MRPL20

Summary

MRPL20 (mitochondrial ribosomal protein L20, HGNC:14478) is a protein-coding gene on chromosome 1p36.33, encoding Large ribosomal subunit protein bL20m (Q9BYC9). It is a selective cancer dependency (DepMap: 37.6% of cell lines).

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. A pseudogene corresponding to this gene is found on chromosome 21q. Alternative splicing results in multiple transcript variants encoding different isoforms.

Source: NCBI Gene 55052 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• Clinical variants (ClinVar): 46 total
• Cancer dependency (DepMap): dependent in 37.6% of screened cell lines
• MANE Select transcript: NM_017971

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:14478
Approved symbol	MRPL20
Name	mitochondrial ribosomal protein L20
Location	1p36.33
Locus type	gene with protein product
Status	Approved
Aliases	FLJ10024, bL20m
Ensembl gene	ENSG00000242485
Ensembl biotype	protein_coding
OMIM	611833
Entrez	55052

Gene structure

Transcript identifiers

Ensembl transcripts: 13 — 10 protein_coding, 2 protein_coding_CDS_not_defined, 1 retained_intron

ENST00000344843, ENST00000477686, ENST00000482352, ENST00000487659, ENST00000492508, ENST00000493287, ENST00000872275, ENST00000872276, ENST00000872277, ENST00000914256, ENST00000914257, ENST00000914258, ENST00000914259

RefSeq mRNA: 2 — MANE Select: NM_017971 NM_001318485, NM_017971

CCDS: CCDS26

Canonical transcript exons

ENST00000344843 — 4 exons

Exon	Start	End
ENSE00001735034	1407131	1407293
ENSE00001940545	1401909	1402256
ENSE00003478955	1405809	1405886
ENSE00003480468	1406909	1407019

Expression profiles

Bgee: expression breadth ubiquitous, 288 present calls, max score 99.61.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 110.6662 / max 489.9961, expressed in 1828 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
9781	110.6662	1828

Top tissues by expression

288 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
palpebral conjunctiva	UBERON:0001812	99.61	gold quality
epithelium of nasopharynx	UBERON:0001951	99.30	gold quality
germinal epithelium of ovary	UBERON:0001304	99.28	gold quality
esophagus squamous epithelium	UBERON:0006920	99.15	gold quality
cervix squamous epithelium	UBERON:0006922	98.98	gold quality
squamous epithelium	UBERON:0006914	98.96	gold quality
gingival epithelium	UBERON:0001949	98.95	gold quality
epithelium of esophagus	UBERON:0001976	98.77	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	98.76	gold quality
gingiva	UBERON:0001828	98.57	gold quality
hindlimb stylopod muscle	UBERON:0004252	98.55	gold quality
amniotic fluid	UBERON:0000173	98.54	gold quality
corpus epididymis	UBERON:0004359	98.53	gold quality
mucosa of paranasal sinus	UBERON:0005030	98.51	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	98.46	gold quality
Brodmann (1909) area 23	UBERON:0013554	98.45	gold quality
parietal pleura	UBERON:0002400	98.43	gold quality
endothelial cell	CL:0000115	98.41	gold quality
biceps brachii	UBERON:0001507	98.38	gold quality
heart right ventricle	UBERON:0002080	98.38	gold quality
adult organism	UBERON:0007023	98.38	gold quality
oral cavity	UBERON:0000167	98.32	gold quality
gastrocnemius	UBERON:0001388	98.31	gold quality
pigmented layer of retina	UBERON:0001782	98.29	gold quality
muscle of leg	UBERON:0001383	98.28	gold quality
vastus lateralis	UBERON:0001379	98.27	gold quality
adenohypophysis	UBERON:0002196	98.26	gold quality
caput epididymis	UBERON:0004358	98.26	gold quality
cardiac ventricle	UBERON:0002082	98.23	gold quality
heart left ventricle	UBERON:0002084	98.23	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

