MRPL48

Summary

MRPL48 (mitochondrial ribosomal protein L48, HGNC:16653) is a protein-coding gene on chromosome 11q13.4, encoding Large ribosomal subunit protein mL48 (Q96GC5). It is a selective cancer dependency (DepMap: 15.1% of cell lines).

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. A pseudogene corresponding to this gene is found on chromosome 6p. Several transcript variants, some protein-coding and some non-protein coding, have been found for this gene.

Source: NCBI Gene 51642 — RefSeq curated summary.

At a glance

• GWAS associations: 3
• Clinical variants (ClinVar): 40 total
• Cancer dependency (DepMap): dependent in 15.1% of screened cell lines
• MANE Select transcript: NM_016055

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:16653
Approved symbol	MRPL48
Name	mitochondrial ribosomal protein L48
Location	11q13.4
Locus type	gene with protein product
Status	Approved
Aliases	CGI-118, mL48
Ensembl gene	ENSG00000175581
Ensembl biotype	protein_coding
OMIM	611853
Entrez	51642

Gene structure

Transcript identifiers

Ensembl transcripts: 17 — 11 protein_coding, 5 nonsense_mediated_decay, 1 retained_intron

ENST00000310614, ENST00000314282, ENST00000398483, ENST00000411840, ENST00000497094, ENST00000508278, ENST00000535277, ENST00000537007, ENST00000540162, ENST00000542303, ENST00000543058, ENST00000543374, ENST00000544140, ENST00000544819, ENST00000889271, ENST00000930868, ENST00000930869

RefSeq mRNA: 4 — MANE Select: NM_016055 NM_001318498, NM_001318499, NM_001318500, NM_016055

CCDS: CCDS44676, CCDS81594

Canonical transcript exons

ENST00000310614 — 8 exons

Exon	Start	End
ENSE00002304630	73864296	73865133
ENSE00002308823	73787874	73787992
ENSE00003537545	73808313	73808350
ENSE00003541477	73805027	73805079
ENSE00003562003	73825708	73825796
ENSE00003591357	73844807	73844976
ENSE00003600762	73863172	73863261
ENSE00003671203	73859907	73860009

Expression profiles

Bgee: expression breadth ubiquitous, 287 present calls, max score 95.79.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 29.0974 / max 354.5567, expressed in 1809 samples.

FANTOM5 promoters (2 alternative TSS)

Promoter ID	TPM avg	Samples expressed
115828	28.5547	1809
115829	0.5426	314

Top tissues by expression

291 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
C1 segment of cervical spinal cord	UBERON:0006469	95.79	gold quality
spinal cord	UBERON:0002240	94.73	gold quality
hindlimb stylopod muscle	UBERON:0004252	94.46	gold quality
mucosa of transverse colon	UBERON:0004991	94.46	gold quality
ganglionic eminence	UBERON:0004023	94.30	gold quality
cortical plate	UBERON:0005343	94.14	gold quality
corpus callosum	UBERON:0002336	93.75	gold quality
pons	UBERON:0000988	93.73	gold quality
prefrontal cortex	UBERON:0000451	93.65	gold quality
cerebellar cortex	UBERON:0002129	92.88	gold quality
cerebellar hemisphere	UBERON:0002245	92.86	gold quality
putamen	UBERON:0001874	92.57	gold quality
right hemisphere of cerebellum	UBERON:0014890	92.36	gold quality
islet of Langerhans	UBERON:0000006	92.21	gold quality
caudate nucleus	UBERON:0001873	92.20	gold quality
nucleus accumbens	UBERON:0001882	92.16	gold quality
ventricular zone	UBERON:0003053	92.15	gold quality
anterior cingulate cortex	UBERON:0009835	92.08	gold quality
cingulate cortex	UBERON:0003027	92.00	gold quality
amygdala	UBERON:0001876	91.97	gold quality
inferior vagus X ganglion	UBERON:0005363	91.96	gold quality
cerebellum	UBERON:0002037	91.95	gold quality
granulocyte	CL:0000094	91.87	gold quality
right frontal lobe	UBERON:0002810	91.85	gold quality
body of pancreas	UBERON:0001150	91.56	gold quality
Brodmann (1909) area 9	UBERON:0013540	91.50	gold quality
rectum	UBERON:0001052	91.48	gold quality
apex of heart	UBERON:0002098	91.46	gold quality
hypothalamus	UBERON:0001898	91.41	gold quality
right adrenal gland	UBERON:0001233	91.39	gold quality

Single-cell (SCXA)

