MRPL2

Summary

MRPL2 (mitochondrial ribosomal protein L2, HGNC:14056) is a protein-coding gene on chromosome 6p21.1, encoding Large ribosomal subunit protein uL2m (Q5T653). It is a selective cancer dependency (DepMap: 41.2% of cell lines).

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the EcoL2 ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome 12q. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Source: NCBI Gene 51069 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 57 total
• Cancer dependency (DepMap): dependent in 41.2% of screened cell lines
• MANE Select transcript: NM_015950

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:14056
Approved symbol	MRPL2
Name	mitochondrial ribosomal protein L2
Location	6p21.1
Locus type	gene with protein product
Status	Approved
Aliases	MRP-L14, RPML14, CGI-22, uL2m
Ensembl gene	ENSG00000112651
Ensembl biotype	protein_coding
OMIM	611822
Entrez	51069

Gene structure

Transcript identifiers

Ensembl transcripts: 15 — 11 protein_coding, 4 retained_intron

ENST00000230413, ENST00000388752, ENST00000468957, ENST00000470667, ENST00000480286, ENST00000485654, ENST00000487429, ENST00000489623, ENST00000491898, ENST00000927866, ENST00000927867, ENST00000927868, ENST00000927869, ENST00000927870, ENST00000927871

RefSeq mRNA: 2 — MANE Select: NM_015950 NM_001300848, NM_015950

CCDS: CCDS34454, CCDS75458

Canonical transcript exons

ENST00000388752 — 7 exons

Exon	Start	End
ENSE00000751770	43055897	43056007
ENSE00001138070	43054029	43054486
ENSE00001823866	43059286	43059434
ENSE00003492005	43055545	43055618
ENSE00003524324	43056307	43056445
ENSE00003524666	43058065	43058233
ENSE00003566867	43056081	43056196

Expression profiles

Bgee: expression breadth ubiquitous, 263 present calls, max score 96.92.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 52.6137 / max 413.8488, expressed in 1824 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
73664	51.3921	1824
73665	1.2216	752

Top tissues by expression

280 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
hindlimb stylopod muscle	UBERON:0004252	96.92	gold quality
mucosa of transverse colon	UBERON:0004991	96.27	gold quality
right lobe of liver	UBERON:0001114	95.89	gold quality
gastrocnemius	UBERON:0001388	95.83	gold quality
right atrium auricular region	UBERON:0006631	95.65	gold quality
muscle of leg	UBERON:0001383	95.52	gold quality
apex of heart	UBERON:0002098	95.17	gold quality
metanephros cortex	UBERON:0010533	94.81	gold quality
transverse colon	UBERON:0001157	94.80	gold quality
left adrenal gland	UBERON:0001234	94.74	gold quality
adenohypophysis	UBERON:0002196	94.73	gold quality
left adrenal gland cortex	UBERON:0035825	94.69	gold quality
right adrenal gland	UBERON:0001233	94.63	gold quality
cardiac atrium	UBERON:0002081	94.62	gold quality
heart left ventricle	UBERON:0002084	94.61	gold quality
body of pancreas	UBERON:0001150	94.50	gold quality
right lobe of thyroid gland	UBERON:0001119	94.37	gold quality
left lobe of thyroid gland	UBERON:0001120	94.36	gold quality
right adrenal gland cortex	UBERON:0035827	94.25	gold quality
cardiac ventricle	UBERON:0002082	94.17	gold quality
lower esophagus muscularis layer	UBERON:0035833	94.13	gold quality
lower esophagus	UBERON:0013473	94.12	gold quality
muscle layer of sigmoid colon	UBERON:0035805	94.11	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	94.11	gold quality
body of stomach	UBERON:0001161	93.78	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	93.73	gold quality
adrenal cortex	UBERON:0001235	93.65	gold quality
endocervix	UBERON:0000458	93.63	gold quality
tibial artery	UBERON:0007610	93.61	gold quality
popliteal artery	UBERON:0002250	93.60	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	7.18

