MRPL22

Summary

MRPL22 (mitochondrial ribosomal protein L22, HGNC:14480) is a protein-coding gene on chromosome 5q33.2, encoding Large ribosomal subunit protein uL22m (Q9NWU5). It is a selective cancer dependency (DepMap: 26.5% of cell lines).

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein that belongs to the L22 ribosomal protein family. A pseudogene corresponding to this gene is found on chromosome 4q. Two transcript variants encoding different isoforms have been found for this gene.

Source: NCBI Gene 29093 — RefSeq curated summary.

At a glance

• GWAS associations: 5
• Clinical variants (ClinVar): 38 total
• Cancer dependency (DepMap): dependent in 26.5% of screened cell lines
• MANE Select transcript: NM_014180

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:14480
Approved symbol	MRPL22
Name	mitochondrial ribosomal protein L22
Location	5q33.2
Locus type	gene with protein product
Status	Approved
Aliases	MRP-L25, RPML25, HSPC158, uL22m
Ensembl gene	ENSG00000082515
Ensembl biotype	protein_coding
OMIM	611835
Entrez	29093

Gene structure

Transcript identifiers

Ensembl transcripts: 8 — 5 protein_coding, 1 protein_coding_CDS_not_defined, 1 nonsense_mediated_decay, 1 retained_intron

ENST00000265229, ENST00000439747, ENST00000518364, ENST00000519059, ENST00000520040, ENST00000522038, ENST00000523037, ENST00000906691

RefSeq mRNA: 2 — MANE Select: NM_014180 NM_001014990, NM_014180

CCDS: CCDS4331, CCDS43391

Canonical transcript exons

ENST00000523037 — 7 exons

Exon	Start	End
ENSE00001381368	154966686	154969411
ENSE00001892134	154941073	154941138
ENSE00002287179	154950821	154950938
ENSE00003490468	154956371	154956436
ENSE00003531059	154959980	154960049
ENSE00003534814	154957135	154957212
ENSE00003673273	154941217	154941265

Expression profiles

Bgee: expression breadth ubiquitous, 288 present calls, max score 94.58.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 26.5351 / max 332.3969, expressed in 1810 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
59758	26.5351	1810

Top tissues by expression

291 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
mucosa of transverse colon	UBERON:0004991	94.58	gold quality
heart left ventricle	UBERON:0002084	94.45	gold quality
cardiac ventricle	UBERON:0002082	94.30	gold quality
right atrium auricular region	UBERON:0006631	94.22	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	94.16	gold quality
islet of Langerhans	UBERON:0000006	94.08	gold quality
heart right ventricle	UBERON:0002080	93.71	gold quality
right adrenal gland	UBERON:0001233	93.69	gold quality
left testis	UBERON:0004533	93.58	gold quality
heart	UBERON:0000948	93.53	gold quality
apex of heart	UBERON:0002098	93.34	gold quality
cardiac atrium	UBERON:0002081	93.30	gold quality
left adrenal gland	UBERON:0001234	93.26	gold quality
testis	UBERON:0000473	93.23	gold quality
left adrenal gland cortex	UBERON:0035825	93.17	gold quality
right testis	UBERON:0004534	93.14	gold quality
right adrenal gland cortex	UBERON:0035827	93.14	gold quality
body of pancreas	UBERON:0001150	93.05	gold quality
hindlimb stylopod muscle	UBERON:0004252	92.77	gold quality
male germ line stem cell (sensu Vertebrata) in testis	CL:0000089 ∩ UBERON:0000473	92.64	gold quality
adrenal gland	UBERON:0002369	92.45	gold quality
colonic epithelium	UBERON:0000397	92.44	gold quality
right lobe of liver	UBERON:0001114	92.43	gold quality
lower esophagus	UBERON:0013473	92.33	gold quality
lower esophagus muscularis layer	UBERON:0035833	92.33	gold quality
pancreas	UBERON:0001264	92.30	gold quality
adenohypophysis	UBERON:0002196	92.30	gold quality
adrenal cortex	UBERON:0001235	92.29	gold quality
rectum	UBERON:0001052	92.25	gold quality
muscle layer of sigmoid colon	UBERON:0035805	92.18	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	10.61

