MRPL55

Summary

MRPL55 (mitochondrial ribosomal protein L55, HGNC:16686) is a protein-coding gene on chromosome 1q42.13, encoding Large ribosomal subunit protein mL55 (Q7Z7F7). It is a selective cancer dependency (DepMap: 64.7% of cell lines).

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 39S subunit protein. Multiple transcript variants encoding two different isoforms were identified through sequence analysis.

Source: NCBI Gene 128308 — RefSeq curated summary.

At a glance

• Clinical variants (ClinVar): 38 total
• Cancer dependency (DepMap): dependent in 64.7% of screened cell lines
• MANE Select transcript: NM_181463

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:16686
Approved symbol	MRPL55
Name	mitochondrial ribosomal protein L55
Location	1q42.13
Locus type	gene with protein product
Status	Approved
Aliases	bL31m
Ensembl gene	ENSG00000162910
Ensembl biotype	protein_coding
OMIM	611859
Entrez	128308

Gene structure

Transcript identifiers

Ensembl transcripts: 123 — 115 protein_coding, 5 retained_intron, 3 protein_coding_CDS_not_defined

ENST00000295008, ENST00000336300, ENST00000336520, ENST00000348259, ENST00000366731, ENST00000366732, ENST00000366733, ENST00000366734, ENST00000366735, ENST00000366736, ENST00000366738, ENST00000366739, ENST00000366740, ENST00000366741, ENST00000366742, ENST00000366744, ENST00000366746, ENST00000366747, ENST00000391867, ENST00000411464, ENST00000430433, ENST00000457264, ENST00000459783, ENST00000464148, ENST00000465268, ENST00000473066, ENST00000475832, ENST00000476267, ENST00000483159, ENST00000489430, ENST00000492170, ENST00000495434, ENST00000495899, ENST00000497758, ENST00000877018, ENST00000877019, ENST00000877020, ENST00000877021, ENST00000877022, ENST00000877023, ENST00000877024, ENST00000877025, ENST00000877026, ENST00000877027, ENST00000877028, ENST00000877029, ENST00000877030, ENST00000877031, ENST00000877032, ENST00000877033, ENST00000877034, ENST00000877035, ENST00000877036, ENST00000877037, ENST00000877038, ENST00000877039, ENST00000877040, ENST00000877041, ENST00000877042, ENST00000877043, ENST00000877044, ENST00000877045, ENST00000877046, ENST00000877047, ENST00000877048, ENST00000877049, ENST00000877050, ENST00000877051, ENST00000877052, ENST00000877053, ENST00000877054, ENST00000877055, ENST00000877056, ENST00000877057, ENST00000927937, ENST00000927938, ENST00000927939, ENST00000927940, ENST00000927941, ENST00000927942, ENST00000927943, ENST00000927944, ENST00000927945, ENST00000927946, ENST00000927947, ENST00000927948, ENST00000927949, ENST00000927950, ENST00000927951, ENST00000927952, ENST00000927953, ENST00000927954, ENST00000927955, ENST00000927956, ENST00000927957, ENST00000927958, ENST00000927959, ENST00000927960, ENST00000927961, ENST00000927962, ENST00000927963, ENST00000927964, ENST00000927965, ENST00000927966, ENST00000927967, ENST00000927968, ENST00000927969, ENST00000927970, ENST00000927971, ENST00000927972, ENST00000927973, ENST00000927974, ENST00000927975, ENST00000927976, ENST00000927977, ENST00000927978, ENST00000927979, ENST00000927980, ENST00000927981, ENST00000927982, ENST00000957205, ENST00000957206, ENST00000957207

RefSeq mRNA: 9 — MANE Select: NM_181463 NM_001321284, NM_181441, NM_181454, NM_181455, NM_181456, NM_181462, NM_181463, NM_181464, NM_181465

CCDS: CCDS1567, CCDS44325

Canonical transcript exons

ENST00000336520 — 5 exons

Exon	Start	End
ENSE00001337183	228108955	228109021
ENSE00001897589	228109149	228109299
ENSE00003556550	228107668	228107869
ENSE00003680201	228108235	228108318
ENSE00003841621	228106685	228106918

Expression profiles

Bgee: expression breadth ubiquitous, 234 present calls, max score 96.89.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 40.8619 / max 256.1624, expressed in 1820 samples.

