MRPL47

Summary

MRPL47 (mitochondrial ribosomal protein L47, HGNC:16652) is a protein-coding gene on chromosome 3q26.33, encoding Large ribosomal subunit protein uL29m (Q9HD33). It is a selective cancer dependency (DepMap: 22.9% of cell lines).

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. This gene is immediately adjacent to the gene for BAF complex 53 kDa subunit protein a (BAF53a), in a tail-to-tail orientation. Two transcript variants encoding different protein isoforms have been identified.

Source: NCBI Gene 57129 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 48 total
• Cancer dependency (DepMap): dependent in 22.9% of screened cell lines
• MANE Select transcript: NM_020409

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:16652
Approved symbol	MRPL47
Name	mitochondrial ribosomal protein L47
Location	3q26.33
Locus type	gene with protein product
Status	Approved
Aliases	CGI-204, NCM1, uL29m
Ensembl gene	ENSG00000136522
Ensembl biotype	protein_coding
OMIM	611852
Entrez	57129

Gene structure

Transcript identifiers

Ensembl transcripts: 5 — 5 protein_coding

ENST00000259038, ENST00000392659, ENST00000476781, ENST00000937961, ENST00000937962

RefSeq mRNA: 2 — MANE Select: NM_020409 NM_020409, NM_177988

CCDS: CCDS3232, CCDS3233

Canonical transcript exons

ENST00000476781 — 7 exons

Exon	Start	End
ENSE00000924284	179592644	179592739
ENSE00000924285	179593765	179593895
ENSE00001870688	179604527	179604638
ENSE00001921076	179588285	179588995
ENSE00002285161	179602652	179602797
ENSE00003498247	179601730	179601790
ENSE00003510817	179598675	179598771

Expression profiles

Bgee: expression breadth ubiquitous, 260 present calls, max score 98.48.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 36.5464 / max 664.7939, expressed in 1810 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
45728	32.3956	1807
45729	4.1508	1578

Top tissues by expression

260 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
left ventricle myocardium	UBERON:0006566	98.48	gold quality
tibialis anterior	UBERON:0001385	98.00	gold quality
myocardium	UBERON:0002349	97.78	gold quality
heart right ventricle	UBERON:0002080	97.34	gold quality
cardiac muscle of right atrium	UBERON:0003379	96.98	gold quality
ileal mucosa	UBERON:0000331	96.58	gold quality
deltoid	UBERON:0001476	96.56	gold quality
upper arm skin	UBERON:0004263	96.31	gold quality
kidney epithelium	UBERON:0004819	96.03	gold quality
nasal cavity epithelium	UBERON:0005384	95.78	gold quality
quadriceps femoris	UBERON:0001377	95.74	gold quality
gingival epithelium	UBERON:0001949	95.48	gold quality
vastus lateralis	UBERON:0001379	95.47	gold quality
mucosa of sigmoid colon	UBERON:0004993	95.22	gold quality
vena cava	UBERON:0004087	95.16	gold quality
biceps brachii	UBERON:0001507	95.09	gold quality
colonic mucosa	UBERON:0000317	95.02	gold quality
gingiva	UBERON:0001828	95.02	gold quality
body of tongue	UBERON:0011876	94.96	gold quality
adrenal tissue	UBERON:0018303	94.89	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	94.85	gold quality
islet of Langerhans	UBERON:0000006	94.83	gold quality
sperm	CL:0000019	94.80	gold quality
adult organism	UBERON:0007023	94.80	gold quality
epithelial cell of pancreas	CL:0000083	94.66	gold quality
oral cavity	UBERON:0000167	94.36	gold quality
skeletal muscle tissue	UBERON:0001134	94.36	gold quality
muscle tissue	UBERON:0002385	94.23	gold quality
pharyngeal mucosa	UBERON:0000355	94.19	gold quality
left testis	UBERON:0004533	94.06	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	7.94

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

22 targeting MRPL47, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-340-5P	100.00	72.50	4437
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-196A-1-3P	99.99	72.15	2772
HSA-MIR-4699-3P	99.71	70.15	3142
HSA-MIR-497-3P	99.61	69.71	1990
HSA-MIR-486-5P	99.51	70.39	707
HSA-MIR-377-3P	99.37	70.18	1905
HSA-MIR-6507-3P	99.35	67.32	1059
HSA-MIR-12113	99.32	67.54	1072
HSA-MIR-877-3P	99.09	68.10	1637
HSA-MIR-4796-3P	99.08	68.38	1681
HSA-MIR-224-3P	98.91	68.42	1815
HSA-MIR-522-3P	98.91	68.56	1817
HSA-MIR-4539	98.78	67.18	888
HSA-MIR-513B-3P	98.76	68.12	1577
HSA-MIR-216B-3P	98.55	67.19	1223
HSA-MIR-3144-3P	98.15	67.34	677
HSA-MIR-4257	97.86	68.05	1190
HSA-MIR-3665	97.73	65.08	975
HSA-MIR-596	97.48	63.13	469
HSA-MIR-875-5P	96.74	66.48	579
HSA-MIR-103B	95.51	66.85	441

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 22.9% of screened cell lines.

