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MRPL37

gene
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Also known as RPML2MRP-L2mL37

Summary

MRPL37 (mitochondrial ribosomal protein L37, HGNC:14034) is a protein-coding gene on chromosome 1p32.3, encoding Large ribosomal subunit protein mL37 (Q9BZE1). It is a selective cancer dependency (DepMap: 28.1% of cell lines).

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein.

Source: NCBI Gene 51253 — RefSeq curated summary.

At a glance

  • GWAS associations: 3
  • Clinical variants (ClinVar): 67 total
  • Druggable target: yes
  • Cancer dependency (DepMap): dependent in 28.1% of screened cell lines
  • MANE Select transcript: NM_016491

Identifiers

Gene identifiers

FieldValue
HGNC IDHGNC:14034
Approved symbolMRPL37
Namemitochondrial ribosomal protein L37
Location1p32.3
Locus typegene with protein product
StatusApproved
AliasesRPML2, MRP-L2, mL37
Ensembl geneENSG00000116221
Ensembl biotypeprotein_coding
OMIM611843
Entrez51253

Gene structure

Transcript identifiers

Ensembl transcripts: 11 — 9 protein_coding, 2 protein_coding_CDS_not_defined

ENST00000336230, ENST00000360840, ENST00000398219, ENST00000487096, ENST00000490670, ENST00000605337, ENST00000896015, ENST00000896016, ENST00000931406, ENST00000931407, ENST00000931408

RefSeq mRNA: 2 — MANE Select: NM_016491 NM_001330602, NM_016491

CCDS: CCDS589, CCDS81331

Canonical transcript exons

ENST00000360840 — 7 exons

ExonStartEnd
ENSE000011401185421614154216344
ENSE000011897165421250154212658
ENSE000014224435420016754200589
ENSE000017966595421817254218383
ENSE000035234955420994654210131
ENSE000035481935420529554205410
ENSE000035734645420501854205201

Expression profiles

Bgee: expression breadth ubiquitous, 252 present calls, max score 97.08.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 105.0933 / max 539.6619, expressed in 1827 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter IDTPM avgSamples expressed
2939103.25291827
29400.9957443
29420.8446546

Top tissues by expression

256 total, by Bgee expression score (0-100, higher = more expressed):

TissueAnatomy IDExpression scoreQuality
gastrocnemiusUBERON:000138897.08gold quality
hindlimb stylopod muscleUBERON:000425296.99gold quality
muscle of legUBERON:000138396.74gold quality
right adrenal glandUBERON:000123396.41gold quality
upper arm skinUBERON:000426396.38gold quality
right adrenal gland cortexUBERON:003582796.20gold quality
tibialis anteriorUBERON:000138596.18gold quality
heart left ventricleUBERON:000208495.94gold quality
right lobe of liverUBERON:000111495.92gold quality
left adrenal glandUBERON:000123495.92gold quality
apex of heartUBERON:000209895.77gold quality
cardiac ventricleUBERON:000208295.75gold quality
quadriceps femorisUBERON:000137795.73gold quality
left adrenal gland cortexUBERON:003582595.67gold quality
skeletal muscle tissueUBERON:000113495.65gold quality
mucosa of transverse colonUBERON:000499195.58gold quality
vastus lateralisUBERON:000137995.43gold quality
adrenal glandUBERON:000236995.12gold quality
primordial germ cell in gonadCL:0000670 ∩ UBERON:000099195.11gold quality
rectumUBERON:000105295.11gold quality
biceps brachiiUBERON:000150795.07gold quality
adrenal cortexUBERON:000123594.99gold quality
body of pancreasUBERON:000115094.95gold quality
deltoidUBERON:000147694.91gold quality
muscle tissueUBERON:000238594.78gold quality
skeletal muscle tissue of rectus abdominisUBERON:000451194.73gold quality
heartUBERON:000094894.63gold quality
esophagus mucosaUBERON:000246994.60gold quality
skeletal muscle tissue of biceps brachiiUBERON:000450294.56gold quality
right atrium auricular regionUBERON:000663194.39gold quality

Single-cell (SCXA)

Detected in 3 experiment(s), a significant marker in 2.

