MRPL57

Summary

MRPL57 (mitochondrial ribosomal protein L57, HGNC:14514) is a protein-coding gene on chromosome 13q12.11, encoding Large ribosomal subunit protein mL63 (Q9BQC6). It is a selective cancer dependency (DepMap: 82.4% of cell lines).

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a protein which belongs to an undetermined ribosomal subunit and which seems to be specific to animal mitoribosomes. Pseudogenes corresponding to this gene are found on chromosomes 1p, 1q, 3p, 5q, 8q, 14q, and Y.

Source: NCBI Gene 78988 — RefSeq curated summary.

At a glance

• GWAS associations: 2
• Clinical variants (ClinVar): 12 total
• Cancer dependency (DepMap): dependent in 82.4% of screened cell lines
• MANE Select transcript: NM_024026

Identifiers

Gene identifiers

Field	Value
HGNC ID	HGNC:14514
Approved symbol	MRPL57
Name	mitochondrial ribosomal protein L57
Location	13q12.11
Locus type	gene with protein product
Status	Approved
Aliases	mL63
Ensembl gene	ENSG00000173141
Ensembl biotype	protein_coding
OMIM	611997
Entrez	78988

Gene structure

Transcript identifiers

Ensembl transcripts: 6 — 6 protein_coding

ENST00000309594, ENST00000861772, ENST00000861773, ENST00000861774, ENST00000912375, ENST00000912376

RefSeq mRNA: 1 — MANE Select: NM_024026 NM_024026

CCDS: CCDS9296

Canonical transcript exons

ENST00000309594 — 2 exons

Exon	Start	End
ENSE00001200768	21176912	21179084
ENSE00001295301	21176658	21176717

Expression profiles

Bgee: expression breadth ubiquitous, 289 present calls, max score 99.09.

FANTOM5 (CAGE): breadth ubiquitous, TPM avg 114.3029 / max 606.2834, expressed in 1826 samples.

FANTOM5 promoters (4 alternative TSS)

Promoter ID	TPM avg	Samples expressed
134335	110.8881	1826
134334	3.0077	1499
134333	0.4047	214
134332	0.0024	1

Top tissues by expression

289 total, by Bgee expression score (0-100, higher = more expressed):

Tissue	Anatomy ID	Expression score	Quality
endothelial cell	CL:0000115	99.09	gold quality
gluteal muscle	UBERON:0002000	98.56	gold quality
cerebellar vermis	UBERON:0004720	98.37	gold quality
nephron tubule	UBERON:0001231	98.27	gold quality
parotid gland	UBERON:0001831	98.21	gold quality
cervix squamous epithelium	UBERON:0006922	98.21	gold quality
thymus	UBERON:0002370	98.10	gold quality
renal medulla	UBERON:0000362	98.08	gold quality
triceps brachii	UBERON:0001509	98.01	gold quality
sperm	CL:0000019	97.97	gold quality
heart right ventricle	UBERON:0002080	97.91	gold quality
male germ cell	CL:0000015	97.88	gold quality
skeletal muscle tissue of biceps brachii	UBERON:0004502	97.77	gold quality
pigmented layer of retina	UBERON:0001782	97.75	gold quality
biceps brachii	UBERON:0001507	97.58	gold quality
corpus epididymis	UBERON:0004359	97.55	gold quality
epithelium of bronchus	UBERON:0002031	97.53	gold quality
bronchial epithelial cell	CL:0002328	97.51	gold quality
bronchus	UBERON:0002185	97.51	gold quality
body of tongue	UBERON:0011876	97.40	gold quality
ventral tegmental area	UBERON:0002691	97.37	gold quality
type B pancreatic cell	CL:0000169	97.35	gold quality
caput epididymis	UBERON:0004358	97.34	gold quality
renal glomerulus	UBERON:0000074	97.27	gold quality
cardia of stomach	UBERON:0001162	97.27	gold quality
nipple	UBERON:0002030	97.26	gold quality
inferior vagus X ganglion	UBERON:0005363	97.21	gold quality
metanephric glomerulus	UBERON:0004736	97.13	gold quality
diaphragm	UBERON:0001103	97.07	gold quality
pylorus	UBERON:0001166	96.99	gold quality

Single-cell (SCXA)

Detected in 5 experiment(s), a significant marker in 3.

