MRPL24

Summary

MRPL24 (mitochondrial ribosomal protein L24, HGNC:14037) is a protein-coding gene on chromosome 1q23.1, encoding Large ribosomal subunit protein uL24m (Q96A35). It is a selective cancer dependency (DepMap: 38.5% of cell lines).

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein which is more than twice the size of its E.coli counterpart (EcoL24). Sequence analysis identified two transcript variants that encode the same protein.

Source: NCBI Gene 79590 — RefSeq curated summary.

At a glance

• Gene–disease (curated): mitochondrial disease (Limited, ClinGen)
• GWAS associations: 1
• Clinical variants (ClinVar): 47 total
• Cancer dependency (DepMap): dependent in 38.5% of screened cell lines
• MANE Select transcript: NM_145729

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:14037
Approved symbol	MRPL24
Name	mitochondrial ribosomal protein L24
Location	1q23.1
Locus type	gene with protein product
Status	Approved
Aliases	MRP-L18, uL24m
Ensembl gene	ENSG00000143314
Ensembl biotype	protein_coding
OMIM	611836
Entrez	79590

Gene structure

Transcript identifiers

Ensembl transcripts: 35 — 34 protein_coding, 1 protein_coding_CDS_not_defined

ENST00000361531, ENST00000368211, ENST00000412846, ENST00000420938, ENST00000434558, ENST00000478899, ENST00000858113, ENST00000858114, ENST00000858115, ENST00000858116, ENST00000858117, ENST00000858118, ENST00000858119, ENST00000858120, ENST00000858121, ENST00000858122, ENST00000858123, ENST00000858124, ENST00000858125, ENST00000858126, ENST00000858127, ENST00000858128, ENST00000858129, ENST00000915500, ENST00000915501, ENST00000915502, ENST00000915503, ENST00000915504, ENST00000915505, ENST00000915506, ENST00000915507, ENST00000915508, ENST00000966308, ENST00000966309, ENST00000966310

RefSeq mRNA: 2 — MANE Select: NM_145729 NM_024540, NM_145729

CCDS: CCDS1155

Canonical transcript exons

ENST00000361531 — 6 exons

Exon	Start	End
ENSE00000959208	156738343	156738438
ENSE00001054758	156738522	156738764
ENSE00001343250	156741012	156741088
ENSE00001434575	156738031	156738134
ENSE00003547363	156737303	156737534
ENSE00003602731	156737646	156737776

Expression profiles

Bgee: expression breadth ubiquitous, 279 present calls, max score 97.81.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 24.0940 / max 164.1041, expressed in 1798 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
15195	20.6385	1792
15196	3.3869	1557
15197	0.0687	16

Top tissues by expression

286 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
body of pancreas	UBERON:0001150	97.81	gold quality
apex of heart	UBERON:0002098	97.56	gold quality
hindlimb stylopod muscle	UBERON:0004252	97.39	gold quality
right adrenal gland	UBERON:0001233	97.37	gold quality
left adrenal gland cortex	UBERON:0035825	97.25	gold quality
islet of Langerhans	UBERON:0000006	97.19	gold quality
left adrenal gland	UBERON:0001234	97.17	gold quality
right adrenal gland cortex	UBERON:0035827	97.14	gold quality
adrenal cortex	UBERON:0001235	97.06	gold quality
muscle of leg	UBERON:0001383	96.93	gold quality
right lobe of liver	UBERON:0001114	96.90	gold quality
gastrocnemius	UBERON:0001388	96.88	gold quality
mucosa of transverse colon	UBERON:0004991	96.87	gold quality
pancreas	UBERON:0001264	96.79	gold quality
skeletal muscle tissue of rectus abdominis	UBERON:0004511	96.78	silver quality
adrenal gland	UBERON:0002369	96.68	gold quality
calcaneal tendon	UBERON:0003701	96.68	gold quality
heart left ventricle	UBERON:0002084	96.66	gold quality
cardiac ventricle	UBERON:0002082	96.57	gold quality
muscle organ	UBERON:0001630	96.46	gold quality
lower esophagus muscularis layer	UBERON:0035833	96.43	gold quality
lower esophagus	UBERON:0013473	96.42	gold quality
rectum	UBERON:0001052	96.39	gold quality
muscle layer of sigmoid colon	UBERON:0035805	96.39	gold quality
right uterine tube	UBERON:0001302	96.37	gold quality
lateral globus pallidus	UBERON:0002476	96.19	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	96.17	gold quality
heart	UBERON:0000948	96.09	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	96.08	gold quality
substantia nigra pars reticulata	UBERON:0001966	95.97	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	12.73
E-CURD-112	no	3.84

Regulation

Is transcription factor: no

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 38.5% of screened cell lines.