24 targeting MRPL20, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-548AJ-3P	99.96	73.38	5345
HSA-MIR-548X-3P	99.96	73.38	5345
HSA-MIR-551B-5P	99.96	71.28	3493
HSA-MIR-548J-3P	99.94	72.61	4881
HSA-MIR-548AE-3P	99.93	72.66	4867
HSA-MIR-548AH-3P	99.93	72.54	4872
HSA-MIR-548AM-3P	99.93	72.54	4872
HSA-MIR-548AQ-3P	99.93	72.66	4867
HSA-MIR-548AR-3P	99.85	71.26	3889
HSA-MIR-548AZ-3P	99.82	70.56	3549
HSA-MIR-548BC	99.82	70.61	3524
HSA-MIR-548E-3P	99.82	70.59	3514
HSA-MIR-548F-3P	99.82	70.59	3540
HSA-MIR-577	99.78	69.13	2479
HSA-MIR-548A-3P	99.76	70.58	3524
HSA-MIR-12130	99.75	65.47	452
HSA-MIR-4802-3P	99.72	70.13	1273
HSA-MIR-377-3P	99.37	70.18	1905
HSA-MIR-4316	99.37	65.75	1360
HSA-MIR-520F-5P	99.34	70.40	1632
HSA-MIR-3940-5P	99.14	65.26	493
HSA-MIR-4507	99.14	65.27	515
HSA-MIR-548L	99.06	70.90	2560
HSA-MIR-3935	96.33	66.79	797

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 37.6% of screened cell lines.

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	mrpl20	ENSDARG00000090462
mus_musculus	Mrpl20	ENSMUSG00000029066
rattus_norvegicus	Mrpl20	ENSRNOG00000018647
drosophila_melanogaster	mRpL20	FBGN0036335
caenorhabditis_elegans		WBGENE00012992

Protein

Protein identifiers

Large ribosomal subunit protein bL20m — Q9BYC9 (reviewed: Q9BYC9)

Alternative names: 39S ribosomal protein L20, mitochondrial

All UniProt accessions (2): I3L2X1, Q9BYC9

UniProt curated annotations — full annotation on UniProt →

Subunit / interactions. Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins. Interacts with OXA1L.

Subcellular location. Mitochondrion.

Similarity. Belongs to the bacterial ribosomal protein bL20 family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q9BYC9-1	1	yes
Q9BYC9-2	2

RefSeq proteins (2): NP_001305414, NP_060441* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR005813	Ribosomal_bL20	Family
IPR035566	Ribosomal_protein_bL20_C	Homologous_superfamily

Pfam: PF00453

UniProt features (12 total): helix 6, turn 2, transit peptide 1, chain 1, strand 1, splice variant 1

Structure

Experimental structures (PDB)

86 structures, top 30 by resolution.

PDB	Method	Resolution (Å)
7OF0	ELECTRON MICROSCOPY	2.2
7QI4	ELECTRON MICROSCOPY	2.21
8RRI	ELECTRON MICROSCOPY	2.4
8QU5	ELECTRON MICROSCOPY	2.42
9OLF	ELECTRON MICROSCOPY	2.46
7OF7	ELECTRON MICROSCOPY	2.5
7PO4	ELECTRON MICROSCOPY	2.56
6ZM6	ELECTRON MICROSCOPY	2.59
7O9M	ELECTRON MICROSCOPY	2.6
7OF6	ELECTRON MICROSCOPY	2.6
9CN3	ELECTRON MICROSCOPY	2.62
7QI5	ELECTRON MICROSCOPY	2.63
7OF2	ELECTRON MICROSCOPY	2.7
7OF3	ELECTRON MICROSCOPY	2.7
7OF4	ELECTRON MICROSCOPY	2.7
8QU1	ELECTRON MICROSCOPY	2.74
9PR4	ELECTRON MICROSCOPY	2.77
9PRA	ELECTRON MICROSCOPY	2.83
8ANY	ELECTRON MICROSCOPY	2.85
6ZM5	ELECTRON MICROSCOPY	2.89
7QH7	ELECTRON MICROSCOPY	2.89
7ODR	ELECTRON MICROSCOPY	2.9
7OF5	ELECTRON MICROSCOPY	2.9
8K2A	ELECTRON MICROSCOPY	2.9
8OIT	ELECTRON MICROSCOPY	2.9
9PGL	ELECTRON MICROSCOPY	2.9
9PGF	ELECTRON MICROSCOPY	2.93
6VMI	ELECTRON MICROSCOPY	2.96
6VLZ	ELECTRON MICROSCOPY	2.97
7QI6	ELECTRON MICROSCOPY	2.98

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9BYC9-F1	90.90	0.80

Function

Pathways and Gene Ontology

Reactome pathways

7 pathways

ID	Pathway
R-HSA-5368286	Mitochondrial translation initiation
R-HSA-5389840	Mitochondrial translation elongation
R-HSA-5419276	Mitochondrial translation termination
R-HSA-9937383	Mitochondrial ribosome-associated quality control
R-HSA-392499	Metabolism of proteins
R-HSA-5368287	Mitochondrial translation
R-HSA-72766	Translation