ExperimentMarker?Max mean expression
E-CURD-122yes17.85
E-MTAB-6524no201.91
E-ANND-3no0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

10 targeting MRPL37, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNAMax scoreAvg scoremiRNA target_count
HSA-MIR-607799.9968.042299
HSA-MIR-148A-3P99.7473.771700
HSA-MIR-148B-3P99.7473.751700
HSA-MIR-152-3P99.7473.751703
HSA-MIR-570198.9769.541502
HSA-MIR-5088-5P97.9764.28487
HSA-MIR-197297.6767.381172
HSA-MIR-519496.7763.911021
HSA-MIR-6738-5P96.3363.61815
HSA-MIR-1914-3P95.0763.37762

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 28.1% of screened cell lines.

Literature-anchored findings (GeneRIF, showing 2)

  • MRPL37 gene is widely represented in the lymphoma populations of Raji B cells and MT4 T cells, as well as in pancreas, liver, and lung embryonic fibroblasts, which may imply the MRPL37 involvement in the process of apoptosis. (PMID:15562971)
  • male VTE patients with MRPL37 polymorphism had a significantly higher risk of VTE recurrence (PMID:29671165)

Cross-species orthologs

5 orthologs

OrganismSymbolGene ID
danio_reriomrpl37ENSDARG00000062916
mus_musculusMrpl37ENSMUSG00000028622
rattus_norvegicusMrpl37ENSRNOG00000009078
drosophila_melanogastermRpL37FBGN0261380
caenorhabditis_elegansWBGENE00013004

Protein

Protein identifiers

Large ribosomal subunit protein mL37 — Q9BZE1 (reviewed: Q9BZE1)

Alternative names: 39S ribosomal protein L2, mitochondrial, 39S ribosomal protein L37, mitochondrial

All UniProt accessions (4): Q9BZE1, A6NHR2, H0Y4J2, S4R369

UniProt curated annotations — full annotation on UniProt →

Subunit / interactions. Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins. mL37 forms a heterodimer with mL65.

Subcellular location. Mitochondrion.

Similarity. Belongs to the mitochondrion-specific ribosomal protein mL37 family.

RefSeq proteins (2): NP_001317531, NP_057575* (*=MANE)

Domains & families (InterPro)

IDNameType
IPR010793Ribosomal_mL37/mL65Family
IPR052482mtLSU_mL37Family

Pfam: PF07147

UniProt features (44 total): strand 21, helix 13, turn 6, sequence variant 2, transit peptide 1, chain 1

Structure

Experimental structures (PDB)

86 structures, top 30 by resolution.

PDBMethodResolution (Å)
7OF0ELECTRON MICROSCOPY2.2
7QI4ELECTRON MICROSCOPY2.21
8RRIELECTRON MICROSCOPY2.4
8QU5ELECTRON MICROSCOPY2.42
9OLFELECTRON MICROSCOPY2.46
7OF7ELECTRON MICROSCOPY2.5
7PO4ELECTRON MICROSCOPY2.56
6ZM6ELECTRON MICROSCOPY2.59
7O9MELECTRON MICROSCOPY2.6
7OF6ELECTRON MICROSCOPY2.6
9CN3ELECTRON MICROSCOPY2.62
7QI5ELECTRON MICROSCOPY2.63
7OF2ELECTRON MICROSCOPY2.7
7OF3ELECTRON MICROSCOPY2.7
7OF4ELECTRON MICROSCOPY2.7
8QU1ELECTRON MICROSCOPY2.74
9PR4ELECTRON MICROSCOPY2.77
9PRAELECTRON MICROSCOPY2.83
8ANYELECTRON MICROSCOPY2.85
6ZM5ELECTRON MICROSCOPY2.89
7QH7ELECTRON MICROSCOPY2.89
7ODRELECTRON MICROSCOPY2.9
7OF5ELECTRON MICROSCOPY2.9
8K2AELECTRON MICROSCOPY2.9
8OITELECTRON MICROSCOPY2.9
9PGLELECTRON MICROSCOPY2.9
9PGFELECTRON MICROSCOPY2.93
6VMIELECTRON MICROSCOPY2.96
6VLZELECTRON MICROSCOPY2.97
7QI6ELECTRON MICROSCOPY2.98