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

23 targeting MRPL2, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-196A-1-3P	99.99	72.15	2772
HSA-MIR-3617-3P	99.98	67.86	918
HSA-MIR-3065-5P	99.97	71.56	3281
HSA-MIR-3682-5P	99.93	67.97	1163
HSA-MIR-6721-5P	99.93	68.92	2981
HSA-MIR-3529-3P	99.90	73.55	3045
HSA-MIR-4729	99.69	72.18	4233
HSA-MIR-885-5P	99.59	68.59	879
HSA-MIR-486-5P	99.51	70.39	707
HSA-MIR-7109-5P	99.18	66.13	1057
HSA-MIR-328-5P	99.08	64.65	1000
HSA-MIR-140-3P	99.04	67.69	1324
HSA-MIR-194-5P	99.01	69.65	1465
HSA-MIR-6885-5P	98.71	64.33	902
HSA-MIR-6887-5P	98.56	68.49	1295
HSA-MIR-6795-5P	98.52	68.51	1277
HSA-MIR-3074-3P	97.83	67.26	922
HSA-MIR-192-3P	97.52	67.66	1001
HSA-MIR-6892-5P	97.27	68.60	847
HSA-MIR-1915-5P	95.25	65.78	571
HSA-MIR-4707-5P	90.95	65.69	110
HSA-MIR-598-3P	89.25	67.61	112

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 41.2% of screened cell lines.

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	mrpl2	ENSDARG00000062568
mus_musculus	Mrpl2	ENSMUSG00000002767
rattus_norvegicus	Mrpl2	ENSRNOG00000018057
drosophila_melanogaster	mRpL2	FBGN0036135
caenorhabditis_elegans		WBGENE00018932

Paralogs (1): RPL8 (ENSG00000161016)

Protein

Protein identifiers

Large ribosomal subunit protein uL2m — Q5T653 (reviewed: Q5T653)

Alternative names: 39S ribosomal protein L2, mitochondrial

All UniProt accessions (5): C9IY40, C9J5E0, Q5T653, C9JZG7, C9JZW2

UniProt curated annotations — full annotation on UniProt →

Subunit / interactions. Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.

Subcellular location. Mitochondrion.

Similarity. Belongs to the universal ribosomal protein uL2 family.

RefSeq proteins (2): NP_001287777, NP_057034* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR002171	Ribosomal_uL2	Family
IPR008991	Translation_prot_SH3-like_sf	Homologous_superfamily
IPR012340	NA-bd_OB-fold	Homologous_superfamily
IPR014722	Rib_uL2_dom2	Homologous_superfamily
IPR022666	Ribosomal_uL2_RNA-bd_dom	Domain
IPR022669	Ribosomal_uL2_C	Domain

Pfam: PF00181, PF03947

UniProt features (32 total): strand 18, helix 5, turn 2, sequence conflict 2, transit peptide 1, chain 1, region of interest 1, compositionally biased region 1, sequence variant 1

Structure

Experimental structures (PDB)

86 structures, top 30 by resolution.

PDB	Method	Resolution (Å)
7OF0	ELECTRON MICROSCOPY	2.2
7QI4	ELECTRON MICROSCOPY	2.21
8RRI	ELECTRON MICROSCOPY	2.4
8QU5	ELECTRON MICROSCOPY	2.42
9OLF	ELECTRON MICROSCOPY	2.46
7OF7	ELECTRON MICROSCOPY	2.5
7PO4	ELECTRON MICROSCOPY	2.56
6ZM6	ELECTRON MICROSCOPY	2.59
7O9M	ELECTRON MICROSCOPY	2.6
7OF6	ELECTRON MICROSCOPY	2.6
9CN3	ELECTRON MICROSCOPY	2.62
7QI5	ELECTRON MICROSCOPY	2.63
7OF2	ELECTRON MICROSCOPY	2.7
7OF3	ELECTRON MICROSCOPY	2.7
7OF4	ELECTRON MICROSCOPY	2.7
8QU1	ELECTRON MICROSCOPY	2.74
9PR4	ELECTRON MICROSCOPY	2.77
9PRA	ELECTRON MICROSCOPY	2.83
8ANY	ELECTRON MICROSCOPY	2.85
6ZM5	ELECTRON MICROSCOPY	2.89
7QH7	ELECTRON MICROSCOPY	2.89
7ODR	ELECTRON MICROSCOPY	2.9
7OF5	ELECTRON MICROSCOPY	2.9
8K2A	ELECTRON MICROSCOPY	2.9
8OIT	ELECTRON MICROSCOPY	2.9
9PGL	ELECTRON MICROSCOPY	2.9
9PGF	ELECTRON MICROSCOPY	2.93
6VMI	ELECTRON MICROSCOPY	2.96
6VLZ	ELECTRON MICROSCOPY	2.97
7QI6	ELECTRON MICROSCOPY	2.98

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q5T653-F1	86.03	0.75

Function

Pathways and Gene Ontology

Reactome pathways

7 pathways

ID	Pathway
R-HSA-5368286	Mitochondrial translation initiation
R-HSA-5389840	Mitochondrial translation elongation
R-HSA-5419276	Mitochondrial translation termination
R-HSA-9937383	Mitochondrial ribosome-associated quality control
R-HSA-392499	Metabolism of proteins
R-HSA-5368287	Mitochondrial translation
R-HSA-72766	Translation