Detected in 4 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	yes	6.59
E-MTAB-7606	no	394.22
E-MTAB-6058	no	183.55
E-CURD-112	no	2.62

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

10 targeting MRPL48, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-1184	99.99	68.19	1458
HSA-MIR-96-5P	99.95	72.80	2140
HSA-MIR-5004-5P	99.68	66.63	1294
HSA-MIR-10394-5P	99.65	66.83	1852
HSA-MIR-1205	99.65	66.76	1826
HSA-MIR-942-5P	99.41	68.40	1977
HSA-MIR-4777-3P	99.15	68.92	626
HSA-MIR-892B	98.00	67.11	821
HSA-MIR-1225-5P	96.76	66.85	417
HSA-MIR-4680-5P	96.43	67.15	893

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 15.1% of screened cell lines.

Literature-anchored findings (GeneRIF, showing 1)

• MRPL48 is a novel prognostic and predictive biomarker of hepatocellular carcinoma. (PMID:38093387)

Cross-species orthologs

5 orthologs

Organism	Symbol	Gene ID
danio_rerio	mrpl48	ENSDARG00000035167
mus_musculus	Mrpl48	ENSMUSG00000030706
rattus_norvegicus	Mrpl48	ENSRNOG00000018042
drosophila_melanogaster	mRpL48	FBGN0031357
caenorhabditis_elegans		WBGENE00016989

Protein

Protein identifiers

Large ribosomal subunit protein mL48 — Q96GC5 (reviewed: Q96GC5)

Alternative names: 39S ribosomal protein L48, mitochondrial

All UniProt accessions (10): Q96GC5, A0A140TA24, F5GWB4, F5GZH8, F5H1L2, F5H471, F5H4A2, F5H702, F5H717, F5H8D0

UniProt curated annotations — full annotation on UniProt →

Subunit / interactions. Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins. mL48 is located at the central protuberance. Interacts with OXA1L.

Subcellular location. Mitochondrion.

Similarity. Belongs to the mitochondrion-specific ribosomal protein mL48 family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q96GC5-1	1	yes
Q96GC5-3	2

RefSeq proteins (4): NP_001305427, NP_001305428, NP_001305429, NP_057139* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR027486	Ribosomal_uS10_dom	Domain
IPR027487	Ribosomal_mL48	Family
IPR036838	Ribosomal_uS10_dom_sf	Homologous_superfamily

Pfam: PF00338

UniProt features (14 total): strand 5, helix 3, transit peptide 1, chain 1, modified residue 1, splice variant 1, sequence variant 1, turn 1

Structure

Experimental structures (PDB)

83 structures, top 30 by resolution.

PDB	Method	Resolution (Å)
7OF0	ELECTRON MICROSCOPY	2.2
7QI4	ELECTRON MICROSCOPY	2.21
8RRI	ELECTRON MICROSCOPY	2.4
8QU5	ELECTRON MICROSCOPY	2.42
9OLF	ELECTRON MICROSCOPY	2.46
7OF7	ELECTRON MICROSCOPY	2.5
7PO4	ELECTRON MICROSCOPY	2.56
6ZM6	ELECTRON MICROSCOPY	2.59
7O9M	ELECTRON MICROSCOPY	2.6
7OF6	ELECTRON MICROSCOPY	2.6
9CN3	ELECTRON MICROSCOPY	2.62
7QI5	ELECTRON MICROSCOPY	2.63
7OF2	ELECTRON MICROSCOPY	2.7
7OF3	ELECTRON MICROSCOPY	2.7
7OF4	ELECTRON MICROSCOPY	2.7
9PR4	ELECTRON MICROSCOPY	2.77
9PRA	ELECTRON MICROSCOPY	2.83
8ANY	ELECTRON MICROSCOPY	2.85
6ZM5	ELECTRON MICROSCOPY	2.89
7QH7	ELECTRON MICROSCOPY	2.89
7ODR	ELECTRON MICROSCOPY	2.9
7OF5	ELECTRON MICROSCOPY	2.9
8K2A	ELECTRON MICROSCOPY	2.9
8OIT	ELECTRON MICROSCOPY	2.9
9PGL	ELECTRON MICROSCOPY	2.9
9PGF	ELECTRON MICROSCOPY	2.93
6VMI	ELECTRON MICROSCOPY	2.96
6VLZ	ELECTRON MICROSCOPY	2.97
7QI6	ELECTRON MICROSCOPY	2.98
9PSM	ELECTRON MICROSCOPY	2.98