Predicted structure (AlphaFold)

ModelpLDDTFraction very-high
AF-Q9BZE1-F189.930.84

Function

Pathways and Gene Ontology

Reactome pathways

7 pathways

IDPathway
R-HSA-5368286Mitochondrial translation initiation
R-HSA-5389840Mitochondrial translation elongation
R-HSA-5419276Mitochondrial translation termination
R-HSA-9937383Mitochondrial ribosome-associated quality control
R-HSA-392499Metabolism of proteins
R-HSA-5368287Mitochondrial translation
R-HSA-72766Translation

MSigDB gene sets: 121 (showing top): RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_UP, GOBP_MITOCHONDRIAL_TRANSLATION, TGACCTY_ERR1_Q2, GOBP_TRANSLATION, GOMF_STRUCTURAL_CONSTITUENT_OF_RIBOSOME, GOCC_MITOCHONDRIAL_ENVELOPE, TGGAAA_NFAT_Q4_01, GOCC_LARGE_RIBOSOMAL_SUBUNIT, GOCC_RIBOSOME, GOCC_ORGANELLAR_RIBOSOME, GOCC_MITOCHONDRIAL_MATRIX, GOCC_ORGANELLE_INNER_MEMBRANE, GOCC_RIBOSOMAL_SUBUNIT, GOCC_RIBONUCLEOPROTEIN_COMPLEX, GOCC_MITOCHONDRIAL_PROTEIN_CONTAINING_COMPLEX

GO Biological Process (2): translation (GO:0006412), mitochondrial translation (GO:0032543)

GO Molecular Function (2): RNA binding (GO:0003723), structural constituent of ribosome (GO:0003735)

GO Cellular Component (6): mitochondrion (GO:0005739), mitochondrial inner membrane (GO:0005743), mitochondrial ribosome (GO:0005761), mitochondrial large ribosomal subunit (GO:0005762), ribosome (GO:0005840), ribonucleoprotein complex (GO:1990904)

Reactome top-level categories

Rollup of top-3 pathways:

CategoryPathways
Mitochondrial translation4
Translation1
Metabolism of proteins1

GO top-level categories

Rollup of top GO terms by namespace:

CategoryTerms
peptidyltransferase activity1
translational initiation1
translational elongation1
translational termination1
macromolecule biosynthetic process1
protein metabolic process1
protein biosynthetic process1
mitochondrion1
translation1
mitochondrial gene expression1
nucleic acid binding1
structural molecule activity1
ribosome1
cytoplasm1
intracellular membrane-bounded organelle1
organelle inner membrane1
mitochondrial membrane1
organellar ribosome1
mitochondrial matrix1
organellar large ribosomal subunit1
mitochondrial ribosome1
mitochondrial protein-containing complex1
intracellular membraneless organelle1
protein-containing complex1

Protein interactions and networks

STRING

1302 interactions, top by confidence (×1000):

Protein AProtein BPartner UniProtScore
MRPL37MRPL41Q8IXM3666
MRPL37MRPS30Q9NP92634
MRPL37MRPL42Q9Y6G3615
MRPL37MRPS18BQ9Y676597
MRPL37MRPL11Q9Y3B7591
MRPL37MRPS23Q9Y3D9572
MRPL37GADD45GIP1Q8TAE8537
MRPL37MRPS21P82921505
MRPL37DAP3P51398502
MRPL37MRPS10P82664435
MRPL37MRPL40Q9NQ50430
MRPL37RNF144AP50876428
MRPL37RPL37P02403421
MRPL37MRPS7Q9Y2R9419
MRPL37CMPK2Q5EBM0406