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	mrpl47	ENSDARG00000075743
mus_musculus	Mrpl47	ENSMUSG00000037531
rattus_norvegicus	Mrpl47	ENSRNOG00000011639
drosophila_melanogaster	mRpL47	FBGN0014023
caenorhabditis_elegans	mrpl-47	WBGENE00015092

Protein

Protein identifiers

Large ribosomal subunit protein uL29m — Q9HD33 (reviewed: Q9HD33)

Alternative names: 39S ribosomal protein L47, mitochondrial, Nasopharyngeal carcinoma metastasis-related protein 1

All UniProt accessions (1): Q9HD33

UniProt curated annotations — full annotation on UniProt →

Subunit / interactions. Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.

Subcellular location. Mitochondrion.

Similarity. Belongs to the universal ribosomal protein uL29 family.

Isoforms (3)

UniProt ID	Names	Canonical?
Q9HD33-1	1	yes
Q9HD33-2	2
Q9HD33-3	3

RefSeq proteins (2): NP_065142, NP_817125 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR010729	Ribosomal_uL29_mit	Family
IPR038340	MRP-L47_sf	Homologous_superfamily

Pfam: PF06984

UniProt features (22 total): helix 8, strand 5, splice variant 2, sequence variant 2, transit peptide 1, chain 1, turn 1, modified residue 1, sequence conflict 1

Structure

Experimental structures (PDB)

86 structures, top 30 by resolution.

PDB	Method	Resolution (Å)
7OF0	ELECTRON MICROSCOPY	2.2
7QI4	ELECTRON MICROSCOPY	2.21
8RRI	ELECTRON MICROSCOPY	2.4
8QU5	ELECTRON MICROSCOPY	2.42
9OLF	ELECTRON MICROSCOPY	2.46
7OF7	ELECTRON MICROSCOPY	2.5
7PO4	ELECTRON MICROSCOPY	2.56
6ZM6	ELECTRON MICROSCOPY	2.59
7O9M	ELECTRON MICROSCOPY	2.6
7OF6	ELECTRON MICROSCOPY	2.6
9CN3	ELECTRON MICROSCOPY	2.62
7QI5	ELECTRON MICROSCOPY	2.63
7OF2	ELECTRON MICROSCOPY	2.7
7OF3	ELECTRON MICROSCOPY	2.7
7OF4	ELECTRON MICROSCOPY	2.7
8QU1	ELECTRON MICROSCOPY	2.74
9PR4	ELECTRON MICROSCOPY	2.77
9PRA	ELECTRON MICROSCOPY	2.83
8ANY	ELECTRON MICROSCOPY	2.85
6ZM5	ELECTRON MICROSCOPY	2.89
7QH7	ELECTRON MICROSCOPY	2.89
7ODR	ELECTRON MICROSCOPY	2.9
7OF5	ELECTRON MICROSCOPY	2.9
8K2A	ELECTRON MICROSCOPY	2.9
8OIT	ELECTRON MICROSCOPY	2.9
9PGL	ELECTRON MICROSCOPY	2.9
9PGF	ELECTRON MICROSCOPY	2.93
6VMI	ELECTRON MICROSCOPY	2.96
6VLZ	ELECTRON MICROSCOPY	2.97
7QI6	ELECTRON MICROSCOPY	2.98

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9HD33-F1	84.04	0.72

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 144

Function

Pathways and Gene Ontology

Reactome pathways

7 pathways

ID	Pathway
R-HSA-5368286	Mitochondrial translation initiation
R-HSA-5389840	Mitochondrial translation elongation
R-HSA-5419276	Mitochondrial translation termination
R-HSA-9937383	Mitochondrial ribosome-associated quality control
R-HSA-392499	Metabolism of proteins
R-HSA-5368287	Mitochondrial translation
R-HSA-72766	Translation