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	mrpl24	ENSDARG00000019222
mus_musculus	Mrpl24	ENSMUSG00000019710
rattus_norvegicus	mrpl24	ENSRNOG00000022234
drosophila_melanogaster	mRpL24	FBGN0031651
caenorhabditis_elegans	mrpl-24	WBGENE00019076

Protein

Protein identifiers

Large ribosomal subunit protein uL24m — Q96A35 (reviewed: Q96A35)

Alternative names: 39S ribosomal protein L24, mitochondrial

All UniProt accessions (4): Q96A35, X6RHI2, X6RIR5, X6RJ73

UniProt curated annotations — full annotation on UniProt →

Subunit / interactions. Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.

Subcellular location. Mitochondrion.

Similarity. Belongs to the universal ribosomal protein uL24 family.

RefSeq proteins (2): NP_078816, NP_663781* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR003256	Ribosomal_uL24	Family
IPR005824	KOW	Domain
IPR005825	Ribosomal_uL24_CS	Conserved_site
IPR008991	Translation_prot_SH3-like_sf	Homologous_superfamily
IPR014722	Rib_uL2_dom2	Homologous_superfamily
IPR041988	Ribosomal_uL24_KOW	Domain
IPR057264	Ribosomal_uL24_C	Domain

Pfam: PF00467, PF17136

UniProt features (30 total): strand 14, helix 5, sequence conflict 5, turn 2, transit peptide 1, chain 1, domain 1, modified residue 1

Structure

Experimental structures (PDB)

86 structures, top 30 by resolution.

PDB	Method	Resolution (Å)
7OF0	ELECTRON MICROSCOPY	2.2
7QI4	ELECTRON MICROSCOPY	2.21
8RRI	ELECTRON MICROSCOPY	2.4
8QU5	ELECTRON MICROSCOPY	2.42
9OLF	ELECTRON MICROSCOPY	2.46
7OF7	ELECTRON MICROSCOPY	2.5
7PO4	ELECTRON MICROSCOPY	2.56
6ZM6	ELECTRON MICROSCOPY	2.59
7O9M	ELECTRON MICROSCOPY	2.6
7OF6	ELECTRON MICROSCOPY	2.6
9CN3	ELECTRON MICROSCOPY	2.62
7QI5	ELECTRON MICROSCOPY	2.63
7OF2	ELECTRON MICROSCOPY	2.7
7OF3	ELECTRON MICROSCOPY	2.7
7OF4	ELECTRON MICROSCOPY	2.7
8QU1	ELECTRON MICROSCOPY	2.74
9PR4	ELECTRON MICROSCOPY	2.77
9PRA	ELECTRON MICROSCOPY	2.83
8ANY	ELECTRON MICROSCOPY	2.85
6ZM5	ELECTRON MICROSCOPY	2.89
7QH7	ELECTRON MICROSCOPY	2.89
7ODR	ELECTRON MICROSCOPY	2.9
7OF5	ELECTRON MICROSCOPY	2.9
8K2A	ELECTRON MICROSCOPY	2.9
8OIT	ELECTRON MICROSCOPY	2.9
9PGL	ELECTRON MICROSCOPY	2.9
9PGF	ELECTRON MICROSCOPY	2.93
6VMI	ELECTRON MICROSCOPY	2.96
6VLZ	ELECTRON MICROSCOPY	2.97
7QI6	ELECTRON MICROSCOPY	2.98

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q96A35-F1	88.92	0.64

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 24

Function

Pathways and Gene Ontology

Reactome pathways

7 pathways

ID	Pathway
R-HSA-5368286	Mitochondrial translation initiation
R-HSA-5389840	Mitochondrial translation elongation
R-HSA-5419276	Mitochondrial translation termination
R-HSA-9937383	Mitochondrial ribosome-associated quality control
R-HSA-392499	Metabolism of proteins
R-HSA-5368287	Mitochondrial translation
R-HSA-72766	Translation

