MRPL35

Summary

MRPL35 (mitochondrial ribosomal protein L35, HGNC:14489) is a protein-coding gene on chromosome 2p11.2, encoding Large ribosomal subunit protein bL35m (Q9NZE8). It is a selective cancer dependency (DepMap: 71.3% of cell lines).

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Sequence analysis identified three transcript variants. Pseudogenes corresponding to this gene are found on chromosomes 6p, 10q, and Xp.

Source: NCBI Gene 51318 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• Clinical variants (ClinVar): 43 total — 1 pathogenic
• Cancer dependency (DepMap): dependent in 71.3% of screened cell lines
• MANE Select transcript: NM_016622

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:14489
Approved symbol	MRPL35
Name	mitochondrial ribosomal protein L35
Location	2p11.2
Locus type	gene with protein product
Status	Approved
Aliases	bL35m
Ensembl gene	ENSG00000132313
Ensembl biotype	protein_coding
OMIM	611841
Entrez	51318

Gene structure

Transcript identifiers

Ensembl transcripts: 4 — 4 protein_coding

ENST00000254644, ENST00000337109, ENST00000409180, ENST00000605125

RefSeq mRNA: 3 — MANE Select: NM_016622 NM_001363782, NM_016622, NM_145644

CCDS: CCDS1987, CCDS1988, CCDS86858

Canonical transcript exons

ENST00000337109 — 4 exons

Exon	Start	End
ENSE00000902566	86206106	86206295
ENSE00000902567	86207183	86207327
ENSE00001186033	86199457	86199533
ENSE00001390621	86210480	86213790

Expression profiles

Bgee: expression breadth ubiquitous, 283 present calls, max score 95.97.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 37.8312 / max 443.1959, expressed in 1813 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
21291	37.8312	1813

Top tissues by expression

293 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
rectum	UBERON:0001052	95.97	gold quality
heart left ventricle	UBERON:0002084	94.42	gold quality
mucosa of transverse colon	UBERON:0004991	94.40	gold quality
left ventricle myocardium	UBERON:0006566	94.36	gold quality
cardiac ventricle	UBERON:0002082	94.35	gold quality
heart right ventricle	UBERON:0002080	93.73	gold quality
apex of heart	UBERON:0002098	92.99	gold quality
islet of Langerhans	UBERON:0000006	92.97	gold quality
heart	UBERON:0000948	92.94	gold quality
hindlimb stylopod muscle	UBERON:0004252	92.53	gold quality
right atrium auricular region	UBERON:0006631	92.52	gold quality
cardiac atrium	UBERON:0002081	92.29	gold quality
muscle of leg	UBERON:0001383	91.95	gold quality
adrenal tissue	UBERON:0018303	91.84	gold quality
myocardium	UBERON:0002349	91.72	gold quality
gastrocnemius	UBERON:0001388	91.68	gold quality
biceps brachii	UBERON:0001507	91.47	gold quality
transverse colon	UBERON:0001157	91.39	gold quality
duodenum	UBERON:0002114	91.24	gold quality
mucosa of sigmoid colon	UBERON:0004993	91.21	gold quality
diaphragm	UBERON:0001103	91.18	gold quality
colonic mucosa	UBERON:0000317	91.06	gold quality
muscle organ	UBERON:0001630	90.93	gold quality
primordial germ cell in gonad	CL:0000670 ∩ UBERON:0000991	90.65	gold quality
right adrenal gland	UBERON:0001233	90.44	gold quality
large intestine	UBERON:0000059	90.23	gold quality
colon	UBERON:0001155	90.19	gold quality
left adrenal gland	UBERON:0001234	90.09	gold quality
right adrenal gland cortex	UBERON:0035827	90.08	gold quality
intestine	UBERON:0000160	89.88	gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 2.