MSigDB gene sets: 122 (showing top): GOBP_MITOCHONDRIAL_TRANSLATION, TGACCTY_ERR1_Q2, GGGTGGRR_PAX4_03, COUP_01, GOBP_TRANSLATION, GOMF_STRUCTURAL_CONSTITUENT_OF_RIBOSOME, HNF4_DR1_Q3, GOCC_MITOCHONDRIAL_ENVELOPE, CTGYNNCTYTAA_UNKNOWN, HAMAI_APOPTOSIS_VIA_TRAIL_DN, GOCC_LARGE_RIBOSOMAL_SUBUNIT, GOCC_RIBOSOME, GOCC_ORGANELLAR_RIBOSOME, GOCC_MITOCHONDRIAL_MATRIX, GOCC_ORGANELLE_INNER_MEMBRANE

GO Biological Process (2): mitochondrial translation (GO:0032543), translation (GO:0006412)

GO Molecular Function (2): RNA binding (GO:0003723), structural constituent of ribosome (GO:0003735)

GO Cellular Component (6): nucleoplasm (GO:0005654), mitochondrion (GO:0005739), mitochondrial inner membrane (GO:0005743), mitochondrial large ribosomal subunit (GO:0005762), ribosome (GO:0005840), ribonucleoprotein complex (GO:1990904)

Reactome top-level categories

Rollup of top-3 pathways:

Category	Pathways
Mitochondrial translation	4
Translation	1
Metabolism of proteins	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
mitochondrion	1
translation	1
mitochondrial gene expression	1
peptidyltransferase activity	1
translational initiation	1
translational elongation	1
translational termination	1
macromolecule biosynthetic process	1
protein metabolic process	1
protein biosynthetic process	1
nucleic acid binding	1
structural molecule activity	1
ribosome	1
nuclear lumen	1
cellular anatomical structure	1
cytoplasm	1
intracellular membrane-bounded organelle	1
organelle inner membrane	1
mitochondrial membrane	1
organellar large ribosomal subunit	1
mitochondrial ribosome	1
mitochondrial protein-containing complex	1
intracellular membraneless organelle	1
protein-containing complex	1

Protein interactions and networks

STRING

4596 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
MRPL2	MRPL16	Q9NX20	662
MRPL2	MRPS18A	Q9NVS2	646
MRPL2	MRPL1	Q9BYD6	593
MRPL2	IMP4	Q96G21	576
MRPL2	MRPS12	O15235	565
MRPL2	MRPL9	Q9BYD2	534
MRPL2	MRPL17	Q9NRX2	527
MRPL2	MRPL21	Q7Z2W9	496
MRPL2	MRPS16	Q9Y3D3	489
MRPL2	MRPL11	Q9Y3B7	478
MRPL2	PEX5L	Q8IYB4	473
MRPL2	MRPS6	P82932	472
MRPL2	MRPS2	Q9Y399	470
MRPL2	NSA2	O95478	465
MRPL2	MRPS10	P82664	453

IntAct

148 interactions, top by confidence:

A	B	Type	Score
YBX1	HNRNPR	psi-mi:“MI:0914”(association)	0.770
EZH2	EPOP	psi-mi:“MI:0914”(association)	0.730
MALSU1	NDUFAB1	psi-mi:“MI:0914”(association)	0.710
MRPS30	GTPBP10	psi-mi:“MI:0914”(association)	0.640
NP	KPNA6	psi-mi:“MI:0914”(association)	0.550
MRPL50	GTPBP10	psi-mi:“MI:0914”(association)	0.530
MRPL10	ZZEF1	psi-mi:“MI:0914”(association)	0.530
MRPL42	GATC	psi-mi:“MI:0914”(association)	0.530
MRPL28	MRPL3	psi-mi:“MI:0914”(association)	0.530
NSA2	TYW5	psi-mi:“MI:0914”(association)	0.530
MRPL2	GTPBP10	psi-mi:“MI:0914”(association)	0.530
MRPL13	GTPBP10	psi-mi:“MI:0914”(association)	0.530
MRPL18	GTPBP10	psi-mi:“MI:0914”(association)	0.530
MRPL16	MRPL2	psi-mi:“MI:0914”(association)	0.530
MRPL23	BCKDHA	psi-mi:“MI:0914”(association)	0.530
MRPL27	MRPL33	psi-mi:“MI:0914”(association)	0.530
NDUFAB1	MIEF1	psi-mi:“MI:0915”(physical association)	0.490
CMTM4	MRPL2	psi-mi:“MI:0915”(physical association)	0.370
TRIM63	MRPL2	psi-mi:“MI:0915”(physical association)	0.370
MRPL2	SMURF2	psi-mi:“MI:0915”(physical association)	0.370
MASTL	MED26	psi-mi:“MI:0914”(association)	0.350
Brwd3	WDR91	psi-mi:“MI:0914”(association)	0.350
Ncstn	DERL1	psi-mi:“MI:0914”(association)	0.350
MRPL50	MRPL43	psi-mi:“MI:0914”(association)	0.350

