MRPL52

Summary

MRPL52 (mitochondrial ribosomal protein L52, HGNC:16655) is a protein-coding gene on chromosome 14q11.2, encoding Large ribosomal subunit protein mL52 (Q86TS9).

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein which has no bacterial homolog. Multiple transcript variants encoding different protein isoforms were identified through sequence analysis.

Source: NCBI Gene 122704 — RefSeq curated summary.

At a glance

• GWAS associations: 1
• Clinical variants (ClinVar): 34 total
• MANE Select transcript: NM_180982

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:16655
Approved symbol	MRPL52
Name	mitochondrial ribosomal protein L52
Location	14q11.2
Locus type	gene with protein product
Status	Approved
Aliases	mL52
Ensembl gene	ENSG00000172590
Ensembl biotype	protein_coding
OMIM	611856
Entrez	122704

Gene structure

Transcript identifiers

Ensembl transcripts: 18 — 11 protein_coding, 4 retained_intron, 3 protein_coding_CDS_not_defined

ENST00000311892, ENST00000355151, ENST00000397496, ENST00000397505, ENST00000432849, ENST00000461594, ENST00000553482, ENST00000553711, ENST00000553965, ENST00000555345, ENST00000555536, ENST00000556214, ENST00000556465, ENST00000556654, ENST00000556840, ENST00000557221, ENST00000557543, ENST00000923455

RefSeq mRNA: 7 — MANE Select: NM_180982 NM_001318870, NM_178336, NM_180982, NM_181304, NM_181305, NM_181306, NM_181307

CCDS: CCDS41917, CCDS41918, CCDS81791, CCDS9575, CCDS9576

Canonical transcript exons

ENST00000397496 — 5 exons

Exon	Start	End
ENSE00001891228	22834172	22835037
ENSE00003568817	22830053	22830110
ENSE00003578043	22830187	22830254
ENSE00003591692	22833418	22833482
ENSE00003663306	22829887	22829940

Expression profiles

Bgee: expression breadth ubiquitous, 257 present calls, max score 98.32.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 161.9663 / max 843.6880, expressed in 1828 samples.

FANTOM5 promoters (1 alternative TSS)

Promoter ID	TPM avg	Samples expressed
138822	161.9663	1828

Top tissues by expression

257 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
mucosa of transverse colon	UBERON:0004991	98.32	gold quality
apex of heart	UBERON:0002098	98.26	gold quality
lower esophagus mucosa	UBERON:0035834	98.05	gold quality
body of stomach	UBERON:0001161	97.79	gold quality
body of pancreas	UBERON:0001150	97.78	gold quality
heart left ventricle	UBERON:0002084	97.76	gold quality
cardiac ventricle	UBERON:0002082	97.60	gold quality
right lobe of thyroid gland	UBERON:0001119	97.48	gold quality
esophagus mucosa	UBERON:0002469	97.46	gold quality
left lobe of thyroid gland	UBERON:0001120	97.44	gold quality
right atrium auricular region	UBERON:0006631	97.43	gold quality
metanephros cortex	UBERON:0010533	97.43	gold quality
skin of abdomen	UBERON:0001416	97.31	gold quality
left coronary artery	UBERON:0001626	97.31	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	97.25	gold quality
left adrenal gland cortex	UBERON:0035825	97.25	gold quality
right lobe of liver	UBERON:0001114	97.24	gold quality
left adrenal gland	UBERON:0001234	97.21	gold quality
skin of leg	UBERON:0001511	97.19	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	97.09	gold quality
muscle layer of sigmoid colon	UBERON:0035805	97.07	gold quality
esophagus	UBERON:0001043	97.06	gold quality
right adrenal gland	UBERON:0001233	97.06	gold quality
ascending aorta	UBERON:0001496	97.03	gold quality
heart	UBERON:0000948	97.00	gold quality
thoracic aorta	UBERON:0001515	96.99	gold quality
cardiac atrium	UBERON:0002081	96.99	gold quality
gastrocnemius	UBERON:0001388	96.94	gold quality
granulocyte	CL:0000094	96.92	gold quality
lower esophagus	UBERON:0013473	96.91	gold quality

Single-cell (SCXA)