MSigDB gene sets: 116 (showing top): RODRIGUES_THYROID_CARCINOMA_ANAPLASTIC_UP, RODRIGUES_THYROID_CARCINOMA_POORLY_DIFFERENTIATED_UP, MODULE_255, GOBP_MITOCHONDRIAL_TRANSLATION, MODULE_317, TGACCTY_ERR1_Q2, chr3q26, GOBP_TRANSLATION, WEI_MYCN_TARGETS_WITH_E_BOX, MILI_PSEUDOPODIA_HAPTOTAXIS_UP, GOMF_STRUCTURAL_CONSTITUENT_OF_RIBOSOME, GOCC_MITOCHONDRIAL_ENVELOPE, AACTTT_UNKNOWN, DING_LUNG_CANCER_EXPRESSION_BY_COPY_NUMBER, FOXJ2_02

GO Biological Process (2): mitochondrial translation (GO:0032543), translation (GO:0006412)

GO Molecular Function (1): structural constituent of ribosome (GO:0003735)

GO Cellular Component (6): mitochondrion (GO:0005739), mitochondrial inner membrane (GO:0005743), mitochondrial large ribosomal subunit (GO:0005762), mitochondrial ribosome (GO:0005761), ribosome (GO:0005840), ribonucleoprotein complex (GO:1990904)

Reactome top-level categories

Rollup of top-3 pathways:

Category	Pathways
Mitochondrial translation	4
Translation	1
Metabolism of proteins	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
mitochondrion	1
translation	1
mitochondrial gene expression	1
peptidyltransferase activity	1
translational initiation	1
translational elongation	1
translational termination	1
macromolecule biosynthetic process	1
protein metabolic process	1
protein biosynthetic process	1
structural molecule activity	1
ribosome	1
cytoplasm	1
intracellular membrane-bounded organelle	1
organelle inner membrane	1
mitochondrial membrane	1
organellar large ribosomal subunit	1
mitochondrial ribosome	1
mitochondrial protein-containing complex	1
organellar ribosome	1
mitochondrial matrix	1
intracellular membraneless organelle	1
protein-containing complex	1

Protein interactions and networks

STRING

2684 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
MRPL47	MRPL9	Q9BYD2	661
MRPL47	MRPS33	Q9Y291	644
MRPL47	CHCHD1	Q96BP2	625
MRPL47	MRPL4	Q9BYD3	623
MRPL47	MRPL20	Q9BYC9	619
MRPL47	MRPL23	Q16540	606
MRPL47	MRPL12	P52815	587
MRPL47	MRPL33	O75394	529
MRPL47	MRPS18B	Q9Y676	512
MRPL47	MRPL42	Q9Y6G3	494
MRPL47	MRPL53	Q96EL3	491
MRPL47	MRPS5	P82675	491
MRPL47	MRPL36	Q9P0J6	488
MRPL47	MRPL54	Q6P161	486
MRPL47	MRPL50	Q8N5N7	483

IntAct

131 interactions, top by confidence:

A	B	Type	Score
MRPL37	HSPD1	psi-mi:“MI:0914”(association)	0.710
MRPS30	GTPBP10	psi-mi:“MI:0914”(association)	0.640
LIN28A	IGF2BP3	psi-mi:“MI:0914”(association)	0.640
NP	KPNA6	psi-mi:“MI:0914”(association)	0.550
HSPD1	MRPL47	psi-mi:“MI:0915”(physical association)	0.540
MRPL50	GTPBP10	psi-mi:“MI:0914”(association)	0.530
MRPL2	GTPBP10	psi-mi:“MI:0914”(association)	0.530
ZNF324B	ZNF316	psi-mi:“MI:0914”(association)	0.530
PDGFB	DKC1	psi-mi:“MI:0914”(association)	0.530
MRPL13	GTPBP10	psi-mi:“MI:0914”(association)	0.530
MRPL18	GTPBP10	psi-mi:“MI:0914”(association)	0.530
ABT1	ZNF316	psi-mi:“MI:0914”(association)	0.530
MRPL23	BCKDHA	psi-mi:“MI:0914”(association)	0.530
MRPL27	MRPL33	psi-mi:“MI:0914”(association)	0.530
NDUFAB1	MIEF1	psi-mi:“MI:0915”(physical association)	0.490
MRPL47	PDIA3	psi-mi:“MI:0915”(physical association)	0.400
Ybx1	MRPS18B	psi-mi:“MI:0915”(physical association)	0.400
NP	KPNA6	psi-mi:“MI:0914”(association)	0.350
NP	TRIM66	psi-mi:“MI:0914”(association)	0.350
		psi-mi:“MI:0914”(association)	0.350
ESR1	ESYT2	psi-mi:“MI:0914”(association)	0.350
LRRK2		psi-mi:“MI:0914”(association)	0.350
ATAD3B	GTPBP10	psi-mi:“MI:0914”(association)	0.350