Experiment	Marker?	Max mean expression
E-GEOD-100618	yes	223.69
E-MTAB-6386	no	94.51
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

116 targeting MRPL35, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-3163	100.00	77.23	8605
HSA-MIR-4481	100.00	66.42	1669
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-548AW	99.99	72.57	3559
HSA-MIR-520G-5P	99.99	66.76	658
HSA-MIR-4745-5P	99.98	65.95	1028
HSA-MIR-507	99.97	70.11	1915
HSA-MIR-557	99.96	70.01	1640
HSA-MIR-1468-3P	99.96	72.74	3797
HSA-MIR-548AT-5P	99.96	70.83	2666
HSA-MIR-3658	99.96	73.87	4379
HSA-MIR-767-5P	99.95	70.85	993
HSA-MIR-9983-3P	99.94	71.48	3631
HSA-MIR-144-3P	99.94	73.98	2698
HSA-MIR-335-3P	99.93	73.36	4958
HSA-MIR-450B-5P	99.92	71.48	3175
HSA-MIR-6508-5P	99.92	70.67	2465
HSA-MIR-1297	99.91	73.41	3162
HSA-MIR-10523-5P	99.91	69.22	2038
HSA-MIR-627-3P	99.90	71.42	3316
HSA-MIR-95-5P	99.89	72.17	3973
HSA-MIR-129-5P	99.88	70.26	3273
HSA-MIR-5582-3P	99.86	72.48	4221
HSA-MIR-8067	99.86	69.59	2260
HSA-MIR-629-3P	99.85	67.99	1875
HSA-MIR-5003-3P	99.85	69.29	2517
HSA-MIR-4799-5P	99.82	70.60	2663
HSA-MIR-548AJ-5P	99.78	71.12	3085
HSA-MIR-548F-5P	99.78	71.02	3093
HSA-MIR-548G-5P	99.78	71.12	3085

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 71.3% of screened cell lines.

Literature-anchored findings (GeneRIF, showing 3)

• High MRPL35 expression Cooperate in Colorectal Cancer. (PMID:30862482)
• Knockdown of MRPL35 promotes cell apoptosis and inhibits cell proliferation in non-small-cell lung cancer. (PMID:38093266)
• MRPL35 Induces Proliferation, Invasion, and Glutamine Metabolism in NSCLC Cells by Upregulating SLC7A5 Expression. (PMID:38987867)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	mrpl35	ENSDARG00000070589
mus_musculus	Mrpl35	ENSMUSG00000052962
rattus_norvegicus	Mrpl35	ENSRNOG00000008546
drosophila_melanogaster	mRpL35	FBGN0038923
caenorhabditis_elegans		WBGENE00010812

Protein

Protein identifiers

Large ribosomal subunit protein bL35m — Q9NZE8 (reviewed: Q9NZE8)

Alternative names: 39S ribosomal protein L35, mitochondrial

All UniProt accessions (3): Q9NZE8, D3YTC1, S4R348

UniProt curated annotations — full annotation on UniProt →

Subunit / interactions. Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.

Subcellular location. Mitochondrion.

Similarity. Belongs to the bacterial ribosomal protein bL35 family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q9NZE8-1	1	yes
Q9NZE8-2	2

RefSeq proteins (3): NP_001350711, NP_057706, NP_663619 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR019338	Ribosomal_bL35m	Family
IPR021137	Ribosomal_bL35-like	Family
IPR037229	Ribosomal_bL35_sf	Homologous_superfamily

Pfam: PF01632

UniProt features (23 total): helix 6, sequence variant 6, strand 4, turn 4, transit peptide 1, chain 1, splice variant 1

Structure

Experimental structures (PDB)

85 structures, top 30 by resolution.

