MRPL45

Summary

MRPL45 (mitochondrial ribosomal protein L45, HGNC:16651) is a protein-coding gene on chromosome 17q12, encoding Large ribosomal subunit protein mL45 (Q9BRJ2). Component of the mitochondrial large ribosomal subunit (mt-LSU). It is a selective cancer dependency (DepMap: 85.6% of cell lines).

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Alternative splicing results in multiple transcript variants. Pseudogenes corresponding to this gene are found on chromosomes 2p and 17q.

Source: NCBI Gene 84311 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 73 total
• Cancer dependency (DepMap): dependent in 85.6% of screened cell lines
• MANE Select transcript: NM_032351

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:16651
Approved symbol	MRPL45
Name	mitochondrial ribosomal protein L45
Location	17q12
Locus type	gene with protein product
Status	Approved
Aliases	MGC11321, Mba1, mL45
Ensembl gene	ENSG00000278845
Ensembl biotype	protein_coding
OMIM	611850
Entrez	84311

Gene structure

Transcript identifiers

Ensembl transcripts: 7 — 7 protein_coding

ENST00000613675, ENST00000619548, ENST00000862418, ENST00000862419, ENST00000862420, ENST00000862421, ENST00000923665

RefSeq mRNA: 2 — MANE Select: NM_032351 NM_001278279, NM_032351

CCDS: CCDS11326, CCDS74047

Canonical transcript exons

ENST00000613675 — 8 exons

Exon	Start	End
ENSE00003712130	38318687	38318735
ENSE00003717728	38322126	38322299
ENSE00003734020	38322509	38323211
ENSE00003749332	38299351	38299468
ENSE00003750715	38298449	38298626
ENSE00003751713	38306533	38306631
ENSE00003752416	38320618	38320767
ENSE00003849743	38297168	38297249

Expression profiles

Bgee: expression breadth ubiquitous, 134 present calls, max score 94.35.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 6.3839 / max 88.6392, expressed in 1715 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
160474	6.0845	1708
160475	0.2994	134

Top tissues by expression

134 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
gastrocnemius	UBERON:0001388	94.35	gold quality
muscle of leg	UBERON:0001383	94.19	gold quality
islet of Langerhans	UBERON:0000006	93.39	gold quality
cortical plate	UBERON:0005343	93.03	gold quality
body of pancreas	UBERON:0001150	92.97	gold quality
hindlimb stylopod muscle	UBERON:0004252	92.79	gold quality
rectum	UBERON:0001052	92.73	gold quality
pancreas	UBERON:0001264	92.67	gold quality
skeletal muscle tissue	UBERON:0001134	92.14	gold quality
ganglionic eminence	UBERON:0004023	92.14	gold quality
right adrenal gland cortex	UBERON:0035827	92.12	gold quality
right adrenal gland	UBERON:0001233	91.87	gold quality
mucosa of transverse colon	UBERON:0004991	91.76	gold quality
heart left ventricle	UBERON:0002084	91.42	gold quality
body of stomach	UBERON:0001161	91.41	gold quality
fundus of stomach	UBERON:0001160	91.03	gold quality
left ovary	UBERON:0002119	90.94	gold quality
adult mammalian kidney	UBERON:0000082	90.93	gold quality
left adrenal gland	UBERON:0001234	90.92	gold quality
muscle tissue	UBERON:0002385	90.90	gold quality
ovary	UBERON:0000992	90.84	gold quality
duodenum	UBERON:0002114	90.79	gold quality
smooth muscle tissue	UBERON:0001135	90.54	gold quality
heart	UBERON:0000948	90.47	gold quality
left adrenal gland cortex	UBERON:0035825	90.39	gold quality
placenta	UBERON:0001987	90.38	gold quality
lymph node	UBERON:0000029	90.21	gold quality
adrenal gland	UBERON:0002369	90.19	gold quality
cortex of kidney	UBERON:0001225	90.10	gold quality
stomach	UBERON:0000945	90.02	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	5.32