Experiment	Marker?	Max mean expression
E-HCAD-4	yes	64.13
E-ANND-3	yes	16.13
E-MTAB-9067	yes	10.48
E-GEOD-100618	no	1249.13
E-MTAB-8911	no	179.09

Regulation

Is transcription factor: no

miRNA regulators (miRDB)

59 targeting MRPL57, top 30 by miRDB confidence (max_score; target_count = how many genes the miRNA targets in total — lower means more specific):

miRNA	Max score	Avg score	miRNA target_count
HSA-MIR-656-3P	100.00	72.15	2788
HSA-MIR-4795-3P	100.00	74.62	4024
HSA-MIR-4425	100.00	67.59	1049
HSA-MIR-4668-3P	100.00	68.74	2635
HSA-MIR-3613-3P	100.00	76.36	7965
HSA-MIR-126-5P	100.00	72.71	3180
HSA-MIR-3924	100.00	72.09	2394
HSA-MIR-150-5P	99.99	66.69	1976
HSA-MIR-8068	99.98	73.85	2376
HSA-MIR-6778-3P	99.96	67.29	2693
HSA-MIR-1250-3P	99.96	70.04	4038
HSA-MIR-590-3P	99.96	74.34	6478
HSA-MIR-9983-3P	99.94	71.48	3631
HSA-MIR-10527-5P	99.91	72.28	3754
HSA-MIR-1305	99.91	71.43	3443
HSA-MIR-129-5P	99.88	70.26	3273
HSA-MIR-30A-3P	99.87	69.74	2928
HSA-MIR-30D-3P	99.87	69.92	2917
HSA-MIR-30E-3P	99.87	69.68	2942
HSA-MIR-4307	99.82	70.45	3374
HSA-MIR-6752-3P	99.72	66.71	1587
HSA-MIR-4802-3P	99.72	70.13	1273
HSA-MIR-33A-3P	99.70	70.27	3362
HSA-MIR-378A-5P	99.65	66.33	1311
HSA-MIR-6832-5P	99.58	64.82	1132
HSA-MIR-6751-5P	99.56	64.99	1145
HSA-MIR-186-3P	99.51	66.24	1685
HSA-MIR-409-3P	99.50	66.33	1192
HSA-MIR-4735-5P	99.43	68.49	1780
HSA-MIR-584-3P	99.35	67.69	1082

Functional genomics

DepMap (CRISPR cell-line fitness): dependent in 82.4% of screened cell lines.

Cross-species orthologs

3 orthologs

Organism	Symbol	Gene ID
danio_rerio	mrpl57	ENSDARG00000007285
mus_musculus	Mrpl57	ENSMUSG00000021967
rattus_norvegicus	Mrpl57	ENSRNOG00000081514

Protein

Protein identifiers

Large ribosomal subunit protein mL63 — Q9BQC6 (reviewed: Q9BQC6)

Alternative names: Mitochondrial ribosomal protein 63, Mitochondrial ribosomal protein L57, Ribosomal protein 63, mitochondrial

All UniProt accessions (1): Q9BQC6

UniProt curated annotations — full annotation on UniProt →

Subunit / interactions. Component of the mitochondrial large ribosomal subunit (mt-LSU). Mature mammalian 55S mitochondrial ribosomes consist of a small (28S) and a large (39S) subunit. The 28S small subunit contains a 12S ribosomal RNA (12S mt-rRNA) and 30 different proteins. The 39S large subunit contains a 16S rRNA (16S mt-rRNA), a copy of mitochondrial valine transfer RNA (mt-tRNA(Val)), which plays an integral structural role, and 52 different proteins.

Subcellular location. Mitochondrion.

Similarity. Belongs to the mitochondrion-specific ribosomal protein mL63 family.

RefSeq proteins (1): NP_076931* (*=MANE)

Domains & families (InterPro)

ID	Name	Type
IPR016576	Ribosomal_mL63	Family

Pfam: PF14978

UniProt features (9 total): helix 5, strand 2, chain 1, turn 1

Structure

Experimental structures (PDB)

85 structures, top 30 by resolution.

