0.490
Ybx1	MRPS18B	psi-mi:“MI:0915”(physical association)	0.400
Sgo2a	GPA33	psi-mi:“MI:0914”(association)	0.350
APC	BBX	psi-mi:“MI:0914”(association)	0.350

BioGRID (283): MRPL18 (Affinity Capture-RNA), MRPL18 (Affinity Capture-RNA), MRPL18 (Affinity Capture-MS), MRPL18 (Affinity Capture-MS), MRPL18 (Affinity Capture-MS), MRPL18 (Affinity Capture-MS), MRPL18 (Affinity Capture-MS), MRPL18 (Affinity Capture-MS), MRPL18 (Affinity Capture-MS), ICT1 (Co-fractionation), MRPL13 (Co-fractionation), MRPL17 (Co-fractionation), MRPL18 (Co-fractionation), MRPL18 (Co-fractionation), MRPL18 (Co-fractionation)

ESM2 similar proteins: A2VD95, A5WUX7, B5XAM2, D2HD32, E7EXT2, O75879, P82673, Q08CK1, Q08DT6, Q0V9C9, Q12322, Q13405, Q14197, Q32LB9, Q3T116, Q3UFY8, Q3ZBR7, Q498P2, Q4R380, Q4R5K7, Q5EA71, Q5I0K8, Q5R8X0, Q5U2R4, Q5XIC2, Q5ZI74, Q640B4, Q6PI78, Q7JUX9, Q7SXA9, Q80VP5, Q80X85, Q8BJZ4, Q8K126, Q8K2Y7, Q8R035, Q8VCE1, Q8VEG4, Q9CQ40, Q9H0U6

Diamond homologs: P34378, Q3ZBR7, Q9CQL5, Q9H0U6, A0KRP0, A0Q4J9, A1RED0, A1S234, A1WVA6, A3DA56, A4IZR8, A4WFB2, A4XLR4, A4YBW7, A5IM99, A6WHU4, A7HM36, A7N9U1, A8F4S7, A8GKI1, A9IW06, A9KJH8, A9KWB8, B0JHY8, B1LBM4, B2ITP0, B2SDW9, B4F1K0, B5FG25, B5XNA9, B5YDV9, B8E1E9, B8EBI9, B8F6Q5, B9K8A2, C4Z2U6, C4ZBT4, C5CGI6, P46182, P52863

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
MRPL18	“form complex”	“39S mitochondrial large ribosomal subunit”	binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 116 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Mitochondrial ribosome-associated quality control	31	48.2×	1e-43
Mitochondrial translation initiation	28	45.0×	2e-38
Mitochondrial translation elongation	28	45.0×	2e-38
Mitochondrial translation	25	43.5×	7e-34
Mitochondrial translation termination	28	38.9×	1e-36
Translation	29	22.8×	9e-31
Peptide chain elongation	9	14.5×	4e-07
Viral mRNA Translation	9	14.5×	4e-07

GO biological processes:

GO term	Partners	Fold	FDR
mitochondrial translation	29	50.9×	3e-40
translation	22	22.8×	7e-22
cytoplasmic translation	9	16.8×	4e-07
RNA splicing	7	6.2×	6e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

38 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	1
Likely pathogenic	0
Uncertain significance	28
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (1)

Variant ID	HGVS	Classification
563245	GRCh37/hg19 6q25.3-27(chr6:159844762-170919482)x3	Pathogenic

SpliceAI

584 predictions. Top by Δscore:

Variant	Effect	Δscore
6:159790773:G:GT	donor_gain	1.0000
6:159791077:A:T	donor_gain	1.0000
6:159798036:T:A	acceptor_gain	1.0000
6:159798044:A:AG	acceptor_gain	1.0000
6:159798045:A:G	acceptor_gain	1.0000
6:159790600:T:TA	donor_gain	0.9900
6:159790777:T:G	donor_gain	0.9900
6:159790811:GGCA:G	donor_gain	0.9900
6:159790812:GCA:G	donor_gain	0.9900
6:159791076:G:GT	donor_gain	0.9900
6:159791124:CAGGT:C	donor_loss	0.9900
6:159791126:GG:G	donor_loss	0.9900
6:159791127:GTA:G	donor_loss	0.9900
6:159791128:T:G	donor_loss	0.9900
6:159797370:G:GG	donor_gain	0.9900
6:159790561:C:T	donor_gain	0.9800
6:159790615:T:TA	donor_gain	0.9800
6:159790769:G:GG	donor_gain	0.9800
6:159790782:G:GT	donor_gain	0.9800
6:159790938:AG:A	acceptor_gain	0.9800
6:159790939:GG:G	acceptor_gain	0.9800
6:159791111:G:GG	donor_gain	0.9800
6:159794885:C:G	donor_gain	0.9800
6:159797344:C:T	donor_gain	0.9800
6:159798050:A:AG	acceptor_gain	0.9800
6:159798051:G:GG	acceptor_gain	0.9800
6:159790933:T:A	acceptor_gain	0.9700
6:159790937:CAGG:C	acceptor_gain	0.9700
6:159790938:AGGG:A	acceptor_gain	0.9700
6:159797374:G:GG	donor_gain	0.9700

