MRPL38

Summary

MRPL38 (mitochondrial ribosomal protein L38, HGNC:14033) is a protein-coding gene on chromosome 17q25.1, encoding Large ribosomal subunit protein mL38 (Q96DV4). It is a selective cancer dependency (DepMap: 81.0% of cell lines).

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein.

Source: NCBI Gene 64978 — RefSeq curated summary.

At a glance

• Gene–disease (curated): mitochondrial disease (Limited, ClinGen)
• GWAS associations: 2
• Clinical variants (ClinVar): 79 total
• Druggable target: yes
• Cancer dependency (DepMap): dependent in 81.0% of screened cell lines
• MANE Select transcript: NM_032478

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:14033
Approved symbol	MRPL38
Name	mitochondrial ribosomal protein L38
Location	17q25.1
Locus type	gene with protein product
Status	Approved
Aliases	RPML3, MRP-L3, HSPC262, MGC4810, mL38
Ensembl gene	ENSG00000204316
Ensembl biotype	protein_coding
OMIM	611844
Entrez	64978

Gene structure

Transcript identifiers

Ensembl transcripts: 26 — 11 retained_intron, 10 protein_coding, 5 protein_coding_CDS_not_defined

ENST00000309352, ENST00000410030, ENST00000461602, ENST00000464758, ENST00000471434, ENST00000474548, ENST00000477023, ENST00000477371, ENST00000477736, ENST00000480203, ENST00000483393, ENST00000486101, ENST00000493104, ENST00000493383, ENST00000494179, ENST00000585475, ENST00000588620, ENST00000884825, ENST00000884827, ENST00000884829, ENST00000922024, ENST00000922025, ENST00000922026, ENST00000957221, ENST00000957222, ENST00000957223

RefSeq mRNA: 1 — MANE Select: NM_032478 NM_032478

CCDS: CCDS11733

Canonical transcript exons

ENST00000309352 — 9 exons

Exon	Start	End
ENSE00001295882	75904809	75904884
ENSE00001352100	75898644	75898986
ENSE00003459321	75902020	75902154
ENSE00003481404	75901201	75901273
ENSE00003499490	75904540	75904719
ENSE00003524869	75901712	75901920
ENSE00003556659	75900982	75901027
ENSE00003599355	75899516	75899674
ENSE00003646259	75899158	75899294

Expression profiles

Bgee: expression breadth ubiquitous, 134 present calls, max score 97.53.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 37.0102 / max 188.0957, expressed in 1811 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
168138	32.7853	1806
168140	2.7187	1479
168139	1.0193	695
168137	0.4869	272

Top tissues by expression

134 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
right hemisphere of cerebellum	UBERON:0014890	97.53	gold quality
apex of heart	UBERON:0002098	97.49	gold quality
gastrocnemius	UBERON:0001388	97.37	gold quality
cerebellar hemisphere	UBERON:0002245	97.37	gold quality
cerebellum	UBERON:0002037	97.35	gold quality
cerebellar cortex	UBERON:0002129	97.35	gold quality
pituitary gland	UBERON:0000007	97.31	gold quality
hindlimb stylopod muscle	UBERON:0004252	97.13	gold quality
mucosa of transverse colon	UBERON:0004991	97.05	gold quality
adenohypophysis	UBERON:0002196	97.04	gold quality
heart left ventricle	UBERON:0002084	97.00	gold quality
skeletal muscle tissue	UBERON:0001134	96.98	gold quality
right uterine tube	UBERON:0001302	96.95	gold quality
lower esophagus mucosa	UBERON:0035834	96.90	gold quality
muscle layer of sigmoid colon	UBERON:0035805	96.86	gold quality
fundus of stomach	UBERON:0001160	96.84	gold quality
muscle of leg	UBERON:0001383	96.83	gold quality
right lobe of thyroid gland	UBERON:0001119	96.82	gold quality
body of uterus	UBERON:0009853	96.82	gold quality
metanephros cortex	UBERON:0010533	96.74	gold quality
right lobe of liver	UBERON:0001114	96.70	gold quality
right adrenal gland	UBERON:0001233	96.70	gold quality
left ovary	UBERON:0002119	96.66	gold quality
tibial nerve	UBERON:0001323	96.65	gold quality
endocervix	UBERON:0000458	96.63	gold quality
right testis	UBERON:0004534	96.61	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	96.61	gold quality
right adrenal gland cortex	UBERON:0035827	96.60	gold quality
lower esophagus muscularis layer	UBERON:0035833	96.60	gold quality
lower esophagus	UBERON:0013473	96.59	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	7.63