MSigDB gene sets: 163 (showing top): BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_DN, GOBP_MITOCHONDRIAL_TRANSLATION, ACEVEDO_NORMAL_TISSUE_ADJACENT_TO_LIVER_TUMOR_DN, GGAMTNNNNNTCCY_UNKNOWN, AACWWCAANK_UNKNOWN, GOBP_TRANSLATION, CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_1, TGCTGAY_UNKNOWN, GOMF_STRUCTURAL_CONSTITUENT_OF_RIBOSOME, KMCATNNWGGA_UNKNOWN, GOCC_MITOCHONDRIAL_ENVELOPE, GARCIA_TARGETS_OF_FLI1_AND_DAX1_DN, DODD_NASOPHARYNGEAL_CARCINOMA_UP, TANAKA_METHYLATED_IN_ESOPHAGEAL_CARCINOMA, RYTTCCTG_ETS2_B

GO Biological Process (2): translation (GO:0006412), mitochondrial translation (GO:0032543)

GO Molecular Function (2): RNA binding (GO:0003723), structural constituent of ribosome (GO:0003735)

GO Cellular Component (5): mitochondrion (GO:0005739), mitochondrial inner membrane (GO:0005743), mitochondrial large ribosomal subunit (GO:0005762), ribosome (GO:0005840), ribonucleoprotein complex (GO:1990904)

Reactome top-level categories

Rollup of top-3 pathways:

Category	Pathways
Mitochondrial translation	4
Translation	1
Metabolism of proteins	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
peptidyltransferase activity	1
translational initiation	1
translational elongation	1
translational termination	1
macromolecule biosynthetic process	1
protein metabolic process	1
protein biosynthetic process	1
mitochondrion	1
translation	1
mitochondrial gene expression	1
nucleic acid binding	1
structural molecule activity	1
ribosome	1
cytoplasm	1
intracellular membrane-bounded organelle	1
organelle inner membrane	1
mitochondrial membrane	1
organellar large ribosomal subunit	1
mitochondrial ribosome	1
mitochondrial protein-containing complex	1
intracellular membraneless organelle	1
protein-containing complex	1

Protein interactions and networks

STRING

3311 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
MRPL24	MRPL17	Q9NRX2	753
MRPL24	MRPL16	Q9NX20	717
MRPL24	MRPL13	Q9BYD1	705
MRPL24	MRPL11	Q9Y3B7	689
MRPL24	MRPL4	Q9BYD3	645
MRPL24	MRPS14	O60783	644
MRPL24	MRPL36	Q9P0J6	628
MRPL24	MRPL20	Q9BYC9	626
MRPL24	MRPL19	P49406	611
MRPL24	MRPL33	O75394	604
MRPL24	MRPL9	Q9BYD2	604
MRPL24	MRPL21	Q7Z2W9	570
MRPL24	MRPL1	Q9BYD6	564
MRPL24	MRPS9	P82933	559
MRPL24	MRPS18C	Q9Y3D5	558

IntAct

156 interactions, top by confidence:

A	B	Type	Score
MRPL37	HSPD1	psi-mi:“MI:0914”(association)	0.710
CFTR	ESYT2	psi-mi:“MI:2364”(proximity)	0.710
MRPS30	GTPBP10	psi-mi:“MI:0914”(association)	0.640
LIN28A	IGF2BP3	psi-mi:“MI:0914”(association)	0.640
NP	KPNA6	psi-mi:“MI:0914”(association)	0.550
CENPE	CLASP2	psi-mi:“MI:0914”(association)	0.530
MRPL50	GTPBP10	psi-mi:“MI:0914”(association)	0.530
RPL18	NOP56	psi-mi:“MI:0914”(association)	0.530
MRPL10	ZZEF1	psi-mi:“MI:0914”(association)	0.530
MRPL42	GATC	psi-mi:“MI:0914”(association)	0.530
RPL6	MRPS14	psi-mi:“MI:0914”(association)	0.530
MRPL28	MRPL3	psi-mi:“MI:0914”(association)	0.530
MRPL41	MRPL3	psi-mi:“MI:0914”(association)	0.530
MRPL2	GTPBP10	psi-mi:“MI:0914”(association)	0.530
ZC3HAV1	KHNYN	psi-mi:“MI:0914”(association)	0.530
MRPL13	GTPBP10	psi-mi:“MI:0914”(association)	0.530
MRPL18	GTPBP10	psi-mi:“MI:0914”(association)	0.530
ABT1	ZNF316	psi-mi:“MI:0914”(association)	0.530
MRPL27	MRPL33	psi-mi:“MI:0914”(association)	0.530
NDUFAB1	MIEF1	psi-mi:“MI:0915”(physical association)	0.490
Ybx1	MRPS18B	psi-mi:“MI:0915”(physical association)	0.400
Kctd5		psi-mi:“MI:0914”(association)	0.350
Tnks	SDC2	psi-mi:“MI:0914”(association)	0.350