MSigDB gene sets: 149 (showing top): PAL_PRMT5_TARGETS_UP, GOBP_MITOCHONDRIAL_TRANSLATION, GOBP_TRANSLATION, GOMF_STRUCTURAL_CONSTITUENT_OF_RIBOSOME, GOCC_MITOCHONDRIAL_ENVELOPE, GARY_CD5_TARGETS_DN, TIEN_INTESTINE_PROBIOTICS_24HR_UP, BURTON_ADIPOGENESIS_5, GRYDER_PAX3FOXO1_ENHANCERS_IN_TADS, MULLIGAN_NTF3_SIGNALING_VIA_INSR_AND_IGF1R_UP, GOCC_LARGE_RIBOSOMAL_SUBUNIT, GOCC_RIBOSOME, GRYDER_PAX3FOXO1_TOP_ENHANCERS, GOCC_ORGANELLAR_RIBOSOME, GOCC_MITOCHONDRIAL_MATRIX

GO Biological Process (2): mitochondrial translation (GO:0032543), translation (GO:0006412)

GO Molecular Function (4): RNA binding (GO:0003723), structural constituent of ribosome (GO:0003735), rRNA binding (GO:0019843), protein binding (GO:0005515)

GO Cellular Component (6): mitochondrion (GO:0005739), mitochondrial inner membrane (GO:0005743), mitochondrial ribosome (GO:0005761), mitochondrial large ribosomal subunit (GO:0005762), ribosome (GO:0005840), ribonucleoprotein complex (GO:1990904)

Reactome top-level categories

Rollup of top-3 pathways:

Category	Pathways
Mitochondrial translation	4
Translation	1
Metabolism of proteins	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
mitochondrion	1
translation	1
mitochondrial gene expression	1
peptidyltransferase activity	1
translational initiation	1
translational elongation	1
translational termination	1
macromolecule biosynthetic process	1
protein metabolic process	1
protein biosynthetic process	1
nucleic acid binding	1
structural molecule activity	1
ribosome	1
RNA binding	1
binding	1
cytoplasm	1
intracellular membrane-bounded organelle	1
organelle inner membrane	1
mitochondrial membrane	1
organellar ribosome	1
mitochondrial matrix	1
organellar large ribosomal subunit	1
mitochondrial ribosome	1
mitochondrial protein-containing complex	1
intracellular membraneless organelle	1
protein-containing complex	1

Protein interactions and networks

STRING

2897 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
MRPL20	MRPL51	Q4U2R6	689
MRPL20	MRPL33	O75394	645
MRPL20	MTERF3	Q96E29	626
MRPL20	MRPL24	Q96A35	626
MRPL20	MRPL47	Q9HD33	619
MRPL20	MRPL48	Q96GC5	596
MRPL20	MRPL23	Q16540	587
MRPL20	MRPL13	Q9BYD1	574
MRPL20	MRPL12	P52815	573
MRPL20	NDUFB9	Q9Y6M9	567
MRPL20	MRPL49	Q13405	559
MRPL20	MRPL34	Q9BQ48	557
MRPL20	MRPS7	Q9Y2R9	548
MRPL20	MRPL41	Q8IXM3	548
MRPL20	MRPS9	P82933	544

IntAct

164 interactions, top by confidence:

A	B	Type	Score
MIS12	ZWINT	psi-mi:“MI:0914”(association)	0.900
YBX1	HNRNPR	psi-mi:“MI:0914”(association)	0.770
MRPS30	GTPBP10	psi-mi:“MI:0914”(association)	0.640
MRPL50	GTPBP10	psi-mi:“MI:0914”(association)	0.530
RPL18	NOP56	psi-mi:“MI:0914”(association)	0.530
MRPL10	ZZEF1	psi-mi:“MI:0914”(association)	0.530
MRPL42	GATC	psi-mi:“MI:0914”(association)	0.530
PEX19	FAM20B	psi-mi:“MI:0914”(association)	0.530
MRPL41	MRPL3	psi-mi:“MI:0914”(association)	0.530
YBX1	IGF2BP3	psi-mi:“MI:0914”(association)	0.530
MRPL2	GTPBP10	psi-mi:“MI:0914”(association)	0.530
CASQ2	PES1	psi-mi:“MI:0914”(association)	0.530
RHOT2	UBC	psi-mi:“MI:0914”(association)	0.530
MRPL13	GTPBP10	psi-mi:“MI:0914”(association)	0.530
MRPL18	GTPBP10	psi-mi:“MI:0914”(association)	0.530
IPO5	SLC27A2	psi-mi:“MI:0914”(association)	0.530
PEX19	MYO1D	psi-mi:“MI:0914”(association)	0.530
RPL19	ZBTB24	psi-mi:“MI:0914”(association)	0.530
RPL27A	MRPS9	psi-mi:“MI:0914”(association)	0.530
RPL13A	NVL	psi-mi:“MI:0914”(association)	0.530
PRR3	MRPS14	psi-mi:“MI:0914”(association)	0.530
MRPL27	MRPL33	psi-mi:“MI:0914”(association)	0.530