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

5 targeting MRPL38, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-12123	99.52	71.79	2990
HSA-MIR-31-5P	98.58	68.35	1239
HSA-MIR-6882-3P	98.23	67.01	1119
HSA-MIR-96-3P	97.47	68.03	839
HSA-MIR-2861	95.24	65.47	1056

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 81.0% of screened cell lines.

Literature-anchored findings (GeneRIF, showing 1)

• A Multi-Trait Approach Identified Genetic Variants Including a Rare Mutation in RGS3 with Impact on Abnormalities of Cardiac Structure/Function. (PMID:30971721)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	mrpl38	ENSDARG00000039667
mus_musculus	Mrpl38	ENSMUSG00000020775
rattus_norvegicus	Mrpl38	ENSRNOG00000008256
drosophila_melanogaster	mRpL38	FBGN0030552
caenorhabditis_elegans	mrpl-38	WBGENE00021327

Paralogs (2): PEBP1 (ENSG00000089220), PEBP4 (ENSG00000134020)

Protein

Protein identifiers

Large ribosomal subunit protein mL38 — Q96DV4 (reviewed: Q96DV4)

Alternative names: 39S ribosomal protein L38, mitochondrial

All UniProt accessions (1): Q96DV4

UniProt curated annotations — full annotation on UniProt →

Subunit / interactions. Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins. mL38 is located at the central protuberance.

Subcellular location. Mitochondrion.

Similarity. Belongs to the phosphatidylethanolamine-binding protein family. Mitochondrion-specific ribosomal protein mL38 subfamily.

Isoforms (2)

UniProt ID	Names	Canonical?
Q96DV4-1	1	yes
Q96DV4-2	2

RefSeq proteins (1): NP_115867* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR008914	PEBP	Family
IPR035810	PEBP_euk	Family
IPR036610	PEBP-like_sf	Homologous_superfamily

Pfam: PF01161

UniProt features (34 total): strand 12, helix 11, turn 5, sequence variant 2, transit peptide 1, chain 1, coiled-coil region 1, splice variant 1

Structure

Experimental structures (PDB)

86 structures, top 30 by resolution.

PDB	Method	Resolution (Å)
7OF0	ELECTRON MICROSCOPY	2.2
7QI4	ELECTRON MICROSCOPY	2.21
8RRI	ELECTRON MICROSCOPY	2.4
8QU5	ELECTRON MICROSCOPY	2.42
9OLF	ELECTRON MICROSCOPY	2.46
7OF7	ELECTRON MICROSCOPY	2.5
7PO4	ELECTRON MICROSCOPY	2.56
6ZM6	ELECTRON MICROSCOPY	2.59
7O9M	ELECTRON MICROSCOPY	2.6
7OF6	ELECTRON MICROSCOPY	2.6
9CN3	ELECTRON MICROSCOPY	2.62
7QI5	ELECTRON MICROSCOPY	2.63
7OF2	ELECTRON MICROSCOPY	2.7
7OF3	ELECTRON MICROSCOPY	2.7
7OF4	ELECTRON MICROSCOPY	2.7
8QU1	ELECTRON MICROSCOPY	2.74
9PR4	ELECTRON MICROSCOPY	2.77
9PRA	ELECTRON MICROSCOPY	2.83
8ANY	ELECTRON MICROSCOPY	2.85
6ZM5	ELECTRON MICROSCOPY	2.89
7QH7	ELECTRON MICROSCOPY	2.89
7ODR	ELECTRON MICROSCOPY	2.9
7OF5	ELECTRON MICROSCOPY	2.9
8K2A	ELECTRON MICROSCOPY	2.9
8OIT	ELECTRON MICROSCOPY	2.9
9PGL	ELECTRON MICROSCOPY	2.9
9PGF	ELECTRON MICROSCOPY	2.93
6VMI	ELECTRON MICROSCOPY	2.96
6VLZ	ELECTRON MICROSCOPY	2.97
7QI6	ELECTRON MICROSCOPY	2.98