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

89 targeting MRPL22, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-340-5P	100.00	72.50	4437
HSA-MIR-4747-5P	100.00	67.90	2681
HSA-MIR-5196-5P	100.00	67.98	2761
HSA-MIR-3185	99.99	68.12	1959
HSA-MIR-4789-5P	99.98	70.76	2721
HSA-MIR-607	99.97	73.62	5593
HSA-MIR-548AT-5P	99.96	70.83	2666
HSA-MIR-548AA	99.96	70.64	3753
HSA-MIR-548AP-3P	99.96	70.64	3753
HSA-MIR-548T-3P	99.96	70.64	3753
HSA-MIR-651-3P	99.94	73.48	5177
HSA-MIR-141-3P	99.94	72.79	2421
HSA-MIR-200A-3P	99.94	72.68	2420
HSA-MIR-335-3P	99.93	73.36	4958
HSA-MIR-4760-3P	99.93	70.50	2385
HSA-MIR-539-5P	99.93	70.30	2855
HSA-MIR-6835-3P	99.93	70.49	2904
HSA-MIR-4778-3P	99.93	70.40	1818
HSA-MIR-548E-5P	99.89	72.73	4486
HSA-MIR-345-3P	99.89	70.23	1421
HSA-MIR-95-5P	99.89	72.17	3973
HSA-MIR-30A-3P	99.87	69.74	2928
HSA-MIR-30D-3P	99.87	69.92	2917
HSA-MIR-30E-3P	99.87	69.68	2942
HSA-MIR-520F-3P	99.82	71.32	1216
HSA-MIR-4495	99.82	72.08	3080
HSA-MIR-6739-5P	99.80	67.87	2806
HSA-MIR-204-5P	99.79	71.62	2439
HSA-MIR-211-5P	99.79	71.65	2440
HSA-MIR-548AJ-5P	99.78	71.12	3085

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 26.5% of screened cell lines.

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	mrpl22	ENSDARG00000109961
mus_musculus	Mrpl22	ENSMUSG00000020514
rattus_norvegicus	Mrpl22	ENSRNOG00000027039
drosophila_melanogaster	mRpL22	FBGN0030786
caenorhabditis_elegans		WBGENE00012645

Protein

Protein identifiers

Large ribosomal subunit protein uL22m — Q9NWU5 (reviewed: Q9NWU5)

Alternative names: 39S ribosomal protein L22, mitochondrial, 39S ribosomal protein L25, mitochondrial

All UniProt accessions (4): Q9NWU5, E7ESL0, H0YBZ7, J3KQY1

UniProt curated annotations — full annotation on UniProt →

Subunit / interactions. Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.

Subcellular location. Mitochondrion.

Similarity. Belongs to the universal ribosomal protein uL22 family.

Isoforms (3)

UniProt ID	Names	Canonical?
Q9NWU5-1	1	yes
Q9NWU5-2	2
Q9NWU5-3	3

RefSeq proteins (2): NP_001014990, NP_054899* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR001063	Ribosomal_uL22	Family
IPR036394	Ribosomal_uL22_sf	Homologous_superfamily
IPR047867	Ribosomal_uL22_bact_org	Family

Pfam: PF00237

UniProt features (19 total): strand 8, helix 6, splice variant 2, transit peptide 1, chain 1, sequence variant 1

Structure

Experimental structures (PDB)

73 structures, top 30 by resolution.