FANTOM5 promoters (3 alternative TSS)

Promoter ID	TPM avg	Samples expressed
17817	39.2329	1820
17816	1.2775	833
17815	0.3516	157

Top tissues by expression

250 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
apex of heart	UBERON:0002098	96.89	gold quality
prefrontal cortex	UBERON:0000451	96.41	gold quality
right lobe of liver	UBERON:0001114	96.30	gold quality
Brodmann (1909) area 9	UBERON:0013540	96.07	gold quality
anterior cingulate cortex	UBERON:0009835	95.84	gold quality
olfactory segment of nasal mucosa	UBERON:0005386	95.71	gold quality
hindlimb stylopod muscle	UBERON:0004252	95.68	gold quality
adenohypophysis	UBERON:0002196	95.67	gold quality
right adrenal gland	UBERON:0001233	95.60	gold quality
left adrenal gland cortex	UBERON:0035825	95.53	gold quality
right adrenal gland cortex	UBERON:0035827	95.53	gold quality
right frontal lobe	UBERON:0002810	95.38	gold quality
left adrenal gland	UBERON:0001234	95.30	gold quality
esophagogastric junction muscularis propria	UBERON:0035841	95.02	gold quality
amygdala	UBERON:0001876	94.89	gold quality
hypothalamus	UBERON:0001898	94.82	gold quality
muscle layer of sigmoid colon	UBERON:0035805	94.75	gold quality
body of stomach	UBERON:0001161	94.74	gold quality
adrenal cortex	UBERON:0001235	94.72	gold quality
C1 segment of cervical spinal cord	UBERON:0006469	94.72	gold quality
lower esophagus muscularis layer	UBERON:0035833	94.71	gold quality
lower esophagus	UBERON:0013473	94.70	gold quality
putamen	UBERON:0001874	94.69	gold quality
nucleus accumbens	UBERON:0001882	94.61	gold quality
metanephros cortex	UBERON:0010533	94.48	gold quality
left coronary artery	UBERON:0001626	94.41	gold quality
left lobe of thyroid gland	UBERON:0001120	94.37	gold quality
endocervix	UBERON:0000458	94.31	gold quality
right lobe of thyroid gland	UBERON:0001119	94.30	gold quality
right atrium auricular region	UBERON:0006631	94.30	gold quality

Single-cell (SCXA)

Detected in 2 experiment(s), a significant marker in 1.

Experiment	Marker?	Max mean expression
E-GEOD-75367	no	416.70
E-ANND-3	no	0.00

Regulation

Is transcription factor: no

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 64.7% of screened cell lines.

Cross-species orthologs

2 orthologs

Organism	Symbol	Gene ID
mus_musculus	Mrpl55	ENSMUSG00000036860
rattus_norvegicus	Mrpl55	ENSRNOG00000002943

Protein

Protein identifiers

Large ribosomal subunit protein mL55 — Q7Z7F7 (reviewed: Q7Z7F7)

Alternative names: 39S ribosomal protein L55, mitochondrial, Mitochondrial large ribosomal subunit protein bL31m

All UniProt accessions (6): A0A087X2A2, A0A0A0MST4, A0A0G2JMK5, Q7Z7F7, X6R631, X6RIW1

UniProt curated annotations — full annotation on UniProt →

Subunit / interactions. Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.

Subcellular location. Mitochondrion.

Similarity. Belongs to the mitochondrion-specific ribosomal protein mL55 family.