PDB	Method	Resolution (Å)
7OF0	ELECTRON MICROSCOPY	2.2
7QI4	ELECTRON MICROSCOPY	2.21
8RRI	ELECTRON MICROSCOPY	2.4
8QU5	ELECTRON MICROSCOPY	2.42
9OLF	ELECTRON MICROSCOPY	2.46
7OF7	ELECTRON MICROSCOPY	2.5
7PO4	ELECTRON MICROSCOPY	2.56
6ZM6	ELECTRON MICROSCOPY	2.59
7O9M	ELECTRON MICROSCOPY	2.6
7OF6	ELECTRON MICROSCOPY	2.6
9CN3	ELECTRON MICROSCOPY	2.62
7QI5	ELECTRON MICROSCOPY	2.63
7OF2	ELECTRON MICROSCOPY	2.7
7OF3	ELECTRON MICROSCOPY	2.7
7OF4	ELECTRON MICROSCOPY	2.7
8QU1	ELECTRON MICROSCOPY	2.74
9PR4	ELECTRON MICROSCOPY	2.77
9PRA	ELECTRON MICROSCOPY	2.83
8ANY	ELECTRON MICROSCOPY	2.85
6ZM5	ELECTRON MICROSCOPY	2.89
7QH7	ELECTRON MICROSCOPY	2.89
7ODR	ELECTRON MICROSCOPY	2.9
7OF5	ELECTRON MICROSCOPY	2.9
8K2A	ELECTRON MICROSCOPY	2.9
8OIT	ELECTRON MICROSCOPY	2.9
9PGL	ELECTRON MICROSCOPY	2.9
9PGF	ELECTRON MICROSCOPY	2.93
6VMI	ELECTRON MICROSCOPY	2.96
6VLZ	ELECTRON MICROSCOPY	2.97
7QI6	ELECTRON MICROSCOPY	2.98

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9NZE8-F1	76.58	0.54

Function

Pathways and Gene Ontology

Reactome pathways

7 pathways

ID	Pathway
R-HSA-5368286	Mitochondrial translation initiation
R-HSA-5389840	Mitochondrial translation elongation
R-HSA-5419276	Mitochondrial translation termination
R-HSA-9937383	Mitochondrial ribosome-associated quality control
R-HSA-392499	Metabolism of proteins
R-HSA-5368287	Mitochondrial translation
R-HSA-72766	Translation

MSigDB gene sets: 193 (showing top): GNF2_CKS1B, GOBP_MITOCHONDRIAL_TRANSLATION, GNF2_RRM1, GOBP_TRANSLATION, WEI_MYCN_TARGETS_WITH_E_BOX, RUTELLA_RESPONSE_TO_CSF2RB_AND_IL4_UP, GNF2_SMC4L1, GOMF_STRUCTURAL_CONSTITUENT_OF_RIBOSOME, BYSTRYKH_HEMATOPOIESIS_STEM_CELL_AND_BRAIN_QTL_CIS, GNF2_RFC3, GOCC_MITOCHONDRIAL_ENVELOPE, AAAGGGA_MIR204_MIR211, YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_13, GARY_CD5_TARGETS_DN, ZHOU_INFLAMMATORY_RESPONSE_LIVE_DN

GO Biological Process (2): translation (GO:0006412), mitochondrial translation (GO:0032543)

GO Molecular Function (2): structural constituent of ribosome (GO:0003735), protein binding (GO:0005515)

GO Cellular Component (6): mitochondrion (GO:0005739), mitochondrial inner membrane (GO:0005743), mitochondrial ribosome (GO:0005761), mitochondrial large ribosomal subunit (GO:0005762), ribosome (GO:0005840), ribonucleoprotein complex (GO:1990904)

Reactome top-level categories

Rollup of top-3 pathways:

Category	Pathways
Mitochondrial translation	4
Translation	1
Metabolism of proteins	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
peptidyltransferase activity	1
translational initiation	1
translational elongation	1
translational termination	1
macromolecule biosynthetic process	1
protein metabolic process	1
protein biosynthetic process	1
mitochondrion	1
translation	1
mitochondrial gene expression	1
structural molecule activity	1
ribosome	1
binding	1
cytoplasm	1
intracellular membrane-bounded organelle	1
organelle inner membrane	1
mitochondrial membrane	1
organellar ribosome	1
mitochondrial matrix	1
organellar large ribosomal subunit	1
mitochondrial ribosome	1
mitochondrial protein-containing complex	1
intracellular membraneless organelle	1
protein-containing complex	1