Detected in 1 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

20 targeting MRPL52, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-6876-5P	100.00	67.68	2126
HSA-MIR-34A-5P	99.99	71.21	1784
HSA-MIR-449A	99.99	71.05	1776
HSA-MIR-34C-5P	99.97	70.45	1577
HSA-MIR-449B-5P	99.97	70.26	1580
HSA-MIR-570-3P	99.96	72.41	4910
HSA-MIR-6778-3P	99.96	67.29	2693
HSA-MIR-335-3P	99.93	73.36	4958
HSA-MIR-7154-5P	99.69	70.52	1900
HSA-MIR-520A-5P	99.35	66.72	1632
HSA-MIR-525-5P	99.35	66.85	1615
HSA-MIR-504-3P	99.30	67.18	1745
HSA-MIR-3064-5P	99.26	66.13	1497
HSA-MIR-3085-3P	99.26	66.16	1490
HSA-MIR-6504-5P	99.26	65.95	1487
HSA-MIR-3926	98.95	69.26	1438
HSA-MIR-4718	98.55	68.61	814
HSA-MIR-122-5P	97.23	64.92	1024
HSA-MIR-6735-3P	96.10	63.81	600
HSA-MIR-4259	95.68	65.25	582

Literature-anchored findings (GeneRIF, showing 1)

• HIF-1-induced mitochondrial ribosome protein L52: a mechanism for breast cancer cellular adaptation and metastatic initiation in response to hypoxia. (PMID:34158854)

Cross-species orthologs

4 orthologs

Organism	Symbol	Gene ID
danio_rerio	mrpl52	ENSDARG00000090568
mus_musculus	Mrpl52	ENSMUSG00000010406
rattus_norvegicus	Mrpl52	ENSRNOG00000039297
drosophila_melanogaster	mRpL52	FBGN0033208

Protein

Protein identifiers

Large ribosomal subunit protein mL52 — Q86TS9 (reviewed: Q86TS9)

Alternative names: 39S ribosomal protein L52, mitochondrial

All UniProt accessions (5): Q86TS9, G3V3U6, G3V4H9, G3V4J1, G5E9P5

UniProt curated annotations — full annotation on UniProt →

Subunit / interactions. Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins. mL52 connects the central protuberance to the body of the ribosome.

Subcellular location. Mitochondrion.

Similarity. Belongs to the mitochondrion-specific ribosomal protein mL52 family.

Isoforms (4)

UniProt ID	Names	Canonical?
Q86TS9-1	1	yes
Q86TS9-2	2
Q86TS9-3	3
Q86TS9-4	4

RefSeq proteins (7): NP_001305799, NP_848026, NP_851313, NP_851821, NP_851822, NP_851823, NP_851824 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR034596	Ribosomal_mL52	Family

Pfam: PF18699

UniProt features (17 total): splice variant 4, sequence variant 3, helix 3, strand 2, transit peptide 1, chain 1, sequence conflict 1, region of interest 1, compositionally biased region 1

Structure

Experimental structures (PDB)

73 structures, top 30 by resolution.

PDB	Method	Resolution (Å)
7OF0	ELECTRON MICROSCOPY	2.2
7QI4	ELECTRON MICROSCOPY	2.21
8RRI	ELECTRON MICROSCOPY	2.4
8QU5	ELECTRON MICROSCOPY	2.42
9OLF	ELECTRON MICROSCOPY	2.46
7OF7	ELECTRON MICROSCOPY	2.5
7PO4	ELECTRON MICROSCOPY	2.56
6ZM6	ELECTRON MICROSCOPY	2.59
7O9M	ELECTRON MICROSCOPY	2.6
7OF6	ELECTRON MICROSCOPY	2.6
9CN3	ELECTRON MICROSCOPY	2.62
7QI5	ELECTRON MICROSCOPY	2.63
7OF2	ELECTRON MICROSCOPY	2.7
7OF3	ELECTRON MICROSCOPY	2.7
7OF4	ELECTRON MICROSCOPY	2.7
9PR4	ELECTRON MICROSCOPY	2.77
9PRA	ELECTRON MICROSCOPY	2.83
8ANY	ELECTRON MICROSCOPY	2.85
6ZM5	ELECTRON MICROSCOPY	2.89
7QH7	ELECTRON MICROSCOPY	2.89
7ODR	ELECTRON MICROSCOPY	2.9
7OF5	ELECTRON MICROSCOPY	2.9
8OIT	ELECTRON MICROSCOPY	2.9
9PGL	ELECTRON MICROSCOPY	2.9
9PGF	ELECTRON MICROSCOPY	2.93
7QI6	ELECTRON MICROSCOPY	2.98
9PSM	ELECTRON MICROSCOPY	2.98
8QSJ	ELECTRON MICROSCOPY	3
9UWH	ELECTRON MICROSCOPY	3
9PGI	ELECTRON MICROSCOPY	3.02