Isoforms (2)

UniProt ID	Names	Canonical?
Q7Z7F7-1	1	yes
Q7Z7F7-2	2

RefSeq proteins (9): NP_001308213, NP_852106, NP_852119, NP_852120, NP_852121, NP_852127, NP_852128, NP_852129, NP_852130 (=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR018615	Ribosomal_mL55	Family
IPR044884	Ribosomal_mL55_sf	Homologous_superfamily

Pfam: PF09776

UniProt features (11 total): strand 4, sequence variant 2, transit peptide 1, chain 1, modified residue 1, splice variant 1, helix 1

Structure

Experimental structures (PDB)

82 structures, top 30 by resolution.

PDB	Method	Resolution (Å)
7OF0	ELECTRON MICROSCOPY	2.2
7QI4	ELECTRON MICROSCOPY	2.21
8RRI	ELECTRON MICROSCOPY	2.4
8QU5	ELECTRON MICROSCOPY	2.42
9OLF	ELECTRON MICROSCOPY	2.46
7OF7	ELECTRON MICROSCOPY	2.5
7PO4	ELECTRON MICROSCOPY	2.56
6ZM6	ELECTRON MICROSCOPY	2.59
7O9M	ELECTRON MICROSCOPY	2.6
7OF6	ELECTRON MICROSCOPY	2.6
9CN3	ELECTRON MICROSCOPY	2.62
7QI5	ELECTRON MICROSCOPY	2.63
7OF2	ELECTRON MICROSCOPY	2.7
7OF3	ELECTRON MICROSCOPY	2.7
7OF4	ELECTRON MICROSCOPY	2.7
9PR4	ELECTRON MICROSCOPY	2.77
9PRA	ELECTRON MICROSCOPY	2.83
8ANY	ELECTRON MICROSCOPY	2.85
6ZM5	ELECTRON MICROSCOPY	2.89
7ODR	ELECTRON MICROSCOPY	2.9
7OF5	ELECTRON MICROSCOPY	2.9
8K2A	ELECTRON MICROSCOPY	2.9
8OIT	ELECTRON MICROSCOPY	2.9
9PGL	ELECTRON MICROSCOPY	2.9
9PGF	ELECTRON MICROSCOPY	2.93
6VMI	ELECTRON MICROSCOPY	2.96
6VLZ	ELECTRON MICROSCOPY	2.97
7QI6	ELECTRON MICROSCOPY	2.98
9PSM	ELECTRON MICROSCOPY	2.98
8OIS	ELECTRON MICROSCOPY	3

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q7Z7F7-F1	79.80	0.38

Functional residue map

Curated UniProt residues grouped by drug-discovery relevance — catalytic, ligand-binding, modification, and mutation-validated positions. Source: UniProtKB sequence features.

Post-translational modifications (1): 85

Function

Pathways and Gene Ontology

Reactome pathways

7 pathways

ID	Pathway
R-HSA-5368286	Mitochondrial translation initiation
R-HSA-5389840	Mitochondrial translation elongation
R-HSA-5419276	Mitochondrial translation termination
R-HSA-9937383	Mitochondrial ribosome-associated quality control
R-HSA-392499	Metabolism of proteins
R-HSA-5368287	Mitochondrial translation
R-HSA-72766	Translation

MSigDB gene sets: 87 (showing top): STARK_PREFRONTAL_CORTEX_22Q11_DELETION_DN, GOBP_MITOCHONDRIAL_TRANSLATION, GOBP_TRANSLATION, GOMF_STRUCTURAL_CONSTITUENT_OF_RIBOSOME, GOCC_MITOCHONDRIAL_ENVELOPE, GOCC_LARGE_RIBOSOMAL_SUBUNIT, GOCC_RIBOSOME, GOCC_ORGANELLAR_RIBOSOME, GOCC_MITOCHONDRIAL_MATRIX, GOCC_ORGANELLE_INNER_MEMBRANE, GOCC_RIBOSOMAL_SUBUNIT, GOCC_RIBONUCLEOPROTEIN_COMPLEX, GOCC_MITOCHONDRIAL_PROTEIN_CONTAINING_COMPLEX, GOMF_STRUCTURAL_MOLECULE_ACTIVITY, GOCC_ORGANELLE_ENVELOPE