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

33 targeting MRPL45, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-4282	99.99	75.36	6408
HSA-MIR-8075	99.97	67.20	962
HSA-MIR-6844	99.82	70.69	2423
HSA-MIR-944	99.82	70.85	3042
HSA-MIR-4668-5P	99.79	70.58	3782
HSA-MIR-6752-3P	99.72	66.71	1587
HSA-MIR-494-3P	99.70	71.45	2795
HSA-MIR-587	99.64	70.86	2611
HSA-MIR-5004-3P	99.54	68.27	1371
HSA-MIR-4728-3P	99.47	68.94	981
HSA-MIR-6731-5P	99.28	67.42	2375
HSA-MIR-8085	99.28	67.56	2362
HSA-MIR-5584-3P	99.23	68.79	1351
HSA-MIR-3925-5P	99.21	67.90	1466
HSA-MIR-146A-3P	99.13	68.99	1881
HSA-MIR-6871-5P	98.90	66.67	671
HSA-MIR-6895-3P	98.79	65.69	996
HSA-MIR-6830-3P	98.62	68.07	1760
HSA-MIR-2117	98.48	67.97	1307
HSA-MIR-93-3P	98.15	66.65	1309
HSA-MIR-4769-3P	97.95	68.17	1002
HSA-MIR-6817-5P	97.95	67.86	1026
HSA-MIR-3151-3P	97.80	66.16	479
HSA-MIR-30C-1-3P	97.80	66.36	1499
HSA-MIR-30C-2-3P	97.80	66.45	1499
HSA-MIR-6788-5P	97.80	66.41	1532
HSA-MIR-3620-3P	97.78	64.88	772
HSA-MIR-6511A-3P	97.60	66.61	713
HSA-MIR-6511B-3P	97.60	66.61	713
HSA-MIR-4732-3P	97.15	65.45	881

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 85.6% of screened cell lines.

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	mrpl45	ENSDARG00000044942
mus_musculus	Mrpl45	ENSMUSG00000018882
rattus_norvegicus	Mrpl45	ENSRNOG00000010540
drosophila_melanogaster	mRpL45	FBGN0263863
caenorhabditis_elegans		WBGENE00022493

Protein

Protein identifiers

Large ribosomal subunit protein mL45 — Q9BRJ2 (reviewed: Q9BRJ2)

Alternative names: 39S ribosomal protein L45, mitochondrial

All UniProt accessions (2): A0A087WU62, A0A087X2D5

UniProt curated annotations — full annotation on UniProt →

Function. Component of the mitochondrial large ribosomal subunit (mt-LSU). Within the mitochondrial ribosomes, required to direct the nascent polypeptide toward the tunnel exit and position the exit at a distance from the membrane surface.

Subunit / interactions. Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.

Subcellular location. Mitochondrion.

Similarity. Belongs to the mitochondrion-specific ribosomal protein mL45 family.

RefSeq proteins (2): NP_001265208, NP_115727* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR007379	Tim44-like_dom	Domain
IPR032710	NTF2-like_dom_sf	Homologous_superfamily
IPR051975	mtLSU_mL45	Family

Pfam: PF04280

UniProt features (23 total): strand 9, helix 6, turn 3, transit peptide 1, chain 1, region of interest 1, sequence variant 1, sequence conflict 1

Structure

Experimental structures (PDB)

85 structures, top 30 by resolution.

PDB	Method	Resolution (Å)
7OF0	ELECTRON MICROSCOPY	2.2
7QI4	ELECTRON MICROSCOPY	2.21
8RRI	ELECTRON MICROSCOPY	2.4
8QU5	ELECTRON MICROSCOPY	2.42
9OLF	ELECTRON MICROSCOPY	2.46
7OF7	ELECTRON MICROSCOPY	2.5
7PO4	ELECTRON MICROSCOPY	2.56
6ZM6	ELECTRON MICROSCOPY	2.59
7O9M	ELECTRON MICROSCOPY	2.6
7OF6	ELECTRON MICROSCOPY	2.6
9CN3	ELECTRON MICROSCOPY	2.62
7QI5	ELECTRON MICROSCOPY	2.63
7OF2	ELECTRON MICROSCOPY	2.7
7OF3	ELECTRON MICROSCOPY	2.7
7OF4	ELECTRON MICROSCOPY	2.7
9PR4	ELECTRON MICROSCOPY	2.77
9PRA	ELECTRON MICROSCOPY	2.83
8ANY	ELECTRON MICROSCOPY	2.85
6ZM5	ELECTRON MICROSCOPY	2.89
7QH7	ELECTRON MICROSCOPY	2.89
7ODR	ELECTRON MICROSCOPY	2.9
7OF5	ELECTRON MICROSCOPY	2.9
8K2A	ELECTRON MICROSCOPY	2.9
8OIT	ELECTRON MICROSCOPY	2.9
9PGL	ELECTRON MICROSCOPY	2.9
9PGF	ELECTRON MICROSCOPY	2.93
6VMI	ELECTRON MICROSCOPY	2.96
6VLZ	ELECTRON MICROSCOPY	2.97
7QI6	ELECTRON MICROSCOPY	2.98
9PSM	ELECTRON MICROSCOPY	2.98

