MRPL20-AS1

Summary

MRPL20-AS1 (MRPL20 antisense RNA 1, HGNC:27125) is a long non-coding RNA gene on chromosome 1p36.33.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:27125
Approved symbol	MRPL20-AS1
Name	MRPL20 antisense RNA 1
Location	1p36.33
Locus type	RNA, long non-coding
Status	Approved
Ensembl gene	ENSG00000224870
Ensembl biotype	lncRNA
Entrez	148413
RNAcentral	URS000075B363 — lncRNA, 1766 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 18 — 16 lncRNA, 2 retained_intron

ENST00000418833, ENST00000444362, ENST00000447725, ENST00000448629, ENST00000453521, ENST00000570344, ENST00000572242, ENST00000576232, ENST00000659048, ENST00000685968, ENST00000689419, ENST00000690954, ENST00000702056, ENST00000702620, ENST00000780220, ENST00000780221, ENST00000780222, ENST00000780223

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000418833 — 2 exons

Exon	Start	End
ENSE00001677315	1399530	1400303
ENSE00002666913	1400605	1402026

Expression profiles

Bgee: expression breadth ubiquitous, 241 present calls, max score 94.08.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 10.8611 / max 90.4846, expressed in 1790 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
95	9.5614	1789
94	1.1888	856
96	0.1109	22

Top tissues by expression

250 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
tendon of biceps brachii	UBERON:0008188	94.08	gold quality
upper arm skin	UBERON:0004263	90.39	gold quality
medial globus pallidus	UBERON:0002477	89.76	gold quality
right lobe of liver	UBERON:0001114	89.59	gold quality
globus pallidus	UBERON:0001875	89.06	gold quality
myocardium	UBERON:0002349	88.03	silver quality
subthalamic nucleus	UBERON:0001906	88.00	gold quality
cardiac muscle of right atrium	UBERON:0003379	87.97	gold quality
tendon	UBERON:0000043	87.68	gold quality
inferior vagus X ganglion	UBERON:0005363	87.67	gold quality
left ventricle myocardium	UBERON:0006566	87.55	gold quality
ventral tegmental area	UBERON:0002691	87.16	gold quality
dorsal plus ventral thalamus	UBERON:0001897	87.15	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	87.06	gold quality
vena cava	UBERON:0004087	86.90	silver quality
spinal cord	UBERON:0002240	86.83	gold quality
granulocyte	CL:0000094	86.81	gold quality
thymus	UBERON:0002370	86.63	gold quality
lateral globus pallidus	UBERON:0002476	86.59	silver quality
cardia of stomach	UBERON:0001162	86.49	gold quality
pylorus	UBERON:0001166	86.45	gold quality
lateral nuclear group of thalamus	UBERON:0002736	86.36	gold quality
pharyngeal mucosa	UBERON:0000355	86.34	gold quality
trachea	UBERON:0003126	86.15	gold quality
cerebellar vermis	UBERON:0004720	86.13	gold quality
mucosa of transverse colon	UBERON:0004991	86.02	gold quality
liver	UBERON:0002107	85.90	gold quality
pons	UBERON:0000988	85.89	gold quality
midbrain	UBERON:0001891	85.60	gold quality
calcaneal tendon	UBERON:0003701	85.49	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	2.50

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 1)

• The lncRNA MRPL20-AS1 is associated with severe OSAS and downregulated upon hypoxic injury of endothelial cells. (PMID:35988669)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.