BioGRID (373): MRPL47 (Affinity Capture-MS), MRPL47 (Affinity Capture-MS), MRPL47 (Affinity Capture-MS), MRPL47 (Affinity Capture-MS), MRPL47 (Affinity Capture-MS), MRPL47 (Affinity Capture-MS), MRPL47 (Affinity Capture-MS), MRPL47 (Affinity Capture-MS), MRPL47 (Affinity Capture-MS), MRPL47 (Affinity Capture-MS), MRPL47 (Affinity Capture-MS), MRPL47 (Affinity Capture-MS), MRPL12 (Affinity Capture-MS), MRPL45 (Affinity Capture-MS), MRPL46 (Affinity Capture-MS)

ESM2 similar proteins: A1C6F8, A1DH31, A1Z897, A2QCC7, A3KP74, A4RHR8, A6RDX3, A6SLT9, A7EWR0, B0XK69, B3MI37, B3N6D9, B3N8S9, B4GDB3, B4GG58, B4HMQ1, B4HRL4, B4KN44, B4KPG8, B4LKE5, B4MRE7, B4N665, B4NXN5, B4P2P8, B4QFP7, B4QID8, B5DZ31, B5E0U2, P0CR32, P0CR33, P36527, P87232, Q08DT6, Q0CXX1, Q0U6J9, Q178L7, Q1DNY5, Q1K5G1, Q1K6U7, Q2H080

Diamond homologs: A1C6F8, A1DH31, A2QCC7, A3LYY9, A4RHR8, A5DH98, A5E713, A6RDX3, A6SLT9, A7A1V9, A7EWR0, A7TNQ2, P36517, P87232, Q08DT6, Q0CXX1, Q0U6J9, Q1DNY5, Q2H080, Q4X156, Q59RP7, Q5B0N3, Q6BQK3, Q6CF20, Q6CWC4, Q6FK61, Q756Y8, Q7S910, Q8K2Y7, Q9HD33

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
MRPL47	“form complex”	“39S mitochondrial large ribosomal subunit”	binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 130 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Mitochondrial ribosome-associated quality control	33	40.5×	2e-43
Mitochondrial translation	29	39.9×	3e-38
Mitochondrial translation initiation	31	39.3×	1e-40
Mitochondrial translation elongation	31	39.3×	1e-40
Mitochondrial translation termination	31	34.0×	2e-38
Translation	32	19.9×	1e-31
Peptide chain elongation	9	11.4×	4e-06
Viral mRNA Translation	9	11.4×	4e-06

GO biological processes:

GO term	Partners	Fold	FDR
mitochondrial translation	31	46.4×	1e-41
translation	26	23.0×	6e-26
cytoplasmic translation	10	16.0×	2e-07
negative regulation of translation	7	11.8×	4e-04
ribosomal small subunit biogenesis	6	11.8×	1e-03
regulation of alternative mRNA splicing, via spliceosome	5	10.5×	9e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

48 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	39
Likely benign	1
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1351 predictions. Top by Δscore:

Variant	Effect	Δscore
3:179583348:CCTA:C	acceptor_loss	1.0000
3:179583349:CTAG:C	acceptor_loss	1.0000
3:179583350:TAG:T	acceptor_loss	1.0000
3:179583351:A:AG	acceptor_gain	1.0000
3:179583351:AG:A	acceptor_gain	1.0000
3:179583351:AGGGT:A	acceptor_loss	1.0000
3:179583352:G:GG	acceptor_gain	1.0000
3:179583352:GG:G	acceptor_gain	1.0000
3:179583352:GGGT:G	acceptor_gain	1.0000
3:179583444:CTCCA:C	donor_gain	1.0000
3:179583445:TCCA:T	donor_gain	1.0000
3:179583446:CCA:C	donor_gain	1.0000
3:179583447:CA:C	donor_gain	1.0000
3:179583448:AG:A	donor_loss	1.0000
3:179583449:G:GG	donor_gain	1.0000
3:179583450:TA:T	donor_loss	1.0000
3:179583451:AA:A	donor_loss	1.0000
3:179586448:G:GT	donor_gain	1.0000
3:179586544:A:AG	acceptor_gain	1.0000
3:179586545:G:GG	acceptor_gain	1.0000
3:179586545:GA:G	acceptor_gain	1.0000
3:179586545:GAGT:G	acceptor_gain	1.0000
3:179587926:ACAG:A	acceptor_gain	1.0000
3:179587928:AG:A	acceptor_gain	1.0000
3:179587929:GG:G	acceptor_gain	1.0000
3:179588996:C:CC	acceptor_gain	1.0000
3:179593761:ATAC:A	donor_loss	1.0000
3:179593762:TACC:T	donor_loss	1.0000
3:179593763:A:AC	donor_gain	1.0000
3:179593763:A:AG	donor_loss	1.0000