GO Biological Process (2): translation (GO:0006412), mitochondrial translation (GO:0032543)

GO Molecular Function (1): structural constituent of ribosome (GO:0003735)

GO Cellular Component (5): mitochondrion (GO:0005739), mitochondrial inner membrane (GO:0005743), mitochondrial large ribosomal subunit (GO:0005762), ribosome (GO:0005840), ribonucleoprotein complex (GO:1990904)

Reactome top-level categories

Rollup of top-3 pathways:

Category	Pathways
Mitochondrial translation	4
Translation	1
Metabolism of proteins	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
peptidyltransferase activity	1
translational initiation	1
translational elongation	1
translational termination	1
macromolecule biosynthetic process	1
protein metabolic process	1
protein biosynthetic process	1
mitochondrion	1
translation	1
mitochondrial gene expression	1
structural molecule activity	1
ribosome	1
cytoplasm	1
intracellular membrane-bounded organelle	1
organelle inner membrane	1
mitochondrial membrane	1
organellar large ribosomal subunit	1
mitochondrial ribosome	1
mitochondrial protein-containing complex	1
intracellular membraneless organelle	1
protein-containing complex	1

Protein interactions and networks

STRING

1488 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
MRPL55	MRPL52	Q86TS9	721
MRPL55	MRPS30	Q9NP92	644
MRPL55	MRPL51	Q4U2R6	614
MRPL55	MRPS14	O60783	577
MRPL55	RPL6	Q02878	555
MRPL55	RPL26	P61254	522
MRPL55	MRPS25	P82663	510
MRPL55	MRPL43	Q8N983	484
MRPL55	SYF2	O95926	480
MRPL55	MRPS21	P82921	478
MRPL55	BEAN1	Q3B7T3	475
MRPL55	COMMD5	Q9GZQ3	469
MRPL55	LDHD	Q86WU2	464
MRPL55	CCNDBP1	O95273	455
MRPL55	MRPS15	P82914	452

IntAct

111 interactions, top by confidence:

A	B	Type	Score
PLK1	EVI5	psi-mi:“MI:0914”(association)	0.660
MRPS30	GTPBP10	psi-mi:“MI:0914”(association)	0.640
LIN28A	IGF2BP3	psi-mi:“MI:0914”(association)	0.640
NP	KPNA6	psi-mi:“MI:0914”(association)	0.550
MRPL50	GTPBP10	psi-mi:“MI:0914”(association)	0.530
MRPL2	GTPBP10	psi-mi:“MI:0914”(association)	0.530
MRPL46	MRPL55	psi-mi:“MI:0914”(association)	0.530
MRPL13	GTPBP10	psi-mi:“MI:0914”(association)	0.530
MRPL18	GTPBP10	psi-mi:“MI:0914”(association)	0.530
MRPL27	MRPL33	psi-mi:“MI:0914”(association)	0.530
NDUFAB1	MIEF1	psi-mi:“MI:0915”(physical association)	0.490
Cdca5	ATP5MF-PTCD1	psi-mi:“MI:0914”(association)	0.350
CHORDC1	SSR3	psi-mi:“MI:0914”(association)	0.350
PARD6B	PARD3	psi-mi:“MI:0914”(association)	0.350
Cdc26		psi-mi:“MI:0914”(association)	0.350
Rab5c		psi-mi:“MI:0914”(association)	0.350
MYO1C	PLEKHG3	psi-mi:“MI:0914”(association)	0.350
RAB5C		psi-mi:“MI:0914”(association)	0.350
CBX4	SDC2	psi-mi:“MI:0914”(association)	0.350
Cdkn2aip	SF1	psi-mi:“MI:0914”(association)	0.350
UGGT1	SF3B1	psi-mi:“MI:0914”(association)	0.350
HNRNPD	ARHGAP32	psi-mi:“MI:0914”(association)	0.350
BAG6	CNOT1	psi-mi:“MI:0914”(association)	0.350
SORT1	SH3PXD2B	psi-mi:“MI:0914”(association)	0.350