PDB	Method	Resolution (Å)
7OF0	ELECTRON MICROSCOPY	2.2
7QI4	ELECTRON MICROSCOPY	2.21
8RRI	ELECTRON MICROSCOPY	2.4
8QU5	ELECTRON MICROSCOPY	2.42
9OLF	ELECTRON MICROSCOPY	2.46
7OF7	ELECTRON MICROSCOPY	2.5
7PO4	ELECTRON MICROSCOPY	2.56
6ZM6	ELECTRON MICROSCOPY	2.59
7O9M	ELECTRON MICROSCOPY	2.6
7OF6	ELECTRON MICROSCOPY	2.6
9CN3	ELECTRON MICROSCOPY	2.62
7QI5	ELECTRON MICROSCOPY	2.63
7OF2	ELECTRON MICROSCOPY	2.7
7OF3	ELECTRON MICROSCOPY	2.7
7OF4	ELECTRON MICROSCOPY	2.7
9PR4	ELECTRON MICROSCOPY	2.77
9PRA	ELECTRON MICROSCOPY	2.83
8ANY	ELECTRON MICROSCOPY	2.85
6ZM5	ELECTRON MICROSCOPY	2.89
7QH7	ELECTRON MICROSCOPY	2.89
7ODR	ELECTRON MICROSCOPY	2.9
7OF5	ELECTRON MICROSCOPY	2.9
8K2A	ELECTRON MICROSCOPY	2.9
8OIT	ELECTRON MICROSCOPY	2.9
9PGL	ELECTRON MICROSCOPY	2.9
9PGF	ELECTRON MICROSCOPY	2.93
6VMI	ELECTRON MICROSCOPY	2.96
6VLZ	ELECTRON MICROSCOPY	2.97
7QI6	ELECTRON MICROSCOPY	2.98
9PSM	ELECTRON MICROSCOPY	2.98

Predicted structure (AlphaFold)

Model	pLDDT	Fraction very-high
AF-Q9BQC6-F1	92.37	0.77

Function

Pathways and Gene Ontology

Reactome pathways

7 pathways

ID	Pathway
R-HSA-5368286	Mitochondrial translation initiation
R-HSA-5389840	Mitochondrial translation elongation
R-HSA-5419276	Mitochondrial translation termination
R-HSA-9937383	Mitochondrial ribosome-associated quality control
R-HSA-392499	Metabolism of proteins
R-HSA-5368287	Mitochondrial translation
R-HSA-72766	Translation

MSigDB gene sets: 139 (showing top): BUYTAERT_PHOTODYNAMIC_THERAPY_STRESS_DN, STARK_PREFRONTAL_CORTEX_22Q11_DELETION_DN, GRAESSMANN_APOPTOSIS_BY_SERUM_DEPRIVATION_UP, GRAESSMANN_RESPONSE_TO_MC_AND_SERUM_DEPRIVATION_UP, GOBP_MITOCHONDRIAL_TRANSLATION, GOBP_TRANSLATION, MODULE_205, WANG_LMO4_TARGETS_DN, MILI_PSEUDOPODIA_HAPTOTAXIS_UP, BLALOCK_ALZHEIMERS_DISEASE_UP, GOMF_STRUCTURAL_CONSTITUENT_OF_RIBOSOME, GOCC_MITOCHONDRIAL_ENVELOPE, GOCC_LARGE_RIBOSOMAL_SUBUNIT, GOCC_RIBOSOME, NUYTTEN_EZH2_TARGETS_DN

GO Biological Process (2): mitochondrial translation (GO:0032543), translation (GO:0006412)

GO Molecular Function (2): structural constituent of ribosome (GO:0003735), protein binding (GO:0005515)

GO Cellular Component (6): mitochondrion (GO:0005739), mitochondrial inner membrane (GO:0005743), mitochondrial ribosome (GO:0005761), mitochondrial large ribosomal subunit (GO:0005762), ribosome (GO:0005840), ribonucleoprotein complex (GO:1990904)

Reactome top-level categories

Rollup of top-3 pathways:

Category	Pathways
Mitochondrial translation	4
Translation	1
Metabolism of proteins	1

GO top-level categories

Rollup of top GO terms by namespace:

Category	Terms
mitochondrion	1
translation	1
mitochondrial gene expression	1
peptidyltransferase activity	1
translational initiation	1
translational elongation	1
translational termination	1
macromolecule biosynthetic process	1
protein metabolic process	1
protein biosynthetic process	1
structural molecule activity	1
ribosome	1
binding	1
cytoplasm	1
intracellular membrane-bounded organelle	1
organelle inner membrane	1
mitochondrial membrane	1
organellar ribosome	1
mitochondrial matrix	1
organellar large ribosomal subunit	1
mitochondrial ribosome	1
mitochondrial protein-containing complex	1
intracellular membraneless organelle	1
protein-containing complex	1