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9BRJ2-F1	80.90	0.52

Function

Pathways and Gene Ontology

Reactome pathways

4 pathways

ID	Pathway
R-HSA-5368286	Mitochondrial translation initiation
R-HSA-5389840	Mitochondrial translation elongation
R-HSA-5419276	Mitochondrial translation termination
R-HSA-9937383	Mitochondrial ribosome-associated quality control

MSigDB gene sets: 146 (showing top): TGCGCANK_UNKNOWN, MIDORIKAWA_AMPLIFIED_IN_LIVER_CANCER, GOBP_MITOCHONDRIAL_TRANSLATION, CHANDRAN_METASTASIS_DN, GOBP_TRANSLATION, GOMF_STRUCTURAL_CONSTITUENT_OF_RIBOSOME, GGARNTKYCCA_UNKNOWN, GOCC_MITOCHONDRIAL_ENVELOPE, YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_13, WONG_MITOCHONDRIA_GENE_MODULE, IVANOVA_HEMATOPOIESIS_EARLY_PROGENITOR, TGGAAA_NFAT_Q4_01, GOCC_LARGE_RIBOSOMAL_SUBUNIT, GOCC_RIBOSOME, GOCC_ORGANELLAR_RIBOSOME

GO Biological Process (1): mitochondrial translation (GO:0032543)

GO Molecular Function (2): RNA binding (GO:0003723), structural constituent of ribosome (GO:0003735)

GO Cellular Component (5): mitochondrion (GO:0005739), mitochondrial inner membrane (GO:0005743), mitochondrial large ribosomal subunit (GO:0005762), ribosome (GO:0005840), ribonucleoprotein complex (GO:1990904)

Reactome top-level categories

Rollup of top-1 pathways:

Category	Pathways
Mitochondrial translation	4

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
mitochondrion	1
translation	1
mitochondrial gene expression	1
nucleic acid binding	1
structural molecule activity	1
ribosome	1
cytoplasm	1
intracellular membrane-bounded organelle	1
organelle inner membrane	1
mitochondrial membrane	1
organellar large ribosomal subunit	1
mitochondrial ribosome	1
mitochondrial protein-containing complex	1
intracellular membraneless organelle	1
protein-containing complex	1

Protein interactions and networks

STRING

1456 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
MRPL45	MRPL11	Q9Y3B7	742
MRPL45	MRPS18B	Q9Y676	648
MRPL45	MRPL48	Q96GC5	646
MRPL45	MRPS22	P82650	641
MRPL45	MRPL12	P52815	634
MRPL45	MRPL53	Q96EL3	616
MRPL45	MRPL49	Q13405	616
MRPL45	TIMM44	O43615	607
MRPL45	MRPS31	Q92665	607
MRPL45	OXA1L	Q15070	588
MRPL45	LRPPRC	P42704	579
MRPL45	MRPL40	Q9NQ50	578
MRPL45	MRPS27	Q92552	576
MRPL45	MRPS18A	Q9NVS2	568
MRPL45	DAP3	P51398	566

IntAct

84 interactions, top by confidence:

A	B	Type	Score
MRPL37	HSPD1	psi-mi:“MI:0914”(association)	0.710
MRPS30	GTPBP10	psi-mi:“MI:0914”(association)	0.640
TRIM23	MRPL45	psi-mi:“MI:0915”(physical association)	0.560
MRPL45	TRIM23	psi-mi:“MI:0915”(physical association)	0.560
CAVIN1	MRPL45	psi-mi:“MI:0915”(physical association)	0.560
PFDN5	MRPL45	psi-mi:“MI:0915”(physical association)	0.560
MRPL45	PLEKHA3	psi-mi:“MI:0915”(physical association)	0.560
EMD	MRPL45	psi-mi:“MI:0915”(physical association)	0.560
NP	KPNA6	psi-mi:“MI:0914”(association)	0.550
MRPL50	GTPBP10	psi-mi:“MI:0914”(association)	0.530
ZNF324B	ZNF316	psi-mi:“MI:0914”(association)	0.530
ZNF331	USP9Y	psi-mi:“MI:0914”(association)	0.530
MRPL10	ZZEF1	psi-mi:“MI:0914”(association)	0.530
MRPL42	GATC	psi-mi:“MI:0914”(association)	0.530
RPL6	MRPS14	psi-mi:“MI:0914”(association)	0.530
PDGFB	DKC1	psi-mi:“MI:0914”(association)	0.530
MRPL28	MRPL3	psi-mi:“MI:0914”(association)	0.530
MRPL41	MRPL3	psi-mi:“MI:0914”(association)	0.530
NDUFAB1	MIEF1	psi-mi:“MI:0915”(physical association)	0.490
Nup188	RPS3	psi-mi:“MI:0914”(association)	0.350
Rpl35	RPS6	psi-mi:“MI:0914”(association)	0.350
Pip4k2c	LAMA5	psi-mi:“MI:0914”(association)	0.350
Dctn5	VWA8	psi-mi:“MI:0914”(association)	0.350
NCAPD3	SMC2	psi-mi:“MI:0914”(association)	0.350
MRPL50	MRPL43	psi-mi:“MI:0914”(association)	0.350
MRPL9	MRPL43	psi-mi:“MI:0914”(association)	0.350
MRPL1	MRPL43	psi-mi:“MI:0914”(association)	0.350
FOXB1	DDX39A	psi-mi:“MI:0914”(association)	0.350
FOXL1	DDX39A	psi-mi:“MI:0914”(association)	0.350