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q86TS9-F1	86.30	0.70

Function

Pathways and Gene Ontology

Reactome pathways

7 pathways

ID	Pathway
R-HSA-5368286	Mitochondrial translation initiation
R-HSA-5389840	Mitochondrial translation elongation
R-HSA-5419276	Mitochondrial translation termination
R-HSA-9937383	Mitochondrial ribosome-associated quality control
R-HSA-392499	Metabolism of proteins
R-HSA-5368287	Mitochondrial translation
R-HSA-72766	Translation

MSigDB gene sets: 147 (showing top): SHEPARD_CRASH_AND_BURN_MUTANT_UP, GOBP_MITOCHONDRIAL_TRANSLATION, GOBP_TRANSLATION, CREIGHTON_ENDOCRINE_THERAPY_RESISTANCE_1, MARTINEZ_RB1_TARGETS_DN, GOMF_STRUCTURAL_CONSTITUENT_OF_RIBOSOME, MCCABE_HOXC6_TARGETS_CANCER_DN, GOCC_MITOCHONDRIAL_ENVELOPE, AAAGGGA_MIR204_MIR211, YAO_TEMPORAL_RESPONSE_TO_PROGESTERONE_CLUSTER_13, AFFAR_YY1_TARGETS_DN, CETS1P54_01, GOCC_LARGE_RIBOSOMAL_SUBUNIT, GOCC_RIBOSOME, GOCC_ORGANELLAR_RIBOSOME

GO Biological Process (2): translation (GO:0006412), mitochondrial translation (GO:0032543)

GO Molecular Function (2): structural constituent of ribosome (GO:0003735), protein binding (GO:0005515)

GO Cellular Component (6): nucleoplasm (GO:0005654), mitochondrion (GO:0005739), mitochondrial inner membrane (GO:0005743), mitochondrial large ribosomal subunit (GO:0005762), ribosome (GO:0005840), ribonucleoprotein complex (GO:1990904)

Reactome top-level categories

Rollup of top-3 pathways:

Category	Pathways
Mitochondrial translation	4
Translation	1
Metabolism of proteins	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
peptidyltransferase activity	1
translational initiation	1
translational elongation	1
translational termination	1
macromolecule biosynthetic process	1
protein metabolic process	1
protein biosynthetic process	1
mitochondrion	1
translation	1
mitochondrial gene expression	1
structural molecule activity	1
ribosome	1
binding	1
nuclear lumen	1
cellular anatomical structure	1
cytoplasm	1
intracellular membrane-bounded organelle	1
organelle inner membrane	1
mitochondrial membrane	1
organellar large ribosomal subunit	1
mitochondrial ribosome	1
mitochondrial protein-containing complex	1
intracellular membraneless organelle	1
protein-containing complex	1

Protein interactions and networks

STRING

1132 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
MRPL52	MRPL55	Q7Z7F7	721
MRPL52	MRPS30	Q9NP92	638
MRPL52	RPL26	P61254	586
MRPL52	RPL6	Q02878	585
MRPL52	MRPS21	P82921	578
MRPL52	MRPL1	Q9BYD6	557
MRPL52	MRPL54	Q6P161	536
MRPL52	GADD45GIP1	Q8TAE8	524
MRPL52	MRPL38	Q96DV4	521
MRPL52	MRPS18A	Q9NVS2	519
MRPL52	MRPL4	Q9BYD3	485
MRPL52	MRPL33	O75394	476
MRPL52	MRPL24	Q96A35	473
MRPL52	KGD4	P82909	457
MRPL52	MRPL51	Q4U2R6	456

IntAct

94 interactions, top by confidence:

A	B	Type	Score
MRPS30	GTPBP10	psi-mi:“MI:0914”(association)	0.640
MRPL38	MRPL52	psi-mi:“MI:0915”(physical association)	0.560
MRPL50	GTPBP10	psi-mi:“MI:0914”(association)	0.530
RPS2	MPHOSPH10	psi-mi:“MI:0914”(association)	0.530
ZNF2	MPHOSPH10	psi-mi:“MI:0914”(association)	0.530
MRPL2	GTPBP10	psi-mi:“MI:0914”(association)	0.530
HNRNPA1	PTCD1	psi-mi:“MI:0914”(association)	0.530
MRPL13	GTPBP10	psi-mi:“MI:0914”(association)	0.530
MRPL18	GTPBP10	psi-mi:“MI:0914”(association)	0.530
MRPL27	MRPL33	psi-mi:“MI:0914”(association)	0.530
NDUFAB1	MIEF1	psi-mi:“MI:0915”(physical association)	0.490
KIF2C	WDR62	psi-mi:“MI:0914”(association)	0.350
Cul1	GPS1	psi-mi:“MI:0914”(association)	0.350
Pcgf1	SCAMP3	psi-mi:“MI:0914”(association)	0.350
MRPL50	MRPL43	psi-mi:“MI:0914”(association)	0.350
MRPL9	MRPL43	psi-mi:“MI:0914”(association)	0.350
MRPL1	MRPL43	psi-mi:“MI:0914”(association)	0.350
ALYREF		psi-mi:“MI:0914”(association)	0.350
MRPL4	ZSWIM8	psi-mi:“MI:0914”(association)	0.350
MRPL12		psi-mi:“MI:0914”(association)	0.350
FGF8	ANKHD1	psi-mi:“MI:0914”(association)	0.350
RRS1	MPHOSPH10	psi-mi:“MI:0914”(association)	0.350
LUC7L	CASC3	psi-mi:“MI:0914”(association)	0.350
HNRNPA1	HNRNPR	psi-mi:“MI:0914”(association)	0.350
rl36a_rl36l_human	IPO5	psi-mi:“MI:0914”(association)	0.350

