MRPL19

Summary

MRPL19 (mitochondrial ribosomal protein L19, HGNC:14052) is a protein-coding gene on chromosome 2p12, encoding Large ribosomal subunit protein bL19m (P49406). It is a selective cancer dependency (DepMap: 33.9% of cell lines).

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein.

Source: NCBI Gene 9801 — RefSeq curated summary.

At a glance

• GWAS associations: 6
• Clinical variants (ClinVar): 54 total
• Druggable target: yes
• Cancer dependency (DepMap): dependent in 33.9% of screened cell lines
• MANE Select transcript: NM_014763

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:14052
Approved symbol	MRPL19
Name	mitochondrial ribosomal protein L19
Location	2p12
Locus type	gene with protein product
Status	Approved
Aliases	MRP-L15, RPML15, KIAA0104, RLX1, bL19m
Ensembl gene	ENSG00000115364
Ensembl biotype	protein_coding
OMIM	611832
Entrez	9801

Gene structure

Transcript identifiers

Ensembl transcripts: 10 — 9 protein_coding, 1 retained_intron

ENST00000358788, ENST00000393909, ENST00000409374, ENST00000453233, ENST00000476622, ENST00000492255, ENST00000493686, ENST00000884931, ENST00000930104, ENST00000930105

RefSeq mRNA: 1 — MANE Select: NM_014763 NM_014763

CCDS: CCDS1960

Canonical transcript exons

ENST00000393909 — 6 exons

Exon	Start	End
ENSE00001516881	75655064	75662206
ENSE00001696460	75647102	75647219
ENSE00003471768	75646783	75646910
ENSE00003575107	75652523	75652657
ENSE00003623099	75654736	75654917
ENSE00003627294	75652142	75652260

Expression profiles

Bgee: expression breadth ubiquitous, 285 present calls, max score 94.12.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 64.9197 / max 686.9537, expressed in 1821 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
21097	63.7428	1821
21098	1.1768	793

Top tissues by expression

293 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
adrenal tissue	UBERON:0018303	94.12	gold quality
gastrocnemius	UBERON:0001388	93.04	gold quality
muscle of leg	UBERON:0001383	92.54	gold quality
right adrenal gland	UBERON:0001233	91.87	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	91.65	gold quality
left adrenal gland	UBERON:0001234	91.59	gold quality
biceps brachii	UBERON:0001507	91.41	gold quality
rectum	UBERON:0001052	91.24	gold quality
right adrenal gland cortex	UBERON:0035827	91.23	gold quality
adrenal gland	UBERON:0002369	90.97	gold quality
gingival epithelium	UBERON:0001949	90.94	gold quality
gingiva	UBERON:0001828	90.93	gold quality
left adrenal gland cortex	UBERON:0035825	90.73	gold quality
islet of Langerhans	UBERON:0000006	90.58	gold quality
muscle organ	UBERON:0001630	90.47	gold quality
hindlimb stylopod muscle	UBERON:0004252	90.37	gold quality
adrenal cortex	UBERON:0001235	90.35	gold quality
oocyte	CL:0000023	90.26	gold quality
secondary oocyte	CL:0000655	90.23	gold quality
calcaneal tendon	UBERON:0003701	90.19	gold quality
heart right ventricle	UBERON:0002080	90.18	gold quality
right lobe of liver	UBERON:0001114	90.17	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	90.05	gold quality
liver	UBERON:0002107	89.94	gold quality
heart left ventricle	UBERON:0002084	89.80	gold quality
cardiac ventricle	UBERON:0002082	89.74	gold quality
nephron tubule	UBERON:0001231	89.58	gold quality
oral cavity	UBERON:0000167	89.29	gold quality
ventricular zone	UBERON:0003053	89.28	gold quality
endometrium	UBERON:0001295	89.08	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	8.60