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q96GC5-F1	76.45	0.39

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 199

Function

Pathways and Gene Ontology

Reactome pathways

7 pathways

ID	Pathway
R-HSA-5368286	Mitochondrial translation initiation
R-HSA-5389840	Mitochondrial translation elongation
R-HSA-5419276	Mitochondrial translation termination
R-HSA-9937383	Mitochondrial ribosome-associated quality control
R-HSA-392499	Metabolism of proteins
R-HSA-5368287	Mitochondrial translation
R-HSA-72766	Translation

MSigDB gene sets: 159 (showing top): HORIUCHI_WTAP_TARGETS_DN, PAL_PRMT5_TARGETS_UP, GRAESSMANN_APOPTOSIS_BY_SERUM_DEPRIVATION_DN, GOBP_MITOCHONDRIAL_TRANSLATION, chr11q13, GOBP_TRANSLATION, JAZAG_TGFB1_SIGNALING_VIA_SMAD4_UP, GOCC_MITOCHONDRIAL_ENVELOPE, GARCIA_TARGETS_OF_FLI1_AND_DAX1_DN, AFP1_Q6, LASTOWSKA_NEUROBLASTOMA_COPY_NUMBER_DN, AACTGGA_MIR145, NAKAMURA_TUMOR_ZONE_PERIPHERAL_VS_CENTRAL_UP, GOCC_LARGE_RIBOSOMAL_SUBUNIT, GOCC_RIBOSOME

GO Biological Process (1): mitochondrial translation (GO:0032543)

GO Molecular Function (1): protein binding (GO:0005515)

GO Cellular Component (6): mitochondrion (GO:0005739), mitochondrial inner membrane (GO:0005743), mitochondrial ribosome (GO:0005761), mitochondrial large ribosomal subunit (GO:0005762), ribosome (GO:0005840), ribonucleoprotein complex (GO:1990904)

Reactome top-level categories

Rollup of top-3 pathways:

Category	Pathways
Mitochondrial translation	4
Translation	1
Metabolism of proteins	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
mitochondrion	1
translation	1
mitochondrial gene expression	1
binding	1
cytoplasm	1
intracellular membrane-bounded organelle	1
organelle inner membrane	1
mitochondrial membrane	1
organellar ribosome	1
mitochondrial matrix	1
organellar large ribosomal subunit	1
mitochondrial ribosome	1
mitochondrial protein-containing complex	1
intracellular membraneless organelle	1
protein-containing complex	1

Protein interactions and networks

STRING

1488 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
MRPL48	MRPL51	Q4U2R6	710
MRPL48	MRPL45	Q9BRJ2	646
MRPL48	MRPL49	Q13405	618
MRPL48	MRPL20	Q9BYC9	596
MRPL48	MRPL4	Q9BYD3	585
MRPL48	DAP3	P51398	575
MRPL48	MRPS18B	Q9Y676	558
MRPL48	ELOF1	P60002	547
MRPL48	MICOS10	Q5TGZ0	543
MRPL48	MRPL40	Q9NQ50	540
MRPL48	ERAL1	O75616	536
MRPL48	PTCD3	Q96EY7	519
MRPL48	MRPL13	Q9BYD1	505
MRPL48	MRPS22	P82650	494
MRPL48	MPV17L2	Q567V2	489

IntAct

131 interactions, top by confidence:

A	B	Type	Score
YBX1	HNRNPR	psi-mi:“MI:0914”(association)	0.770
MRPS30	GTPBP10	psi-mi:“MI:0914”(association)	0.640
IGF2BP1	IGF2BP3	psi-mi:“MI:0914”(association)	0.640
LIN28A	IGF2BP3	psi-mi:“MI:0914”(association)	0.640
NP	KPNA6	psi-mi:“MI:0914”(association)	0.550
KSR2	POLR3A	psi-mi:“MI:0914”(association)	0.530
MRPL50	GTPBP10	psi-mi:“MI:0914”(association)	0.530
RPL18	NOP56	psi-mi:“MI:0914”(association)	0.530
MRPL46	NDUFAB1	psi-mi:“MI:0914”(association)	0.530
MRPL10	ZZEF1	psi-mi:“MI:0914”(association)	0.530
MRPL42	GATC	psi-mi:“MI:0914”(association)	0.530
MRPL41	MRPL3	psi-mi:“MI:0914”(association)	0.530
MRPL2	GTPBP10	psi-mi:“MI:0914”(association)	0.530
MRPL46	MRPL55	psi-mi:“MI:0914”(association)	0.530
MRPL13	GTPBP10	psi-mi:“MI:0914”(association)	0.530
MRPL18	GTPBP10	psi-mi:“MI:0914”(association)	0.530
MRPL27	MRPL33	psi-mi:“MI:0914”(association)	0.530
NDUFAB1	MIEF1	psi-mi:“MI:0915”(physical association)	0.490
MRPL48		psi-mi:“MI:0915”(physical association)	0.370
Papss1	TCOF1	psi-mi:“MI:0914”(association)	0.350
Shoc2	GABPB1	psi-mi:“MI:0914”(association)	0.350
Rpl35	RPS6	psi-mi:“MI:0914”(association)	0.350
Kifc5b	KPNA3	psi-mi:“MI:0914”(association)	0.350
Cbx1		psi-mi:“MI:0914”(association)	0.350