BioGRID (275): MRPL24 (Affinity Capture-RNA), MRPL24 (Affinity Capture-MS), MRPL24 (Affinity Capture-MS), MRPL24 (Affinity Capture-MS), MRPL24 (Affinity Capture-MS), MRPL24 (Affinity Capture-MS), MRPL24 (Affinity Capture-MS), MRPL24 (Affinity Capture-MS), MRPL24 (Affinity Capture-MS), MRPL24 (Affinity Capture-MS), MRPL24 (Affinity Capture-MS), MRPL24 (Affinity Capture-MS), MRPL24 (Co-fractionation), MRPL24 (Co-fractionation), MRPL24 (Co-fractionation)

ESM2 similar proteins: A3BN26, A6QPQ5, A9X1A9, O95707, P02385, P08429, P82915, P82916, Q0VC21, Q13084, Q1RP77, Q29MA5, Q2HJJ1, Q2KIB9, Q2TA12, Q2TBK2, Q3SYS0, Q3T197, Q498T4, Q5E996, Q5E9N5, Q5M882, Q5R7B0, Q5RAT0, Q5T653, Q60649, Q641X9, Q66H47, Q6DH02, Q6GPM4, Q7XTG7, Q8GS60, Q8VDP2, Q96A35, Q99N85, Q99N94, Q9BYD6, Q9CPT5, Q9CPX7, Q9CQ06

Diamond homologs: A0ALV7, A0JZ73, A0PM76, A0QL01, A0QSG0, A0R8J1, A1KGJ6, A1R8T4, A1T4R7, A1UBP9, A3PVD6, A4FPL4, A4TEC6, A5U0A1, A6U870, A7GK31, A8EZK5, A8LC45, A9VP88, A9WSU6, B1HMW9, B1MGD6, B1W3Z6, B1YGW1, B2GDV8, B2GJ04, B2HCT2, B3CT16, B3WAK6, B7HJ59, B7HQV5, B7IT30, B7JKD0, B8DB19, B8HCZ5, B8ZSA8, B9DM36, B9IZK5, C1AL49, C1ET50

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
MRPL24	“form complex”	“39S mitochondrial large ribosomal subunit”	binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 155 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Mitochondrial ribosome-associated quality control	35	38.4×	2e-45
Mitochondrial translation	30	36.9×	2e-38
Mitochondrial translation initiation	32	36.2×	9e-41
Mitochondrial translation elongation	32	36.2×	9e-41
Mitochondrial translation termination	32	31.4×	2e-38
Translation	34	18.8×	6e-33
Peptide chain elongation	13	14.7×	1e-10
Viral mRNA Translation	13	14.7×	1e-10

GO biological processes:

GO term	Partners	Fold	FDR
mitochondrial translation	34	43.1×	9e-45
translation	31	23.2×	2e-31
cytoplasmic translation	13	17.6×	1e-10
regulation of alternative mRNA splicing, via spliceosome	7	12.5×	2e-04
ribosomal small subunit biogenesis	7	11.6×	3e-04
negative regulation of translation	8	11.4×	9e-05
mRNA processing	9	5.2×	6e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

47 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	34
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1295 predictions. Top by Δscore:

Variant	Effect	Δscore
1:156737535:C:CC	acceptor_gain	1.0000
1:156737707:C:CA	donor_gain	1.0000
1:156738130:TAATG:T	acceptor_gain	1.0000
1:156738132:ATG:A	acceptor_gain	1.0000
1:156738132:ATGC:A	acceptor_loss	1.0000
1:156738133:TG:T	acceptor_gain	1.0000
1:156738134:GC:G	acceptor_loss	1.0000
1:156738135:C:CC	acceptor_gain	1.0000
1:156738135:C:T	acceptor_loss	1.0000
1:156738141:A:T	acceptor_gain	1.0000
1:156738340:TACT:T	donor_loss	1.0000
1:156738341:A:AC	donor_gain	1.0000
1:156738341:A:C	donor_loss	1.0000
1:156738342:C:CA	donor_gain	1.0000
1:156738342:CT:C	donor_gain	1.0000
1:156738342:CTG:C	donor_gain	1.0000
1:156738342:CTGT:C	donor_gain	1.0000
1:156738389:TGA:T	donor_gain	1.0000
1:156738434:TCCAC:T	acceptor_gain	1.0000
1:156738435:CCAC:C	acceptor_gain	1.0000
1:156738435:CCACC:C	acceptor_gain	1.0000
1:156738436:CAC:C	acceptor_gain	1.0000
1:156738436:CACC:C	acceptor_gain	1.0000
1:156738437:AC:A	acceptor_gain	1.0000
1:156738437:ACC:A	acceptor_loss	1.0000
1:156738438:CC:C	acceptor_gain	1.0000
1:156738439:C:CC	acceptor_gain	1.0000
1:156738439:CTGT:C	acceptor_loss	1.0000
1:156737530:GCCAT:G	acceptor_gain	0.9900
1:156737531:CCAT:C	acceptor_gain	0.9900