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

240 targeting MRPL19, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3646	100.00	73.56	5283
HSA-MIR-5011-5P	100.00	83.46	5820
HSA-MIR-30E-5P	100.00	76.32	3242
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-30A-5P	100.00	76.31	3233
HSA-MIR-30B-5P	100.00	76.29	3248
HSA-MIR-30C-5P	100.00	76.29	3248
HSA-MIR-30D-5P	100.00	76.32	3233
HSA-MIR-190A-3P	100.00	80.35	5520
HSA-MIR-450A-1-3P	100.00	69.33	1837
HSA-MIR-1252-5P	100.00	69.80	2774
HSA-MIR-1277-5P	100.00	73.95	5056
HSA-MIR-4682	100.00	68.89	1258
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-196A-5P	100.00	68.16	684
HSA-MIR-196B-5P	100.00	68.16	681
HSA-MIR-371B-5P	99.99	75.34	4759
HSA-MIR-513B-5P	99.99	69.96	2150
HSA-MIR-548AW	99.99	72.57	3559
HSA-MIR-3185	99.99	68.12	1959
HSA-MIR-3662	99.99	73.82	5684
HSA-MIR-12136	99.98	72.81	5713
HSA-MIR-373-5P	99.98	75.36	4753
HSA-MIR-616-5P	99.98	75.58	4775
HSA-MIR-548N	99.98	71.94	4170
HSA-MIR-19A-3P	99.98	75.33	2762
HSA-MIR-19B-3P	99.98	75.44	2754
HSA-MIR-4775	99.98	75.00	6394
HSA-MIR-103A-3P	99.98	69.14	1595
HSA-MIR-107	99.98	69.14	1595

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 33.9% of screened cell lines.

Literature-anchored findings (GeneRIF, showing 4)

• Study refined the 2p12 candidate region in two populations and report evidence supporting MRPL19 and C2ORF3 as candidate susceptibility genes for dyslexia. (PMID:17309879)
• study failed to show any association of MRPL19 SNPs with developmental dyslexia in an Indian population. (PMID:23954868)
• MRPL19 was initially implicated in dyslexia through family-based studies. (PMID:25448322)
• Candidate gene MRPL19 is involved in the development of Reading disorder. (PMID:29566979)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	mrpl19	ENSDARG00000011885
mus_musculus	Mrpl19	ENSMUSG00000030045
rattus_norvegicus	Mrpl19	ENSRNOG00000006968
drosophila_melanogaster	mRpL19	FBGN0037608
caenorhabditis_elegans	mrpl-19	WBGENE00022470

Protein

Protein identifiers

Large ribosomal subunit protein bL19m — P49406 (reviewed: P49406)

Alternative names: 39S ribosomal protein L15, mitochondrial, 39S ribosomal protein L19, mitochondrial

All UniProt accessions (5): P49406, A0A0A0MRF4, H7C2J0, S4R3W9, S4R455

UniProt curated annotations — full annotation on UniProt →

Subunit / interactions. Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.

Subcellular location. Mitochondrion.

Similarity. Belongs to the bacterial ribosomal protein bL19 family.

RefSeq proteins (1): NP_055578* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001857	Ribosomal_bL19	Family
IPR008991	Translation_prot_SH3-like_sf	Homologous_superfamily
IPR038657	Ribosomal_bL19_sf	Homologous_superfamily

Pfam: PF01245

UniProt features (23 total): helix 11, strand 8, transit peptide 1, chain 1, turn 1, modified residue 1

Structure

Experimental structures (PDB)

87 structures, top 30 by resolution.

PDB	Method	Resolution (Å)
7OF0	ELECTRON MICROSCOPY	2.2
7QI4	ELECTRON MICROSCOPY	2.21
8RRI	ELECTRON MICROSCOPY	2.4
8QU5	ELECTRON MICROSCOPY	2.42
9OLF	ELECTRON MICROSCOPY	2.46
7OF7	ELECTRON MICROSCOPY	2.5
7PO4	ELECTRON MICROSCOPY	2.56
6ZM6	ELECTRON MICROSCOPY	2.59
7O9M	ELECTRON MICROSCOPY	2.6
7OF6	ELECTRON MICROSCOPY	2.6
9CN3	ELECTRON MICROSCOPY	2.62
7QI5	ELECTRON MICROSCOPY	2.63
7OF2	ELECTRON MICROSCOPY	2.7
7OF3	ELECTRON MICROSCOPY	2.7
7OF4	ELECTRON MICROSCOPY	2.7
8QU1	ELECTRON MICROSCOPY	2.74
9PR4	ELECTRON MICROSCOPY	2.77
9PRA	ELECTRON MICROSCOPY	2.83
8ANY	ELECTRON MICROSCOPY	2.85
6ZM5	ELECTRON MICROSCOPY	2.89
7QH7	ELECTRON MICROSCOPY	2.89
7ODR	ELECTRON MICROSCOPY	2.9
7OF5	ELECTRON MICROSCOPY	2.9
8K2A	ELECTRON MICROSCOPY	2.9
8OIT	ELECTRON MICROSCOPY	2.9
9PGL	ELECTRON MICROSCOPY	2.9
9PGF	ELECTRON MICROSCOPY	2.93
6VMI	ELECTRON MICROSCOPY	2.96
6VLZ	ELECTRON MICROSCOPY	2.97
7QI6	ELECTRON MICROSCOPY	2.98