BioGRID (204): MRPL48 (Affinity Capture-MS), MRPL48 (Affinity Capture-MS), MRPL48 (Affinity Capture-MS), MRPL48 (Affinity Capture-MS), MRPL48 (Affinity Capture-MS), MRPL48 (Affinity Capture-MS), MRPL48 (Affinity Capture-MS), MRPL48 (Affinity Capture-MS), MRPL48 (Affinity Capture-MS), MRPL48 (Affinity Capture-MS), MRPL48 (Co-fractionation), MRPL55 (Co-fractionation), SDHB (Co-fractionation), MRPL48 (Affinity Capture-MS), MRPL48 (Affinity Capture-MS)

ESM2 similar proteins: A6ZPE1, A7TQZ1, B3LJX0, B4JWR9, C4R0B5, C4R8C9, C4XW03, C5DKM2, C5DYE7, C5E3P3, C6Y4D2, C7GNV5, C8ZH56, O13744, O13882, O14006, O60186, O74356, O74464, O94150, P21560, P25642, P36520, P42797, P42847, P53266, Q08774, Q09142, Q09705, Q09759, Q10234, Q10325, Q2YDI5, Q54WP3, Q6BIJ5, Q6BMB3, Q6CJ65, Q6CJB5, Q6FL25, Q6FL71

Diamond homologs: Q2YDI5, Q8JZS9, Q96GC5

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
MRPL48	“form complex”	“39S mitochondrial large ribosomal subunit”	binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 128 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Mitochondrial ribosome-associated quality control	34	45.4×	5e-47
Mitochondrial translation	29	43.4×	1e-39
Mitochondrial translation initiation	31	42.8×	5e-42
Mitochondrial translation elongation	31	42.8×	5e-42
Mitochondrial translation termination	31	37.0×	7e-40
Translation	33	22.3×	1e-34
Peptide chain elongation	13	17.9×	8e-12
Viral mRNA Translation	13	17.9×	8e-12

GO biological processes:

GO term	Partners	Fold	FDR
mitochondrial translation	35	54.3×	2e-50
mitochondrial large ribosomal subunit assembly	5	44.2×	7e-06
translation	30	27.5×	5e-33
cytoplasmic translation	14	23.1×	2e-13
negative regulation of translation	11	19.2×	1e-09

Disease & clinical

Clinical variants and AI predictions

ClinVar

40 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	24
Likely benign	0
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

1438 predictions. Top by Δscore:

Variant	Effect	Δscore
11:73825766:A:T	donor_gain	1.0000
11:73844793:T:TA	acceptor_gain	1.0000
11:73844802:TTCA:T	acceptor_loss	1.0000
11:73844803:TCAGC:T	acceptor_loss	1.0000
11:73844804:CAGCC:C	acceptor_loss	1.0000
11:73844805:A:AG	acceptor_gain	1.0000
11:73844806:G:GA	acceptor_gain	1.0000
11:73844806:GC:G	acceptor_gain	1.0000
11:73844806:GCC:G	acceptor_gain	1.0000
11:73844806:GCCC:G	acceptor_gain	1.0000
11:73844806:GCCCA:G	acceptor_gain	1.0000
11:73844929:G:GG	donor_gain	1.0000
11:73844973:A:T	donor_gain	1.0000
11:73844976:GGTA:G	donor_loss	1.0000
11:73844977:G:GA	donor_loss	1.0000
11:73859905:A:AG	acceptor_gain	1.0000
11:73859906:G:GG	acceptor_gain	1.0000
11:73864291:CTTAG:C	acceptor_loss	1.0000
11:73864294:A:AG	acceptor_gain	1.0000
11:73864294:AGCAC:A	acceptor_loss	1.0000
11:73864295:G:GA	acceptor_gain	1.0000
11:73864295:GC:G	acceptor_gain	1.0000
11:73864295:GCA:G	acceptor_gain	1.0000
11:73864295:GCAC:G	acceptor_gain	1.0000
11:73864295:GCACA:G	acceptor_gain	1.0000
11:73823347:G:GT	donor_gain	0.9900
11:73825702:TTTTA:T	acceptor_loss	0.9900
11:73825703:TTTAG:T	acceptor_loss	0.9900
11:73825704:TTAG:T	acceptor_loss	0.9900
11:73825705:TAGGT:T	acceptor_loss	0.9900