Protein interactions and networks

STRING

1430 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
MRPL35	MRPS11	P82912	524
MRPL35	MRPL39	Q9NYK5	467
MRPL35	MTRF1	O75570	467
MRPL35	SMPDL3B	Q92485	443
MRPL35	PPIF	P30405	441
MRPL35	MGAT4A	Q9UM21	438
MRPL35	HCCS	P53701	436
MRPL35	MTMR7	Q9Y216	421
MRPL35	LIMD2	Q9BT23	418
MRPL35	FAH	P16930	414
MRPL35	MRPS23	Q9Y3D9	408
MRPL35	SERTAD4	Q9NUC0	408
MRPL35	CCNL1	Q9UK58	396
MRPL35	PTGR3	Q8N4Q0	395
MRPL35	KRCC1	Q9NPI7	394

IntAct

94 interactions, top by confidence:

A	B	Type	Score
H2AX	PPM1G	psi-mi:“MI:0914”(association)	0.730
MRPS30	GTPBP10	psi-mi:“MI:0914”(association)	0.640
NSA2	GNL2	psi-mi:“MI:0914”(association)	0.640
MRPL50	GTPBP10	psi-mi:“MI:0914”(association)	0.530
MRPL42	GATC	psi-mi:“MI:0914”(association)	0.530
MRPL13	GTPBP10	psi-mi:“MI:0914”(association)	0.530
MRPL18	GTPBP10	psi-mi:“MI:0914”(association)	0.530
MRPL2	GTPBP10	psi-mi:“MI:0914”(association)	0.530
MRPL16	MRPL2	psi-mi:“MI:0914”(association)	0.530
ABT1	ZNF316	psi-mi:“MI:0914”(association)	0.530
MRPL27	MRPL33	psi-mi:“MI:0914”(association)	0.530
NDUFAB1	MIEF1	psi-mi:“MI:0915”(physical association)	0.490
Kif4	UMPS	psi-mi:“MI:0914”(association)	0.350
RACGAP1	STX18	psi-mi:“MI:0914”(association)	0.350
MRPL50	MRPL43	psi-mi:“MI:0914”(association)	0.350
MRPL9	MRPL43	psi-mi:“MI:0914”(association)	0.350
MRPL1	MRPL43	psi-mi:“MI:0914”(association)	0.350
HSCB	RBP5	psi-mi:“MI:0914”(association)	0.350
		psi-mi:“MI:0914”(association)	0.350
MRPL35	IPO5	psi-mi:“MI:0914”(association)	0.350
LUC7L	CASC3	psi-mi:“MI:0914”(association)	0.350
TFAM	MRPS14	psi-mi:“MI:0914”(association)	0.350
SSBP1	MRPS14	psi-mi:“MI:0914”(association)	0.350
ATAD3A	TMEM223	psi-mi:“MI:0914”(association)	0.350
rl36a_rl36l_human	IPO5	psi-mi:“MI:0914”(association)	0.350
PIPSL	C1orf226	psi-mi:“MI:0914”(association)	0.350

BioGRID (144): MRPL35 (Affinity Capture-MS), MRPL35 (Affinity Capture-MS), MRPL35 (Affinity Capture-MS), MRPL35 (Affinity Capture-MS), MRPL35 (Reconstituted Complex), MRPL35 (Affinity Capture-MS), MRPL35 (Affinity Capture-MS), MRPL35 (Affinity Capture-MS), MRPL35 (Affinity Capture-MS), MRPL35 (Affinity Capture-MS), MRPL35 (Affinity Capture-MS), MRPL47 (Affinity Capture-MS), MRPS30 (Affinity Capture-MS), MRPL35 (Affinity Capture-MS), MRPL4 (Affinity Capture-MS)