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q96DV4-F1	82.80	0.46

Function

Pathways and Gene Ontology

Reactome pathways

7 pathways

ID	Pathway
R-HSA-5368286	Mitochondrial translation initiation
R-HSA-5389840	Mitochondrial translation elongation
R-HSA-5419276	Mitochondrial translation termination
R-HSA-9937383	Mitochondrial ribosome-associated quality control
R-HSA-392499	Metabolism of proteins
R-HSA-5368287	Mitochondrial translation
R-HSA-72766	Translation

MSigDB gene sets: 102 (showing top): GGGNRMNNYCAT_UNKNOWN, GOBP_MITOCHONDRIAL_TRANSLATION, GOBP_TRANSLATION, GOCC_MITOCHONDRIAL_ENVELOPE, NIKOLSKY_BREAST_CANCER_17Q21_Q25_AMPLICON, GATGKMRGCG_UNKNOWN, GOCC_LARGE_RIBOSOMAL_SUBUNIT, GOCC_RIBOSOME, GOCC_ORGANELLAR_RIBOSOME, GOCC_MITOCHONDRIAL_MATRIX, GOCC_ORGANELLE_INNER_MEMBRANE, SANSOM_APC_MYC_TARGETS, SANSOM_APC_TARGETS_REQUIRE_MYC, GOCC_RIBOSOMAL_SUBUNIT, GOCC_RIBONUCLEOPROTEIN_COMPLEX

GO Biological Process (1): mitochondrial translation (GO:0032543)

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (6): mitochondrion (GO:0005739), mitochondrial inner membrane (GO:0005743), mitochondrial large ribosomal subunit (GO:0005762), cytosol (GO:0005829), ribosome (GO:0005840), ribonucleoprotein complex (GO:1990904)

Reactome top-level categories

Rollup of top-3 pathways:

Category	Pathways
Mitochondrial translation	4
Translation	1
Metabolism of proteins	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
cytoplasm	2
mitochondrion	1
translation	1
mitochondrial gene expression	1
binding	1
intracellular membrane-bounded organelle	1
organelle inner membrane	1
mitochondrial membrane	1
organellar large ribosomal subunit	1
mitochondrial ribosome	1
mitochondrial protein-containing complex	1
cellular anatomical structure	1
intracellular membraneless organelle	1
protein-containing complex	1

Protein interactions and networks

STRING

2902 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
MRPL38	TRIM47	Q96LD4	657
MRPL38	FBF1	Q8TES7	619
MRPL38	TRIM65	Q6PJ69	612
MRPL38	MRPS27	Q92552	608
MRPL38	WBP2	Q969T9	581
MRPL38	DAP3	P51398	574
MRPL38	MRPL10	Q7Z7H8	566
MRPL38	MRPL19	P49406	542
MRPL38	MRPL40	Q9NQ50	529
MRPL38	MRPL52	Q86TS9	521
MRPL38	MRPL4	Q9BYD3	499
MRPL38	MRPS10	P82664	488
MRPL38	MRPL1	Q9BYD6	473
MRPL38	ERMP1	Q7Z2K6	456
MRPL38	MRPL41	Q8IXM3	455

IntAct

204 interactions, top by confidence:

A	B	Type	Score
PIK3CA	PIK3R2	psi-mi:“MI:0914”(association)	0.900
MRPL18	MRPL38	psi-mi:“MI:0915”(physical association)	0.800
MRPL38	MRPL18	psi-mi:“MI:0915”(physical association)	0.800
YBX1	HNRNPR	psi-mi:“MI:0914”(association)	0.770
GADD45GIP1	MRPL38	psi-mi:“MI:0915”(physical association)	0.740
CFTR	ESYT2	psi-mi:“MI:2364”(proximity)	0.710
MRPS30	GTPBP10	psi-mi:“MI:0914”(association)	0.640
LIN28A	IGF2BP3	psi-mi:“MI:0914”(association)	0.640
MRPL38	RPL13	psi-mi:“MI:0915”(physical association)	0.560
MRPL38	MRPL52	psi-mi:“MI:0915”(physical association)	0.560
BEX2	MRPL38	psi-mi:“MI:0915”(physical association)	0.560
CCDC120	MRPL38	psi-mi:“MI:0915”(physical association)	0.560
RALY	MRPL38	psi-mi:“MI:0915”(physical association)	0.560
MRPL38	GOLGA6A	psi-mi:“MI:0915”(physical association)	0.560
BAG3	MRPL38	psi-mi:“MI:0915”(physical association)	0.560
MYOZ3	MRPL38	psi-mi:“MI:0915”(physical association)	0.560
MRPL38	CCDC120	psi-mi:“MI:0915”(physical association)	0.560
PPP1R18	MRPL38	psi-mi:“MI:0915”(physical association)	0.560
TSEN54	MRPL38	psi-mi:“MI:0915”(physical association)	0.560
MKRN3	MRPL38	psi-mi:“MI:0915”(physical association)	0.560
CENATAC	MRPL38	psi-mi:“MI:0915”(physical association)	0.560
MRPL38	ARHGAP9	psi-mi:“MI:0915”(physical association)	0.560
LONRF1	MRPL38	psi-mi:“MI:0915”(physical association)	0.560
MRPL38	BEX2	psi-mi:“MI:0915”(physical association)	0.560

BioGRID (358): DOCK8 (Two-hybrid), MRPL38 (Affinity Capture-MS), MRPL38 (Affinity Capture-MS), MRPL38 (Affinity Capture-MS), MRPL38 (Affinity Capture-MS), MRPL38 (Affinity Capture-MS), MRPL38 (Affinity Capture-MS), MRPL38 (Affinity Capture-MS), MRPL38 (Affinity Capture-MS), MRPL38 (Affinity Capture-MS), MRPL38 (Affinity Capture-MS), MRPL38 (Affinity Capture-MS), MRPL38 (Affinity Capture-MS), MRPL38 (Co-fractionation), MRPL38 (Co-fractionation)

ESM2 similar proteins: A2T7D9, B0S8I0, B3DL53, D3Z4S3, O00142, O00746, O35385, O43304, O75038, O75414, O88425, O88426, P42898, P56597, P87355, Q05B52, Q09M05, Q14994, Q1LX49, Q3SZ85, Q3ZBF3, Q4FZX0, Q4KLI9, Q4U2V3, Q4V7A9, Q5CZL1, Q5EBA1, Q5PQN9, Q5XGM5, Q60HE5, Q6AYQ3, Q6DGQ8, Q6DI51, Q6GMV3, Q80YD1, Q810A5, Q8HY87, Q8NFF5, Q969U6, Q96DV4

Diamond homologs: A0A0Q3IBS1, I1H0V9, O16264, O82088, P13696, P30086, P31044, P31729, P48737, P54185, P54186, P54187, P54188, P54190, P70296, Q06252, Q3YIX4, Q3ZBF3, Q41261, Q5PQN9, Q5R4R0, Q5RDL7, Q5UR88, Q656A5, Q8K2M0, Q8MK67, Q8VIN1, Q8VWH2, Q93WI9, Q96DV4, Q96S96, Q9ASJ1, Q9D9G2, Q9FIT4, Q9S7R5, Q9SXZ2, Q9X9Z8, Q9XFK7, Q9XH42, Q9XH43

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
MRPL38	“form complex”	“39S mitochondrial large ribosomal subunit”	binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 153 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Mitochondrial ribosome-associated quality control	35	39.8×	5e-46
Mitochondrial translation	30	38.2×	5e-39
Mitochondrial translation initiation	32	37.6×	3e-41
Mitochondrial translation elongation	32	37.6×	3e-41
Mitochondrial translation termination	32	32.5×	5e-39
Translation	32	18.4×	2e-30
Peptide chain elongation	9	10.6×	8e-06
Viral mRNA Translation	9	10.6×	8e-06