IntAct

129 interactions, top by confidence:

ABTypeScore
YBX1HNRNPRpsi-mi:“MI:0914”(association)0.770
MRPL37HSPD1psi-mi:“MI:0914”(association)0.710
HSPD1NUDT19psi-mi:“MI:0914”(association)0.710
MALSU1NDUFAB1psi-mi:“MI:0914”(association)0.710
MRPS30GTPBP10psi-mi:“MI:0914”(association)0.640
NPKPNA6psi-mi:“MI:0914”(association)0.550
RPS6IPO7psi-mi:“MI:0914”(association)0.530
MRPL50GTPBP10psi-mi:“MI:0914”(association)0.530
MRPL38DUSP14psi-mi:“MI:0914”(association)0.530
MRPL28MRPL3psi-mi:“MI:0914”(association)0.530
MRPL2GTPBP10psi-mi:“MI:0914”(association)0.530
MRPL13GTPBP10psi-mi:“MI:0914”(association)0.530
MRPL18GTPBP10psi-mi:“MI:0914”(association)0.530
MRPL23BCKDHApsi-mi:“MI:0914”(association)0.530
MRPL27MRPL33psi-mi:“MI:0914”(association)0.530
NDUFAB1MIEF1psi-mi:“MI:0915”(physical association)0.490
TGOLN2PGRMC1psi-mi:“MI:0914”(association)0.420
SMN1MRPL37psi-mi:“MI:0915”(physical association)0.370
TK1MRPL37psi-mi:“MI:0915”(physical association)0.370
SIRT4VWA8psi-mi:“MI:0914”(association)0.350
Cdc26psi-mi:“MI:0914”(association)0.350
Brwd3WDR91psi-mi:“MI:0914”(association)0.350
Mapre1TPM1psi-mi:“MI:0914”(association)0.350

BioGRID (337): MRPL37 (Affinity Capture-RNA), MRPL37 (Affinity Capture-RNA), MRPL37 (Affinity Capture-RNA), MRPL37 (Affinity Capture-RNA), MRPL37 (Affinity Capture-MS), MRPL37 (Affinity Capture-MS), MRPL37 (Affinity Capture-MS), MRPL37 (Affinity Capture-MS), HSPD1 (Affinity Capture-MS), MRPL45 (Affinity Capture-MS), MRPL46 (Affinity Capture-MS), MRPL9 (Affinity Capture-MS), MRPL11 (Affinity Capture-MS), MRPL40 (Affinity Capture-MS), MRPL3 (Affinity Capture-MS)

ESM2 similar proteins: A2A9C3, A2RRP1, A4FUC0, F1PLN3, O75153, O76024, O88480, P03271, P03272, P03273, P12539, P12540, P48752, P56695, P82649, P82650, P82918, P82924, P83565, Q1T765, Q1XHY1, Q32LL9, Q5EA18, Q5R7X0, Q5SW19, Q5T011, Q5TM62, Q5U2W4, Q5ZI69, Q5ZKP2, Q6AXT0, Q6AXZ5, Q6DIK0, Q6GLY5, Q6NUV0, Q767K8, Q80UJ7, Q8BGW1, Q8QZV7, Q8VE18

Diamond homologs: A4FUC0, Q5ZI69, Q6AXT0, Q921S7, Q9BZE1, Q9D0G0, Q9NP92, P82924

SIGNOR signaling

1 interactions.