PDB	Method	Resolution (Å)
7OF0	ELECTRON MICROSCOPY	2.2
7QI4	ELECTRON MICROSCOPY	2.21
8RRI	ELECTRON MICROSCOPY	2.4
8QU5	ELECTRON MICROSCOPY	2.42
9OLF	ELECTRON MICROSCOPY	2.46
7OF7	ELECTRON MICROSCOPY	2.5
7PO4	ELECTRON MICROSCOPY	2.56
6ZM6	ELECTRON MICROSCOPY	2.59
7OF6	ELECTRON MICROSCOPY	2.6
9CN3	ELECTRON MICROSCOPY	2.62
7QI5	ELECTRON MICROSCOPY	2.63
7OF2	ELECTRON MICROSCOPY	2.7
7OF3	ELECTRON MICROSCOPY	2.7
7OF4	ELECTRON MICROSCOPY	2.7
8QU1	ELECTRON MICROSCOPY	2.74
9PR4	ELECTRON MICROSCOPY	2.77
9PRA	ELECTRON MICROSCOPY	2.83
8ANY	ELECTRON MICROSCOPY	2.85
6ZM5	ELECTRON MICROSCOPY	2.89
7QH7	ELECTRON MICROSCOPY	2.89
7ODR	ELECTRON MICROSCOPY	2.9
7OF5	ELECTRON MICROSCOPY	2.9
8K2A	ELECTRON MICROSCOPY	2.9
8OIT	ELECTRON MICROSCOPY	2.9
9PGL	ELECTRON MICROSCOPY	2.9
9PGF	ELECTRON MICROSCOPY	2.93
7QI6	ELECTRON MICROSCOPY	2.98
9PSM	ELECTRON MICROSCOPY	2.98
8QSJ	ELECTRON MICROSCOPY	3
9UWH	ELECTRON MICROSCOPY	3

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9NWU5-F1	86.07	0.75

Function

Pathways and Gene Ontology

Reactome pathways

7 pathways

ID	Pathway
R-HSA-5368286	Mitochondrial translation initiation
R-HSA-5389840	Mitochondrial translation elongation
R-HSA-5419276	Mitochondrial translation termination
R-HSA-9937383	Mitochondrial ribosome-associated quality control
R-HSA-392499	Metabolism of proteins
R-HSA-5368287	Mitochondrial translation
R-HSA-72766	Translation

MSigDB gene sets: 105 (showing top): TGCGCANK_UNKNOWN, SHEPARD_CRASH_AND_BURN_MUTANT_UP, GOBP_MITOCHONDRIAL_TRANSLATION, ACEVEDO_NORMAL_TISSUE_ADJACENT_TO_LIVER_TUMOR_DN, GOBP_TRANSLATION, WEI_MYCN_TARGETS_WITH_E_BOX, GOMF_STRUCTURAL_CONSTITUENT_OF_RIBOSOME, GOCC_MITOCHONDRIAL_ENVELOPE, TIEN_INTESTINE_PROBIOTICS_24HR_UP, NAKAMURA_TUMOR_ZONE_PERIPHERAL_VS_CENTRAL_UP, GOCC_LARGE_RIBOSOMAL_SUBUNIT, GOCC_RIBOSOME, GOCC_ORGANELLAR_RIBOSOME, GOCC_MITOCHONDRIAL_MATRIX, GOCC_ORGANELLE_INNER_MEMBRANE

GO Biological Process (2): translation (GO:0006412), mitochondrial translation (GO:0032543)

GO Molecular Function (2): RNA binding (GO:0003723), structural constituent of ribosome (GO:0003735)

GO Cellular Component (6): mitochondrion (GO:0005739), mitochondrial inner membrane (GO:0005743), mitochondrial large ribosomal subunit (GO:0005762), ribosome (GO:0005840), large ribosomal subunit (GO:0015934), ribonucleoprotein complex (GO:1990904)

Reactome top-level categories

Rollup of top-3 pathways:

Category	Pathways
Mitochondrial translation	4
Translation	1
Metabolism of proteins	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
peptidyltransferase activity	1
translational initiation	1
translational elongation	1
translational termination	1
macromolecule biosynthetic process	1
protein metabolic process	1
protein biosynthetic process	1
mitochondrion	1
translation	1
mitochondrial gene expression	1
nucleic acid binding	1
structural molecule activity	1
ribosome	1
cytoplasm	1
intracellular membrane-bounded organelle	1
organelle inner membrane	1
mitochondrial membrane	1
organellar large ribosomal subunit	1
mitochondrial ribosome	1
mitochondrial protein-containing complex	1
intracellular membraneless organelle	1
ribosomal subunit	1
protein-containing complex	1