BioGRID (215): MRPL20 (Affinity Capture-MS), MRPL20 (Affinity Capture-MS), MRPL20 (Affinity Capture-MS), MRPL20 (Affinity Capture-MS), MRPL20 (Affinity Capture-MS), MRPL20 (Affinity Capture-MS), MRPL20 (Affinity Capture-MS), MRPL20 (Affinity Capture-MS), MRPL20 (Affinity Capture-MS), MRPL20 (Affinity Capture-MS), MRPL20 (Affinity Capture-MS), MRPL20 (Affinity Capture-MS), MRPL20 (Co-fractionation), MRPL20 (Co-fractionation), MRPL20 (Co-fractionation)

ESM2 similar proteins: A0AJY7, B1VKG7, O60783, P56556, P82915, P82920, P82933, Q02366, Q0MQA3, Q0MQA4, Q0MQA5, Q0VFH6, Q13084, Q19V89, Q1JQ99, Q29IK4, Q2HJJ1, Q2TA12, Q2TBR2, Q3T040, Q3T0J3, Q498T4, Q58DQ5, Q58DV5, Q5I0K8, Q5T653, Q5U4Z8, Q5ZMU0, Q6B860, Q6DDY9, Q6P1L8, Q71YD4, Q7M0E7, Q7SF85, Q7ZUH5, Q80X85, Q8MFA1, Q8Y620, Q92AC7, Q9BYC9

Diamond homologs: A0KWV7, A0L4J9, A1ARE2, A1K4E4, A1RJI6, A1S6G7, A1SWU2, A3D4I5, A3QEJ7, A4G616, A4Y703, A5EZ15, A5VT72, A6SY33, A6WNG9, A7HPK9, A7N012, A8FV59, A8H4U3, A9L2Q6, A9M9V2, B0CJL8, B0TT23, B1KG58, B1XYZ6, B1YP16, B2A5N9, B2J0D0, B2S9B6, B2SZF9, B2UGJ5, B3E1T8, B3PYE1, B3R4J4, B4RSL5, B4UAN7, B5EBY2, B5ZXR9, B6EN31, B6IPJ8

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
MRPL20	“form complex”	“39S mitochondrial large ribosomal subunit”	binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 142 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Mitochondrial ribosome-associated quality control	38	44.0×	3e-52
Mitochondrial translation	32	41.5×	5e-43
Mitochondrial translation initiation	34	40.7×	2e-45
Mitochondrial translation elongation	34	40.7×	2e-45
Mitochondrial translation termination	34	35.2×	5e-43
Translation	33	19.3×	4e-32
ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA	10	11.1×	2e-06
Peptide chain elongation	9	10.8×	8e-06

GO biological processes:

GO term	Partners	Fold	FDR
mitochondrial translation	36	48.1×	1e-49
mitochondrial large ribosomal subunit assembly	6	45.8×	5e-07
translation	28	22.1×	1e-27
cytoplasmic translation	9	12.8×	5e-06
negative regulation of translation	7	10.6×	6e-04

Disease & clinical

Clinical variants and AI predictions

ClinVar

46 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	37
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

446 predictions. Top by Δscore:

Variant	Effect	Δscore
1:1402252:TGGCA:T	acceptor_gain	1.0000
1:1402253:GGCA:G	acceptor_gain	1.0000
1:1402254:GCA:G	acceptor_gain	1.0000
1:1402255:CAC:C	acceptor_gain	1.0000
1:1402257:C:CC	acceptor_gain	1.0000
1:1405813:A:C	donor_gain	1.0000
1:1406907:ACGGT:A	donor_gain	1.0000
1:1406908:CGGTC:C	donor_gain	1.0000
1:1407127:TCACC:T	donor_loss	1.0000
1:1407128:CA:C	donor_loss	1.0000
1:1407129:A:AC	donor_gain	1.0000
1:1407129:AC:A	donor_gain	1.0000
1:1407129:ACC:A	donor_gain	1.0000
1:1407130:C:CT	donor_gain	1.0000
1:1407130:CC:C	donor_gain	1.0000
1:1407130:CCC:C	donor_gain	1.0000
1:1407130:CCCT:C	donor_gain	1.0000
1:1407130:CCCTG:C	donor_gain	1.0000
1:1407150:T:TA	donor_gain	1.0000
1:1402255:CA:C	acceptor_gain	0.9900
1:1405841:T:TA	donor_gain	0.9900
1:1405882:CAGAG:C	acceptor_gain	0.9900
1:1405883:AGAGC:A	acceptor_loss	0.9900
1:1405886:GC:G	acceptor_loss	0.9900
1:1405887:C:CA	acceptor_loss	0.9900
1:1405887:C:CC	acceptor_gain	0.9900
1:1406908:CGGT:C	donor_gain	0.9900
1:1407016:AGTG:A	acceptor_gain	0.9900
1:1407018:TG:T	acceptor_gain	0.9900
1:1407020:C:CC	acceptor_gain	0.9900