ESM2 similar proteins: A0A0R0IHP4, A2Y5T7, A2YLX7, A3BKF2, F4I933, F4K6X0, O22795, O64654, P16180, P17092, P23326, P30956, P31164, P41348, P41349, P42732, P51412, P82130, P82162, P82163, P82191, P82245, P82248, P82413, Q0JG75, Q1K4P1, Q3SZA9, Q5KQI6, Q5R9N0, Q6K471, Q84JH7, Q8RXX5, Q8VY88, Q8VZ55, Q8W463, Q940U6, Q94A65, Q9ASV6, Q9CQL6, Q9FFU1

Diamond homologs: Q21454, Q3SZA9, Q5R9N0, Q61JI9, Q8MS27, Q9CQL6, Q9NZE8

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
MRPL35	“form complex”	“39S mitochondrial large ribosomal subunit”	binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 88 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Mitochondrial ribosome-associated quality control	30	61.4×	2e-46
Mitochondrial translation	26	59.6×	9e-40
Mitochondrial translation initiation	27	57.1×	1e-40
Mitochondrial translation elongation	27	57.1×	1e-40
Mitochondrial translation termination	27	49.4×	6e-39
Translation	27	27.9×	1e-31
Peptide chain elongation	5	10.6×	2e-03
Viral mRNA Translation	5	10.6×	2e-03

GO biological processes:

GO term	Partners	Fold	FDR
mitochondrial translation	28	60.8×	1e-41
translation	20	25.7×	4e-21
cytoplasmic translation	5	11.6×	3e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

43 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	1
Likely pathogenic	0
Uncertain significance	29
Likely benign	2
Benign	0

Top pathogenic / likely-pathogenic (1)

Variant ID	HGVS	Classification
2426780	NC_000002.11:g.(?85766411)(86564633_?)del	Pathogenic

SpliceAI

458 predictions. Top by Δscore:

Variant	Effect	Δscore
2:86206100:TTACA:T	acceptor_loss	1.0000
2:86206101:TACAG:T	acceptor_loss	1.0000
2:86206103:CAGG:C	acceptor_loss	1.0000
2:86206104:A:AG	acceptor_gain	1.0000
2:86206104:A:G	acceptor_loss	1.0000
2:86206105:G:GG	acceptor_gain	1.0000
2:86207181:A:AG	acceptor_gain	1.0000
2:86207181:AGAAT:A	acceptor_gain	1.0000
2:86207182:G:GG	acceptor_gain	1.0000
2:86207182:GA:G	acceptor_gain	1.0000
2:86207182:GAAT:G	acceptor_gain	1.0000
2:86207182:GAATG:G	acceptor_gain	1.0000
2:86210468:A:AG	acceptor_gain	1.0000
2:86210478:A:AG	acceptor_gain	1.0000
2:86210479:G:GG	acceptor_gain	1.0000
2:86210479:GGCT:G	acceptor_gain	1.0000
2:86199515:GC:G	donor_gain	0.9900
2:86199532:AGGTC:A	donor_loss	0.9900
2:86199533:GGTC:G	donor_loss	0.9900
2:86199534:GTC:G	donor_loss	0.9900
2:86199535:T:G	donor_loss	0.9900
2:86206104:AG:A	acceptor_gain	0.9900
2:86206105:GG:G	acceptor_gain	0.9900
2:86206105:GGA:G	acceptor_gain	0.9900
2:86206193:G:GT	donor_gain	0.9900
2:86206267:T:G	donor_gain	0.9900
2:86207177:TTTTA:T	acceptor_loss	0.9900
2:86207178:TTTA:T	acceptor_loss	0.9900
2:86207179:TTA:T	acceptor_loss	0.9900
2:86207181:A:C	acceptor_loss	0.9900