GO biological processes:

GO term	Partners	Fold	FDR
mitochondrial large ribosomal subunit assembly	6	44.4×	5e-07
mitochondrial translation	34	44.1×	4e-45
translation	27	20.7×	1e-25
cytoplasmic translation	10	13.8×	5e-07
negative regulation of translation	9	13.2×	4e-06

Disease & clinical

Clinical variants and AI predictions

ClinVar

79 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	66
Likely benign	4
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1134 predictions. Top by Δscore:

Variant	Effect	Δscore
17:75898982:CATGT:C	acceptor_gain	1.0000
17:75898984:TGT:T	acceptor_gain	1.0000
17:75898987:C:CC	acceptor_gain	1.0000
17:75899153:CTTA:C	donor_loss	1.0000
17:75899155:TACCC:T	donor_loss	1.0000
17:75899156:A:AC	donor_gain	1.0000
17:75899156:AC:A	donor_gain	1.0000
17:75899156:ACC:A	donor_gain	1.0000
17:75899157:C:CA	donor_gain	1.0000
17:75899157:CC:C	donor_gain	1.0000
17:75899157:CCC:C	donor_gain	1.0000
17:75899157:CCCA:C	donor_gain	1.0000
17:75899157:CCCAG:C	donor_gain	1.0000
17:75899290:GATAG:G	acceptor_gain	1.0000
17:75899291:ATAG:A	acceptor_gain	1.0000
17:75899292:TAG:T	acceptor_gain	1.0000
17:75899293:AG:A	acceptor_gain	1.0000
17:75899295:C:CC	acceptor_gain	1.0000
17:75899297:A:AC	acceptor_gain	1.0000
17:75899297:A:C	acceptor_gain	1.0000
17:75899305:A:AC	acceptor_gain	1.0000
17:75899305:A:C	acceptor_gain	1.0000
17:75899534:T:TA	donor_gain	1.0000
17:75899675:C:CC	acceptor_gain	1.0000
17:75901707:GTTA:G	donor_loss	1.0000
17:75901709:TAC:T	donor_loss	1.0000
17:75901710:A:T	donor_loss	1.0000
17:75901711:C:T	donor_loss	1.0000
17:75901916:ACTGG:A	acceptor_loss	1.0000
17:75901917:CTGG:C	acceptor_gain	1.0000

AlphaMissense

2443 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
17:75901225:A:G	W214R	0.975
17:75901225:A:T	W214R	0.975
17:75901273:C:G	A198P	0.969
17:75901802:A:C	F167L	0.969
17:75901802:A:T	F167L	0.969
17:75901804:A:G	F167L	0.969
17:75898967:A:C	F342L	0.968
17:75898967:A:T	F342L	0.968
17:75898969:A:G	F342L	0.968
17:75899270:G:C	F298L	0.963
17:75899270:G:T	F298L	0.963
17:75899272:A:G	F298L	0.963
17:75899567:A:G	F273S	0.963
17:75898922:G:C	F357L	0.961
17:75898922:G:T	F357L	0.961
17:75898924:A:G	F357L	0.961
17:75899171:G:C	F331L	0.958
17:75899171:G:T	F331L	0.958
17:75899173:A:G	F331L	0.958
17:75900985:A:G	L236P	0.956
17:75899207:G:C	F319L	0.952
17:75899207:G:T	F319L	0.952
17:75899209:A:G	F319L	0.952
17:75899277:C:G	R296P	0.950
17:75899203:A:G	C321R	0.948
17:75901205:G:C	S220R	0.948
17:75901205:G:T	S220R	0.948
17:75901207:T:G	S220R	0.948
17:75899197:A:G	W323R	0.947
17:75899197:A:T	W323R	0.947