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-P49406-F1	84.98	0.73

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 77

Function

Pathways and Gene Ontology

Reactome pathways

7 pathways

ID	Pathway
R-HSA-5368286	Mitochondrial translation initiation
R-HSA-5389840	Mitochondrial translation elongation
R-HSA-5419276	Mitochondrial translation termination
R-HSA-9937383	Mitochondrial ribosome-associated quality control
R-HSA-392499	Metabolism of proteins
R-HSA-5368287	Mitochondrial translation
R-HSA-72766	Translation

MSigDB gene sets: 179 (showing top): SHEPARD_BMYB_MORPHOLINO_UP, GRAESSMANN_APOPTOSIS_BY_DOXORUBICIN_DN, GRAESSMANN_RESPONSE_TO_MC_AND_DOXORUBICIN_DN, GOBP_MITOCHONDRIAL_TRANSLATION, MITSIADES_RESPONSE_TO_APLIDIN_DN, DARWICHE_SKIN_TUMOR_PROMOTER_DN, DARWICHE_PAPILLOMA_RISK_LOW_UP, DARWICHE_PAPILLOMA_RISK_HIGH_DN, DARWICHE_SQUAMOUS_CELL_CARCINOMA_DN, PUJANA_CHEK2_PCC_NETWORK, GOBP_TRANSLATION, WEI_MYCN_TARGETS_WITH_E_BOX, ONKEN_UVEAL_MELANOMA_UP, GOMF_STRUCTURAL_CONSTITUENT_OF_RIBOSOME, GOCC_MITOCHONDRIAL_ENVELOPE

GO Biological Process (2): mitochondrial translation (GO:0032543), translation (GO:0006412)

GO Molecular Function (2): structural constituent of ribosome (GO:0003735), protein binding (GO:0005515)

GO Cellular Component (6): nucleus (GO:0005634), mitochondrion (GO:0005739), mitochondrial inner membrane (GO:0005743), mitochondrial large ribosomal subunit (GO:0005762), ribosome (GO:0005840), ribonucleoprotein complex (GO:1990904)

Reactome top-level categories

Rollup of top-3 pathways:

Category	Pathways
Mitochondrial translation	4
Translation	1
Metabolism of proteins	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
intracellular membrane-bounded organelle	2
mitochondrion	1
translation	1
mitochondrial gene expression	1
peptidyltransferase activity	1
translational initiation	1
translational elongation	1
translational termination	1
macromolecule biosynthetic process	1
protein metabolic process	1
protein biosynthetic process	1
structural molecule activity	1
ribosome	1
binding	1
cytoplasm	1
organelle inner membrane	1
mitochondrial membrane	1
organellar large ribosomal subunit	1
mitochondrial ribosome	1
mitochondrial protein-containing complex	1
intracellular membraneless organelle	1
protein-containing complex	1

Protein interactions and networks

STRING

3315 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
MRPL19	GCFC2	P16383	773
MRPL19	DNAAF4	Q8WXU2	729
MRPL19	KIAA0319	Q5VV43	727
MRPL19	DCDC2	Q9UHG0	703
MRPL19	MRPL11	Q9Y3B7	700
MRPL19	PSMC4	P43686	667
MRPL19	RPLP0	P05388	665
MRPL19	MRPL13	Q9BYD1	628
MRPL19	MRPL17	Q9NRX2	627
MRPL19	SF3A1	Q15459	620
MRPL19	MRPL4	Q9BYD3	612
MRPL19	MRPL24	Q96A35	611
MRPL19	PUM1	Q14671	602
MRPL19	EIF2B1	Q14232	598
MRPL19	MRPL9	Q9BYD2	589