AlphaMissense

1388 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:156738055:A:T	V120D	0.972
1:156738526:T:G	D60A	0.966
1:156738527:C:G	D60H	0.961
1:156737720:G:A	S147F	0.959
1:156738526:T:A	D60V	0.957
1:156737521:G:C	D176E	0.952
1:156737521:G:T	D176E	0.952
1:156737523:C:G	D176H	0.952
1:156737721:A:G	S147P	0.952
1:156737720:G:T	S147Y	0.951
1:156737723:A:T	V146D	0.947
1:156738437:A:T	V62E	0.947
1:156738365:A:T	V86E	0.945
1:156738526:T:C	D60G	0.943
1:156737727:G:C	R145G	0.941
1:156737749:A:C	F137L	0.941
1:156737749:A:T	F137L	0.941
1:156737751:A:G	F137L	0.941
1:156737757:A:G	W135R	0.941
1:156737757:A:T	W135R	0.941
1:156738395:A:T	V76E	0.939
1:156737522:T:G	D176A	0.932
1:156738127:C:G	R96P	0.931
1:156738525:G:C	D60E	0.931
1:156738525:G:T	D60E	0.931
1:156738070:A:G	L115S	0.930
1:156738043:T:C	D124G	0.929
1:156738374:C:G	R83P	0.923
1:156737505:C:G	A182P	0.917
1:156737726:C:G	R145P	0.912

dbSNP variants (sampled 300 via entrez): RS1000389800 (1:156740947 G>A), RS1000464108 (1:156741091 G>A,C), RS1000659619 (1:156737792 GGT>G), RS1000713410 (1:156744009 C>T), RS1001011810 (1:156738048 A>C), RS1001253811 (1:156741351 G>C), RS1001594924 (1:156739402 T>C), RS1002256206 (1:156740411 G>A), RS1002666524 (1:156740542 A>G,T), RS1003295500 (1:156744611 G>A,T), RS1004074828 (1:156741525 G>A), RS1004673046 (1:156743083 G>A), RS1004694108 (1:156737969 T>A,C,G), RS1005001875 (1:156743398 A>T), RS1005301136 (1:156740612 G>A)

Disease associations

OMIM: gene MIM:611836 | disease phenotypes:

GenCC curated gene-disease

ClinGen Gene-Disease Validity (1)

Expert-panel classifications — Definitive > Strong > Moderate > Limited > Disputed > Refuted.

Disease	Classification	Inheritance
mitochondrial disease	Limited	AR

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST010002_368	Refractive error	7.000000e-38

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

34 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
sodium arsenite	affects cotreatment, decreases expression, increases abundance	3
Acetaminophen	decreases expression, affects expression, affects cotreatment	3
Tretinoin	affects cotreatment, decreases expression	3
bisphenol A	decreases expression	2
Arsenic	decreases expression, increases abundance	2
Valproic Acid	affects expression, increases expression	2
aristolochic acid I	decreases expression	1
TAK-243	increases sumoylation	1
arsenite	affects binding, increases reaction	1
gossypol acetic acid	decreases expression	1
beta-methylcholine	affects expression	1
di-n-butylphosphoric acid	affects expression	1
perfluorooctane sulfonic acid	increases expression	1
corosolic acid	decreases expression	1
K 7174	decreases expression	1
erucylphospho-N,N,N-trimethylpropylammonium	decreases expression	1
bisphenol S	affects expression	1
jinfukang	increases expression	1
(+)-JQ1 compound	decreases expression	1
Arsenic Trioxide	increases expression	1
Benzo(a)pyrene	increases methylation	1
Cisplatin	decreases expression	1
Enzyme Inhibitors	decreases activity, increases O-linked glycosylation	1
Ethyl Methanesulfonate	decreases expression	1
Lipopolysaccharides	affects cotreatment, decreases expression	1
Methyl Methanesulfonate	decreases expression	1
Ribonucleotides	affects binding	1
Thiram	decreases expression	1
Tobacco Smoke Pollution	decreases methylation	1
Urethane	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.