ESM2 similar proteins: A3LYQ7, A5D9T6, A5DTQ6, A6ZML5, A6ZQJ9, A7TQZ1, B3LM44, B3LPY7, B5VL46, B5VPS9, C4QWY8, C4R8C9, C4XVT2, C4XW03, C4Y2I7, C5DKM2, C5DQ08, C5DV23, C7GPZ8, C7GQ96, C8ZB86, C8ZF15, O60186, O94618, P21560, P32453, P38300, P46956, P47015, P53266, P53736, P59480, Q02204, Q03798, Q04472, Q09218, Q09705, Q10275, Q3T142, Q4QQQ4

Diamond homologs: P59480, Q3T142, Q4QQQ4, Q616T6, Q95Y71, Q9BRJ2, Q9D0Q7, Q9VCX3

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
MRPL45	“form complex”	“39S mitochondrial large ribosomal subunit”	binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 101 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Mitochondrial ribosome-associated quality control	26	45.0×	4e-35
Mitochondrial translation initiation	24	42.9×	5e-32
Mitochondrial translation elongation	24	42.9×	5e-32
Mitochondrial translation	22	42.6×	2e-29
Mitochondrial translation termination	24	37.1×	2e-30
Translation	25	21.9×	7e-26
Influenza Infection	5	12.4×	2e-03

GO biological processes:

GO term	Partners	Fold	FDR
mitochondrial translation	25	49.9×	6e-34
translation	17	20.1×	2e-15

Disease & clinical

Clinical variants and AI predictions

ClinVar

73 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	63
Likely benign	3
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1202 predictions. Top by Δscore:

Variant	Effect	Δscore
17:38298447:A:AG	acceptor_gain	1.0000
17:38298448:G:GG	acceptor_gain	1.0000
17:38298448:GCCA:G	acceptor_gain	1.0000
17:38299349:A:AG	acceptor_gain	1.0000
17:38299349:AGCT:A	acceptor_gain	1.0000
17:38299350:G:GG	acceptor_gain	1.0000
17:38299350:GCT:G	acceptor_gain	1.0000
17:38299350:GCTG:G	acceptor_gain	1.0000
17:38299464:GTGTC:G	donor_gain	1.0000
17:38299466:GTC:G	donor_gain	1.0000
17:38299469:G:GG	donor_gain	1.0000
17:38306531:A:AG	acceptor_gain	1.0000
17:38306532:G:GG	acceptor_gain	1.0000
17:38306627:AATAA:A	donor_gain	1.0000
17:38306628:A:G	donor_gain	1.0000
17:38306628:ATAA:A	donor_gain	1.0000
17:38306629:TAA:T	donor_gain	1.0000
17:38306630:AA:A	donor_gain	1.0000
17:38306631:AG:A	donor_loss	1.0000
17:38306632:G:GG	donor_gain	1.0000
17:38306633:TAA:T	donor_loss	1.0000
17:38320612:CCTTA:C	acceptor_loss	1.0000
17:38320613:CTTA:C	acceptor_loss	1.0000
17:38320614:TTAG:T	acceptor_loss	1.0000
17:38320616:A:AG	acceptor_gain	1.0000
17:38320616:A:C	acceptor_loss	1.0000
17:38320616:AG:A	acceptor_gain	1.0000
17:38320617:G:A	acceptor_loss	1.0000
17:38320617:G:GG	acceptor_gain	1.0000
17:38320617:GG:G	acceptor_gain	1.0000