Protein interactions and networks

STRING

3672 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
MRPL22	RPL17	P18621	571
MRPL22	MRPS6	P82932	552
MRPL22	MRPL11	Q9Y3B7	550
MRPL22	MRPS11	P82912	541
MRPL22	MRPL19	P49406	528
MRPL22	UQCRHL	A0A096LP55	512
MRPL22	RPS17	P08708	478
MRPL22	PSMA4	P25789	404
MRPL22	UBL5	Q9BZL1	401
MRPL22	RPL37	P02403	384
MRPL22	COA5	Q86WW8	380
MRPL22	EARS2	Q5JPH6	376
MRPL22	UQCRQ	O14949	374
MRPL22	CHCHD7	Q9BUK0	366
MRPL22	MRPL1	Q9BYD6	353
MRPL22	MRPS14	O60783	353

IntAct

133 interactions, top by confidence:

A	B	Type	Score
NDUFS3	NDUFS8	psi-mi:“MI:0914”(association)	0.730
CFTR	ESYT2	psi-mi:“MI:2364”(proximity)	0.710
MRPS30	GTPBP10	psi-mi:“MI:0914”(association)	0.640
NP	KPNA6	psi-mi:“MI:0914”(association)	0.550
GLP1R	MRPL22	psi-mi:“MI:0915”(physical association)	0.540
MRPL22	GLP1R	psi-mi:“MI:0915”(physical association)	0.540
GLP1R	MRPL22	psi-mi:“MI:0403”(colocalization)	0.540
MRPL50	GTPBP10	psi-mi:“MI:0914”(association)	0.530
MRPL10	ZZEF1	psi-mi:“MI:0914”(association)	0.530
MRPL42	GATC	psi-mi:“MI:0914”(association)	0.530
MRPL41	MRPL3	psi-mi:“MI:0914”(association)	0.530
MRPL2	GTPBP10	psi-mi:“MI:0914”(association)	0.530
H1-4	RRP8	psi-mi:“MI:0914”(association)	0.530
MRPL13	GTPBP10	psi-mi:“MI:0914”(association)	0.530
MRPL18	GTPBP10	psi-mi:“MI:0914”(association)	0.530
MRPL27	MRPL33	psi-mi:“MI:0914”(association)	0.530
NDUFAB1	MIEF1	psi-mi:“MI:0915”(physical association)	0.490
steC	SCD	psi-mi:“MI:0914”(association)	0.460
MRPL22	SF3A1	psi-mi:“MI:0915”(physical association)	0.400
Ppp2ca	DKFZP586J0619	psi-mi:“MI:0914”(association)	0.350
MRPL50	MRPL43	psi-mi:“MI:0914”(association)	0.350
MRPL9	MRPL43	psi-mi:“MI:0914”(association)	0.350

BioGRID (255): MRPL22 (Affinity Capture-RNA), MRPL22 (Affinity Capture-RNA), MRPL22 (Affinity Capture-MS), MRPL22 (Affinity Capture-MS), MRPL22 (Affinity Capture-MS), MRPL22 (Affinity Capture-MS), MRPL22 (Affinity Capture-MS), MRPL22 (Affinity Capture-MS), MRPL22 (Affinity Capture-MS), MRPL10 (Co-fractionation), MRPL17 (Co-fractionation), MRPL2 (Co-fractionation), MRPL22 (Co-fractionation), MRPL22 (Co-fractionation), MRPL22 (Co-fractionation)