BioGRID (172): MRPL55 (Affinity Capture-MS), MRPL55 (Affinity Capture-MS), MRPL55 (Affinity Capture-MS), MRPL55 (Affinity Capture-MS), MRPL55 (Affinity Capture-MS), MRPL55 (Affinity Capture-MS), MRPL55 (Affinity Capture-MS), MRPL55 (Affinity Capture-MS), MRPL55 (Affinity Capture-MS), MRPL55 (Affinity Capture-MS), MRPL55 (Co-fractionation), MRPL55 (Co-fractionation), MRPL55 (Co-fractionation), MRPL55 (Affinity Capture-MS), MRPL55 (Affinity Capture-MS)

ESM2 similar proteins: A1A4P4, M0R3K6, O09111, P0C2B7, P0C2B8, P0C2B9, P56181, P82649, P82927, P83565, Q08DT6, Q0MQJ0, Q0MQJ1, Q0MQJ2, Q0MQJ3, Q0MQJ4, Q0MQJ5, Q1ECT8, Q290P4, Q3SZ86, Q4G0I0, Q4V7Q1, Q5R4S3, Q5RFR4, Q5TC12, Q5XIC2, Q5XJW2, Q6DQX6, Q7Z7F7, Q80ZS3, Q811I0, Q86TS9, Q8HXG5, Q8K2Y7, Q8SPE7, Q8TAE8, Q9BYN8, Q9C086, Q9CPV3, Q9CR59

Diamond homologs: P0C2B8, Q7Z7F7, Q9CZ83, Q9VE04

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
MRPL55	“form complex”	“39S mitochondrial large ribosomal subunit”	binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 98 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Mitochondrial ribosome-associated quality control	29	46.9×	4e-40
Mitochondrial translation	24	43.5×	2e-32
Mitochondrial translation initiation	26	43.4×	4e-35
Mitochondrial translation elongation	26	43.4×	4e-35
Mitochondrial translation termination	26	37.6×	2e-33
Translation	26	21.2×	2e-26
Peptide chain elongation	10	16.7×	1e-08
Viral mRNA Translation	10	16.7×	1e-08

GO biological processes:

GO term	Partners	Fold	FDR
mitochondrial translation	28	54.7×	1e-39
translation	24	27.7×	4e-26
cytoplasmic translation	10	20.8×	7e-09
negative regulation of translation	7	15.4×	4e-05

Disease & clinical

Clinical variants and AI predictions

ClinVar

38 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	28
Likely benign	1
Benign	1

Top pathogenic / likely-pathogenic (0)

SpliceAI

396 predictions. Top by Δscore:

Variant	Effect	Δscore
1:228106914:GGCAT:G	acceptor_gain	1.0000
1:228106915:GCAT:G	acceptor_gain	1.0000
1:228106916:CATC:C	acceptor_gain	1.0000
1:228106919:C:CC	acceptor_gain	1.0000
1:228106919:CTG:C	acceptor_loss	1.0000
1:228107661:AGCTT:A	donor_loss	1.0000
1:228107663:CTTA:C	donor_loss	1.0000
1:228107665:TACCG:T	donor_loss	1.0000
1:228107666:A:AC	donor_gain	1.0000
1:228107666:ACCG:A	donor_gain	1.0000
1:228107667:C:A	donor_loss	1.0000
1:228107667:C:CC	donor_gain	1.0000
1:228107667:CCG:C	donor_gain	1.0000
1:228107667:CCGC:C	donor_gain	1.0000
1:228106916:CAT:C	acceptor_gain	0.9900
1:228106917:AT:A	acceptor_gain	0.9900
1:228107662:GCTT:G	donor_gain	0.9900
1:228107664:TTA:T	donor_gain	0.9900
1:228107665:T:TC	donor_gain	0.9900
1:228107666:A:G	donor_gain	0.9900
1:228107666:ACCGC:A	donor_gain	0.9900
1:228107667:C:T	donor_gain	0.9900
1:228107667:CCGCC:C	donor_gain	0.9900
1:228107688:C:CA	donor_gain	0.9900
1:228107866:CCGG:C	acceptor_gain	0.9900
1:228107867:CGG:C	acceptor_gain	0.9900
1:228107867:CGGC:C	acceptor_gain	0.9900
1:228107870:C:CC	acceptor_gain	0.9900
1:228106915:GCATC:G	acceptor_gain	0.9800
1:228106916:CATCT:C	acceptor_gain	0.9800

