MRPL23-AS1

Summary

MRPL23-AS1 (MRPL23 antisense RNA 1, HGNC:42812) is a long non-coding RNA gene on chromosome 11p15.5.

At a glance

• Gene type: non-coding (lncRNA) — no protein product; not a drug target. Variant/disease associations are omitted (they would be positional, from an overlapping protein-coding gene).

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:42812
Approved symbol	MRPL23-AS1
Name	MRPL23 antisense RNA 1
Location	11p15.5
Locus type	RNA, long non-coding
Status	Approved
Aliases	TP53LC10
Ensembl gene	ENSG00000226416
Ensembl biotype	lncRNA
Entrez	100133545
RNAcentral	URS000075DE97 — lncRNA, 1904 nt, 1 organism(s)

Gene structure

Transcript identifiers

Ensembl transcripts: 4 — 4 lncRNA

ENST00000419080, ENST00000733385, ENST00000733386, ENST00000733387

RefSeq mRNA: 0 — MANE Select: None

Canonical transcript exons

ENST00000419080 — 4 exons

Exon	Start	End
ENSE00001726148	1984850	1984982
ENSE00001739541	1985443	1985641
ENSE00003981149	1989826	1989993
ENSE00003981150	1983237	1984685

Expression profiles

Bgee: expression breadth ubiquitous, 125 present calls, max score 81.15.

FANTOM5 (CAGE): breadth tissue_specific, TPM avg 0.2024 / max 30.8453, expressed in 63 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
118064	0.1875	58
118063	0.0149	10

Top tissues by expression

125 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
muscle of leg	UBERON:0001383	81.15	gold quality
gastrocnemius	UBERON:0001388	79.83	gold quality
hindlimb stylopod muscle	UBERON:0004252	79.45	gold quality
right uterine tube	UBERON:0001302	79.27	gold quality
skeletal muscle tissue	UBERON:0001134	78.36	gold quality
right hemisphere of cerebellum	UBERON:0014890	75.12	gold quality
cerebellar hemisphere	UBERON:0002245	73.98	gold quality
cerebellar cortex	UBERON:0002129	73.89	gold quality
cerebellum	UBERON:0002037	73.76	gold quality
right frontal lobe	UBERON:0002810	70.73	gold quality
left uterine tube	UBERON:0001303	69.71	gold quality
left ovary	UBERON:0002119	69.61	gold quality
fallopian tube	UBERON:0003889	69.60	gold quality
body of uterus	UBERON:0009853	69.54	gold quality
right coronary artery	UBERON:0001625	69.30	gold quality
myometrium	UBERON:0001296	68.56	gold quality
ovary	UBERON:0000992	68.55	gold quality
Brodmann (1909) area 9	UBERON:0013540	68.38	gold quality
lower esophagus muscularis layer	UBERON:0035833	67.88	gold quality
right ovary	UBERON:0002118	67.87	gold quality
fundus of stomach	UBERON:0001160	67.86	gold quality
lower esophagus	UBERON:0013473	67.82	gold quality
muscle layer of sigmoid colon	UBERON:0035805	67.71	gold quality
apex of heart	UBERON:0002098	67.68	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	67.60	gold quality
body of pancreas	UBERON:0001150	67.49	gold quality
superior frontal gyrus	UBERON:0002661	67.16	gold quality
dorsolateral prefrontal cortex	UBERON:0009834	66.82	gold quality
brain	UBERON:0000955	66.53	gold quality
popliteal artery	UBERON:0002250	66.32	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 0.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.31

Regulation

Is transcription factor: no

Literature-anchored findings (GeneRIF, showing 2)

• Long Noncoding RNA MRPL23-AS1 Promoteoid Cystic Carcinoma Lung Metastasis. (PMID:32098781)
• Long non-coding RNA (LncRNA) MRPL23-AS1 promotes tumor progression and carcinogenesis in osteosarcoma by activating Wnt/beta-catenin signaling via inhibiting microRNA miR-30b and upregulating myosin heavy chain 9 (MYH9). (PMID:33356805)

Cross-species orthologs

0 orthologs

Protein

Non-coding RNA — no protein product; not a drug target.

Function

No curated pathway, Gene-Ontology, or interaction data.

Disease & clinical

No curated disease, variant, or cancer-driver associations.

Drugs & pharmacology

No drug or pharmacology data — not an established drug target.