IntAct

119 interactions, top by confidence:

A	B	Type	Score
YBX1	HNRNPR	psi-mi:“MI:0914”(association)	0.770
YBX1	SSB	psi-mi:“MI:0914”(association)	0.710
MRPS30	GTPBP10	psi-mi:“MI:0914”(association)	0.640
MRPL19	LRRK2	psi-mi:“MI:0407”(direct interaction)	0.590
NP	KPNA6	psi-mi:“MI:0914”(association)	0.550
MRPL50	GTPBP10	psi-mi:“MI:0914”(association)	0.530
MRPL10	ZZEF1	psi-mi:“MI:0914”(association)	0.530
MRPL42	GATC	psi-mi:“MI:0914”(association)	0.530
MRPL28	MRPL3	psi-mi:“MI:0914”(association)	0.530
MRPL41	MRPL3	psi-mi:“MI:0914”(association)	0.530
MRPL2	GTPBP10	psi-mi:“MI:0914”(association)	0.530
MRPL13	GTPBP10	psi-mi:“MI:0914”(association)	0.530
MRPL18	GTPBP10	psi-mi:“MI:0914”(association)	0.530
RPL13A	NVL	psi-mi:“MI:0914”(association)	0.530
MRPL27	MRPL33	psi-mi:“MI:0914”(association)	0.530
NDUFAB1	MIEF1	psi-mi:“MI:0915”(physical association)	0.490
MRPL19	MAGEC1	psi-mi:“MI:0915”(physical association)	0.370
MRPL19	TRIM63	psi-mi:“MI:0915”(physical association)	0.370
SMURF2	MRPL19	psi-mi:“MI:0915”(physical association)	0.370
Ppp2r1a	CCHCR1	psi-mi:“MI:0914”(association)	0.350
Smchd1	SETD1A	psi-mi:“MI:0914”(association)	0.350
Max	PABPN1	psi-mi:“MI:0914”(association)	0.350
MRPL50	MRPL43	psi-mi:“MI:0914”(association)	0.350
MRPL9	MRPL43	psi-mi:“MI:0914”(association)	0.350
MRPL1	MRPL43	psi-mi:“MI:0914”(association)	0.350
CENPA	ATP5PD	psi-mi:“MI:0914”(association)	0.350

BioGRID (238): MRPL19 (Two-hybrid), MRPL19 (Two-hybrid), MRPL19 (Affinity Capture-MS), MRPL19 (Affinity Capture-MS), MRPL19 (Affinity Capture-MS), MRPL19 (Affinity Capture-MS), MRPL19 (Affinity Capture-MS), MRPL19 (Affinity Capture-MS), MRPL19 (Affinity Capture-MS), MRPL19 (Affinity Capture-MS), MRPL19 (Affinity Capture-MS), MRPL19 (Affinity Capture-MS), MRPL19 (Affinity Capture-MS), ICT1 (Co-fractionation), MRPL19 (Co-fractionation)

ESM2 similar proteins: A2C4Z2, A9BCP0, B6YSL3, B8GKD3, O15235, O26110, O35680, P09001, P12629, P18665, P25998, P29766, P31165, P31334, P32611, P38064, P49404, P49406, Q0ID12, Q0VC21, Q0W1Y9, Q1K8T6, Q29IK4, Q29RU1, Q3T0J3, Q3ZBX6, Q46IR6, Q5JDJ0, Q5M818, Q5R7L3, Q5R8M4, Q5ZKT8, Q6AZN4, Q6DGM3, Q7SCX7, Q7V9W9, Q7XYP4, Q93425, Q97BX7, Q99N93

Diamond homologs: A0L4Y9, A0RPR5, A1B8V6, A1KSJ8, A1UR22, A4G2T8, A4YK97, A5EXX6, A5V9Q3, A5VKN2, A5VSN4, A6LNY4, A6SVI7, A6UE47, A6WXG3, A7GZB0, A7I0V8, A7IIA9, A7ZDX6, A8IKV6, A9IZA0, A9M2D0, A9M8P3, A9W963, B0CIF8, B0T3B9, B0U8L6, B1I2N2, B1LZR8, B1MZW8, B1ZAP4, B2G816, B2GD23, B2IFY8, B2S861, B3PR19, B3Q853, B3WET9, B4RIW2, B7KVM8