AlphaMissense

1624 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
3:179601782:A:G	W85R	0.995
3:179601782:A:T	W85R	0.995
3:179593851:T:A	R149S	0.993
3:179593851:T:G	R149S	0.993
3:179601756:T:A	K93N	0.993
3:179601756:T:G	K93N	0.993
3:179598756:T:A	K107N	0.992
3:179598756:T:G	K107N	0.992
3:179601780:C:A	W85C	0.992
3:179601780:C:G	W85C	0.992
3:179593844:C:G	A152P	0.991
3:179598693:A:C	S128R	0.991
3:179598693:A:T	S128R	0.991
3:179598695:T:G	S128R	0.991
3:179598722:C:G	A119P	0.990
3:179598760:A:G	L106P	0.990
3:179601766:A:G	L90P	0.990
3:179593886:A:G	S138P	0.988
3:179598747:G:C	N110K	0.988
3:179598747:G:T	N110K	0.988
3:179601731:A:G	W102R	0.988
3:179601731:A:T	W102R	0.988
3:179593885:G:A	S138F	0.986
3:179598733:A:G	L115P	0.986
3:179598742:A:G	L112P	0.986
3:179601762:C:A	R91S	0.986
3:179601762:C:G	R91S	0.986
3:179602695:A:C	F67L	0.986
3:179602695:A:T	F67L	0.986
3:179602697:A:G	F67L	0.986

dbSNP variants (sampled 300 via entrez): RS1000484349 (3:179596553 C>T), RS1000577197 (3:179599666 G>T), RS1000631110 (3:179592423 T>C), RS1000642297 (3:179605703 A>G), RS1000732963 (3:179605335 AAGACAGGTAATATGT>A), RS1000869720 (3:179591543 T>C), RS1000902589 (3:179587815 A>G), RS1001077561 (3:179598098 C>T), RS1001210667 (3:179605477 GT>G), RS1001226889 (3:179604176 A>T), RS1001290658 (3:179603727 C>A,T), RS1001530382 (3:179597733 G>A,C), RS1001634194 (3:179593312 C>G), RS1001861685 (3:179606162 C>T), RS1001876677 (3:179592941 G>A)

Disease associations

OMIM: gene MIM:611852 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

PharmGKB variants

1 variants.

Variant	Genes	Level	Score	#Clin annots	Drugs
rs10513762	MRPL47		0.00	0

CTD chemical–gene interactions

30 total (human), top 30 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol S	affects expression, increases expression	2
Tobacco Smoke Pollution	increases expression	2
dicrotophos	decreases expression	1
bisphenol A	decreases expression	1
arsenite	affects binding, increases reaction	1
mono-(2-ethylhexyl)phthalate	decreases expression	1
sodium arsenite	increases abundance, increases expression	1
gossypol acetic acid	decreases expression	1
cylindrospermopsin	increases expression	1
CGP 52608	affects binding, increases reaction	1
corosolic acid	decreases expression	1
ICG 001	decreases expression	1
abrine	increases expression	1
Resveratrol	affects cotreatment, decreases expression, increases expression	1
Acetaminophen	affects cotreatment, decreases expression	1
Arsenic	increases abundance, increases expression	1
Diuron	decreases expression	1
Ivermectin	decreases expression	1
Lead	affects expression	1
Lipopolysaccharides	affects cotreatment, decreases expression	1
Oligomycins	affects response to substance, increases expression	1
Plant Extracts	affects cotreatment, decreases expression, increases expression	1
Quercetin	decreases expression	1
Ribonucleotides	affects binding	1
Rotenone	decreases expression	1
Urethane	decreases expression	1
Lithium Chloride	decreases expression	1
Lactic Acid	decreases expression	1
Acrylamide	increases expression	1
Particulate Matter	decreases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.