AlphaMissense

1376 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
11:73860005:T:A	V157D	0.984
11:73859999:G:C	R155P	0.982
11:73844945:T:C	C114R	0.981
11:73844947:C:G	C114W	0.968
11:73844943:T:C	L113P	0.966
11:73844975:A:C	S124R	0.966
11:73859907:T:A	S124R	0.966
11:73859907:T:G	S124R	0.966
11:73844934:T:A	V110D	0.963
11:73864328:A:C	K199N	0.963
11:73864328:A:T	K199N	0.963
11:73844889:T:C	L95P	0.958
11:73844946:G:A	C114Y	0.956
11:73863242:T:A	V182D	0.954
11:73864321:G:C	R197P	0.954
11:73859912:C:A	A126E	0.952
11:73844924:G:C	A107P	0.951
11:73844881:T:A	N92K	0.947
11:73844881:T:G	N92K	0.947
11:73844894:G:C	A97P	0.947
11:73860008:A:C	Q158P	0.946
11:73863238:G:A	G181R	0.942
11:73863238:G:C	G181R	0.942
11:73859984:T:C	L150P	0.938
11:73844883:T:A	I93N	0.933
11:73844895:C:A	A97E	0.932
11:73844967:T:A	V121D	0.927
11:73863173:T:A	I159N	0.927
11:73859992:C:G	H153D	0.926
11:73864320:C:G	R197G	0.926

dbSNP variants (sampled 300 via entrez): RS1000063933 (11:73837878 C>T), RS1000064498 (11:73827277 G>A,C), RS1000141840 (11:73787124 T>C), RS1000148895 (11:73853157 A>C,G), RS1000180415 (11:73852873 A>C), RS1000210691 (11:73796857 G>A), RS1000220801 (11:73844677 G>A), RS1000233101 (11:73808163 C>G,T), RS1000242111 (11:73794227 TCTAA>T), RS1000242922 (11:73799490 G>A), RS1000259462 (11:73845963 G>A), RS1000289959 (11:73806421 G>A,T), RS1000322032 (11:73824480 G>T), RS1000331239 (11:73851373 T>TA), RS1000341987 (11:73806170 T>C)

Disease associations

OMIM: gene MIM:611853 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

3 associations (top):

Study	Trait	p-value
GCST001762_405	Obesity-related traits	4.000000e-06
GCST005231_56	Major depressive disorder	2.000000e-07
GCST005760_4	Dimensional psychopathology (Cognitive)	2.000000e-07

EFO canonical traits (2, from GWAS)

EFO ID	Trait name
EFO:0003939	energy intake
EFO:0009098	cognitive domain measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

23 total (human), top 23 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Air Pollutants	affects expression, increases abundance, decreases expression	2
bisphenol F	increases expression, affects cotreatment	1
dicrotophos	decreases expression	1
arsenite	affects binding, increases reaction	1
sodium arsenite	affects cotreatment, increases abundance, increases expression	1
di-n-butylphosphoric acid	affects expression	1
perfluorooctane sulfonic acid	increases expression	1
2-palmitoylglycerol	increases expression	1
ICG 001	decreases expression	1
bisphenol B	increases expression	1
4-(4-((5-(4,5-dimethyl-2-nitrophenyl)-2-furanyl)methylene)-4,5-dihydro-3-methyl-5-oxo-1H-pyrazol-1-yl)benzoic acid	decreases expression	1
Acetaminophen	decreases expression	1
Arsenic	affects cotreatment, increases abundance, increases expression	1
Benzo(a)pyrene	affects methylation	1
Dexamethasone	affects cotreatment, increases expression	1
Indomethacin	affects cotreatment, increases expression	1
Ozone	affects expression, increases abundance	1
Ribonucleotides	affects binding	1
Tretinoin	decreases expression	1
1-Methyl-3-isobutylxanthine	affects cotreatment, increases expression	1
Antirheumatic Agents	increases expression	1
tert-Butylhydroperoxide	decreases expression	1
Particulate Matter	decreases expression, increases abundance	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.