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
MRPL19	“form complex”	“39S mitochondrial large ribosomal subunit”	binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 110 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Mitochondrial ribosome-associated quality control	33	50.0×	3e-47
Mitochondrial translation initiation	30	47.0×	5e-42
Mitochondrial translation elongation	30	47.0×	5e-42
Mitochondrial translation	27	45.9×	2e-37
Mitochondrial translation termination	30	40.7×	6e-40
Translation	28	21.4×	1e-28

GO biological processes:

GO term	Partners	Fold	FDR
mitochondrial translation	31	54.4×	3e-44
mitochondrial large ribosomal subunit assembly	5	50.1×	7e-06
translation	20	20.8×	1e-18

Disease & clinical

Clinical variants and AI predictions

ClinVar

54 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	36
Likely benign	4
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

2647 predictions. Top by Δscore:

Variant	Effect	Δscore
2:75646908:GCA:G	donor_gain	1.0000
2:75646911:G:GG	donor_gain	1.0000
2:75647100:A:AG	acceptor_gain	1.0000
2:75647100:AG:A	acceptor_gain	1.0000
2:75647101:G:GG	acceptor_gain	1.0000
2:75647101:GG:G	acceptor_gain	1.0000
2:75652213:A:G	donor_gain	1.0000
2:75652261:GTCA:G	donor_gain	1.0000
2:75652265:G:GG	donor_gain	1.0000
2:75652269:GAGCT:G	donor_gain	1.0000
2:75652271:GCT:G	donor_gain	1.0000
2:75652512:T:TA	acceptor_gain	1.0000
2:75652515:A:AG	acceptor_gain	1.0000
2:75652516:T:G	acceptor_gain	1.0000
2:75652518:T:TA	acceptor_gain	1.0000
2:75652518:TGTA:T	acceptor_loss	1.0000
2:75652520:TA:T	acceptor_loss	1.0000
2:75652521:A:G	acceptor_loss	1.0000
2:75652521:AG:A	acceptor_gain	1.0000
2:75652522:GG:G	acceptor_gain	1.0000
2:75652522:GGAA:G	acceptor_gain	1.0000
2:75652653:ACAAG:A	donor_gain	1.0000
2:75652654:CAAG:C	donor_gain	1.0000
2:75652654:CAAGG:C	donor_loss	1.0000
2:75652655:AAGG:A	donor_loss	1.0000
2:75652656:AG:A	donor_gain	1.0000
2:75652657:GG:G	donor_gain	1.0000
2:75652657:GGTA:G	donor_loss	1.0000
2:75652658:G:GG	donor_gain	1.0000
2:75652658:GTAA:G	donor_loss	1.0000

AlphaMissense

1921 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
2:75652525:A:C	S115R	0.995
2:75652527:T:A	S115R	0.995
2:75652527:T:G	S115R	0.995
2:75655103:T:A	W233R	0.993
2:75655103:T:C	W233R	0.993
2:75655105:G:C	W233C	0.993
2:75655105:G:T	W233C	0.993
2:75652593:C:G	C137W	0.992
2:75655091:T:A	W229R	0.991
2:75655091:T:C	W229R	0.991
2:75652251:T:C	F111L	0.988
2:75652253:C:A	F111L	0.988
2:75652253:C:G	F111L	0.988
2:75654852:A:C	S198R	0.988
2:75654854:C:A	S198R	0.988
2:75654854:C:G	S198R	0.988
2:75652532:T:C	L117P	0.987
2:75652538:T:A	V119D	0.987
2:75652638:G:C	R152S	0.987
2:75652638:G:T	R152S	0.987
2:75652579:T:C	F133L	0.985
2:75652581:T:A	F133L	0.985
2:75652581:T:G	F133L	0.985
2:75652637:G:C	R152T	0.985
2:75654837:G:C	A193P	0.985
2:75654829:T:C	L190S	0.984
2:75652585:G:T	G135W	0.983
2:75652591:T:C	C137R	0.983
2:75652637:G:T	R152M	0.983
2:75655093:G:C	W229C	0.982