AEffectBMechanism
MRPL37“form complex”“39S mitochondrial large ribosomal subunit”binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 110 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

PathwayPartnersFoldFDR
Mitochondrial ribosome-associated quality control3450.9×4e-49
Mitochondrial translation2948.7×3e-41
Mitochondrial translation initiation3148.0×7e-44
Mitochondrial translation elongation3148.0×7e-44
Mitochondrial translation termination3141.5×1e-41
Translation3123.5×2e-33

GO biological processes:

GO termPartnersFoldFDR
mitochondrial translation3155.5×2e-44
translation2021.2×8e-19

Disease & clinical

Clinical variants and AI predictions

ClinVar

67 variants total. Per-class counts are floors (≥ shown; pagination cap):

ClassificationCount (floor)
Pathogenic0
Likely pathogenic0
Uncertain significance51
Likely benign1
Benign0

Top pathogenic / likely-pathogenic (0)

SpliceAI

2043 predictions. Top by Δscore:

VariantEffectΔscore
1:54184266:C:CCacceptor_gain1.0000
1:54204993:A:AGacceptor_gain1.0000
1:54204998:T:Aacceptor_gain1.0000
1:54205000:T:TAacceptor_gain1.0000
1:54205001:G:Aacceptor_gain1.0000
1:54209943:TAGA:Tacceptor_loss1.0000
1:54209944:A:AGacceptor_gain1.0000
1:54209945:G:GCacceptor_loss1.0000
1:54209945:G:GGacceptor_gain1.0000
1:54209945:GA:Gacceptor_gain1.0000
1:54209945:GAGT:Gacceptor_gain1.0000
1:54210129:CAGG:Cdonor_loss1.0000
1:54210130:AGGT:Adonor_loss1.0000
1:54210131:GGTAA:Gdonor_loss1.0000
1:54210132:GTAAG:Gdonor_loss1.0000
1:54216137:TCA:Tacceptor_loss1.0000
1:54216138:CA:Cacceptor_loss1.0000
1:54216139:A:AGacceptor_gain1.0000
1:54216139:AGAAT:Aacceptor_gain1.0000
1:54216140:G:GAacceptor_gain1.0000
1:54216140:GA:Gacceptor_gain1.0000
1:54216140:GAA:Gacceptor_gain1.0000
1:54216140:GAAT:Gacceptor_gain1.0000
1:54216140:GAATG:Gacceptor_gain1.0000
1:54184156:CTGA:Cdonor_loss0.9900
1:54184157:TGA:Tdonor_loss0.9900
1:54184158:GA:Gdonor_loss0.9900
1:54184159:A:Cdonor_loss0.9900
1:54184159:ACCTG:Adonor_loss0.9900
1:54184160:C:Adonor_loss0.9900

AlphaMissense

2741 scored. Top likely-pathogenic:

VariantProtein changeam_pathogenicity
1:54216266:T:AN372K0.988
1:54216266:T:GN372K0.988
1:54205401:T:AW213R0.981
1:54205401:T:CW213R0.981
1:54216180:A:CS344R0.981
1:54216182:C:AS344R0.981
1:54216182:C:GS344R0.981
1:54216226:T:CL359P0.981
1:54216273:T:AW375R0.980
1:54216273:T:CW375R0.980
1:54212641:G:CA325P0.972
1:54205039:T:CL123P0.969
1:54216230:T:AN360K0.967
1:54216230:T:GN360K0.967
1:54216264:A:GN372D0.965
1:54205315:T:CL184P0.964
1:54216204:T:CF352L0.964
1:54216206:C:AF352L0.964
1:54216206:C:GF352L0.964
1:54210093:T:CL265P0.961
1:54212620:T:CF318L0.961
1:54212622:T:AF318L0.961
1:54212622:T:GF318L0.961
1:54212629:G:CA321P0.961
1:54212630:C:AA321D0.960
1:54216226:T:AL359Q0.957
1:54216263:G:CK371N0.956
1:54216263:G:TK371N0.956
1:54218218:T:CF414S0.955
1:54205029:G:CA120P0.953

dbSNP variants (sampled 300 via entrez): RS1000084632 (1:54202070 G>A,T), RS1000229995 (1:54221365 G>C), RS1000242823 (1:54215870 C>T), RS1000452424 (1:54220106 C>T), RS1000464287 (1:54223751 T>C), RS1000482820 (1:54207858 T>G), RS1000838921 (1:54211211 C>T), RS1000878030 (1:54200997 T>C), RS1000885415 (1:54220405 T>C), RS1001206586 (1:54221748 C>T), RS1001583055 (1:54212734 A>G), RS1001638120 (1:54221943 A>G), RS1001656714 (1:54213069 C>T), RS1001685136 (1:54199649 T>C), RS1001769988 (1:54206058 G>A)