Protein interactions and networks

STRING

962 interactions, top by confidence (×1000):

Protein A	Protein B	Partner UniProt	Score
MRPL57	MRPL1	Q9BYD6	477
MRPL57	CCDC70	Q6NSX1	457
MRPL57	MRPL58	Q14197	440
MRPL57	SLC25A21	Q9BQT8	412
MRPL57	MRPL54	Q6P161	407
MRPL57	MRPL34	Q9BQ48	400
MRPL57	MRPL52	Q86TS9	393
MRPL57	MRPL43	Q8N983	393
MRPL57	TMEM168	Q9H0V1	388
MRPL57	SLC25A26	Q70HW3	387
MRPL57	SLC25A29	Q8N8R3	384
MRPL57	MRPL51	Q4U2R6	371
MRPL57	MRPS15	P82914	366
MRPL57	ARMCX2	Q7L311	353
MRPL57	CHCHD1	Q96BP2	328

IntAct

121 interactions, top by confidence:

A	B	Type	Score
KBTBD7	METTL15	psi-mi:“MI:0914”(association)	0.730
MRPS30	GTPBP10	psi-mi:“MI:0914”(association)	0.640
LYRM7	NDUFAB1	psi-mi:“MI:0914”(association)	0.640
MRPL57	CIDEB	psi-mi:“MI:0915”(physical association)	0.560
LEUTX	MRPL57	psi-mi:“MI:0915”(physical association)	0.560
MRPL50	GTPBP10	psi-mi:“MI:0914”(association)	0.530
MRPL10	ZZEF1	psi-mi:“MI:0914”(association)	0.530
MRPL42	GATC	psi-mi:“MI:0914”(association)	0.530
MRPL28	MRPL3	psi-mi:“MI:0914”(association)	0.530
MRPL41	MRPL3	psi-mi:“MI:0914”(association)	0.530
KBTBD7	PLD2	psi-mi:“MI:0914”(association)	0.530
MRPL2	GTPBP10	psi-mi:“MI:0914”(association)	0.530
FBXW11	AHCYL1	psi-mi:“MI:0914”(association)	0.530
HNRNPA1	PTCD1	psi-mi:“MI:0914”(association)	0.530
MRPL13	GTPBP10	psi-mi:“MI:0914”(association)	0.530
MRPL18	GTPBP10	psi-mi:“MI:0914”(association)	0.530
NDUFAB1	MIEF1	psi-mi:“MI:0915”(physical association)	0.490
Sars1	PARP10	psi-mi:“MI:0914”(association)	0.350
MRPL1	MRPL43	psi-mi:“MI:0914”(association)	0.350
MRPL4	ZSWIM8	psi-mi:“MI:0914”(association)	0.350
MRPL12		psi-mi:“MI:0914”(association)	0.350
RPS8	RRP8	psi-mi:“MI:0914”(association)	0.350
HNRNPA1	HNRNPR	psi-mi:“MI:0914”(association)	0.350
MRPL39	PTCD1	psi-mi:“MI:0914”(association)	0.350
FBXW11	PTCD1	psi-mi:“MI:0914”(association)	0.350

BioGRID (135): MRPL57 (Affinity Capture-MS), MRPL57 (Affinity Capture-MS), MRPL57 (Affinity Capture-MS), MRPL57 (Affinity Capture-MS), MRPL57 (Affinity Capture-MS), MRPL57 (Affinity Capture-MS), MRPL57 (Two-hybrid), MRPL57 (Affinity Capture-MS), MRPL57 (Affinity Capture-MS), MRPL57 (Affinity Capture-MS), MRPL57 (Affinity Capture-MS), MRPL57 (Affinity Capture-MS), MRPL57 (Affinity Capture-MS), MRPL57 (Affinity Capture-MS), MRPL57 (Affinity Capture-MS)

ESM2 similar proteins: A1TYV1, A3M7E7, A4SHF6, A7HUX6, A7IDK1, A8IM57, A9HHS1, A9L948, B0VBX6, B0VUE9, B1VFG4, B2HVM2, B2ICM8, B4RYA0, B6INQ0, B7GZ34, B7I4A2, B8EK30, B8H4M5, C1D0Z8, G2TRQ8, O14187, P00129, P16135, P90993, Q02950, Q15N51, Q1GDB7, Q22438, Q28GD1, Q29PG4, Q2G8J9, Q2RVH2, Q4U2R6, Q5BJJ8, Q5FNB8, Q5ZKG1, Q61SE7, Q66KZ3, Q6CAD1

Diamond homologs: Q3ZC04, Q6PBR7, Q9BQC6, Q9CQF8

SIGNOR signaling

1 interactions.