AlphaMissense

1202 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
2:86207289:T:C	F114L	0.992
2:86207291:T:A	F114L	0.992
2:86207291:T:G	F114L	0.992
2:86207313:T:A	W122R	0.987
2:86207313:T:C	W122R	0.987
2:86210551:C:G	C150W	0.979
2:86210574:T:C	L158S	0.978
2:86207315:G:C	W122C	0.977
2:86207315:G:T	W122C	0.977
2:86207290:T:C	F114S	0.976
2:86210594:T:C	F165L	0.975
2:86210596:C:A	F165L	0.975
2:86210596:C:G	F165L	0.975
2:86210584:G:A	M161I	0.974
2:86210584:G:C	M161I	0.974
2:86210584:G:T	M161I	0.974
2:86210597:T:A	W166R	0.974
2:86210597:T:C	W166R	0.974
2:86210550:G:A	C150Y	0.972
2:86210564:A:C	S155R	0.965
2:86210566:T:A	S155R	0.965
2:86210566:T:G	S155R	0.965
2:86207287:G:T	R113M	0.963
2:86207288:G:C	R113S	0.963
2:86207288:G:T	R113S	0.963
2:86210571:T:C	L157P	0.961
2:86207321:G:C	R124S	0.960
2:86207321:G:T	R124S	0.960
2:86210501:T:A	W134R	0.960
2:86210501:T:C	W134R	0.960

dbSNP variants (sampled 300 via entrez): RS1000006173 (2:86212059 T>C), RS1000034783 (2:86204088 G>A), RS1000370968 (2:86213580 C>T), RS1000631067 (2:86198223 C>A), RS1000639324 (2:86199771 C>G), RS1000710675 (2:86208384 G>GT), RS1000743118 (2:86208168 A>G), RS1000923042 (2:86201365 A>G), RS1001028818 (2:86208867 A>G), RS1001543472 (2:86209224 T>C), RS1001583271 (2:86209852 T>C,G), RS1001586422 (2:86203683 A>T), RS1001702257 (2:86204026 C>T), RS1001927887 (2:86210079 T>G), RS1002132325 (2:86197825 C>A,G,T)

Disease associations

OMIM: gene MIM:611841 | disease phenotypes: MIM:610250

GenCC curated gene-disease

Mondo (1): hereditary spastic paraplegia 31 (MONDO:0012453)

Orphanet (1): Autosomal dominant spastic paraplegia type 31 (Orphanet:101011)

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST003542_125	Night sleep phenotypes	5.000000e-06
GCST004730_1	Facial emotion recognition (sad faces)	2.000000e-06
GCST007267_289	Systolic blood pressure	7.000000e-11

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0008329	facial emotion recognition measurement
EFO:0006335	systolic blood pressure

MeSH disease descriptors (1)

Descriptor	Name	Tree numbers
C565210	Spastic Paraplegia 31, Autosomal Dominant (supp.)

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

33 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Acetaminophen	decreases expression	2
Cyclosporine	decreases expression	2
dicrotophos	decreases expression	1
triphenyl phosphate	affects expression	1
bisphenol A	decreases expression	1
arsenite	affects binding, increases reaction	1
sodium arsenite	increases expression, increases abundance	1
cobaltous chloride	decreases expression	1
nickel sulfate	decreases expression	1
isobutyl alcohol	affects cotreatment, decreases expression, increases abundance	1
beta-methylcholine	affects expression	1
di-n-butylphosphoric acid	affects expression	1
K 7174	decreases expression	1
ICG 001	increases expression	1
Sunitinib	decreases expression	1
Arsenic	increases expression, increases abundance	1
Atrazine	decreases expression	1
Dichlorodiphenyl Dichloroethylene	increases expression	1
Diethylhexyl Phthalate	increases expression	1
Dinitrochlorobenzene	decreases expression	1
Ethyl Methanesulfonate	decreases expression	1
Eugenol	decreases expression	1
Formaldehyde	decreases expression	1
Gasoline	affects cotreatment, decreases expression, increases abundance	1
Methyl Methanesulfonate	decreases expression	1
Oxazolone	decreases expression	1
Polycyclic Aromatic Hydrocarbons	affects cotreatment, decreases expression, increases abundance	1
Thiram	decreases expression	1
Valproic Acid	affects expression	1
Vitamin E	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.