Disease associations

OMIM: gene MIM:611843 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

StudyTraitp-value
GCST002616_17Mitochondrial DNA levels4.000000e-06
GCST004162_7Carotid plaque burden8.000000e-06
GCST90006993_3Gut microbiota relative abundance (unclassified genus belonging to the order Clostridiales)4.000000e-06

EFO canonical traits (3, from GWAS)

EFO IDTrait name
EFO:0006312mitochondrial DNA measurement
EFO:0006501carotid plaque build
EFO:0007874gut microbiome measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL6066470 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

PharmGKB variants

1 variants.

VariantGenesLevelScore#Clin annotsDrugs
rs642990MRPL3732.501gemcitabine

ChEMBL bioactivities

2 potent at pChembl≥5 of 2 total, top 2 by pChembl (potency: 10 = 0.1 nM, 6 = 1 µM).

pChemblTypeValueUnitMolecule
7.69Kd20.3nMCHEMBL5653589
7.69ED5020.3nMCHEMBL5653589

PubChem BioAssay actives

1 with measured affinity, of 2 total; 1 most potent distinct compounds. Largely complementary to BindingDB; screening values are coarse (µM, 4 dp), so sub-nM hits tie at the floor.

CompoundAssayTypeValueUnit
4-methyl-3-[(2-methyl-6-pyridin-3-ylpyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-[3-(trifluoromethyl)phenyl]benzamide2148772: Binding affinity to human MRPL37 incubated for 45 mins by Kinobead based pull down assaykd0.0203uM

CTD chemical–gene interactions

27 total (human), top 27 by PubMed support.

ChemicalActions (top 5)PubMed papers
Valproic Acidaffects expression, increases expression2
aristolochic acid Iincreases expression1
bisphenol Fincreases expression1
beta-lapachoneincreases expression1
arseniteaffects binding, increases reaction1
gossypol acetic aciddecreases expression1
2,3-bis(3’-hydroxybenzyl)butyrolactoneaffects cotreatment, increases expression1
4-aminophenylarsenoxidedecreases reaction, affects binding1
di-n-butylphosphoric acidaffects expression1
azoxystrobinincreases expression1
corosolic aciddecreases expression1
4-(5-benzo(1,3)dioxol-5-yl-4-pyridin-2-yl-1H-imidazol-2-yl)benzamideaffects cotreatment, decreases expression1
bisphenol Bincreases expression1
LDN 193189affects cotreatment, decreases expression1
bisphenol AFincreases expression1
Arsenic Trioxidedecreases reaction, affects binding1
Acetaminophenaffects cotreatment, decreases expression1
Coumestrolaffects cotreatment, increases expression1
Diurondecreases expression1
Enzyme Inhibitorsdecreases activity, increases O-linked glycosylation1
Ivermectindecreases expression1
Lipopolysaccharidesaffects cotreatment, decreases expression1
Ribonucleotidesaffects binding1
Rotenoneincreases expression1
Tretinoindecreases expression1
beta-Naphthoflavonedecreases expression1
Copper Sulfatedecreases expression1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay IDTypeDescriptionSource paper
CHEMBL5651814BindingBinding affinity to human MRPL37 incubated for 45 mins by Kinobead based pull down assayNVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family. — ChemMedChem

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.

No linked Atlas pages yet — the cross-entity mesh grows as the corpus expands.

About this page

Generated deterministically by Sugi Atlas from primary biomedical databases via BioBTree. Every record on this page traces to a primary source.

Generated
Atlas version
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BioBTree
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Sources 78

This page pulls from 78 datasets indexed by BioBTree:

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