BioGRID (213): MRPL52 (Affinity Capture-MS), MRPL52 (Affinity Capture-MS), MRPL52 (Affinity Capture-MS), MRPL52 (Affinity Capture-MS), MRPL52 (Affinity Capture-MS), MRPL52 (Affinity Capture-MS), MRPL52 (Affinity Capture-MS), MRPL52 (Affinity Capture-MS), MRPL52 (Affinity Capture-MS), MRPL52 (Affinity Capture-MS), MRPL52 (Affinity Capture-MS), MRPL52 (Affinity Capture-MS), MRPL52 (Affinity Capture-MS), MRPL52 (Affinity Capture-MS), MRPL52 (Affinity Capture-MS)

ESM2 similar proteins: A1A4P4, A1CH36, A2ALW5, A5AAL8, B0BN56, O42911, O70279, P0C2B7, P58468, P83565, Q0CLE8, Q1ECT8, Q290P4, Q2GVC2, Q3SZ86, Q4G0I0, Q4V7Q1, Q5B4U6, Q5BJW9, Q5RFR4, Q5XJW2, Q61733, Q6RUT7, Q753F1, Q7SDU5, Q7SHR9, Q80ZS3, Q86TS9, Q8BGX2, Q8BK72, Q8CHP5, Q8SPE7, Q8TAE8, Q8VD26, Q8WUQ7, Q96AN5, Q96DF8, Q9BRP8, Q9BSF4, Q9BYN8

Diamond homologs: P0C2B7, Q290P4, Q4V7Q1, Q7JWG9, Q86TS9, Q9D0Y8

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
MRPL52	“form complex”	“39S mitochondrial large ribosomal subunit”	binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 92 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Mitochondrial ribosome-associated quality control	25	50.3×	3e-35
Mitochondrial translation	22	49.6×	5e-31
Mitochondrial translation initiation	23	47.8×	5e-32
Mitochondrial translation elongation	23	47.8×	5e-32
Mitochondrial translation termination	23	41.4×	1e-30
Translation	26	26.4×	1e-29
SARS-CoV-1 modulates host translation machinery	5	25.3×	1e-05
Peptide chain elongation	10	20.8×	9e-10

GO biological processes:

GO term	Partners	Fold	FDR
mitochondrial translation	24	50.9×	6e-33
translation	19	23.8×	3e-19
cytoplasmic translation	10	22.6×	2e-09
regulation of alternative mRNA splicing, via spliceosome	5	14.9×	2e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

34 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	21
Likely benign	3
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

660 predictions. Top by Δscore:

Variant	Effect	Δscore
14:22830111:G:GG	donor_gain	1.0000
14:22830251:GCGG:G	donor_gain	1.0000
14:22830252:CGGGT:C	donor_loss	1.0000
14:22830253:GGGTA:G	donor_loss	1.0000
14:22830255:G:T	donor_loss	1.0000
14:22830256:T:G	donor_loss	1.0000
14:22833470:G:GT	donor_gain	1.0000
14:22833483:G:GG	donor_gain	1.0000
14:22833516:G:GT	donor_gain	1.0000
14:22833521:A:T	donor_gain	1.0000
14:22830183:ACAG:A	acceptor_gain	0.9900
14:22830253:GG:G	donor_gain	0.9900
14:22830254:GG:G	donor_gain	0.9900
14:22830255:G:GG	donor_gain	0.9900
14:22830471:A:G	donor_gain	0.9900
14:22833480:GCA:G	donor_gain	0.9900
14:22833517:A:T	donor_gain	0.9900
14:22833520:G:GT	donor_gain	0.9900
14:22834170:A:AG	acceptor_gain	0.9900
14:22834171:G:GG	acceptor_gain	0.9900
14:22834247:G:GT	donor_gain	0.9900
14:22834258:G:GT	donor_gain	0.9900
14:22830182:CACA:C	acceptor_loss	0.9800
14:22830184:CAG:C	acceptor_loss	0.9800
14:22830185:A:AG	acceptor_gain	0.9800
14:22830185:AGG:A	acceptor_loss	0.9800
14:22830186:G:GG	acceptor_gain	0.9800
14:22830186:G:T	acceptor_loss	0.9800
14:22830186:GGCA:G	acceptor_gain	0.9800
14:22830514:G:GT	donor_gain	0.9800