A	Effect	B	Mechanism
MRPL57	“form complex”	“39S mitochondrial large ribosomal subunit”	binding

Enriched among interaction partners

Reactome pathways and GO biological processes over-represented among this gene’s 109 IntAct physical interaction partners (hypergeometric vs the genome-wide background, BH-FDR, gene-set size 15–500, ranked by fold). A functional readout of the neighbourhood — distinct from this gene’s own memberships above, and biased toward well-studied / hub proteins, so read it as themes rather than proof.

Reactome pathways:

Pathway	Partners	Fold	FDR
Mitochondrial ribosome-associated quality control	30	49.8×	1e-42
Mitochondrial translation	26	48.3×	1e-36
Mitochondrial translation initiation	27	46.3×	2e-37
Mitochondrial translation elongation	27	46.3×	2e-37
Mitochondrial translation termination	27	40.1×	1e-35
Translation	28	23.5×	4e-30
Peptide chain elongation	8	13.7×	3e-06
Viral mRNA Translation	8	13.7×	3e-06

GO biological processes:

GO term	Partners	Fold	FDR
mitochondrial translation	29	51.9×	1e-40
translation	23	24.4×	1e-23
cytoplasmic translation	8	15.3×	7e-06
regulation of alternative mRNA splicing, via spliceosome	5	12.6×	4e-03
negative regulation of translation	5	10.1×	7e-03

Disease & clinical

Clinical variants and AI predictions

ClinVar

12 variants total. Per-class counts are floors (≥ shown; pagination cap):

Classification	Count (floor)
Pathogenic	0
Likely pathogenic	0
Uncertain significance	9
Likely benign	3
Benign	0

Top pathogenic / likely-pathogenic (0)

SpliceAI

102 predictions. Top by Δscore:

Variant	Effect	Δscore
13:21176715:CAGG:C	donor_loss	1.0000
13:21176716:AGG:A	donor_loss	1.0000
13:21176717:GGT:G	donor_loss	1.0000
13:21176718:GTG:G	donor_loss	1.0000
13:21176713:GGCAG:G	donor_gain	0.9900
13:21176714:GCAG:G	donor_gain	0.9900
13:21176714:GCAGG:G	donor_gain	0.9900
13:21176718:G:GG	donor_gain	0.9900
13:21176719:T:G	donor_loss	0.9800
13:21176910:A:AG	acceptor_gain	0.9800
13:21176911:G:GG	acceptor_gain	0.9800
13:21176907:CGCA:C	acceptor_loss	0.9700
13:21176908:GCA:G	acceptor_loss	0.9700
13:21176909:CAGGC:C	acceptor_loss	0.9700
13:21176911:G:GT	acceptor_loss	0.9700
13:21176911:GGC:G	acceptor_gain	0.9700
13:21176715:CAG:C	donor_gain	0.9400
13:21176907:C:CA	acceptor_gain	0.9400
13:21176716:AG:A	donor_gain	0.9300
13:21176717:GG:G	donor_gain	0.9300
13:21176911:GGCA:G	acceptor_gain	0.9200
13:21176910:AG:A	acceptor_gain	0.8800
13:21176911:GG:G	acceptor_gain	0.8800
13:21176911:GGCAC:G	acceptor_gain	0.8300
13:21176914:ACCAT:A	acceptor_gain	0.7300
13:21176720:GAG:G	donor_loss	0.7200
13:21176715:C:T	donor_gain	0.7100
13:21176909:CA:C	acceptor_gain	0.6800
13:21176906:CCGCA:C	acceptor_gain	0.6700
13:21176908:GC:G	acceptor_gain	0.6600

AlphaMissense

668 scored. Top likely-pathogenic:

Variant	Protein change	am_pathogenicity
13:21177043:G:C	A43P	0.943
13:21176972:G:A	G19E	0.933
13:21177217:T:A	W101R	0.925
13:21177217:T:C	W101R	0.925
13:21176965:T:A	W17R	0.920
13:21176965:T:C	W17R	0.920
13:21177051:C:A	N45K	0.920
13:21177051:C:G	N45K	0.920
13:21176972:G:T	G19V	0.905
13:21176976:G:C	K20N	0.899
13:21176976:G:T	K20N	0.899
13:21177064:A:C	S50R	0.892
13:21177066:C:A	S50R	0.892
13:21177066:C:G	S50R	0.892
13:21176967:G:C	W17C	0.888
13:21176967:G:T	W17C	0.888
13:21177029:G:C	R38P	0.881
13:21176971:G:T	G19W	0.880
13:21177219:G:C	W101C	0.879
13:21177219:G:T	W101C	0.879
13:21177042:G:C	E42D	0.872
13:21177042:G:T	E42D	0.872
13:21176971:G:A	G19R	0.867
13:21176971:G:C	G19R	0.867
13:21177090:G:C	Q58H	0.855
13:21177090:G:T	Q58H	0.855
13:21177062:T:C	L49P	0.850
13:21177141:G:C	K75N	0.849
13:21177141:G:T	K75N	0.849
13:21177127:T:C	F71L	0.846

dbSNP variants (sampled 300 via entrez): RS1000055454 (13:21174738 A>T), RS1000835557 (13:21177917 C>T), RS1001108435 (13:21177333 C>G,T), RS1001287785 (13:21177699 G>A), RS1001517484 (13:21177331 G>C), RS1002275073 (13:21177030 C>G,T), RS1002551593 (13:21176318 G>A,T), RS1003227511 (13:21178635 ACATGGCGAAACCC>A), RS1004702542 (13:21178710 C>A,T), RS1005231739 (13:21176591 C>A,T), RS1005278643 (13:21174946 T>C), RS1005959117 (13:21178273 C>T), RS1006660465 (13:21176808 G>A,C), RS1006746976 (13:21179184 A>T), RS1007694154 (13:21175779 T>C)

Disease associations

OMIM: gene MIM:611997 | disease phenotypes:

GenCC curated gene-disease

Mondo (0):

Orphanet (0):

HPO phenotypes

0 total (0 of 0 shown, HPO-id order):

GWAS associations

2 associations (top):

Study	Trait	p-value
GCST002932_6	Manganese levels	6.000000e-06
GCST007672_17	3-month functional outcome in ischaemic stroke (modified Rankin score)	5.000000e-06

EFO canonical traits (1, from GWAS)

EFO ID	Trait name
EFO:0009603	stroke outcome severity measurement

Drugs & pharmacology

Drug and pharmacology data

Is drug target: no

PharmGKB: 1 entry (VIP=true, CPIC=false)

CTD chemical–gene interactions

28 total (human), top 28 by PubMed support.

Chemical	Actions (top 5)	PubMed papers
methylmercuric chloride	decreases expression	1
bisphenol A	increases expression	1
sodium arsenite	decreases expression	1
cyclic 3’,5’-uridine monophosphate	affects binding	1
di-n-butylphosphoric acid	affects expression	1
corosolic acid	decreases expression	1
K 7174	decreases expression	1
Resveratrol	affects cotreatment, increases expression	1
Arsenic Trioxide	increases expression	1
Coumestrol	increases expression	1
Doxorubicin	decreases expression	1
Ethyl Methanesulfonate	decreases expression	1
Gasoline	affects cotreatment, decreases expression, increases abundance	1
Methyl Methanesulfonate	decreases expression	1
Plant Extracts	affects cotreatment, increases expression	1
Polycyclic Aromatic Hydrocarbons	increases abundance, affects cotreatment, decreases expression	1
Ribonucleotides	affects binding	1
Smoke	decreases expression	1
Thiram	decreases expression	1
Urethane	decreases expression	1
Valproic Acid	increases expression	1
Vinblastine	affects response to substance	1
Paclitaxel	affects response to substance	1
Sodium Selenite	increases expression	1
Copper Sulfate	decreases expression	1
Topotecan	affects response to substance	1
Acrylamide	decreases expression	1
Particulate Matter	affects cotreatment, decreases expression, increases abundance	1

Clinical trials (associated diseases)

0 trials via MONDO — disease-level, not drug-specific.