BioGRID (301): MRPL2 (Affinity Capture-MS), MRPL2 (Affinity Capture-MS), MRPL2 (Affinity Capture-MS), MRPL2 (Affinity Capture-MS), MRPL2 (Affinity Capture-MS), MRPL2 (Affinity Capture-MS), MRPL2 (Affinity Capture-MS), GFM2 (Co-fractionation), GTPBP4 (Co-fractionation), MRPL13 (Co-fractionation), MRPL17 (Co-fractionation), MRPL2 (Co-fractionation), MRPL2 (Co-fractionation), MRPL2 (Co-fractionation), MRPL2 (Co-fractionation)

ESM2 similar proteins: A0AJY7, B1VKG7, O60783, P56556, P82915, P82920, P82933, Q02366, Q0MQA3, Q0MQA4, Q0MQA5, Q0VFH6, Q13084, Q19V89, Q1JQ99, Q29IK4, Q2HJJ1, Q2TA12, Q2TBR2, Q3T040, Q3T0J3, Q498T4, Q58DQ5, Q58DV5, Q5I0K8, Q5T653, Q5U4Z8, Q5ZMU0, Q6B860, Q6DDY9, Q6P1L8, Q71YD4, Q7M0E7, Q7SF85, Q7ZUH5, Q80X85, Q8MFA1, Q8Y620, Q92AC7, Q9BYC9

Diamond homologs: A0ALW5, A0L5X6, A0LIJ3, A0R8I3, A1ALU4, A1VEB3, A4IJJ2, A4XLS7, A5GAW8, A5IM86, A5USI6, A6KYJ2, A6LEI8, A6LLL6, A7GK23, A7HBM1, A7HWR4, A7IFY4, A7NR60, A8F4R4, A8ZV60, A9B415, A9BHA2, A9WH69, B0K5P6, B0KCK3, B1LBN7, B1YGV3, B2RLY9, B3E7T8, B3EUM0, B3PK40, B4S094, B4S5M4, B4UBA2, B5EFQ3, B5Y985, B5YDU6, B6IRQ9, B7HQU7

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
MRPL2	“form complex”	“39S mitochondrial large ribosomal subunit”	binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 139 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Mitochondrial ribosome-associated quality control	38	44.9×	6e-53
Mitochondrial translation	33	43.7×	2e-45
Mitochondrial translation initiation	35	42.7×	6e-48
Mitochondrial translation elongation	35	42.7×	6e-48
Mitochondrial translation termination	35	37.0×	2e-45
Translation	35	20.9×	8e-36
Peptide chain elongation	9	11.0×	5e-06
Viral mRNA Translation	9	11.0×	5e-06

GO biological processes:

GO term	Partners	Fold	FDR
mitochondrial translation	37	51.8×	1e-52
mitochondrial large ribosomal subunit assembly	5	40.0×	2e-05
translation	26	21.6×	3e-25
cytoplasmic translation	9	13.4×	4e-06
negative regulation of translation	6	9.5×	5e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

57 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	44
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

997 predictions. Top by Δscore:

Variant	Effect	Δscore
6:43055893:ATAC:A	donor_loss	1.0000
6:43055894:TACC:T	donor_loss	1.0000
6:43055895:A:AT	donor_loss	1.0000
6:43055896:C:CT	donor_loss	1.0000
6:43055934:A:AC	donor_gain	1.0000
6:43055935:C:CC	donor_gain	1.0000
6:43056005:CAA:C	acceptor_gain	1.0000
6:43056008:C:CC	acceptor_gain	1.0000
6:43056075:TCTCA:T	donor_loss	1.0000
6:43056076:CTCA:C	donor_loss	1.0000
6:43056077:TCA:T	donor_loss	1.0000
6:43056078:CA:C	donor_loss	1.0000
6:43056079:ACC:A	donor_loss	1.0000
6:43056080:C:CA	donor_loss	1.0000
6:43056195:ACC:A	acceptor_loss	1.0000
6:43058061:CCAC:C	donor_loss	1.0000
6:43058063:A:T	donor_loss	1.0000
6:43058064:C:CT	donor_loss	1.0000
6:43058089:T:TA	donor_gain	1.0000
6:43058090:C:A	donor_gain	1.0000
6:43058095:T:C	donor_gain	1.0000
6:43058234:C:CC	acceptor_gain	1.0000
6:43054486:CCT:C	acceptor_loss	0.9900
6:43054488:T:C	acceptor_loss	0.9900
6:43055614:CGTCC:C	acceptor_gain	0.9900
6:43055619:C:CC	acceptor_gain	0.9900
6:43055938:T:A	donor_gain	0.9900
6:43056003:AGCAA:A	acceptor_gain	0.9900
6:43056004:GCAA:G	acceptor_gain	0.9900
6:43056005:CAAC:C	acceptor_gain	0.9900

AlphaMissense

1955 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
6:43056153:A:G	W150R	0.993
6:43056153:A:T	W150R	0.993
6:43056183:C:G	A140P	0.991
6:43054467:G:T	A242E	0.990
6:43055609:C:T	G214D	0.989
6:43055897:C:A	G211W	0.989
6:43056155:C:G	R149P	0.989
6:43056182:G:T	A140D	0.989
6:43055573:A:T	I226N	0.988
6:43056307:C:G	R135T	0.986
6:43054472:G:C	C240W	0.985
6:43055567:A:G	L228P	0.985
6:43055597:C:G	R218P	0.985
6:43056307:C:A	R135M	0.985
6:43055618:C:A	G211V	0.984
6:43055950:A:T	I193N	0.984
6:43056196:C:A	R135S	0.984
6:43056196:C:G	R135S	0.984
6:43056176:A:T	V142D	0.983
6:43056191:G:T	A137E	0.983
6:43054392:C:A	G267V	0.982
6:43054458:C:A	G245V	0.982
6:43054458:C:T	G245D	0.982
6:43054459:C:G	G245R	0.982
6:43055610:C:G	G214R	0.982
6:43055977:A:T	L184H	0.982
6:43055899:G:T	A210E	0.981
6:43056185:A:T	I139K	0.981
6:43056334:A:T	V126D	0.981
6:43054473:C:T	C240Y	0.980

dbSNP variants (sampled 300 via entrez): RS1000434098 (6:43053884 G>A,C), RS1000465372 (6:43054079 A>C), RS1000810369 (6:43060798 G>A), RS1001162643 (6:43055172 G>A), RS1001426967 (6:43054951 G>A), RS1002704714 (6:43059099 T>A), RS1003236245 (6:43058211 T>C), RS1003297582 (6:43057267 A>C,G), RS1003370186 (6:43055679 C>A,G,T), RS1004142730 (6:43060884 GAC>G), RS1004824855 (6:43057478 G>A), RS1005100018 (6:43057063 T>C), RS1005596433 (6:43054520 T>C), RS1005767494 (6:43059768 C>T), RS1007047532 (6:43060909 C>G)

Disease associations

OMIM: gene MIM:611822 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

26 total (human), top 26 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	decreases expression, affects cotreatment, increases abundance, increases expression	2
aristolochic acid I	increases expression	1
TAK-243	increases sumoylation	1
methylmercuric chloride	decreases expression	1
triphenyl phosphate	affects expression	1
arsenite	affects binding, increases reaction	1
manganese chloride	affects cotreatment, increases abundance, increases expression	1
perfluorooctane sulfonic acid	increases expression	1
CGP 52608	affects binding, increases reaction	1
ICG 001	decreases expression	1
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	decreases expression	1
Temozolomide	increases expression	1
Air Pollutants	decreases expression, increases abundance	1
Arsenic	affects cotreatment, increases abundance, increases expression	1
Atrazine	increases expression	1
Benzo(a)pyrene	decreases expression	1
Ivermectin	decreases expression	1
Manganese	affects cotreatment, increases abundance, increases expression	1
Ribonucleotides	affects binding	1
Selenium	affects cotreatment, increases expression	1
Smoke	decreases expression, increases abundance	1
Valproic Acid	increases expression	1
Vitamin E	affects cotreatment, increases expression	1
Gold Compounds	decreases methylation	1
Acrylamide	decreases expression	1
tert-Butylhydroperoxide	increases expression	1

Cellosaurus cell lines

1 cell lines: 1 transformed cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_B3B9	Abcam HEK293T MRPL2 KO	Transformed cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.