dbSNP variants (sampled 300 via entrez): RS1000060991 (2:75656187 G>T), RS1000581115 (2:75651202 G>A,C,T), RS1000707357 (2:75651761 G>A), RS1000779936 (2:75646770 A>T), RS1000868574 (2:75657894 T>A,C), RS1001065632 (2:75657495 C>A), RS1001211850 (2:75647241 A>G), RS1001384470 (2:75658142 A>G), RS1001516805 (2:75659650 T>A), RS1001707268 (2:75648327 T>G), RS1001747079 (2:75653008 A>C,G), RS1001764702 (2:75646983 G>A,C,T), RS1001823269 (2:75648551 C>T), RS1001893 (2:75645120 G>A), RS1001894 (2:75644820 T>A)

Disease associations

OMIM: gene MIM:611832 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

6 associations (top):

Study	Trait	p-value
GCST006282_1	Diabetic macular edema in type 2 diabetes	4.000000e-06
GCST009391_1464	Metabolite levels	2.000000e-06
GCST009391_1852	Metabolite levels	3.000000e-06
GCST009391_1872	Metabolite levels	1.000000e-06
GCST009391_319	Metabolite levels	3.000000e-06
GCST009391_527	Metabolite levels	7.000000e-06

EFO canonical traits (5, from GWAS)

EFO ID	Trait name
EFO:0010406	triacylglycerol 48:3 measurement
EFO:0010410	triacylglycerol 50:3 measurement
EFO:0010411	triacylglycerol 50:4 measurement
EFO:0010431	triacylglycerol 56:4 measurement
EFO:0010117	pyruvate measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL4295771 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

ChEMBL bioactivities

2 potent at pChembl≥5 of 2 total, top 2 by pChembl (potency: 10 = 0.1 nM, 6 = 1 µM).

pChembl	Type	Value	Unit	Molecule
6.41	Kd	390.8	nM	CHEMBL5653589
6.41	ED50	390.8	nM	CHEMBL5653589

PubChem BioAssay actives

1 with measured affinity, of 3 total; 1 most potent distinct compounds. Largely complementary to BindingDB; screening values are coarse (µM, 4 dp), so sub-nM hits tie at the floor.

Compound	Assay	Type	Value	Unit
4-methyl-3-[(2-methyl-6-pyridin-3-ylpyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-[3-(trifluoromethyl)phenyl]benzamide	2148771: Binding affinity to human MRPL19 incubated for 45 mins by Kinobead based pull down assay	kd	0.3908	uM

CTD chemical–gene interactions

42 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Acetaminophen	decreases expression	3
bisphenol F	increases expression, affects cotreatment	2
Benzo(a)pyrene	affects methylation, decreases expression	2
Rotenone	decreases expression, increases expression	2
aristolochic acid I	decreases expression	1
urushiol	increases expression	1
methylmercuric chloride	decreases expression	1
hydroxyethyl methacrylate	increases expression	1
triphenyl phosphate	affects expression	1
methylselenic acid	decreases expression	1
arsenite	affects binding, increases reaction	1
sodium arsenite	decreases expression	1
deguelin	increases expression	1
corosolic acid	decreases expression	1
K 7174	decreases expression	1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamide	affects cotreatment, decreases expression	1
pyrimidifen	increases expression	1
bisphenol B	increases expression	1
abrine	decreases expression	1
pyrachlostrobin	increases expression	1
jinfukang	decreases expression	1
LDN 193189	affects cotreatment, decreases expression	1
picoxystrobin	increases expression	1
bisphenol AF	increases expression	1
Bortezomib	increases expression	1
Atrazine	increases expression	1
Dexamethasone	affects cotreatment, increases expression	1
Ethyl Methanesulfonate	decreases expression	1
Formaldehyde	decreases expression	1
Gallic Acid	decreases expression	1

ChEMBL screening assays

2 unique, capped per target: 2 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL4118618	Binding	Binding affinity to MRPL19 in human NCI-H23 cells at 1 uM by mass spectrometry based pull down assay	Studies of TAK1-centered polypharmacology with novel covalent TAK1 inhibitors. — Bioorg Med Chem

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.