ESM2 similar proteins: A2VE61, A5PJM7, B5FWC0, D4ABL6, E9PV86, F1QH17, O35972, O95782, P0C2C0, P0C7P0, P13984, P17426, P52848, Q01750, Q02353, Q08200, Q16540, Q2T9L9, Q3SZB3, Q3SZX5, Q3UHN9, Q3UMR5, Q3ZCQ8, Q4V8I4, Q5R7B1, Q5RAH3, Q5RAJ8, Q5U4X8, Q63750, Q6IQS9, Q6P6G7, Q6P6Q9, Q6TH22, Q7ZYA7, Q86TD4, Q8BU88, Q8CIW5, Q8NE86, Q8R0A0, Q8TF64

Diamond homologs: A1B032, A1KB22, A1TJ12, A1VIQ5, A1W2R2, A1WHD0, A2SLF2, A4G9T3, A4SUW6, A4YSJ7, A5ELM2, A5EX77, A5IM88, A5WCJ5, A6LLL8, A6LPR6, A6T3J9, A6U864, A7MWI8, A8F4R6, A8LM59, A8YXL0, A9BPS3, A9IIZ3, A9W4Q6, B0CH27, B0RZU5, B0V6X3, B0VQS3, B1LBN5, B1Z757, B2HZL7, B2IK67, B2UEL4, B3PK42, B4R8M2, B6IRR1, B7IHV1, B7L0R6, B8ELF8

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
MRPL22	“form complex”	“39S mitochondrial large ribosomal subunit”	binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 112 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Mitochondrial ribosome-associated quality control	32	52.4×	1e-46
Mitochondrial translation initiation	28	47.4×	3e-39
Mitochondrial translation elongation	28	47.4×	3e-39
Mitochondrial translation	25	45.9×	2e-34
Mitochondrial translation termination	28	41.0×	3e-37
Translation	26	21.5×	1e-26
Mitochondrial protein degradation	6	9.1×	2e-03

GO biological processes:

GO term	Partners	Fold	FDR
mitochondrial translation	30	54.3×	1e-42
mitochondrial large ribosomal subunit assembly	5	51.6×	4e-06
translation	19	20.3×	1e-17

Disease & clinical

Clinical variants and AI predictions

ClinVar

38 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	26
Likely benign	1
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

1106 predictions. Top by Δscore:

Variant	Effect	Δscore
5:154950936:GCA:G	donor_gain	1.0000
5:154950939:G:GG	donor_gain	1.0000
5:154956361:A:AG	acceptor_gain	1.0000
5:154956361:AATTT:A	acceptor_gain	1.0000
5:154956362:A:AG	acceptor_gain	1.0000
5:154956363:T:G	acceptor_gain	1.0000
5:154956365:T:A	acceptor_gain	1.0000
5:154956368:A:AG	acceptor_gain	1.0000
5:154956368:AAG:A	acceptor_gain	1.0000
5:154956369:A:G	acceptor_gain	1.0000
5:154956433:ATTGG:A	donor_loss	1.0000
5:154956434:TTGGT:T	donor_loss	1.0000
5:154956435:TGG:T	donor_loss	1.0000
5:154956436:GGT:G	donor_loss	1.0000
5:154956437:G:GC	donor_loss	1.0000
5:154956437:G:GG	donor_gain	1.0000
5:154956438:TAAGC:T	donor_loss	1.0000
5:154957120:A:AG	acceptor_gain	1.0000
5:154957121:C:G	acceptor_gain	1.0000
5:154957127:A:AG	acceptor_gain	1.0000
5:154957128:A:AG	acceptor_gain	1.0000
5:154957130:TCTA:T	acceptor_loss	1.0000
5:154957131:CTA:C	acceptor_loss	1.0000
5:154957132:TA:T	acceptor_loss	1.0000
5:154957133:A:AG	acceptor_gain	1.0000
5:154957134:G:GA	acceptor_gain	1.0000
5:154957134:GA:G	acceptor_gain	1.0000
5:154957134:GAT:G	acceptor_gain	1.0000
5:154957134:GATA:G	acceptor_gain	1.0000
5:154957134:GATAC:G	acceptor_gain	1.0000