AlphaMissense

1153 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
6:159791116:T:C	F77L	0.982
6:159791118:C:A	F77L	0.982
6:159791118:C:G	F77L	0.982
6:159797462:G:C	A139P	0.977
6:159797453:T:C	C136R	0.969
6:159797363:T:C	S106P	0.960
6:159791029:T:C	F48L	0.959
6:159791031:C:A	F48L	0.959
6:159791031:C:G	F48L	0.959
6:159791043:C:A	N52K	0.958
6:159791043:C:G	N52K	0.958
6:159797361:C:A	A105D	0.955
6:159797455:C:G	C136W	0.954
6:159797452:A:C	R135S	0.951
6:159797452:A:T	R135S	0.951
6:159791052:C:A	N55K	0.950
6:159791052:C:G	N55K	0.950
6:159797355:T:A	V103D	0.950
6:159791079:A:C	K64N	0.948
6:159791079:A:T	K64N	0.948
6:159791037:C:A	N50K	0.947
6:159791037:C:G	N50K	0.947
6:159797433:G:A	G129E	0.943
6:159797367:C:T	T107I	0.936
6:159797289:T:C	L81S	0.932
6:159791091:G:C	W68C	0.931
6:159791091:G:T	W68C	0.931
6:159797451:G:C	R135T	0.931
6:159791078:A:T	K64I	0.929
6:159797469:T:C	I141T	0.929

dbSNP variants (sampled 300 via entrez): RS1000015394 (6:159794782 G>A), RS1000518769 (6:159789892 G>GT), RS1000636122 (6:159796127 A>T), RS1000860197 (6:159790878 G>C), RS1001093275 (6:159796033 C>A), RS1001913909 (6:159791892 A>C,G), RS1001977996 (6:159789687 A>C), RS1002263104 (6:159792179 A>G), RS1002693876 (6:159789081 G>A), RS1002745965 (6:159798571 G>GT), RS1002745988 (6:159788970 G>A,C,T), RS1002972563 (6:159793565 T>C), RS1003311491 (6:159793415 T>C), RS1003576935 (6:159793234 T>C), RS1003654242 (6:159788897 G>A)

Disease associations

OMIM: gene MIM:611831 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

42 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	affects expression, increases expression	3
Tobacco Smoke Pollution	increases expression	3
bisphenol A	decreases expression, decreases methylation	2
Acetaminophen	decreases expression, increases expression	2
2-methyl-4-isothiazolin-3-one	increases expression	1
beta-lapachone	decreases expression	1
arsenite	affects binding, increases reaction	1
beta-methylcholine	affects expression	1
celastrol	increases expression	1
di-n-butylphosphoric acid	affects expression	1
chloropicrin	increases expression	1
gedunin	increases expression	1
K 7174	decreases expression	1
ICG 001	increases expression	1
licochalcone B	increases expression	1
PCI 5002	affects cotreatment, increases expression	1
2-amino-7-(4-fluoro-2-(6-methoxypyridin-2-yl)phenyl)-4-methyl-7,8-dihydropyrido(4,3-d)pyrimidin-5(6H)-one	increases activity, increases expression	1
Atrazine	decreases expression	1
Benzo(a)pyrene	increases expression	1
Bilirubin	decreases expression	1
Cadmium	increases abundance, increases expression	1
Cisplatin	increases expression	1
Copper	affects binding, decreases expression	1
Diethylstilbestrol	increases expression	1
Disulfiram	affects binding, decreases expression	1
Estradiol	increases expression	1
Hydrogen Peroxide	affects expression	1
Ivermectin	decreases expression	1
Ketoconazole	increases expression	1
Ribonucleotides	affects binding	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.