AlphaMissense

2006 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
17:38320654:T:A	W183R	0.998
17:38320654:T:C	W183R	0.998
17:38322240:T:A	W259R	0.998
17:38322240:T:C	W259R	0.998
17:38322147:T:C	F228L	0.996
17:38322149:T:A	F228L	0.996
17:38322149:T:G	F228L	0.996
17:38306612:G:C	A148P	0.995
17:38306591:G:C	A141P	0.994
17:38306592:C:A	A141D	0.994
17:38320751:G:C	R215P	0.994
17:38320766:A:C	Q220P	0.994
17:38322154:G:C	R230P	0.994
17:38322242:G:C	W259C	0.994
17:38322242:G:T	W259C	0.994
17:38318704:T:C	L160P	0.993
17:38322132:G:C	A223P	0.993
17:38320656:G:C	W183C	0.992
17:38320656:G:T	W183C	0.992
17:38322142:A:T	D226V	0.991
17:38322245:A:C	R260S	0.991
17:38322245:A:T	R260S	0.991
17:38306613:C:A	A148D	0.990
17:38318719:C:T	T165I	0.990
17:38320655:G:C	W183S	0.990
17:38306579:T:C	F137L	0.989
17:38306581:C:A	F137L	0.989
17:38306581:C:G	F137L	0.989
17:38306625:T:C	L152P	0.989
17:38318704:T:A	L160H	0.989

dbSNP variants (sampled 300 via entrez): RS1000020856 (17:38299846 C>T), RS1000033474 (17:38318037 A>G,T), RS1000392358 (17:38322346 T>G), RS1000401130 (17:38296460 A>C), RS1000433911 (17:38295350 A>G,T), RS1000486264 (17:38295596 G>C), RS1000624972 (17:38300990 T>G), RS1000766722 (17:38307122 G>A,C), RS1000999647 (17:38319217 A>G), RS1001013794 (17:38300761 A>G), RS1001071301 (17:38319613 G>A), RS1001434573 (17:38296513 G>A), RS1001491344 (17:38296747 G>C,T), RS1001621153 (17:38302266 C>A), RS1001768648 (17:38308587 C>T)

Disease associations

OMIM: gene MIM:611850 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST001941_16	Ovarian cancer	8.000000e-10

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

35 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Valproic Acid	affects cotreatment, increases expression, affects expression, decreases expression	4
sodium arsenite	decreases expression	2
Thapsigargin	increases reaction, increases expression, decreases expression	2
bisphenol F	increases expression	1
alpha phellandrene	increases expression	1
bisphenol A	increases expression	1
nobiletin	decreases expression, decreases reaction	1
sodium arsenate	decreases expression, decreases reaction	1
arsenite	increases reaction, affects binding	1
caffeic acid	decreases expression, increases reaction	1
2,3,5-(triglutathion-S-yl)hydroquinone	increases ADP-ribosylation	1
4-methoxycinnamate methyl ester	decreases expression, increases reaction	1
CGP 52608	affects binding, increases reaction	1
Sunitinib	increases expression	1
Acetaminophen	affects cotreatment, decreases expression	1
Air Pollutants	affects expression, increases abundance	1
Air Pollutants, Occupational	affects expression	1
Atrazine	decreases expression	1
Benzo(a)pyrene	increases methylation	1
Copper	affects binding, decreases expression	1
Disulfiram	affects binding, decreases expression	1
Drugs, Chinese Herbal	decreases expression, increases reaction	1
Hydralazine	affects cotreatment, increases expression	1
Ivermectin	decreases expression	1
Lead	affects expression	1
Lipopolysaccharides	affects cotreatment, decreases expression	1
Ozone	affects expression, increases abundance	1
Ribonucleotides	affects binding	1
Tobacco Smoke Pollution	decreases methylation	1
Tretinoin	decreases expression	1

Cellosaurus cell lines

16 cell lines: 16 cancer cell line

First 10 cell lines (id-ordered, not curated):

Cellosaurus	Name	Category	Sex
CVCL_0179	BT-474	Cancer cell line	Female
CVCL_4V65	BT474-5FU[r]	Cancer cell line	Female
CVCL_4Y08	BT-474/CMV-Luc	Cancer cell line	Female
CVCL_A2GH	LR-BT474	Cancer cell line	Female
CVCL_A4AK	BT-474 Tam2	Cancer cell line	Female
CVCL_A4CL	BT-474 Ecadherin EmGFP	Cancer cell line	Female
CVCL_AQ07	BT-474 Clone 5	Cancer cell line	Female
CVCL_AR86	BT-474 Tam1	Cancer cell line	Female
CVCL_AR96	BT-474 EEI	Cancer cell line	Female
CVCL_C9CU	BT-474-Luc2	Cancer cell line	Female

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.