AlphaMissense

769 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
14:22830242:T:A	W49R	0.972
14:22830242:T:C	W49R	0.972
14:22830244:G:C	W49C	0.965
14:22830244:G:T	W49C	0.965
14:22834179:T:A	V77D	0.965
14:22833458:A:C	R66S	0.956
14:22833458:A:T	R66S	0.956
14:22834176:G:C	R76P	0.946
14:22830245:T:C	S50P	0.937
14:22830243:G:T	W49L	0.932
14:22833430:C:A	A57D	0.931
14:22830241:C:A	D48E	0.922
14:22830241:C:G	D48E	0.922
14:22834190:T:C	S81P	0.919
14:22830243:G:C	W49S	0.913
14:22834188:T:C	L80P	0.908
14:22834285:A:C	K112N	0.904
14:22834285:A:T	K112N	0.904
14:22833424:G:C	R55P	0.893
14:22830239:G:C	D48H	0.892
14:22833457:G:C	R66T	0.892
14:22833480:G:C	A74P	0.886
14:22830240:A:T	D48V	0.885
14:22830219:G:A	G41E	0.882
14:22830104:G:C	R28P	0.873
14:22833454:G:C	R65P	0.861
14:22833440:G:A	M60I	0.860
14:22833440:G:C	M60I	0.860
14:22833440:G:T	M60I	0.860
14:22830218:G:T	G41W	0.858

dbSNP variants (sampled 300 via entrez): RS1001458828 (14:22835029 T>C), RS1001496993 (14:22828876 G>A,T), RS1001525876 (14:22829490 C>T), RS1001614349 (14:22835450 ATTC>A), RS1001864427 (14:22831069 T>C), RS1001902490 (14:22830876 T>G), RS1002127335 (14:22835090 G>A,C,T), RS1002388542 (14:22830608 A>G), RS1005400061 (14:22833572 T>C), RS1005549084 (14:22834762 C>T), RS1005561287 (14:22828544 C>T), RS1005695367 (14:22828943 G>T), RS1005893736 (14:22829944 A>C), RS1005996176 (14:22834483 T>C), RS1006032571 (14:22830211 C>T)

Disease associations

OMIM: gene MIM:611856 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

1 associations (top):

Study	Trait	p-value
GCST010483_2	Cardiovascular death, myocardial infarction or stroke in response to clopidogrel treatment	5.000000e-06

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0006919	cardiovascular event measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

29 total (human), top 29 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
bisphenol A	decreases expression, affects cotreatment	3
Acetaminophen	affects cotreatment, decreases expression	2
Air Pollutants	affects expression, increases abundance, decreases expression	2
Valproic Acid	affects expression, increases expression	2
Particulate Matter	decreases expression, increases abundance	2
aristolochic acid I	increases expression	1
bisphenol F	affects cotreatment, decreases expression	1
beta-lapachone	increases expression	1
arsenite	affects binding, increases reaction	1
tris(1,3-dichloro-2-propyl)phosphate	decreases expression	1
N-benzyloxycarbonylprolylprolinal	increases expression	1
beta-methylcholine	affects expression	1
di-n-butylphosphoric acid	affects expression	1
ICG 001	decreases expression	1
Sunitinib	increases expression	1
Vehicle Emissions	decreases expression, increases abundance	1
Dexamethasone	affects cotreatment, decreases expression	1
Indomethacin	affects cotreatment, decreases expression	1
Lipopolysaccharides	affects cotreatment, decreases expression	1
Ozone	increases abundance, affects expression	1
Tobacco Smoke Pollution	increases expression	1
Tretinoin	decreases expression	1
Urethane	decreases expression	1
1-Methyl-3-isobutylxanthine	affects cotreatment, decreases expression	1
Cyclosporine	increases expression	1
Aflatoxin B1	increases methylation	1
Cadmium Chloride	increases expression	1
Lactic Acid	decreases expression	1
Acrylamide	increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.