AlphaMissense

809 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
1:228107742:A:C	Y52D	0.907
1:228107712:A:G	S62P	0.903
1:228106881:C:G	R89P	0.875
1:228107714:C:A	G61V	0.870
1:228107699:A:T	I66N	0.865
1:228107684:G:T	P71Q	0.840
1:228106781:G:C	F122L	0.834
1:228106781:G:T	F122L	0.834
1:228106783:A:G	F122L	0.834
1:228107716:A:C	D60E	0.827
1:228107716:A:T	D60E	0.827
1:228107685:G:A	P71S	0.825
1:228107791:G:C	S35R	0.821
1:228107791:G:T	S35R	0.821
1:228107793:T:G	S35R	0.821
1:228107681:C:G	R72P	0.805
1:228107742:A:T	Y52N	0.805
1:228107699:A:C	I66S	0.797
1:228107694:A:C	Y68D	0.795
1:228107718:C:G	D60H	0.789
1:228107763:G:T	R45S	0.784
1:228107741:T:G	Y52S	0.781
1:228107714:C:T	G61D	0.780
1:228107735:A:T	V54E	0.774
1:228107699:A:G	I66T	0.769
1:228107685:G:T	P71T	0.763
1:228107717:T:A	D60V	0.763
1:228106882:G:T	R89S	0.762
1:228106778:C:A	W123C	0.758
1:228106778:C:G	W123C	0.758

dbSNP variants (sampled 300 via entrez): RS1000496843 (1:228109242 A>G), RS1001112946 (1:228107406 A>C), RS1001754115 (1:228110706 G>A), RS1002092502 (1:228109099 G>C), RS1003887443 (1:228109274 G>A,C,T), RS1004001876 (1:228109453 C>CG), RS1004181897 (1:228108389 C>T), RS1004515162 (1:228107282 G>A,C), RS1004896319 (1:228110552 A>G), RS1007243767 (1:228106790 G>A), RS1007857087 (1:228109873 G>C), RS1008475603 (1:228109443 G>A), RS1008817384 (1:228108120 A>G), RS1009369409 (1:228109406 G>T), RS1009730022 (1:228109203 C>T)

Disease associations

OMIM: gene MIM:611859 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

0 associations (top):

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

25 total (human), top 25 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
Benzo(a)pyrene	decreases expression, decreases methylation	3
triphenyl phosphate	affects expression	1
bisphenol A	decreases expression	1
beta-lapachone	increases expression	1
arsenite	increases reaction, affects binding	1
sodium arsenite	increases abundance, increases expression	1
perfluorooctane sulfonic acid	increases expression	1
CGP 52608	affects binding, increases reaction	1
2-palmitoylglycerol	increases expression	1
ICG 001	decreases expression	1
jinfukang	increases expression	1
Acetaminophen	increases expression	1
Ethanol	affects cotreatment, increases abundance, increases expression	1
Arsenic	increases abundance, increases expression	1
Dietary Carbohydrates	decreases expression	1
Diethylstilbestrol	decreases expression	1
Doxorubicin	increases expression	1
Gasoline	affects cotreatment, increases abundance, increases expression	1
Hydrogen Peroxide	affects expression	1
Polycyclic Aromatic Hydrocarbons	affects cotreatment, increases abundance, increases expression	1
Smoke	decreases expression	1
Thiram	decreases expression	1
Urethane	decreases expression	1
Asbestos, Crocidolite	increases expression	1
Particulate Matter	affects cotreatment, increases abundance, increases expression	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.