AlphaMissense

1330 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
5:154959992:G:C	A118P	0.996
5:154966791:T:C	L172S	0.994
5:154959984:T:A	L115H	0.993
5:154957159:G:C	A96P	0.992
5:154959984:T:C	L115P	0.990
5:154966785:T:A	V170E	0.989
5:154966774:C:G	C166W	0.988
5:154956387:G:C	R71P	0.987
5:154957136:T:A	I88K	0.987
5:154959984:T:G	L115R	0.987
5:154960028:T:C	F130L	0.987
5:154960030:C:A	F130L	0.987
5:154960030:C:G	F130L	0.987
5:154960041:T:C	L134S	0.987
5:154960047:T:A	I136K	0.987
5:154957177:T:C	F102L	0.986
5:154957179:C:A	F102L	0.986
5:154957179:C:G	F102L	0.986
5:154966778:T:G	Y168D	0.986
5:154957192:G:A	G107R	0.985
5:154957192:G:C	G107R	0.985
5:154957192:G:T	G107W	0.985
5:154960005:C:A	A122E	0.985
5:154966691:T:C	S139P	0.984
5:154957160:C:A	A96D	0.983
5:154966728:G:C	R151P	0.983
5:154966772:T:C	C166R	0.983
5:154960004:G:C	A122P	0.981
5:154966773:G:A	C166Y	0.981
5:154956404:A:C	S77R	0.980

dbSNP variants (sampled 300 via entrez): RS1000030775 (5:154947487 A>G), RS1000072418 (5:154940356 T>G), RS1000128735 (5:154947368 G>A), RS1000199325 (5:154945776 A>G), RS1000267219 (5:154965693 A>G,T), RS1000291103 (5:154946443 A>G), RS1000485126 (5:154953973 A>C), RS1000760324 (5:154958011 C>G,T), RS1000826347 (5:154959349 C>T), RS1000890618 (5:154955075 G>A), RS1000948316 (5:154957720 G>C), RS1001034324 (5:154968815 G>A), RS1001231744 (5:154956900 G>A,T), RS1001268686 (5:154963377 T>C), RS1001330094 (5:154961843 C>T)

Disease associations

OMIM: gene MIM:611835 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

5 associations (top):

Study	Trait	p-value
GCST004630_150	Mean corpuscular hemoglobin	1.000000e-28
GCST90002390_145	Mean corpuscular hemoglobin	5.000000e-38
GCST90002391_37	Mean corpuscular hemoglobin concentration	1.000000e-11
GCST90002392_641	Mean corpuscular volume	1.000000e-21
GCST90002403_414	Red blood cell count	3.000000e-12

EFO canonical traits (3, from GWAS)

EFO ID	Trait name
EFO:0004527	mean corpuscular hemoglobin
EFO:0004528	mean corpuscular hemoglobin concentration
EFO:0004305	erythrocyte count

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

26 total (human), top 26 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol F	increases expression, affects cotreatment	2
Acetaminophen	decreases expression	2
dicrotophos	decreases expression	1
quercitrin	decreases expression	1
arsenite	affects binding, increases reaction	1
sodium arsenite	decreases activity	1
beta-methylcholine	affects expression	1
cylindrospermopsin	increases expression	1
CGP 52608	affects binding, increases reaction	1
bisphenol B	increases expression	1
abrine	increases expression	1
bisphenol S	affects expression	1
Resveratrol	affects cotreatment, increases expression	1
Air Pollutants	decreases expression, increases abundance	1
Dexamethasone	affects cotreatment, increases expression	1
Hydrogen Peroxide	affects expression	1
Indomethacin	affects cotreatment, increases expression	1
Ivermectin	increases expression	1
Methotrexate	affects cotreatment, decreases expression	1
Phthalic Acids	decreases methylation	1
Plant Extracts	affects cotreatment, increases expression	1
Ribonucleotides	affects binding	1
1-Methyl-3-isobutylxanthine	affects cotreatment, increases expression	1
Antirheumatic Agents	affects cotreatment, decreases expression	1
Lactic Acid	decreases expression	1
Particulate Matter	decreases expression, increases abundance	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.