dbSNP variants (sampled 300 via entrez): RS1000162227 (17:75898241 C>T), RS1000754049 (17:75902352 C>G), RS1000821356 (17:75903667 G>A), RS1000938712 (17:75906646 C>A,T), RS1000949590 (17:75900506 G>A), RS1001067231 (17:75900823 G>A,T), RS1001123895 (17:75902553 C>T), RS1001663576 (17:75902944 C>T), RS1001871615 (17:75901983 C>A), RS1003344998 (17:75904790 A>C,G,T), RS1003511447 (17:75900889 T>C), RS1003543056 (17:75900613 C>T), RS1003576417 (17:75898645 C>A,T), RS1003691519 (17:75906853 C>T), RS1003895262 (17:75905235 A>G)

Disease associations

OMIM: gene MIM:611844 | disease phenotypes:

GenCC curated gene-disease

ClinGen Gene-Disease Validity (1)

Expert-panel classifications — Definitive > Strong > Moderate > Limited > Disputed > Refuted.

Disease	Classification	Inheritance
mitochondrial disease	Limited	AR

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST012580_7	White matter hyperintensities	3.000000e-08
GCST012580_8	White matter hyperintensities	1.000000e-07

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0005665	white matter hyperintensity measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: yes

ChEMBL targets (1): CHEMBL6067246 (SINGLE PROTEIN)

PharmGKB: 1 entry (VIP=true, CPIC=false)

ChEMBL bioactivities

2 potent at pChembl≥5 of 2 total, top 2 by pChembl (potency: 10 = 0.1 nM, 6 = 1 µM).

pChembl	Type	Value	Unit	Molecule
7.91	Kd	12.32	nM	CHEMBL5653589
7.91	ED50	12.32	nM	CHEMBL5653589

PubChem BioAssay actives

1 with measured affinity, of 2 total; 1 most potent distinct compounds. Largely complementary to BindingDB; screening values are coarse (µM, 4 dp), so sub-nM hits tie at the floor.

Compound	Assay	Type	Value	Unit
4-methyl-3-[(2-methyl-6-pyridin-3-ylpyrazolo[3,4-d]pyrimidin-4-yl)amino]-N-[3-(trifluoromethyl)phenyl]benzamide	2148773: Binding affinity to human MRPL38 incubated for 45 mins by Kinobead based pull down assay	kd	0.0123	uM

CTD chemical–gene interactions

25 total (human), top 25 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Air Pollutants	affects cotreatment, increases abundance, increases oxidation, increases expression	2
Smoke	decreases expression, increases abundance, increases expression	2
aristolochic acid I	increases expression	1
alpha-pinene	increases abundance, affects cotreatment, increases oxidation	1
beta-lapachone	decreases expression	1
sodium arsenite	increases abundance, increases expression	1
methacrylaldehyde	affects cotreatment, increases oxidation, increases abundance	1
corosolic acid	decreases expression	1
bisphenol S	increases expression	1
bisphenol AF	increases expression	1
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	decreases expression	1
Acrolein	increases oxidation, increases abundance, affects cotreatment	1
Arsenic	increases abundance, increases expression	1
Benzo(a)pyrene	decreases expression	1
Cadmium	increases abundance, increases expression	1
Dimethyl Sulfoxide	decreases expression	1
Ivermectin	decreases expression	1
Ozone	increases oxidation, increases abundance, affects cotreatment	1
Phthalic Acids	increases expression	1
Ribonucleotides	affects binding	1
Sodium Dodecyl Sulfate	decreases expression	1
Tobacco Smoke Pollution	decreases expression	1
Cadmium Chloride	increases abundance, increases expression	1
Copper Sulfate	decreases expression	1
Volatile Organic Compounds	affects cotreatment, increases oxidation	1

ChEMBL screening assays

1 unique, capped per target: 1 binding

Representative assays (with source publication via chembl_document):

Assay ID	Type	Description	Source paper
CHEMBL5651815	Binding	Binding affinity to human MRPL38 incubated for 45 mins by Kinobead based pull down assay	NVP-BHG712: Effects of Regioisomers on the Affinity and Selectivity toward the EPHrin Family. — ChemMedChem

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.