AlphaMissense

960 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:1402194:G:C	F113L	0.985
1:1402194:G:T	F113L	0.985
1:1402196:A:G	F113L	0.985
1:1407014:G:C	F31L	0.984
1:1407014:G:T	F31L	0.984
1:1407016:A:G	F31L	0.984
1:1405857:G:C	S76R	0.981
1:1405857:G:T	S76R	0.981
1:1405859:T:G	S76R	0.981
1:1402216:G:T	A106D	0.980
1:1407135:G:T	A28D	0.972
1:1402219:A:G	L105P	0.971
1:1405861:G:T	A75D	0.971
1:1402243:A:T	L97H	0.970
1:1405873:C:G	R71P	0.969
1:1402186:A:G	L116S	0.968
1:1402207:T:A	E109V	0.968
1:1402195:A:G	F113S	0.967
1:1402217:C:G	A106P	0.965
1:1406982:G:T	A42E	0.965
1:1402226:C:G	A103P	0.962
1:1405816:A:G	L90S	0.959
1:1406937:C:G	R57P	0.958
1:1405828:A:G	L86P	0.955
1:1406993:G:C	C38W	0.955
1:1402174:G:T	A120D	0.948
1:1406962:C:G	A49P	0.948
1:1402184:C:G	A117P	0.947
1:1402240:T:A	N98I	0.947
1:1402183:G:T	A117D	0.946

dbSNP variants (sampled 300 via entrez): RS1000250273 (1:1407270 T>C), RS1000429563 (1:1403650 A>G), RS1000584590 (1:1406503 C>T), RS1000635236 (1:1406314 C>A,G), RS1000693960 (1:1402447 G>A,C), RS1000759461 (1:1403440 C>T), RS1001086226 (1:1409003 G>A,C), RS1001121972 (1:1409162 G>A), RS1001424518 (1:1408091 G>C), RS1001900382 (1:1407312 C>G), RS1002255236 (1:1405553 C>A,T), RS1002437457 (1:1401741 A>G), RS1002585731 (1:1404683 G>A,C), RS1002944964 (1:1403064 G>A), RS1003145746 (1:1407442 A>C)

Disease associations

OMIM: gene MIM:611833 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST004131_103	Inflammatory bowel disease	2.000000e-07
GCST004133_40	Ulcerative colitis	3.000000e-06
GCST007268_75	Diastolic blood pressure	2.000000e-08

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0006336	diastolic blood pressure

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

34 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	decreases expression, increases expression	2
alpha phellandrene	decreases expression	1
bisphenol A	decreases expression	1
arsenite	affects binding, increases reaction	1
tris(1,3-dichloro-2-propyl)phosphate	decreases expression	1
cobaltous chloride	decreases expression	1
di-n-butylphosphoric acid	affects expression	1
corosolic acid	decreases expression	1
K 7174	decreases expression	1
erucylphospho-N,N,N-trimethylpropylammonium	decreases expression	1
Grape Seed Proanthocyanidins	affects cotreatment, decreases expression	1
Resveratrol	increases expression, affects cotreatment	1
Acetaminophen	decreases expression, affects cotreatment	1
Atrazine	decreases expression	1
Benzo(a)pyrene	decreases methylation	1
Cadmium	increases abundance, increases expression	1
Catechin	affects cotreatment, decreases expression	1
Diazinon	increases methylation	1
Hydrogen Peroxide	affects expression	1
Lipopolysaccharides	affects cotreatment, decreases expression	1
Nickel	increases expression	1
Plant Extracts	affects cotreatment, increases expression	1
Quercetin	decreases expression	1
Ribonucleotides	affects binding	1
Silicon Dioxide	decreases expression	1
Smoke	decreases expression	1
Thiram	decreases expression	1
Tunicamycin	decreases expression	1
Urethane	decreases expression	1
Valproic Acid	increases methylation	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.